Genes encoding insect odorant receptors and uses thereof

ABSTRACT

This invention provides an isolated nucleic acid molecule encoding an insect odorant receptor. This invention provides a nucleic acid molecule of at least 12 nucleotides capable of specifically hybridizing with the nucleic acid molecule encoding an insect odorant receptor. This invention also provides a purified, insect odorant receptor. This invention provides an antibody capable of specifically binding to an insect odorant receptor. This invention provides a method for identifying cDNA inserts encoding an insect odorant receptors. This invention provides a method of identifying a compound capable of specifically bind to an insect odorant receptor. This invention also provides a method of identifying a compound capable of activating the activity of an insect odorant receptor.

[0001] This application claims priority and is a continuation-in-partapplication of U.S. Ser. No. 09/257,706, filed Feb. 25, 1999, thecontents of which is hereby incorporated by reference.

[0002] The invention disclosed herein was made with Government supportunder NIH:NIMH, 5P50, MH50733-05 and the NINDS, NS29832-07 from theDepartment of Health and Human Services. Accordingly, the U.S.Government has certain rights in this invention.

[0003] Throughout this application, various publications are referred toby arabic numeral within parentheses. Full citations for thesepublications are presented immediately before the claims. Disclosures ofthese publications in their entireties are hereby incorporated byreference into this application in order to more fully describe thestate of the art to which this invention pertains.

BACKGROUND OF THE INVENTION

[0004] All animals possess a “nose,” an olfactory sense organ thatallows for the recognition and discrimination of chemosensoryinformation in the environment. Humans, for example, are thought torecognize over 10,000 discrete odors with exquisite discriminatory powersuch that subtle differences in chemical structure can often lead toprofound differences in perceived odor quality. What mechanisms haveevolved to allow the recognition and discrimination of complex olfactoryinformation and how is olfactory perception ultimately translated intoappropriate behavioral responses? The recognition of odors isaccomplished by odorant receptors that reside on olfactory cilia, aspecialization of the dendrite of the olfactory sensory neuron. Theodorant receptor genes encode novel serpentine receptors that traversethe membrane seven times. In several vertebrate species, and in theinvertebrate Caenorhabditis elegans, as many as 1000 genes encodeodorant receptors, suggesting that 1-5% of the coding potential of thegenome in these organisms is devoted to the recognition of olfactorysensory stimuli (Buck and Axel, 1991; Levy et al., 1991; Parmentier etal., 1992; Ben-Arie et al., 1994; Troemel et al., 1995; Sengupta et al.,1996; Robertson, 1998). Thus, unlike color vision in which threephotoreceptors can absorb light across the entire visible spectrum,these data suggest that a small number of odorant receptors areinsufficient to recognize the full spectrum of distinct molecularstructures perceived by the olfactory system. Rather, the olfactorysensory system employs an extremely large number of receptors, eachcapable of recognizing a small number of odorous ligands.

[0005] The discrimination of olfactory information requires that thebrain discern which of the numerous receptors have been activated by anodorant. In mammals, individual olfactory sensory neurons express onlyone of a thousand receptor genes such that the neurons are functionallydistinct (Ngai et al., 1993; Ressler et al., 1993; Vassar et al., 1993;Chess et al., 1994; Dulac and Axel, unpublished). The axons fromolfactory neurons expressing a specific receptor converge upon twospatially invariant glomeruli among the 1800 glomeruli within theolfactory bulb (Ressler et al., 1994; Vassar et al., 1994; Mombaerts etal., 1996; Wang et al., 1998). The bulb therefore provides a spatial mapthat identifies which of the numerous receptors has been activatedwithin the sensory epithelium. The quality of an olfactory stimuluswould therefore be encoded by specific combinations of glomeruliactivated by a given odorant.

[0006] The logic of olfactory discrimination is quite different in thenematode, C. elegans. Despite the large size of the odorant receptorgene family, volatile odorants are recognized by only three pairs ofchemosensory cells each likely to express a large number of receptorgenes (Bargmann and Horvitz, 1991; Colbert and Bargmann, 1995; Troemelet al., 1995). Activation of any one of the multiple receptors in onecell will lead to chemoattraction, whereas activation of receptors in asecond cell will result in chemorepulsion (Troemel et al., 1997). Thespecific neural circuit activated by a given sensory neuron is thereforethe determinant of the behavioral response. Thus, this invertebrateolfactory sensory system retains the ability to recognize a vast arrayof odorants but has only limited discriminatory power.

[0007] Vertebrates create an internal representation of the externalolfactory world that must translate stimulus features into neuralinformation. Despite the elucidation of a precise spatial map, it hasbeen difficult in vertebrates to discern how this information is decodedto relate the recognition of odors to specific behavioral responses.Genetic analysis of olfactory-driven behavior in invertebrates mayultimately afford a system to understand the mechanistic link betweenodor recognition and behavior. Insects provide an attractive modelsystem for studying the peripheral and central events in olfactionbecause they exhibit sophisticated olfactory-driven behaviors undercontrol of an olfactory sensory system that is significantly simpleranatomically than that of vertebrates (Siddiqi, 1987; Carlson, 1996).olfactory-based associative learning, for example, is robust in insectsand results in discernible modifications in the neural representation ofodors in the brain (Faber et al., 1998). It may therefore be possible toassociate modifications in defined olfactory connections with in vivoparadigms for learning and memory.

[0008] Olfactory recognition in the fruit fly Drosophila is accomplishedby sensory hairs distributed over the surface of the third antennalsegment and the maxillary palp. olfactory neurons within sensory hairssend projections to one of 43 glomeruli within the antennal lobe of thebrain (Stocker, 1994; Laissue et al, 1999). The glomeruli are innervatedby dendrites of the projection neurons, the insect equivalent of themitral cells in the vertebrate olfactory bulb, whose cell bodiessurround the glomeruli. These antennal lobe neurons in turn project tothe mushroom body and lateral horn of the protocerebrum (reviewed inStocker, 1994). 2-deoxyglucose mapping in the fruit fly (Rodrigues,1988) and calcium imaging in the honeybee (Joerges et al., 1997; Faberet al., 1998) demonstrate that different odorants elicit definedpatterns of glomerular activity, suggesting that in insects as invertebrates, a topographic map of odor quality is represented in theantennal lobe. However, in the absence of the genes encoding thereceptor molecules, it has not been possible to define a physical basisfor this spatial map.

[0009] In this study, we identify a large family of genes that arelikely to encode theodorant receptors of Drosophila melanogaster.Difference cloning, along with analysis of Drosophila genomic sequences,has led to the identification of a novel family of putative seventransmembrane domain receptors likely to be encoded by 100 to 200 geneswithin the Drosophila genome. Each receptor is expressed in a smallsubset of sensory cells (0.5-1.5%) that is spatially defined within theantenna and maxillary palp. Moreover, different neurons express distinctcomplements of receptor genes such that individual neurons arefunctionally distinct. Identification of a large family of putativeodorant receptors in insects indicates that, as in other species, thediversity and specificity of odor recognition is accommodated by a largefamily of receptor genes. The identification of the family of putativeodorant receptor genes may afford insight into the logic of olfactoryperception in Drosophila.

[0010] Insects provide an attractive system for the study of olfactorysensory perception. We have identified a novel family of seventransmembrane domain proteins, encoded by 100 to 200 genes, that islikely to represent the family of Drosophila odorant receptors. Membersof this gene family are expressed in topographically definedsubpopulations of olfactory sensory neurons in either the antenna or themaxillary palp. Sensory neurons express different complements ofreceptor genes, such that individual neurons are functionally distinct.The isolation of candidate odorant receptor genes along with a geneticanalysis of olfactory-driven behavior in insects may ultimately afford asystem to understand the mechanistic link between odor recognition andbehavior.

SUMMARY OF THE INVENTION

[0011] This invention provides an isolated nucleic acid moleculeencoding an insect odorant receptor. In an embodiment, the isolatednucleic acid molecule comprise: (a) one of the nucleic acid sequences asset forth in FIG. 8, (b) a sequence being degenerated to a sequence of(a) as a result of the genetic code; or (c) a sequence encoding one ofthe amino acid sequences as set forth in FIG. 8.

[0012] This invention provides a nucleic acid molecule of at least 12nucleotides capable of specifically hybridizing with the sequence of theabove-described nucleic acid molecule. This invention provides a vectorwhich comprises the above-described isolated nucleic acid molecule. Inanother embodiment, the vector is a plasmid.

[0013] This invention also provides a host vector system for theproduction of a polypeptide having the biological activity of an insectodorant receptor which comprises the above described vector and asuitable host.

[0014] This invention provides a method of producing a polypeptidehaving the biological activity of an insect odorant receptor whichcomprising growing the above described host vector system underconditions permitting production of the polypeptide and recovering thepolypeptide so produced.

[0015] This invention also provides a purified, insect odorant receptor.This invention further provides a polypeptide encoded by theabove-described isolated nucleic acid molecule.

[0016] This invention provides an antibody capable of specificallybinding to an insect odorant receptor. This invention also provides anantibody capable of competitively inhibiting the binding of the antibodycapable of specifically binding to an insect odorant receptor.

[0017] This invention provides a method for identifying cDNA insertsencoding an insect odorant receptors comprising: (a) generating a cDNAlibrary which contains clones carrying cDNA inserts from antennal ormaxillary palp sensory neurons; (b) hybridizing nucleic acid moleculesof the clones from the cDNA libraries generated in step (a) with probesprepared from the antenna or maxillary palp neurons and probes fromheads lacking antenna or maxillary palp neurons or from virgin femalebody tissue; (c) selecting clones which hybridized with probes from theantenna or maxillary palp neurons but not from head lacking antenna ormaxillary palp neurons or virgin female body tissue; and (d) isolatingclones which carry the hybridized inserts, thereby identifying theinserts encoding odorant receptors.

[0018] This invention also provides cDNA inserts identified by the abovemethod.

[0019] This invention further provides a method for identifying DNAinserts encoding an insect odorant receptors comprising: (a) generatingDNA libraries which contain clones carrying inserts from a sample whichcontains at least one antennal or maxillary palp neuron; (b) contactingclones from the cDNA libraries generated in step (a) with nucleic acidmolecule capable of specifically hybridizing with the sequence whichencodes an insect odorant receptor in appropriate conditions permittingthe hybridization of the nucleic acid molecules of the clones and thenucleic acid molecule; (c) selecting clones which hybridized with thenucleic acid molecule; and (d) isolating the clones which carry thehybridized inserts, thereby identifying the inserts encoding the odorantreceptors.

[0020] This invention also provides a method to identify DNA insertsencoding an insect odorant receptors comprising:

[0021] (a) generating DNA libraries which contain clones with insertsfrom a sample which contains at least one antenna or maxillary palpsensory neuron; (b) contacting the clones from the DNA librariesgenerated in step (a) with appropriate polymerase chain reaction primerscapable of specifically binding to nucleic acid molecules encodingodorant receptors in appropriate conditions permitting the amplificationof the hybridized inserts by polymerase chain reaction; (c) selectingthe amplified inserts; and (d) isolating the amplified inserts, therebyidentifying the inserts encoding the odorant receptors.

[0022] This invention also provides a method to isolate DNA moleculesencoding insect odorant receptors comprising:(a) contacting a biologicalsample known to contain nucleic acids with appropriate polymerase chainreaction primers capable of specifically binding to nucleic acidmolecules encoding insect odorant receptors in appropriate conditionspermitting the amplification of the hybridized molecules by polymerasechain reaction; (b) isolating the amplified molecules, therebyidentifying the DNA molecules encoding the insect odorant receptors.

[0023] This invention also provides a method of transforming cells whichcomprises transfecting a host cell with a suitable vector describedabove. This invention also provides transformed cells produced by theabove method.

[0024] This invention provides a method of identifying a compoundcapable of specifically bind to an insect odorant receptor whichcomprises contacting a transfected cells or membrane fractions of theabove described transfected cells with an appropriate amount of thecompound under conditions permitting binding of the compound to suchreceptor, detecting the presence of any such compound specifically boundto the receptor, and thereby determining whether the compoundspecifically binds to the receptor.

[0025] This invention provides a method of identifying a compoundcapable of specifically binding to an insect odorant receptor whichcomprises contacting an appropriate amount of the purified insectodorant receptor with an appropriate amount of the compound underconditions permitting binding of the compound to such purified receptor,detecting the presence of any such compound specifically bound to thereceptor, and thereby determining whether the compound specificallybinds to the receptor.

[0026] This invention also provides a method of identifying a compoundcapable of activating the activity of an insect odorant receptor whichcomprises contacting the transfected cells or membrane fractions of theabove-described transfected cells with the compound under conditionspermitting the activation of a functional odorant receptor response, theactivation of the receptor indicating that the compound is capable ofactivating the activity of a odorant receptor.

[0027] This invention also provides a method of identifying a compoundcapable of activating the activity of an odorant receptor whichcomprises contacting a purified insect odorant receptor with thecompound under conditions permitting the activation of a functionalodorant receptor response, the activation of the receptor indicatingthat the compound is capable of activating the activity of a odorantreceptor. In an embodiment, the purified receptor is embedded in a lipidbilayer.

[0028] This invention also provides a method of identifying a compoundcapable of inhibiting the activity of a odorant receptor which comprisescontacting the transfected cells or membrane fractions of theabove-described transfected cells with an appropriate amount of thecompound under conditions permitting the inhibition of a functionalodorant receptor response, the inhibition of the receptor responseindicating that the compound is capable of inhibiting the activity of aodorant receptor.

[0029] This invention provides a method of identifying a compoundcapable of inhibiting the activity of a odorant receptor which comprisescontacting an appropriate amount of the purified insect odorant receptorwith an appropriate amount of the compound under conditions permittingthe inhibition of a functional odorant receptor response, the inhibitionof the receptor response indicating that the compound is capable ofactivating the activity of a odorant receptor. In an embodiment, thepurified receptor is embedded in a lipid bilayer.

[0030] This invention also provides the compound identified by theabove-described methods.

[0031] This invention provides a method of controlling pest populationswhich comprises identifying odorant ligands by the above-describedmethod which are alarm odorant ligands and spraying the desired areawith the identified odorant ligands.

[0032] Finally, this invention provides a method of controlling a pestpopulation which comprises identifying odorant ligands by theabove-described method which interfere with the interaction between theodorant ligands and the odorant receptors which are associated withfertility.

BRIEF DESCRIPTION OF FIGURES

[0033]FIG. 1 Identification of Rare Antennal- and MaxillaryPalp-Specific Genes

[0034] Candidate antennal/maxillary palp-specific phage were subjectedto in vivo excision, digestion of resulting pBLUESCRIPT plasmid DNAswith BamHI/Asp718, and electrophoresis on 1.5% agarose gels. Southernblots were hybridized with ³²P-labeled cDNA probes generated fromantennal/maxillary palp mRNA (Panel A), head minus antennal/maxillarypalp mRNA (Panel B), or virgin female body mRNA (Panel C). The ethidiumbromide stained gel is shown in Panel D. Of the thirteen clonesdisplayed in this figure, four appear to be antennal/maxillary palpspecific (lanes 5, 7, 9, and 11). However, only two are selectivelyexpressed in subsets of cells in chemosensory organs of the adult fly.DOR104, a putative maxillary palp odorant receptor, is in Lane 9. Theclone in Lane 11 (RN106) is homologous to lipoprotein and triglyceridelipases and is expressed in a restricted domain in the antenna (data notshown).

[0035]FIG. 2 Expression of DOR104 in a Subset of Maxillary Palp Neurons

[0036] (A) A frontal section of an adult maxillary palp was hybridizedwith a digoxigenin-labeled antisense RNA probe and visualized withanti-digoxigenin conjugated to alkaline phosphatase. Seven cellsexpressing DOR104 are visible in this 15 μm section, which representsabout one third of the diameter of the maxillary palp. Serial sectionsof multiple maxillary palps were scored for DOR104 expression and onaverage 20 cells per maxillary palp are positive for this receptor.

[0037] (B) Transgenic flies carrying a DOR104-lacZ reporter transgenewere stained with X-GAL in a whole mount preparation. Maxillary palpswere dissected from the head and viewed in a flattened cover slippedpreparation under Nomarski optics, which allows the visualization of all20 cells expressing DOR104-lacZ.

[0038] (C) Dendrites and axons of neurons expressing DOR104-lacZ arevisible in this horizontal section of a maxillary palp. LacZ expressionwas visualized with a polyclonal anti-β-galactosidase primary antibodyand a CY3-conjugated secondary antibody. Sections were viewed underepifluorescence and photographed on black and white film.

[0039]FIG. 3 Predicted Amino Acid Sequences of Drosophila odorantReceptor Genes

[0040] Deduced amino acid sequences of 12 DOR genes are aligned usingClustalW (MacVector, Oxford Molecular). Predicted positions oftransmembrane regions (I-VII) are indicated by bars above the alignment.Amino acids identities are marked with dark shading and similarities areindicated with light shading. Protein sequences of DOR87, 53, 67, 104,and 64 were derived from cDNA clones. All others were derived fromGENSCAN predictions of intron-exon arrangements in genomic DNA, asindicated by the letter “g” after the gene name. We obtained a partialcDNA clone for DOR62 and found it to be 100% identical to the GENSCANprotein in the region of amino acids 245-381. A 40 amino acid extensionfor DOR 19 was predicted by GENSCAN analysis. This has been replacedwith an asterisk in the alignment, and isolation of cDNA clones for thisreceptor will resolve whether this extension is physically present inthe protein.

[0041]FIG. 4 Receptor Gene Expression in Spatially Restricted Regions ofthe Antenna Digoxigenin-labeled antisense RNA probes against 8 DOR geneseach hybridize to a small number of cells distributed in distinctregions in the antenna. The total number of cells per antenna expressinga given receptor was obtained by counting positive cells in serialsections of multiple antennae. There are approximately 20 positive cellsper antenna for DOR67 (A), 53 (B), and 24 (data not shown); 15 positivecells for DOR62 (C) and 87 (D); and 10 positive cells for DOR64 (E). Theactual number of cells staining in these sections is a subset of thistotal number. With the exception of DOR53 and DOR67, which stronglycross-hybridize, the receptor genes likely identify different olfactoryneurons, such that the number of cells staining with a mixed probe (F)is equal to the sum of those staining with the individual probes (A-E).The mixture of DOR53, 67, 62, 87 and 64 labels a total of about 60 cellsper antenna. A total of 34 cells stain with the mixed probe in this 15μm section. Expression of the linked genes DOR71, DOR72, and DOR73 isshown in panels (G), (H), and (I), respectively. DOR71 is expressed inapproximately 10 cells in the maxillary palp. Five positive cells areseen in the horizontal section in panel (G). We also examined theexpression of the other members of this linkage group and found DOR72 inapproximately 15 cells (of which 3 label in this section) (H) and DOR73in 1 to 2 cells per antenna (I).

[0042]FIG. 5 Odorant Receptors are Restricted to Distinct Populations ofOlfactory Neurons

[0043] (A-C) Flies of the C155 eIav-GAL4; UAS-lacZ genotype expresscytoplasmic lacZ in all neuronal cells. Panels (A-C) show confocalimages of a horizontal maxillary palp section from such a fly incubatedwith an antisense RNA probe against DOR104 (red) andanti-β-galactosidase antibody (green). DOR104 recognizes five cells inthis maxillary palp section (A), all of which also express elav-lacZ(B), as demonstrated by the yellow cells in the merged image in panel©).

[0044] (D, E) DOR64 and DOR87 are expressed in non-overlapping neuronsat the tip of the antenna. Antisense RNA probes for DOR64(digoxigenin-RNA; red) and DOR87 (FITC-RNA; green) were annealed to thesame antennal sections and viewed by confocal microscopy. Panel (D) is adigital superimposition of confocal images taken at 0.5 μm intervalsthrough a 10 μm section of the antenna. Cells at different focal planesexpress both receptors, but no double labeled cells are found.

[0045] (F, G) Two color RNA in situ hybridization with odorant receptorsand odorant binding proteins demonstrates that these proteins areexpressed in different populations of cells. DORS3 (FITC-RNA; green)labels a few cells internal to the cuticle at the proximal-medial edge,while PBPRP2 (digoxigenin-RNA; red) labels a large number of cellsapposed to the cuticle throughout the antenna (F). The more restrictedodorant binding protein OS-F (digoxigenin-RNA; red) also stains cellsdistinct from those expressing DOR67 (FITC-RNA; green) (G).

[0046]FIG. 6 Receptor Expression is Conserved Between Individuals

[0047] Frontal sections of antennae from six different individuals werehybridized with digoxigenin-labeled antisense RNA probes against DOR53(A-C) or DOR87 (D-F). DOR53 labels approximately 20 cells on theproximal-medial edge of the antenna, of which approximately 5 are shownlabeling in these sections. DOR87 is expressed in about the same numberof cells at the distal tip. Both the position and number of stainingcells is conserved between different individuals and is not sexuallydimorphic.

[0048]FIG. 7 Drosophila Odorant Receptors are Highly Divergent

[0049] Oregon R genomic DNA isolated from whole flies was digested withBamHI (B), EcoRI (E), or HindIII (H), electrophoresed on 0.8% agarosegels, and blotted to nitrocellulose membranes. Blots were annealed with³²P-labeled probes derived from DOR53 cDNA (A), DOR67 cDNA (B), or DNAfragments generated by RT-PCR from antennal mRNA for DOR 24 (C), DOR62(D), and DOR72 (E). Strong crosshybridization of DOR53 and DOR67 is seenat both high and low stringency (A, B), while DOR24, 62, and 72 revealonly a single hybridizing band in each lane at both low stringency (C-E)and high stringency (data not shown).

[0050]FIG. 8 DOR 62, 104, 87, 53, 67, 64, 71g, 72g, 73g, 46, 19g, and24g

[0051] Both nucleic acid sequence of each DOR and its encoded amino acidsequence are described.

[0052]FIG. 9 Analysis of axonal projections of olfactory receptorneurons expressing a given Drosophila odorant receptor. Result: allneurons expressing a given receptor send their axons to a singleglomerulus, or discrete synaptic structure, in the olfactory processingcenter of the fly brain. This result is identical to that obtained withmouse odorant receptors: each glomerulus is dedicated to receivingaxonal input from neurons expressing a given odorant receptor.Therefore, this result strengthens the argument that these genes indeedfunction as odorant receptors in Drosophila.

[0053]FIG. 10 ClustalW alignments of two subfamilies of the Drosophilaodorant receptors, the DOR53 (A-1 and A-2) and DOR64 (B) families. Thisfigure highlights sequence similarities between DOR genes, that arediagnostic hallmarks of the proteins. Residues that are identical indifferent DOR genes are highlighted in black, while residues that aresimilar are highlighted in gray.

DETAILED DESCRIPTION OF THE INVENTION

[0054] In order to facilitate an understanding of the ExperimentalProcedures section which follow, certain frequently occurring methodsand/or terms are described in Sambrook, et al. (1989).

[0055] Throughout this application, the following standard abbreviationsare used throughout the specification to indicate specific nucleotides:

[0056] C=cytosine A=adenosine

[0057] T=thymidine G=guanosine

[0058] This invention provides an isolated nucleic acid moleculeencoding an insect odorant receptor. The nucleic acid includes but isnot limited to DNA, cDNA, genomic DNA, synthetic DNA or RNA. In anembodiment, the nucleic acid molecule encodes a Drosophila odorantreceptor.

[0059] In a further embodiment, the isolated nucleic acid moleculecomprise: (a) one of the nucleic acid sequences as set forth in FIG. 8,(b) a sequence being degenerated to a sequence of (a) as a result of thegenetic code; or (c) a sequence encoding one of the amino acid sequencesas set forth in FIG. 8.

[0060] The nucleic acid molecules encoding a insect receptor includesmolecules coding for polypeptide analogs, fragments or derivatives ofantigenic polypeptides which differ from naturally-occurring forms interms of the identity or location of one or more amino acid residues(deletion analogs containing less than all of the residues specified forthe protein, substitution analogs wherein one or more residues specifiedare replaced by other residues and addition analogs where in one or moreamino acid residues is added to a terminal or medial portion of thepolypeptides) and which share some or all properties ofnaturally-occurring forms. These molecules include but not limited to:the incorporation of codons “preferred” for expression by selectednon-mammalian hosts; the provision of sites for cleavage by restrictionendonuclease enzymes; and the provision of additional initial, terminalor intermediate sequences that facilitate construction of readilyexpressed vectors. Accordingly, these changes may result in a modifiedinsect odorant receptor. It is the intent of this invention to includenucleic acid molecules which encodes modified insect odorant receptor.Also, to facilitate the expression of receptor in different host cells,it may be necessary to modify the molecule such that the expressedreceptors may reach the surface of the host cells. The modified insectodorant receptor should have biological activities similar to theunmodified insect odorant receptor. The molecules may also be modifiedto increase the biological activity of the expressed receptor.

[0061] This invention provides a nucleic acid molecule of at least 12nucleotides capable of specifically hybridizing with the sequence of theabove-described nucleic acid molecule. In an embodiment, the nucleicacid molecule hybridizes with a unique sequence within the sequence ofthe above-described nucleic acid molecule. This nucleic acid moleculemay be DNA, cDNA, genomic DNA, synthetic DNA or RNA.

[0062] This invention provides a vector which comprises theabove-described isolated nucleic acid molecule. In another embodiment,the vector is a plasmid.

[0063] In an embodiment, the above described isolated nucleic acidmolecule is operatively linked to a regulatory element.

[0064] Regulatory elements required for expression include promotersequences to bind RNA polymerase and transcription initiation sequencesfor ribosome binding. For example, a bacterial expression vectorincludes a promoter such as the lac promoter and for transcriptioninitiation the Shine-Dalgarno sequence and the start codon AUG.Similarly, a eukaryotic expression vector includes a heterologous orhomologous promoter for RNA polymerase II, a downstream polyadenylationsignal, the start codon AUG, and a termination codon for detachment ofthe ribosome. Such vectors may be obtained commercially or assembledfrom the sequences described by methods well-known in the art, forexample the methods described above for constructing vectors in general.

[0065] This invention also provides a host vector system for theproduction of a polypeptide having the biological activity of an insectodorant receptor which comprises the above described vector and asuitable host.

[0066] This invention also provides a host vector system, wherein thesuitable host is a bacterial cell, yeast cell, insect cell, or animalcell. The host cell of the above expression system may be selected fromthe group consisting of the cells where the protein of interest isnormally expressed, or foreign cells such as bacterial cells (such as E.coli), yeast cells, fungal cells, insect cells, nematode cells, plant oranimal cells, where the protein of interest is not normally expressed.Suitable animal cells include, but are not limited to Vero cells, HeLacells, Cos cells, CV1 cells and various primary mammalian cells.

[0067] This invention provides a method of producing a polypeptidehaving the biological activity of an insect odorant receptor whichcomprising growing the above described host vector system underconditions permitting production of the polypeptide and recovering thepolypeptide so produced.

[0068] This invention also provides a purified, insect odorant receptor.This invention further provides a polypeptide encoded by theabove-described isolated nucleic acid molecule.

[0069] This invention provides an antibody capable of specificallybinding to an insect odorant receptor. This invention also provides anantibody capable of competitively inhibiting the binding of the antibodycapable of specifically binding to an insect odorant receptor. In anembodiment, the antibody is monoclonal. In another embodiment, theantibody is polyclonal.

[0070] Monoclonal antibody directed to an insect odorant receptor maycomprise, for example, a monoclonal antibody directed to an epitope ofan insect odorant receptor present on the surface of a cell. Amino acidsequences may be analyzed by methods well known to those skilled in theart to determine whether they produce hydrophobic or hydrophilic regionsin the proteins which they build. In the case of cell membrane proteins,hydrophobic regions are well known to form the part of the protein thatis inserted into the lipid bilayer which forms the cell membrane, whilehydrophilic regions are located on the cell surface, in an aqueousenvironment.

[0071] Antibodies directed to an insect odorant receptor may beserum-derived or monoclonal and are prepared using methods well known inthe art. For example, monoclonal antibodies are prepared using hybridomatechnology by fusing antibody producing B cells from immunized animalswith myeloma cells and selecting the resulting hybridoma cell lineproducing the desired antibody. Cells such as NIH3T3 cells or 293 cellswhich express the receptor may be used as immunogens to raise such anantibody. Alternatively, synthetic peptides may be prepared usingcommercially available machines.

[0072] As a still further alternative, DNA, such as a cDNA or a fragmentthereof, encoding the receptor or a portion of the receptor may becloned and expressed. The expressed polypeptide recovered and used as animmunogen.

[0073] The resulting antibodies are useful to detect the presence ofinsect odorant receptors or to inhibit the function of the receptor inliving animals, in humans, or in biological tissues or fluids isolatedfrom animals or humans.

[0074] This antibodies may also be useful for identifying or isolatingother insect odorant receptors. For example, antibodies against theDrosophila odorant receptor may be used to screen an cockroachexpression library for a cockroach odorant receptor. Such antibodies maybe monoclonal or monospecific polyclonal antibody against a selectedinsect odorant receptor. Different insect expression libraries arereadily available and may be made using technologies well-known in theart.

[0075] One means of isolating a nucleic acid molecule which encodes aninsect odorant receptor is to probe a libraries with a natural orartificially designed probes, using methods well known in the art. Theprobes may be DNA or RNA. The library may be cDNA or genomic DNA.

[0076] This invention provides a method for identifying cDNA insertsencoding an insect odorant receptors comprising: (a) generating a cDNAlibrary which contains clones carrying cDNA inserts from antennal ormaxillary palp sensory neurons; (b) hybridizing nucleic acid moleculesof the clones from the cDNA libraries generated in step (a) with probesprepared from the antenna or maxillary palp neurons and probes fromheads lacking antenna or maxillary palp neurons or from virgin femalebody tissue; (c) selecting clones which hybridized with probes from theantenna or maxillary palp neurons but not from head lacking antenna ormaxillary palp neurons or virgin female body tissue; and (d) isolatingclones which carry the hybridized inserts, thereby identifying theinserts encoding odorant receptors.

[0077] In an embodiment of the above method, after step (c), it furthercomprises: (a) amplifying the inserts from the selected clones bypolymerase chain reaction; (b) hybridizing the amplified inserts withprobes from the antennal or maxillary palp neurons; and (c) isolatingthe clones which carry the hybridized inserts, thereby identifying theinserts encoding the odorant receptors.

[0078] In an embodiment, the probes are cDNA probes.

[0079] The appropriate polymerase chain reaction primers may be chosenfrom the conserved regions of the known insect odorant receptorsequences. Alternatively, the primers may be chosen from the regionswhich are the active sites for the binding of ligands.

[0080] This invention also provides cDNA inserts identified by the abovemethod.

[0081] This invention further provides a method for identifying DNAinserts encoding an insect odorant receptors comprising: (a) generatingDNA libraries which contain clones carrying inserts from a sample whichcontains at least one antennal or maxillary palp neuron; (b) contactingclones from the cDNA libraries generated in step (a) with nucleic acidmolecule capable of specifically hybridizing with the sequence whichencodes an insect odorant receptor in appropriate conditions permittingthe hybridization of the nucleic acid molecules of the clones and thenucleic acid molecule; (c) selecting clones which hybridized with thenucleic acid molecule; and (d) isolating the clones which carry thehybridized inserts, thereby identifying the inserts encoding the odorantreceptors.

[0082] This invention also provides a method to identify DNA insertsencoding an insect odorant receptors comprising: (a) generating DNAlibraries which contain clones with inserts from a sample which containsat least one antenna or maxillary palp sensory neuron; (b) contactingthe clones from the DNA libraries generated in step (a) with appropriatepolymerase chain reaction primers capable of specifically binding tonucleic acid molecules encoding odorant receptors in appropriateconditions permitting the amplification of the hybridized inserts bypolymerase chain reaction; (c) selecting the amplified inserts; and (d)isolating the amplified inserts, thereby identifying the insertsencoding the odorant receptors.

[0083] This invention also provides a method to isolate DNA moleculesencoding insect odorant receptors comprising:(a) contacting a biologicalsample known to contain nucleic acids with appropriate polymerase chainreaction primers capable of specifically binding to nucleic acidmolecules encoding insect odorant receptors in appropriate conditionspermitting the amplification of the hybridized molecules by polymerasechain reaction; (b) isolating the amplified molecules, therebyidentifying the DNA molecules encoding the insect odorant receptors.

[0084] This invention also provides a method of transforming cells whichcomprises transfecting a host cell with a suitable vector describedabove.

[0085] This invention also provides transformed cells produced by theabove method. In an embodiment, the host cells are not usuallyexpressing odorant receptors. In another embodiment, the host cells areexpressing odorant receptors.

[0086] This invention provides a method of identifying a compoundcapable of specifically binding to an insect odorant receptor whichcomprises contacting a transfected cells or membrane fractions of theabove described transfected cells with an appropriate amount of thecompound under conditions permitting binding of the compound to suchreceptor, detecting the presence of any such compound specifically boundto the receptor, and thereby determining whether the compoundspecifically binds to the receptor.

[0087] This invention provides a method of identifying a compoundcapable of specifically bind to an insect odorant receptor whichcomprises contacting an appropriate amount of the purified insectodorant receptor with an-appropriate amount of the compound underconditions permitting binding of the compound to such purified receptor,detecting the presence of any such compound specifically bound to thereceptor, and thereby determining whether the compound specificallybinds to the receptor. In an embodiment, the purified receptor isembedded in a lipid bilayer. The purified receptor may be embedded inthe liposomes with proper orientation to carry out normal functions.Liposome technology is well-known in the art.

[0088] This invention also provides a method of identifying a compoundcapable of activating the activity of an insect odorant receptor whichcomprises contacting the transfected cells or membrane fractions of theabove-described transfected cells with the compound under conditionspermitting the activation of a functional odorant receptor response, theactivation of the receptor indicating that the compound is capable ofactivating the activity of a odorant receptor.

[0089] This invention also provides a method of identifying a compoundcapable of activating the activity of an odorant receptor whichcomprises contacting a purified insect odorant receptor with thecompound under conditions permitting the activation of a functionalodorant receptor response, the activation of the receptor indicatingthat the compound is capable of activating the activity of a odorantreceptor. In an embodiment, the purified receptor is embedded in a lipidbilayer.

[0090] This invention also provides a method of identifying a compoundcapable of inhibiting the activity of a odorant receptor which comprisescontacting the transfected cells or membrane fractions of theabove-described transfected cells with an appropriate amount of thecompound under conditions permitting the inhibition of a functionalodorant receptor response, the inhibition of the receptor responseindicating that the compound is capable of inhibiting the activity of aodorant receptor.

[0091] This invention provides a method of identifying a compoundcapable of inhibiting the activity of a odorant receptor which comprisescontacting an appropriate amount of the purified insect odorant receptorwith an appropriated amount of the compound under conditions permittingthe inhibition of a functional odorant receptor response, the inhibitionof the receptor response indicating that the compound is capable ofactivating the activity of a odorant receptor. In an embodiment, thepurified receptor is embedded in a lipid bilayer.

[0092] In a separate embodiment of the above method, the compound is notpreviously known. This invention also provides the compound identifiedby the above-described methods.

[0093] This invention provides a method of controlling pest populationswhich comprises identifying odorant ligands by the above-describedmethod which are alarm odorant ligands and spraying the desired areawith the identified odorant ligands.

[0094] Finally, this invention provides a method of controlling a pestpopulation which comprises identifying odorant ligands by theabove-described method which interfere with the interaction between theodorant ligands and the odorant receptors which are associated withfertility.

[0095] This invention will be better understood from the ExperimentalProcedures which follow. However, one skilled in the art will readilyappreciate that the specific methods and results discussed are merelyillustrative of the invention as described more fully in the claimswhich follow thereafter.

[0096] Experimental Procedures

[0097] Experimental Animals

[0098] Oregon R flies (Drosophila melanogaster) were raised on standardcornmeal-agar-molasses medium at 25° C. Transgenic constructs wereinjected into yw embryos. CISS elav-GAL4 flies were obtained from CoreyGoodman (Lin and Goodman, 1994) and Gary Struhl provided the UAS-(cytoplasmic) lacZ stock.

[0099] Preparation and Differential Screening of a DrosophilaAntennal/Maxillary Palp cDNA Library

[0100] Drosophila antennae and maxillary palps were obtained by manuallydecapitating and freezing 5000 adult flies and shaking antennae andmaxillary palps through a fine metal sieve. mRNA was prepared using apolyA+ RNA Purification Kit (Stratagene). An antennal/maxillary palpcDNA library was made from 0.5 μg mRNA using the LambdaZAPIIXR kit fromStratagene.

[0101] Briefly, phage were plated at low density (500-1000 pfu/150 mmplate) and UV-crosslinked after lifting in triplicate to Hybond-N+(Amersham). Complex probes were generated by random primed labeling(PrimeItII, Stratagene) of reverse transcribed mRNA (RT-PCR kit,Stratagene) from virgin adult female body mRNA and duplicate liftshybridized at high stringency for 36 hours (65° C. in 0.5M SodiumPhosphate buffer [pH7.3] containing 1% bovine serum albumin, 4% SDS, and0.5 mg/ml herring sperm DNA). We prescreened the third lift with a mixof all previously cloned OBPs/PBPs (McKenna et al., 1994; Pikielny etal., 1994; Kim et al., 1998) remove a source of abundant but undesiredolfactory-specific clones. Approximately 5000 individual OBP/PBP andvirgin female body negative phage clones were isolated, their insertsamplified by PCR with T3 and T7 primers, and approximately 3 μg of DNAwere electrophoresed on 1.5% agarose gels. Gels were blotted induplicate to Hybond-N+ (Amersham), filters were UV-crosslinked, and theresulting Southern blots were subjected to reverse Northern analysisusing complex probes generated from virgin female body mRNA.Approximately 500 clones not hybridizing with virgin female body probeswere identified and consolidated onto secondary Southern blots intriplicate. These blots were probed with complex probes derived fromantennal/maxillary palp, head-minus-antenna/maxillary palp, and virginfemale body mRNA. A total of 210 clones negative withhead-minus-antenna/maxillary palp and virgin female body probes andstrongly positive, weakly positive, or negative with antennal/maxillarypalp probes were further analyzed by sequencing and in situhybridization.

[0102] Analysis of Drosophila Genome Project Sequences for TransmembraneProteins

[0103] All Drosophila genomic sequences were batch downloaded in April1998 from the Berkeley Drosophila Genome Project (Berkeley DrosophilaGenome Project, unpublished). Genomic P1 sequences were first analyzedwith the GENSCAN program (Burge and Karlin, 1997;http://CcR-081.mit.edu/GENSCAN.html), which predicts intron-exonstructures and generates hypothetical coding sequences (CDS) and openreading frames. GENSCAN predicted proteins shorter than 50 amino acidswere discarded. The remaining open reading frames were used to searchfor putative transmembrane regions greater than 15 amino acids with twoprograms that were obtained from the authors and used in stand-alonemode locally (see Persson and Argos, 1994; Cserzo et al., 1997). TheDense Surface Alignment (DAS) program is available athttp://www.biokemi.su.se/^(˜) server/DAS/ or from M. Cserzo(miklos@pugh.bip.bham.ac.uk). TMAP is available atftp://ftp.ebi.ac.uk/pub/software/unix/, or by contacting the author,Bengt Persson (bpn@mbb.ki.se). Scripts were written to apply the DAS andTMAP programs repeatedly to genome scale sequence sets. Genes showingsignificant sequence similarity to the NCBI non-redundant proteindatabase using BLAST analysis (Altschul et al., 1990; Altschul et al.,1997) were eliminated. All scripts required for these computations werewritten in standard ANSI C and run on a SUN Enterprise 3000.

[0104] Of 229 novel Drosophila proteins with three or more predictedtransmembrane spanning regions, 35 showed no clear sequence similarityto any known protein and were selected for further analysis by in situhybridization. Probes for in situ hybridization were generated by RT-PCRusing antennal/maxillary palp mRNA as a template.

[0105] Map positions of DOR Genes

[0106] The chromosome position of DOR104 was determined by in situhybridization of a biotin-labeled probe to salivary gland polytenechromosome squashes as described (Amrein et al., 1988).

[0107] Chromosomal positions of all other DOR genes were eased onchromosome assignments of the P1 clones to which they map, as determinedby the Berkeley Drosophila Genome Project (personal communication;http://www.fruitfly.org; see also Hartl et al., 1994; Kimmerly et al.,1996). DOR62 maps to a cosmid sequenced by the European DrosophilaGenome Project (unpublished; http://edgp.ebi.ac.uk/; Siden-Kiamos etal., 1990). RECEPTOR MAP POSITION P1 CLONE ACCESSION NUMBER DOR62 (X) 2F62D9 (EDGP cosmid) DOR67 (2L) 22A3 DS00676 DOR53 (2L) 22A2-3 DS05342DOR64 (2L) 23A1-2 DS06400 DOR72 (2L) 33B1-2 DS07071 DOR72 (2L) 33B1-2DS07071 DOR73 (2L) 33B1-2 DS07071 DOR87 (2R) 43B1-2 DS08779 DOR19 (2R)46F5-6 DS01913 DOR24 (2R) 47D6-E2 DS00724 DOR46 (2R) 59D5-7 DS07462DOR104 (3L) 85B not applicable

[0108] The Isolation of DOR cDNA Clones and Southern Blotting

[0109] We screened 3×10⁶ clones of the antennal/maxillary palp librarydescribed above with PCR probes for the genes DOR87, DOR53, DOR67,DOR64, and DOR62. cDNAs were present at a frequency ranging from1:200,000 (DOR67) to 1:1,000,000 (DOR62) in the library and theirsequences were remarkably similar to the hypothetical CDS predicted bythe GENSCAN program. The frequency of these genes is similar to that ofDOR104, which is present at 1:125,000 in the antennal/maxillary palplibrary. All sequencing was with ABI cycle sequencing kits and reactionswere run on an ABI 310 or 377 sequencing system.

[0110] Five μg of Oregon R genomic DNA isolated from whole flies weredigested with BamHI, EcoRI, or HindIII, electrophoresed on 0.8% agarosegels, and blotted to Nitropure nitrocellulose membranes (MicronSeparations Inc.). Blots were baked and annealed with ³²P-labeled probesderived from cDNA probes of DORS3 and DOR67, or PCR fragments fromDOR24, DOR62, and DOR72. Hybridization was at 42° C. for 36 hours in 5×SSCP, 10× Denhardts, 500 μg/ml herring sperm DNA, and either 50% (highstringency) or 25% (low stringency) formamide (Sambrook et al., 1989).Blots were washed for 1 hour in 0.2× SSC, 0.5% SDS at 65° C. (highstringency) or 1× SSC, 0.5% SDS at 42° C. (low stringency).

[0111] In situ Hybridization

[0112] RNA in situ hybridization was carried out essentially asdescribed (Schaeren-Wiemers and Gerfin-Moser, 1993). This protocol wasmodified to include detergents in most steps to increase sensitivity andreduce background. The hybridization buffer contained 50% formamide, 5×SSC, 5× Denhardts, 250 μg/ml yeast tRNA, 500 μg/ml herring sperm DNA, 50μg/ml Heparin, 2.5 mM EDTA, 0.1% Tween-20, 0.25% CHAPS. All antibodysteps were in the presence of 0.1% Triton X-100, and the reaction wasdeveloped in buffer containing 0.1% Tween-20. Slides were mounted inGlycergel (DAKO) and viewed with Nomarski optics.

[0113] Fluorescent in situ hybridization was carried out as above witheither digoxigenin or FITC labeled RNA probes. The digoxigenin probe wasvisualized with sheep anti-digoxigenin (Boehringer) followed by donkeyanti-sheep CY3 (Jackson). FITC probes were visualized with mouseanti-FITC (Boehringer) and goat anti-mouse Alexa 488 (Molecular Probes)following preincubation with normal goat serum. Sections were mounted invectashield reagent (Vector Labs) and viewed on a Biorad 1024 ConfocalMicroscope.

[0114] For double labeling with a neural marker, animals of the genotypeC155 elav-Gal4; UAS-lacZ were sectioned and first hybridized with adigoxigenin labeled antisense DOR104 RNA probe and developed asdescribed above. Neuron-specific expression of lacZ driven by theelav-Gal4 enhancer trap was visualized with a polyclonal rabbitanti-β-galactosidase antibody (Organon-Technika/Cappel), visualized by agoat anti-rabbit Alexa488 conjugated secondary antibody (MolecularProbes) following preincubation with normal goat serum.

[0115] The proportion of neurons in the third antennal segment wascalculated by comparing the number of nuclei staining with the 44C11ELAV monoclonal (kindly provided by Lily Jan) and those staining withTOTO-3 (Molecular Probes), a nucleic acid counterstain, in severalconfocal sections of multiple antennae. On average, 36% of the nuclei inthe antenna were ELAV positive.

[0116] DOR104-lacZ Transaene Construction and Histochemical Staining

[0117] A genomic clone containing the DOR104 coding region and severalkb of upstream sequence was isolated from a genomic library preparedfrom flies isogenic for the third chromosome (a gift of Kevin Moses andGerry Rubin). Approximately 3 kb of DNA immediately upstream of theputative translation start site of DOR104 were isolated by PCR andsubcloned into the pCasperAUGβGal vector (Thummel et al., 1988).β-galactosidase activity staining was carried out with whole mount headpreparations essentially as described in Wang et al. (1998). Frozensections of DOR104-lacZ maxillary palps were incubated with a polyclonalrabbit anti-β-galactosidase antibody and as described above.

[0118] Experimental Results

[0119] Cloning Candidate Odorant Receptors

[0120] In initial experiments, we isolated a cDNA encoding a putativeodorant receptor by a difference cloning strategy designed to detectcDNA copies of mRNA present at extremely low frequencies in an mRNApopulation. In the antenna and maxillary palp, about 30% of the cellsare olfactory neurons. If each neuron expressed only one of a possible100 different odorant receptor genes at a level of 0.1% of the mRNA in asensory neuron, then a given receptor mRNA would be encountered at afrequency of one in 300,000 in antennal mRNA. If 100 different receptorgenes were expressed, then the entire family of receptor genes would berepresented at a frequency of one in 3,000 mRNAs. We thereforeintroduced experimental modifications into standard difference cloningto allow for the identification of extremely rare mRNAs whose expressionis restricted to either the antenna or the maxillary palp.

[0121] Briefly, 5000 insets from an antennal/maxillary palp cDNA librarywere prescreened (see Experimental Procedures) and then subjected toSouthern blot hybridization with cDNA probes from antennal/maxillarypalp, head minus antenna/maxillary palp, or virgin female body mRNA (seeFIG. 1). This Southern blot hybridization (or reverse Northern) tocandidate cDNAs allows for the detection of sequences present at afrequency of 1 in 100,000 in the probe, a sensitivity about onehundred-fold greater than that of plaque screening (see ExperimentalProcedures). This procedure led to the identification of multipleantennal/maxillary palp-specific cDNAs that were analyzed by DNAsequencing and in situ hybridization. One cDNA, DOR104 (for DrosophilaOdorant Receptor) (FIG. 1, Lane 9), encodes a putativeseven-transmembrane domain protein with no obvious sequence similarityto known serpentine receptors (FIG. 3). In situ hybridization revealedthat this cDNA anneals to about 15% of the 120 sensory neurons withinthe maxillary palp but does not anneal with neurons in either the brainor antenna. Seven cells expressing DOR104 are shown in the frontalmaxillary palp section in FIG. 2A.

[0122] These observations suggested that DOR104 might be one member of alarger family of odorant receptor genes within the Drosophila genome.However, we were unable to identify additional genes homologous toDOR104 by low stringency hybridization to genomic DNA and cDNA librariesor upon analysis of linked genes in a genomic walk. We thereforeanalyzed the Drosophila genome database for families of multipletransmembrane domain proteins that share sequence similarity withDOR104. Sequences representing about 10% of the Drosophila genome weredownloaded (Berkeley Drosophila Genome Project) and subjected to GENSCANanalysis (Burge and Karlin, 1997) to predict the intron-exon structureof all sequences within the database. Open reading frames greater than50 amino acids were searched for proteins with three or more predictedtransmembrane-spanning regions using the dense alignment surface (DAS)and TMAP algorithms (Persson and Argos, 1994; Cserzo et al., 1997; alsosee Experimental Procedures). Of 229 candidate genes identified in thismanner, 11 encoded proteins that define a novel divergent family ofpresumed seven transmembrane domain proteins with sequence similarity tothe DOR104 sequence. This family of candidate odorant receptors does notshare any conserved sequence motifs with previously identified familiesof seven transmembrane domain receptors. cDNA clones containing thecoding regions for 5 of the 11 genes identified by GENSCAN analysis havebeen isolated from an antennal/maxillary palp cDNA library and theirsequences are provided in FIG. 3. The remaining 6 protein sequencesderive from GENSCAN predictions for intron-exon arrangement. Theirorganization conforms well to the actual structure determined from thecDNA sequences of other members of the gene family (FIG. 3).

[0123] The receptors consist of a short extracellular N-terminal domain(usually less than 50 amino acids) and seven presumed membrane-spanningdomains. Analysis of presumed transmembrane domains (Kyte and Doolittle,1982; Persson and Argos, 1994; Cserzo et al., 1997) reveals multiplehydrophobic segments, but it is not possible from this analysis tounequivocally determine either the number or placement of the membranespanning domains. At present, our assignment of transmembrane domains istherefore tentative.

[0124] The individual family members are divergent and most exhibit from17-26% amino acid identity. Two linked clusters of receptor genesconstitute small subfamilies of genes with significantly greatersequence conservation. Two linked genes, DOR53 and DOR67, exhibit 76%amino acid identity, whereas the three linked genes, DOR71, 72 and 73,reveal 30-55% identity (FIG. 3; see below). Despite the divergence, eachof the genes shares short, common motifs in fixed positions within theputative seven transmembrane domain structure that define thesesequences as highly divergent members of a novel family of putativereceptor molecules.

[0125] Expression of the DOR Gene Family in Olfactory Neurons

[0126] If this gene family encodes putative odorant receptors in thefly, we might expect that other members of the family in addition toDOR104 would also be expressed in olfactory sensory neurons. Wetherefore performed in situ hybridization to examine the pattern ofreceptor expression of each of the 11 additional members of the genefamily in adult and developing organisms. In Drosophila, olfactorysensory neurons are restricted to the maxillary palp and third antennalsegment. The third antennal segment is covered with approximately 500fine sensory bristles or sensilla (Stocker, 1994), each containing fromone to four neurons (Venkatesh and Singh, 1984). The maxillary palp iscovered with approximately 60 sensilla, each of which is innervated bytwo or three neurons (Singh and Nayak, 1985). Thus, the third antennalsegment and maxillary palp contain about 1500 and 120 sensory neurons,respectively.

[0127] RNA in situ hybridization experiments were performed withdigoxigenin-labeled RNA antisense probes to each of the 11 new membersof the gene family under conditions of high stringency. One linked pairof homologous genes, DOR53 and DOR67, crosshybridizes, whereas theremaining 10 genes exhibit no crosshybridization under these conditions(see below). Eight of the 11 genes hybridize to a small subpopulation(0.5-1.5%) of the 1500 olfactory sensory neurons in the third antennalsegment (FIG. 4). One gene, DOR71, is expressed in about 10% of thesensory neurons in the maxillary palp but not in the antenna (FIG. 4G).We have not detected expression of DOR46 or DOR19 in the antenna or themaxillary palp. Expression of this gene family is only observed in cellswithin the antenna and maxillary palp. No hybridization was observed inneurons of the brain, nor was hybridization observed in any sectionselsewhere in the adult fly or in any tissue at any stage duringembryonic development. However, we do find hybridization to a smallnumber of cells in the developing antennae in the late pupal stage (datanot shown). We have not yet determined whether this family of receptorsis expressed in the larval olfactory apparatus.

[0128] Only about one third of the cells in the third antennal segmentand the maxillary palp are neurons (data not shown), which areinterspersed with non-neuronal sensillar support cells and glia. We haveperformed two experiments to demonstrate that the family of seventransmembrane domain receptor genes is expressed in sensory neuronsrather than support cells or glia within the antenna and maxillary palp.First, we developed two-color fluorescent antibody detection schemes toco-localize receptor expression in cells that express theneuron-specific RNA binding protein, ELAV (Robinow and White, 1988). Anenhancer trap line carrying an insertion of GAL4 at the elav locusexpresses high levels of lacZ in neurons when crossed to a transgenicUAS-lacZ responder line (Lin and Goodman, 1994). Fluorescent antibodydetection of lacZ identifies the sensory neurons in a horizontal sectionof the maxillary palp (FIG. 5B). Hybridization with the receptor probeDOR104 reveals expression in 5 of the 12 lacZ positive cells in ahorizontal section of the maxillary palp (FIG. 5A). All cells thatexpress DOR104 are also positive for lacZ (FIG. 5C), indicating thatthis receptor is expressed only in neurons.

[0129] In a second experiment we have demonstrated that the receptorgenes are not expressed in non-neuronal cells. The support cells of theantenna express different members of a family of odorant bindingproteins (McKenna et al., 1994; Pikielny et al., 1994; Kim et al.,1998). These genes encode abundant low molecular weight proteins thoughtto transport odorants through the sensillar lymph (reviewed in Pelosi,1994). Two-color in situ experiments with a probe for the odorantbinding protein, PBPRP2 (Pikielny et al., 1994), reveal hybridization toa large number of cells broadly distributed throughout the antenna (FIG.5F). In the same section, however, the probe DOR53 anneals to anon-overlapping subpopulation of neurons restricted to themedial-proximal domain of the antenna. In a similar experiment, in situhybridization with the odorant binding protein, OS-F (McKenna et al.,1994), identifies a spatially restricted subpopulation of support cellsin the antenna, whereas the DOR67 probe identifies a distinctsubpopulation of neurons in a medial-proximal domain (FIG. 5G). Thus,the putative odorant receptor genes are expressed in a subpopulation ofsensory neurons distinct from the support cells that express the odorantbinding proteins. Taken together, these data demonstrate that 10 of the12 family members we have identified are expressed in smallsubpopulations of olfactory sensory neurons in the antenna and maxillarypalp.

[0130] Spatially Defined Patterns of Receptor Expression

[0131] The in situ hybridization experiments reveal that each receptoris expressed in a spatially restricted subpopulation of neurons in theantenna or maxillary palp (FIG. 4). The total number of cells expressingeach receptor per antenna was obtained by counting the positive cells inserial sections of antennae from multiple flies. These numbers arepresented in the legend of FIG. 4. DOR67 and 53, for example, anneal toabout 20 neurons on the medial proximal edge of the antenna (FIGS. 4Aand B), whereas DOR62 and 87 anneal to subpopulations of 20 cells at thedistal edge of the antenna (FIGS. 4C-D). Approximately 10 cells in thedistal domain express DOR64 (FIG. 4E). Each of the three linked genesDOR71, 72, and 73 is expressed in different neurons. DOR72 is expressedin approximately 15 antennal cells (FIG. 4H), while DOR73 is expressedin 1 to 2 cells at the distal edge of the antenna (FIG. 4I). Incontrast, DOR71 is expressed in approximately 10 maxillary palp neuronsbut is not detected in the antenna (FIG. 4G). The three sensillar typesare represented in a coarse topographic map across the third antennalsegment. The proximal-medial region, for example, contains largelybasiconic sensilla. Receptors expressed in this region (DOR53 and 67)are therefore likely to be restricted to the large basiconic sensilla.More distal regions contain a mixture of all three sensilla types and itis therefore not possible from these data to assign specific receptorsto specific sensillar types.

[0132] The spatial pattern of neurons expressing a given receptor isconserved between individuals. In situ hybridization with two receptorprobes to three individual flies reveals that both the frequency andspatial distributions of the hybridizing neurons is conserved indifferent individuals (FIG. 6). At present, we cannot determine theprecision of this topographic map and can only argue that givenreceptors are expressed in localized domains.

[0133] In preliminary experiments, we have demonstrated that the spatialpattern of expression of one receptor, DOR104, can be recapitulated intransgenic flies with a promoter fragment flanking the DOR104 gene. Thefusion of the presumed DOR104 promoter (consisting of 3 kb of 5′ DNAimmediately adjacent to the coding region) to the lacZ reporter gene hasallowed us to visualize a subpopulation of neurons expressing DOR104within the maxillary palp. Whole mount preparations of the heads oftransgenic flies reveal a small subpopulation of sensory neurons withinthe maxillary palp whose cell bodies exhibit blue color after stainingwith X-gal (FIG. 2B). The number of positive cells, approximately 20 permaxillary palp, corresponds well with that seen for DOR104 RNAexpression. Immunofluorescent staining of sections with antibodiesdirected against β-galactosidase more clearly reveals the dendrites andaxons of these bipolar neurons in the maxillary palp (FIG. 2C). Levelsof lacZ expression in these transgenic lines are low and furtheramplification will be necessary to allow us to trace the axons toglomeruli in the antennal lobe. Nonetheless, the data suggest that theinformation governing the spatial pattern of DOR104 expression in arestricted subpopulation of maxillary palp neurons resides within 3 kbof DNA 5′ to the DOR104 gene.

[0134] Individual Neurons Express Different Complements of Receptors

[0135] An understanding of the logic of olfactory discrimination inDrosophila will require a determination of the diversity and specificityof receptor expression in individual neurons. In the vertebrateolfactory epithelium, a given neuron is likely to express only onereceptor from the family of 1,000 genes (Ngai et al., 1993; Ressler etal., 1993; Vassar et al., 1993; Chess et al., 1994; Dulac and Axel,unpublished). In the nematode C. elegans, however, individualchemosensory neurons are thought to express multiple receptor genes(Troemel et al., 1995). Our observations with the putative Drosophilaodorant receptors indicate that a given receptor probe anneals with0.5-1.5% of antennal neurons, suggesting that each cell expresses only asubset of receptor genes. If we demonstrate that each of the differentreceptor probes hybridizes with distinct, nonoverlapping subpopulationsof neurons, this would provide evidence that neurons differ with respectto the receptors they express.

[0136] In situ hybridization was therefore performed with either a mixof five receptor probes (FIG. 4F) or individually with each of the fiveprobes (FIGS. 4A-E). We observe that the number of olfactory neuronsidentified with the mixed probe (about 60 per antenna) approximates thesum of the positive neurons detected with the five individual probes.These results demonstrate that individual receptors are expressed indistinct nonoverlapping populations of olfactory neurons.

[0137] We have performed an additional experiment using two-color RNA insitu hybridization to ask whether two receptor genes, DOR64 and DOR87,expressed in interspersed cells in the distal antenna are expressed indifferent neurons. Antisense RNA probes for the two genes were labeledwith either digoxigenin- or FITC-UTP and were used in pairwisecombinations in in situ hybridization to sections through the Drosophilaantenna. Although these two genes are expressed in overlappinglateral-distal domains, two-color in situ hybridization reveals thatneurons expressing DOR64 do not express DOR87, rather each gene isexpressed in distinct cell populations (FIGS. 5D and E). Taken together,these data suggest that olfactory sensory neurons within the antenna arefunctionally distinct and express different complements of odorantreceptors. At the extreme, the experiments are consistent with a modelin which individual neurons express only a single receptor gene.

[0138] Our differential cloning procedure identified one additionalgene, A45, which shares weak identity (24%) with the DOR gene familyover a short region (93 amino acids). This gene, however, does notappear to be a classical member of the DOR family: it is far moredivergent and significantly larger than the other family members (486amino acids). This gene is expressed in all olfactory sensory neurons(data not shown). If A45 does encode a divergent odorant receptor, thenit would be present in all sensory neurons along with differentcomplements of the more classical members of the DOR gene family.

[0139] The Size and Organization of the Odorant Receptor Gene Family

[0140] How large is the family of odorant receptor genes in Drosophila?Unlike vertebrate odorant receptors, which share 40-98% sequenceidentity at the amino acid level, the fly receptors are extremelydivergent. The extent of sequence similarity between receptorsubfamilies ranges from 20-30%. The maxillary palp receptor DOR104 isthe most distantly related member of the family with about 17% identityto the other receptor genes. Inspection of the receptor sequencessuggests that Southern blot hybridizations, even those performed at lowstringency, are unlikely to reveal multiple additional members of a genefamily. In accord with this, Southern blot hybridization with receptorprobes DOR24, 62, and 72, performed at either high or low stringency,reveals only a single hybridizing band following cleavage of genomic DNAwith three different restriction endonucleases (FIGS. 7C-E). The twolinked clusters of receptors contain genes with a greater degree ofsequence conservation and define small subfamilies of receptor genes. Acluster of three receptors, DOR71, 72, and 73, is located at mapposition 33B1-2. The antennal receptors DOR72 and 73 are 55% identicaland both exhibit about 30% identity to the third gene at the locus,DOR71, which is expressed in the maxillary palp. DOR67 and DOR53,members of a second subfamily, reside within 1 kb of each other at mapposition 22A2-3 and exhibit 76% sequence identity. Not surprisingly,these two linked genes crosshybridize at low stringency. Southern blotsprobed with either DOR67 or DOR53 reveal two hybridizing bandscorresponding to the two genes within the subfamily but fail to detectadditional subfamily members in the chromosome (FIGS. 7A and B).

[0141] The members of the receptor gene family described here arepresent on all but the small fourth chromosome. No bias is observedtoward telomeric or centromeric regions. The map positions, asdetermined from P1 and cosmid clones (Berkeley Drosophila GenomeProject; European Drosophila Genome Project) are provided inExperimental Procedures. A comparatively large number of receptor genesmap to chromosome 2 because the Berkeley Drosophila Genome Project hasconcentrated its efforts on this chromosome. Unlike the distribution ofodorant receptors in nematodes and mammals (Ben-Arie et al., 1994;Troemel et al., 1995; Robertson, 1998), only small linked arrays havebeen identified and the majority of the family members are isolated atmultiple, scattered loci in the Drosophila genome.

[0142] The high degree of divergence among members of the Drosophilaodorant receptor gene family is more reminiscent of the family ofchemoreceptors in C. elegans than the more highly conserved odorantreceptors of vertebrates. Estimates of the size of the Drosophilareceptor gene family, therefore, cannot be obtained by either Southernblot hybridization o

PCR analysis of genomic DNA. Rather, our estimates of the gene familyderive from the statistics of small numbers. We detect 12 members of theodorant receptor gene family from a Drosophila genome database thatincludes roughly 10% of the genome. Recognizing a possible bias in ourestimate, it seem reasonable at present to estimate that the odorantrecepto

family is likely to include 100 to 200 genes. This is i

accord with independent estimates from in situ hybridizatio

experiments that demonstrate that a given receptor prob

hybridizes with 0.5-1.5% of the neurons. If we assume tha

a given neuron expresses only a single receptor gene, thes

observations suggest that the gene family would include 10

to 200 members.

[0143] Experimental Discussion

[0144] The Size and Divergence of the Gene Family

[0145] We have identified a novel family of seven transmembrane domainproteins that is likely to encode the Drosophila odorant receptors. Thenumber of different receptor genes expressed in the neurons of theantenna and maxillary palp will reflect the diversity and specificity ofodor recognition in the fruit fly. How large is the Drosophila odorantreceptor gene family? We have identified 11 members of this divergentgene family in the Drosophila DNA database. The potential for biasnotwithstanding, it seems reasonable to assume then that since only 10%of genomic sequence has been deposited, this gene family is likely tocontain from 100 to 200 genes. However, significant errors in ourestimates could result from bias in the nature of the sequencesrepresented in the 10% of the Drosophila genome analyzed to date. Insitu hybridization experiments demonstrating that each of the receptorgenes labels from 0.5-1.5% of the olfactory sensory neurons are inaccord with the estimate of 100 to 200 receptor genes.

[0146] Several divergent odorant receptor gene families, each encodingseven transmembrane proteins, have been identified in vertebrate andinvertebrate species. In mammals, volatile odorants are detected by afamily of as many as 1,000 receptors each expressed in the mainolfactory epithelium (Buck and Axel, 1991; Levy et al., 1991; Parmentieret al., 1992; Ben-Arie et al., 1994). This gene family shares featureswith the serpentine neurotransmitter receptors and is conserved in allvertebrates examined. Terrestrial vertebrates have a second anatomicallyand functionally distinct olfactory system, the vomeronasal organ,dedicated to the detection of pheromones. Vomeronasal sensory neuronsexpress two distinct families of receptors each thought to contain from100 to 200 genes: one novel family of serpentine receptors (Dulac andAxel, 1995), and a second related to the metabotropic neurotransmitterreceptors (Herrada and Dulac, 1997; Matsunami and Buck, 1997; Ryba andTirindelli, 1997).

[0147] In the invertebrate C. elegans, chemosensory receptors areorganized into four gene families that share 20-40% sequence similaritywithin a family and essentially no sequence similarity between families(Troemel et al., 1995; Sengupta et al., 1996; Robertson, 1998). The fourgene families in C. elegans together contain about 1,000 genes engagedin the detection of odors. The nematode receptors exhibit no sequenceconservation with the three distinct families of vertebrate odorantreceptor genes. Our studies reveal that Drosophila has evolved anadditional divergent gene family of serpentine receptors comprised offrom 100 to 200 genes. The observation that a similar function,chemosensory detection, is accomplished by at least eight highlydivergent gene families, sharing little or no sequence similarity, isquite unusual.

[0148] Why is the evolutionary requirement for odorant receptors sooften met by recruitment of novel gene families rather than exploitingpre-existing odorant receptor families in ancestral genomes? Thecharacter of natural odorants along with their physical properties (e.g.aqueous or volatile) represent important selectors governing theevolution of receptor gene families. The use of common “anthropomorphic”odorant sets in the experimental analysis of olfactory specificity hasled to the prevailing view that significant overlap exists in therepertoire of perceived odors between different species. Studies ofodorant specificity in different species often employ odors atartificially high concentrations and may present an inaccurate image ofthe natural repertoire of odorants. We simply do not know the nature ofthe odors that initially led to the ancestral choice of receptor genesduring the evolution of the nematode, insect, or vertebrate species.Clearly, vastly different properties in salient odors could dictate therecruitment of new gene families to effect an old function, olfaction.The character of the odor is not the only evolutionary selector. Odorantreceptors must interact with other components in the signal transductionpathway [G proteins (for review see Buck, 1996; Bargmann and Kaplan,1998) and perhaps even RAMPs (McLatchie et al, 1998) and rho (Mitchellet al., 1998)] that may govern the choice of one family of serpentinereceptors over another. Moreover, mammalian receptors not only recognizeodorants in the environment but are likely to recognize guidance cuesgoverning formation of a sensory map in the brain (Wang et al., 1998).Thus, the multiple properties required of the odorant receptors mightchange vastly over evolutionary time and this might underlie theindependent origins of the multiple chemosensory receptor gene families.

[0149] Establishing a Topographic Map in the Antenna and the Brain

[0150] We observe that individual receptor genes in the fly areexpressed in topographically conserved domains within the antenna. Thishighly ordered spatial distribution of receptor expression differs fromthat observed in the mammalian olfactory epithelium. In mammals, a givenreceptor can be expressed in one of four broad but circumscribed zonesin the main olfactory epithelium (Ressler et al., 1993; Vassar et al.,1993). A given zone can express up to 250 different receptors andneurons expressing a given receptor within a zone appear to be randomlydispersed (Ressler et al., 1993; Vassar et al., 1993). The highlyordered pattern of expression observed in the Drosophila antenna mighthave important implications for patterning the projections to theantennal lobe. In visual, somatosensory, and auditory systems theperipheral receptor sheet is highly ordered and neighbor relations inthe periphery are maintained in the projections to the brain. Theseobservations suggest that the relative position of the sensory neuron inthe periphery will determine the pattern of projections to the brain.

[0151] Our data on the spatial conservation of receptor expression inthe antenna suggest that superimposed upon coarse spatial patterning ofolfactory sensilla (Venkatesh and Singh, 1984; Ray and Rodrigues, 1995;Reddy et al., 1997) must be more precise positional informationgoverning the choice of receptor expression This spatial informationmight dictate the fixed topographic pattern of receptor expression inthe peripheral receptor sheet and at the same time govern the orderedsensory projections to the brain. This relationship between positionalidentity and the pattern of neuronal projections has been suggested forboth peripheral sensory neurons (Merritt and Whitington, 1995;Grillenzoni et al., 1998) and neurons in the embryonic central nervoussystem of Drosophila (Doe and Skeath, 1996).

[0152] Implications for Sensory Processing

[0153] In mammals, olfactory neurons express only one of the thousandodorant receptor genes. Neurons expressing a given receptor project withprecision to 2 of the 1800 glomeruli in the mouse olfactory bulb.Odorants will therefore elicit spatially defined patterns of glomerularactivity such that the quality of an olfactory stimulus is encoded bythe activation of a specific combination of glomeruli (Stewart et al.,1979; Lancet et al., 1982; Kauer et al., 1987; Imamura et al., 1992;Mori et al., 1992; Katoh et al., 1993; Friedrich and Korsching, 1997).Moreover, the ability of an odorant to activate a combination ofglomeruli allows for the discrimination of a diverse array of odors farexceeding the number of receptors and their associated glomeruli. In thenematode, an equally large family of receptor genes is expressed in 16pairs of chemosensory cells, only three of which respond to volatileodorants (Bargmann and Horvitz, 1991; Bargmann et al., 1993). Thisimmediately implies that a given chemosensory neuron will expressmultiple receptors and that the diversity of odors recognized by thenematode might approach that of mammals, but the discriminatory power isnecessarily dramatically reduced.

[0154] What does the character of the gene family we have identified inDrosophila tell us about the logic of olfactory processing in thisorganism? We estimate that the Drosophila odorant receptors comprise afamily of from 100 to 200 genes. Moreover, the pattern of expression ofthese genes in the third antennal segment suggests that individualsensory neurons express a different complement of receptors and, at theextreme, our data are consistent with the suggestion that individualneurons express one or a small number of receptors. As in the case ofmammals, the problem of odor discrimination therefore reduces to aproblem of the brain discerning which receptors have been activated by agiven odorant. If the number of different types of neurons exceeds thenumber of glomeruli (43) (Stocker, 1994; Laissue et al., 1999), itimmediately follows that a given glomerulus must receive input from morethan one kind of sensory neuron. This implies that a single glomeruluswill integrate multiple olfactory stimuli. One possible consequence ofthis model would be a loss of discriminatory power while maintaining theability to recognize a vast array of odors. Alternatively, significantprocessing of sensory input may occur in the fly antennal lobe to afforddiscrimination commensurate with the large number of receptors.

[0155] This model of olfactory coding is in sharp contrast with the mainolfactory system of vertebrates in which sensory neurons express only asingle receptor and converge on only a single pair of spatially fixedglomeruli in the olfactory bulb. Moreover, each projection neuron in themammalian bulb extends its dendrite to only a single glomerulus. Thusthe integration and decoding of spatial patterns of glomerular activity,in vertebrates, must occur largely in the olfactory cortex. In the fruitfly, the observation that the number of receptors may exceed the numberof glomeruli suggests that individual glomeruli will receive input frommore than one type of sensory neuron. A second level of integration inthe antennal lobe is afforded by subsets of projection neurons thatelaborate extensive dendritic arbors that synapse with multipleglomeruli. Thus, the Drosophila olfactory system reveals levels ofprocessing and integration of sensory input in the antennal lobe that islikely to be restricted to higher cortical centers in the main olfactorysystem of vertebrates.

[0156] Protein and Nucleic Acid (nt) Sequences of 55 Drosophila OdorantReceptor Genes

[0157] The following includes those genes first identified in 1998-1999.Protein sequences used single letter amino acid codes.

[0158] DOR10

[0159] MEKLRSYEDFIFMANMMFKTLGYDLFHTPKPWWRYLLVRGYFVLCTISNFYEASMVTTRIIEWESLAGSPSKIMRQGLHFFYMLSSQLKFITFMINRKRLLQLSHRLKELYPHKEQNQRKYEVNKYYLSCSTRNVLYVYYFVMNVVMALEPLVQSQFIVNVSLGTDLWMMCVSSQISMHLGYLANMLASIRPSPETEQQDCDFLASIIKRHQLMIRLQKDVNYVFGLLLASNLFTTSCLLCCMAYYTVVEGFNWEGISYMMLPASVAAQFYVVSSHGQMLIDLLMTITYRF FAVIRQTVEK

[0160] DOR10nt

[0161] ATGGAAAAACTACGTTCCTATGAGGATTTCATCTTCATGGCCAACATGATGTTCAAGACCCTTGGCTACGATCTATTCCATACACCCAAACCCTGGTGGCGCTATCTGCTTGTGCGAGGATACTTCGTTTTGTGCACGATCAGCAACTTTTACGAGGCTTCCATGGTGACGACAAGGATAATTGAGTGGGAATCCTTGGCCGGAAGTCCCTCCAAAATAATGCGACAGGGTCTGCACTTCTTTTACATGTTGAGTAGCCAATTGAAATTTATCACATTCATGATAAATCGCAAACGCCTACTGCAGCTGAGCCATCGTTTGAAAGAGTTGTATCCTCATAAAGAGCAAAATCAAAGGAAGTACGAGGTGAATAAATACTACCTATCCTGTTCCACGCGCAATGTTTTGTACGTGTACTACTTTGTAATGGTCGTCATGGCACTGGAACCCCTCGTTCAGTCCCAGTTCATAGTGAATGTGAGCCTGGGCACAGATCTGTGGATGATGTGCGTCTCAAGCCAAATATCGATGCACTTGGGCTATCTGGCCAATATGTTGGCCTCCATTCGACCAAGTCCAGAAACGGAACAACAAGACTGTGACTTCTTGGCCAGCATTATAAAGAGACATCAACTAATGATCAGGCTTCAAAAGGACGTGAACTATGTTTTTGGACTCTTATTGGCATCTAATCTGTTTACCACATCCTGTTTACTTTGCTGCATGGCGTACTATACCGTCGTCGAAGGTTTCAATTGGGAGGGCATTTCCTATATGATGCTCTTTGCTAGTGTAGCTGCCCAGTTCTACGTTGTCAGCTCACACGGACAAATGTTAATAGATTTGTTGATGACCATCACATACAGATTTTTCGCGGTTATACGACAAACTGTAGAAAAG

[0162] DOR104

[0163] MASLQFHGNVDADIRYDISLDPARESNLFRLLMGLQLANGTKPSPRLPKWWPKRLEMIGKVLPKAYCSMVI FTSLHLGVLFTKTTLDVLPTGELQAITDALTMT IYFFTGYGTIYWCLRSRRLLAYMEHMNREYRHHSLAGVTFVSSHAAFRMSRNFTVVWIMSCLLGVISWGVSPLMLGIRMLPLQCWYPFDALGPGTYTAVYATQLFGQIMVGMTFGFGGSLFVTLSLLLLGQFDVLYCSLKNLDAHTKLLGGESVNGLSSLQEELLLGDSKRELNQYVLLQEHPTDLLRLSAGRKCPDQGNAFHNALVECIRLHRFILHCSQELENLFSPYCLVKSLQITFQLCLLVFVGVSGTREVLRIVNQLQYLGLTIFELLMFTYCGELLSRHSIRSGDAFWRGAWWKHAHFIRQDILIFLVNSRRAVHVTAGKFYVMDVNRLRSVITQAFSFLTLLQKLAAKKTE SEL

[0164] DOR104nt

[0165] GAATTCGGCACGAGCAGTCGATGGCCAGTCTTCAGTTCCACGGCAACGTCGATGCGGACATCAGGTATGATATTAGCCTGGATCCGGCTAGGGAATCGAATCTCTTCCGTCTGCTAATGGGACTCCAGTTGGCGAATGGCACGAAGCCATCGCCGCGGTTACCCAAATGGTGGCCAAAGCGGCTGGAAATGATTGGTAAAGTGCTGCCCAAAGCCTATTGTTCCATGGTGATTTTCACCTCCCTGCATTTGGGTGTCCTGTTCACGAAAACCACACTGGATGTCCTGCCGACGGGGGAGCTGCAGGCCATAACGGATGCCCTCACCATGACCATAATATACTTTTTCACGGGCTACGGCACCATCTACTGGTGCCTGCGCTCCCGGCGCCTCTTGGCCTACATGGAGCACATGAACCGGGAGTATCGCCATCATTCGCTGGCCGGGGTGACCTTTGTGAGTAGCCATGCGGCCTTTAGGATGTCCAGAAACTTCACGGTGGTGTGGATAATGTCCTGCCTGCTGGGCGTGATTTCCTGGGGCGTTTCGCCACTGATGCTGGGCATCCGGATGCTGCCGCTCCAATGTTGGTATCCCTTCGACGCCCTGGGTCCCGGCACATATACGGCGGTCTATGCTACACAACTTTTCGGTCAGATCATGGTGGGCATGACCTTTGGATTCGGGGGATCACTGTTTGTCACCCTGAGCCTGCTACTCCTGGGACAATTCGATGTGCTCTACTGCAGCCTGAAGAACCTGGATGCCCATACCAAGTTGCTGGGCGGGGAGTCTGTAAATGGCCTGAGTTCGCTGCAAGAGGAGTTGCTGCTGGGGGACTCGAAGAGGGAATTAAATCAGTACGTTTTGCTCCAGGAGCATCCGACGGATCTGCTGAGATTGTCGGCAGGACGAAAATGTCCTGACCAAGGAAATGCGTTTCACAACGCCTTGGTGGAATGCATTCGCTTGCATCGCTTCATTCTGCACTGCTCACAGGAGTTGGAGAATCTATTCAGTCCATATTGTCTGGTCAAGTCACTGCAGATCACCTTTCAGCTTTGCCTGCTGGTCTTTGTGGGCGTTTCGGGTACTCGAGAGGTCCTGCGGATTGTCAACCAGCTACAGTACTTGGGACTGACCATCTTCGAGCTCCTAATGTTCACCTATTGTGGCGAACTCCTCAGTCGGCATAGTATTCGATCTGGCGACGCCTTTTGGAGGGGTGCGTGGTGGAAGCACGCCCATTTCATCCGCCAGGACATCCTCATCTTTCTGGTCAATAGTAGACGTGCAGTTCACGTGACTGCCGGCAAGTTTTATGTGATGGATGTGAATCGTCTAAGATCGGTTATAACGCAGGCGTTCAGCTTCTTGACTTTGCTGCAAAAGTTGGCTGCCAAGAAGACGGAATCGGAGCTCTAAACTGGTACCACGCATCGATATTTATTTAGCGCATTGTCGAGTAAAAGCAAAAAAAASAASAAAAA

[0166] DOR105

[0167] MFEDIQLIYMNIKILRFWALLYDKNLRRYVCIGLASFHIFTQIVYMMSTNEGLTGIIRNSYMLVLWINTVLRAYLLLADHDRYLALIQKLTEAYYDLLNLNDSYISEILDQVNKVGKLMARGNLFFGMLTSMGFGLYPLSSSERVLPFGSKIPGLNEYESPYYEMWYIFQMLITPMGCCMYIPYTSLIVGLIMFGIVRCKALQHRLRQVALKHPYGDRDPRELREEIIACIRYQQSIIEYMDHINELTTMMFLFELMAFSALLCALLFMLIIVSGTSQLIIVCMYINMILAQILALYWYANELREQNLAVATAAYETEWFTFDVPLRKNILFMMMRAQRPAAILLGNIRPITLELFQNLLNTTYTFFTVLKRVYG

[0168] DOR105nt

[0169] ATGTTTGAAGACATTCAGCTAATCTACATGAATATCAAGATATTGCGATTCTGGGCCCTGCTCTATGACAAAAACTTGAGGCGTTATGTGTGCATTGGACTGGCCTCATTCCACATCTTCACCCAAATCGTCTACATGATGAGTACCAATGAAGGACTAACCGGGATAATTCGTAACTCATATATGCTCGTCCTTTGGATTAATACGGTGCTGCGAGCTTATCTCTTGCTGGCGGATCACGACAGATATTTGGCTTTGATCCAAAAACTAACTGAGGCCTATTACGATTTACTGAATCTGAACGATTCGTATATATCGGAAATATTGGACCAGGTGAACAAGGTGGGAAAGTTGATGGCTAGGGGCAATCTGTTCTTTGGCATGCTCACATCCATGGGATTCGGTCTGTACCCATTGTCCTCCAGCGAAAGAGTCCTGCCATTTGGCAGCAAAATTCCTGGTCTAAATGAGTACGAGAGTCCGTACTATGAGATGTGGTACATCTTTCAGATGCTCATCACCCCGATGGGCTGTTGCATGTACATTCCGTACACCAGTCTGATTGTGGGCTTGATAATGTTCGGCATTGTGAGGTGCAAGGCTTTGCAGCATCGCCTCCGCCAGGTGGCGCTTAAGCATCCGTACGOAGATCGCGATCCCCGTGAACTGAGGGAGGAGATCATAGCCTGCATACGTTACCAGCAGAGCATTATCGAGTACATGGATCACATAAACGAGCTGACCACCATGATGTTCCTATTCGAACTGATGGCCTTTTCGGCGCTGCTCTGTGCGCTGCTCTTTATGCTGATTATCGTCAGCGGCACCAGTCAGCTGATAATTGTTTGCATGTACATTAACATGATTCTGGCCCAAATACTGGCCCTCTATTGGTATGCAAATGAGTTAAGGGAACAGAATCTGGCGGTGGCCACCGCAGCCTACGAAACGGAGTGGTTCACCTTCGACGTTCCACTGCGCAAAAACATCCTGTTCATGATGATGAGGGCACAGCGGCCAGCTGCAATACTACTGGGCAATATACGCCCCATCACTTTGGAACTGTTCCAAAACCTACTGAACACAACCTATACATTTTTTACGGTTCTCAAGCGAGTCTACGGA

[0170] DOR107

[0171] MYPRFLSRNYPLAKHLFFVTRYSFGLLGLRFGKEQSWLHLLWLVFNFVNLAHCCQAEFVFGWSHLRTSPVDAMDAFCPLACSFTTLFKLGWMWWRRQEVADLMDRIRLLIGEQEKREDSRRKVAQRSYYLMVTRCGMLVFTLGSITTGAFVLRSLWEMWVRRHQEFKFDMPFRMLFHDFAHRMPWFPVFYLYSTWSGQVTVYAFAGTDGFFFGFTLYMAFLLQALRYDIQDALKPIRDPSLRESKICCQRLADIVDRHNEIEKIVKEFSGIMAAPTFVHFVSASLVIATSVIDILLYSGYNIIRYVVYTFTVSSAIFLYCYGGTEMSTESLSLGEAAYSSAWYTWDRETRRRVFLIILRAQRPITVRVPFFAPSLPVFTSVIKFTGSIVALAKTIL

[0172] DOR107nt

[0173] ATGTATCCGCGATTCCTCAGCCGTAACTATCCGCTGGCCAAGCATTTGTTCTTCGTCACCAGATACTCCTTTGGCCTGCTGGGCCTGAGATTTGGCAAAGAGCAATCGTGGCTTCACCTCTTGTGGCTGGTGTTCAATTTCGTTAACCTGGCGCACTGCTGCCAGGCGGAGTTCGTCTTCGGCTGGAGTCACTTGCGCACCAGTCCCGTGGATGCCATGGACGCCTTTTGTCCTCTGGCCTGCAGTTTCACCACGCTCTTCAAGCTGGGATGGATGTGGTGGCGTCGCCAGGAAGTAGCTGATCTAATGGACCGCATCCGCTTGCTCATCGGGGAGCAGGAGAAGAGGGAGGACTCCCGGAGAAAGGTGGCTCAAAGGAGCTACTATCTCATGGTCACCAGGTGCGGTATGCTGGTCTTCACCCTGGGCAGCATTACCACTGGAGCCTTCGTTCTGCGTTCCCTTTGGGAAATGTGGGTGCGTCGTCATCAGGAGTTCAAATTCGATATGCCCTTTCGCATGCTGTTCCACGACTTTGCGCATCGCATGCCCTGGTTTCCAGTTTTCTATCTCTACTCCACATGGAGTGGCCAGGTCACTGTGTACGCCTTTGCTGGTACAGATGGTTTCTTC TTGGCTTTACCCTCTACATGGCCTTCTTGCTGCAGGCCTTAAGATACGATATCCAGGATGCCCTCAAGCCAATAAGAGATCCCTCGCTTAGGGAATCCAAAATCTGCTGTCAGCGATTGGCGGACATCGTGGATCGCCACAATGAGATAGAGAAGATAGTCAAGGAATTTTCTGGAATTATGGCTGCTCCAACTTTTGTTCACTTCGTATCAGCCAGCTTAGTGATAGCCACCAGCGTCATTGATATACTATTGTATTCCGGCTATAACATCATCCGTTACGTGGTGTACACCTTCACGGTTTCCTCGGCCATCTTCCTCTATTGCTACGGAGGCACAGAAATGTCAACTGAGAGCCTTTCCTTGGGAGAAGCAGCCTACAGCAGTGCCTGGTATACTTGGGATCGAGAGACCCGCAGGCGGGTCTTTCTCATTATCCTGCGTGCTCAACGACCCATTACGGTGAGGGTGCCCTTTTTTGCACCATCGTTACCAGTCTTCACATCGGTCATCAAGTTTACAGGTTCGATTGTGGCACTGGCTAAGACGATACTG

[0174] DOR108

[0175] MDKHKDRIESMRLILQVMQLFGLWPWSLKSEEEWTFTGFVKRNYRFLLHLPITFTFIGLMWLEAFISSNLEQAGQVLYMSITEMALVVKILSIWHYRTEAWRLMYELQHAPDYQLHNQEEVDFWRREQRFFKWFFYIYILISLGVVYSGCTGVLFLEGYELPFAYYVPFEWQNERRYWFAYGYDMAGMTLTCISNITLDTLGCYFLFHISLLYRLLGLRLRETKNMKNDTIFGQQLRAIFIMHQRIRSLTLTCQRIVSPYILSQIILSALIICFSGYRLQHVGIRDNPGQFISMLQFVSVMILQIYLPCYYGNEITVYANQLTNEVYHTNWLECRPPIRKLLNAYMEHLKKPVTIRAGNSFAVGLPIFVKTINNAYSFLALLLNVSN

[0176] DOR108nt

[0177] ATGGATAAACACAAGGATCGCATTGAATCCATGCGCCTAATTCTTCAGGTCATGCAACTATTTGGCCTCTGGCCGTGGTCCTTGAAATCGGAAGAGGAGTGGACTTTCACCGGTTTTGTAAAGCGCAACTATCGCTTCCTGCTCCATCTGCCCATTACCTTCACCTTTATTGGACTCATGTGGCTGGAGGCCTTCATCTCGAGCAATCTGGAGCAGGCTGGCCAGGTTCTGTACATGTCCATCACCGAGATGGCTTTGGTGGTGAAAATCCTGAGCATTTGGCACTATCGCACCGAAGCTTGGCGGCTGATGTACGAACTCCAACATGCTCCGGACTACCAACTCCACAACCAGGAGGAGGTAGACTTTTGGCGCCGGGAGCAACGATTCTTCAAGTGGTTCTTCTACATCTACATTCTGATTAGCTTGGGCGTGGTATATAGTGGCTGCACTGGAGTACTTTTTCTGGAGGGCTACGAACTGCCCTTTGCCTACTACGTGCCCTTCGAATGGCAGAACGAGAGAAGGTACTGGTTCGCCTATGGTTACGATATGGCGGGCATGACGCTGACCTGCATCTCAAACATTACCCTGGACACCCTGGGTTGCTATTTCCTGTTCCATATCTCTCTTTTGTACCGACTGCTTGGTCTGCGATTGAGGGAAACGAAGAATATGAAGAATGATACCATTTTTGGCCAGCAGTTGCGTGCCATCTTCATTATGCATCAGAGGATTAGAAGCCTAACCCTGACCTGCCAGAGAATCGTATCTCCCTATATCCTATCTCAGATCATTTTGAGTGCCCTGATCATCTGCTTTAGTGGATACCGCTTGCAGCATGTGGGAATTCGCGATAATCCCGGCCAGTTTATATCCATGTTGCAGTTTGTCAGTGTGATGATCCTGCAGATTTACTTGCCCTGCTACTATGGAAACGAGATAACCGTGTATGCCAATCAGCTGACCAACGAGGTTTACCATACCAATTGGCTGGAATGTCGGCCACCGATTCGAAAGTTACTCAATGCCTACATGGAGCACCTGAAGAAACCGGTGACCATCCGGGCTGGCAACTCCTTCGCCGTGGGACTACCAATTTTTGTTAAGACCATCAACAACGCCTACAGTTTCTTGGCTTTATTACTAAATGTATCGAA T

[0178] DOR109

[0179] MESTNRLSAIQTLLVIQRWIGLLKWENEGEDGVLTWLKRIYPFVLHLPLTFTYIALMWYEAITSSDFEEAGQVLYMSITELALVTKLLNIWYRRHEAASLIHELQHDPAFNLRNSEEIKFWQQNQRNFKRIFYWYIWGSLFVAVMGYISVFFQEDYELPFGYYVPFEWRTRERYFYAWGYNVVAMTLCCLSNILLDTLGCYFMFHIASLFRLLGMRLEALKNAAEEKARPELRRIFQLHTKVRRLTRECEVLVSPYVLSQVVFSAFIICFSAYRLVHMGFKQRPGLFVTTVQFVAVMIVQIFLPCYYGNELTFHANALTNSVFGTNWLEYSVGTRKLLNCYMEFLKRPVKVRAGVFFEIGLPIFVKTINNAYSFFALLLKISK

[0180] DOR109nt

[0181] ATGGAGTCTACAAATCGCCTAAGTGCCATCCAAACACTTTTAGTAATCCAACGTTGGATAGGACTTCTTAAATGGGAAAACGAGGGCGAGGATGGAGTATTAACCTGGCTAAAACGAATATATCCTTTTGTACTGCACCTTCCACTGACCTTCACGTATATTGCCTTAATGTGGTATGAAGCTATTACATCGTCAGATTTTGAGGAAGCTGGTCAAGTTCTGTACATGTCCATCACCGAACTGGCATTGGTCACTAAACTGCTGAATATTTGGTATCGTCGTCATGAAGCTGCTAGTCTAATCCACGAATTGCAACACGATCCCGCATTTAATCTGCGCAATTCGGAGGAAATCAAATTCTGGCAGCAAAATCAGAGGAACTTTAAGAGAATATTTTACTGGTACATCTGGGGCAGCCTTTTCGTGGCTGTAATGGGTTATATAAGCGTGTTTTTCCAGGAGGATTACGAGCTGCCCTTTGGCTACTACGTGCCATTCGAGTGGCGCACCAGGGAACGATACTTCTACGCTTGGGGCTATAATGTGGTGGCCATGACCCTGTGCTGTCTATCCAACATCCTACTGGACACACTAGGCTGTTATTTCATGTTCCACATCGCCTCGCTTTTCAGGCTTTTGGGAATGCGACTGGAGGCCTTGAAAAATGCAGCCGAAGAGAAAGCCAGACCGGAGTTGCGCCGCATTTTCCAACTGCACACTAAAGTCCGCCGATTGACGAGGGAATGCGAAGTGTTAGTTTCACCCTATGTTCTATCCCAAGTGGTCTTCAGTGCCTTCATCATCTGCTTCAGTGCCTATCGACTGGTGCACATGGGCTTCAAGCAGCGACCTGGACTCTTCGTGACCACCGTGCAATTCGTGGCCGTCATGATCGTCCAGATTTTCTTGCCCTGTTACTACGGCAATGAGTTGACCTTTCATGCCAATGCACTCACTAATAGTGTCTTCGGTACCAATTGGCTGGAGTACTCCGTGGGCACTCGCAAGCTGCTTAACTGCTACATGGAGTTCCTCAAGCGACCGGTTAAAGTGCGAGCTGGGGTGTTCTTTGAAATAGGACTACCCATCTTTGTGAAGACCATCAACAATGCCTACAGTTTCTTCGCCCTGCTGCTAAAGATATCCAAG

[0182] DOR110

[0183] MLFNYLRKPNPTNLLTSPDSFRYFEYGMFCMGWHTPATHKIIYYITSCLIFAWCAVYLPIGIIISFKTDINTFTPNELLTVMQLFFNSVGMPFKVLFFNLYISGFYKAKKLLSEMDKRCTTLKERVEVHQGVVRCNKAYLIYQFIYTAYTISTFLSAALSGKLPWRIYNPFVDFRESRSSFWKAALNETALMLFAVTQTLMSDIYPLLYGLILRVHLKLLRLRVESLCTDSGKSDAENEQDLINYAAAIRPAVTRTIFVQFLLIGICLGLSMINLLFFADIWTGLATVAYINGLMVQTFPFCFVCDLLKKDCELLVSAIFHSNWINSSRSYKSSLRYFLKNAQKsIAFTAGSIFPISTGSNIKVAKLAFSVVTFVNQLNIADRLTKN

[0184] DOR110nt

[0185] ATGTTGTTCAACTATCTGCGAAAGCCGAATCCCACAAACCTTTTGACTTCTCCGGACTCATTTAGATACTTTGAGTATGGAATGTTTTGCATGGGATGGCACACACCAGCAACGCATAAGATAATCTACTATATAACATCCTGTTTGATTTTTGCTTGGTGTGCCGTATACTTGCCAATCGGAATCATCATTAGTTTCAAAACGGATATTAACACATTCACACCGAATGAACTGTTGACAGTTATGCAATTATTTTTCAATTCAGTGGGAATGCCATTCAAGGTTCTGTTCTTCAATTTGTATATTTCTGGATTTTACAAGGCCAAAAAGCTCCTTAGCGAAATGGACAAACGTTGCACCACTTTGAAGGAGCGAGTGGAAGTGCACCAAGGTGTGGTCCGTTGCAACAAGGCCTACCTCATTTACCAGTTCATTTATACCGCGTACACTATTTCAACATTTCTATCGGCGGCTCTTAGTGGAAAATTGCCATGGCGCATCTATAATCCTTTTGTGGATTTTCGAGAAAGTAGATCCAGTTTTTGGAAAGCTGCCCTCAACGAGACAGCACTTATGCTATTTGCTGTGACTCAAACCCTAATGAGTGATATATATOCACTGCTTTATGGTTTGATCCTGAGAGTTCACCTCAAACTTTTGCGACTAAGAGTGGAGAGCCTGTGCACAGATTCTGGAAAAAGCGATGCTGAAAACGAGCAAGATTTGATTAACTATGCTGCAGCAATACGACCAGCGGTTACCCGCACAATTTTCGTTCAATTCCTCTTGATCGGAATTTGCCTTGGCCTTTCAATGATCAATCTACTCTTCTTTGCCGACATCTGGACAGGATTGGCCACAGTGGCTTACATCAATGGTCTAATOGTGCAGACATTTCCATTTTGCTTCGTTTGTGATCTACTCAAAAAGGATTGTGAACTTCTTGTGTCGGCCATATTTCATTCCAACTGGATTAATTCAAGCCGCAGTTACAAGTCATCTTTGAGATATTTTCTGAAGAACGCCCAGAAATCAATTGCTTTTACAGCCGGCTCTATTTTTCCCATTTCTACTGGCTCGAATATTAAGGTGGCTAAGCTGGCATTTTCGGTGGTTACTTTTGTCAATCAACTTAACATAGCTGACAGATTGACAAAGAA C

[0186] DOR 111

[0187] MLFRKRKPKSDDEVITFDELTRFPMTFYKTIGEDLYSDRDPNVIRRYLLRFYLVLGFLNFNAYVVGEIAYFIVHIMSTTTLLEATAVAPCIGFSFMADFKQFGLTVNRKRLVRLLDDLKEIFPLDLEAQRKYNVSFYRKHMNRVMTLFTILCMTYTSSFSFYPAIKSTIKYYLMGSEIFERNYGFHILFPYDAETDLTVYWFSYWGLAHCAYVAGVSYVCVDLLLIATITQLTMHFNFIANDLEAYEGGDHTDEENIKYLHNLVVYHARALDINKKCTFQSSRIGHSAFNQNWLPCSTKYKRILQFIIARSQKPASIRPPTFPPISFNTFMKVISMSYQFFALLRTTY YG

[0188] DOR111nt

[0189] ATGCTGTTCCGCAAACGTAAGCCAAAAAGTGACGATGAAGTCATCACCTTCGACGAACTTACCCGGTTTCCGATGACTTTCTACAAGACCATCGGCGAGGATCTGTACTCCGATAGGGATCCGAATGTGATAAGGCGTTACCTGCTACGTTTTTATCTGGTACTCGGTTTTCTCAACTTCAATGCCTATGTGGTGGGCGAAATCGCGTACTTTATAGTCCATATAATGTCGACGACTACTCTTTTGGAGGCCACTGCAGTGGCACCGTGCATTGGCTTCAGCTTCATGGCCGACTTTAAGCAGTTCGGTCTCACAGTGAATAGAAAGCGATTGGTCAGATTGCTGGATGATCTCAAGGAGATATTTCCTTTAGATTTAGAAGCGCAGCGGAAGTATAACGTATCGTTTTACCGGAAACACATGAACAGGGTCATGACCCTATTCACCATCCTCTGCATGACCTACACCTCGTCATTTAGCTTTTATCCAGCCATCAAGTCGACCATAAAGTATTACCTTATGGGATCGGAAATCTTTGAGCGCAACTACGGATTTCACATTTTGTTTCCCTACGACGCAGAAACGGATCTGACGGTCTACTGGTTTTCCTACTGGGGATTGGCTCATTGTGCCTATGTGGCCGGAGTTTCCTACGTCTGCGTGGATCTCCTGCTGATCGCGACCATAACCCAGCTGACCATGCACTTCAACTTTATAGCGAATGATTTGGAGGCCTACGAAGGAGGTGATCATACGGATGAAGAAAATATCAAATACCTGCACAACTTGGTCGTCTATCATGCCAGGGCGCTGGATATTAACAAGAAATGTACATTTCAGAGCTCTCGGATTGGCCATTCGGCATTTAATCAGAACTGGTTGCCATGCAGCACCAAATACAAACGCATCCTGCAATTTATTATCGCGCGCAGCCAGAAGCCCGCCTCTATAAGACCGCCTACCTTTCCACCCATATCTTTTAATACCTTTATGAAGGTAATCAGCATGTCGTATCAGTTTTTTGCACTGCTCCGCACCACATAT TATGGT

[0190] DOR114

[0191] MLTKKDTQSAKEQEKLKAIPLHSFLKYANVFYLSIGMMAYDHKYSQKWKEVLLHWTFIAQMVNLNTVLISELIYVFLAIGKGSNFLEATMNLSFIGFVIVGDFKIWNISRQRKRLTQVVSRLEELHPQGLAQQEPYNIGHHLSGYSRYSKFYFGMHMVLIWTYNLYWAVYYLVCDFWLGMRQFERMLPYYCWVPWDWSTGYSYYFMYISQNIGGQACLSGQLAADMLMCALVTLVvMHFIRLSAHIESHVAGIGSFQHDLEFLQATVAYHQSLIHLCQDINEIFGVSLLSNFVSSSFIICFVGFQMTIGSKIDNLVMLVLFLFCAMVQVFMIATHAQRLVDASEQIGQAVYNHDWFRADLRYRKMLILIIKRAQQPSRLKATMFLNISLVTVSDLLQLSYKFFALL RTMYVN

[0192] DOR114nt

[0193] ATGTTGACTAAGAAGGATACTCAAAGTGCCAAGGAGCAGGAAAAGTTGAAGGCCATTCCATTGCACAGCTTTCTGAAATATGCCAACGTGTTCTATTTATCGATTGGAATGATGGCCTACGATCACAAGTACAGTCAAAAGTGGAAGGAGGTCCTGCTGCACTGGACATTCATTGCCCAGATGGTCAATCTGAATACAGTGCTCATCTCGGAACTGATTTACGTATTCCTGGCGATCGGCAAAGGTAGCAATTTTCTGGAGGCCACCATGAATCTGTCTTTCATTGGATTTGTCATCGTTGGTGACTTCAAAATCTGGAACATTTCGCGGCAGAGAAAGAGACTCACCCAAGTGGTCAGCCGATTGGAAGAACTGCATCCGCAAGGCTTGGCTCAACAAGAACCCTATAATATAGGGCATCATCTGAGCGGCTATAGCCGATATAGCAAATTTTACTTCGGCATGCACATGGTGCTGATATGGACGTACAACCTGTATTGGGCCGTTTACTATCTGGTCTGTGATTTCTGGCTGGGAATGCGTCAATTTGAGAGGATGCTGCCCTACTACTGCTGGGTTCCCTGGGATTGGAGTACCGGATATAGCTACTATTTCATGTATATCTCACAGAATATCGGCGGTCAGGCTTGTCTGTCCGGTCAGCTAGCAGCTGACATGTTAATGTGCGCCCTGGTCACTTTGGTGGTGATGCACTTCATCCGGCTTTCCGCTCACATCGAGAGTCATGTTGCGGGCATTGGCTCATTCCAGCACGATTTGGAGTTCCTCCAAGCGACGGTGGCGTATCACCAGAGCTTGATCCACCTCTGCCAGGATATCAATGAGATATTCGGTGTTTCACTGTTGTCCAACTTTGTATCCTCGTCGTTTATCATCTGCTTCGTGGGTTTCCAGATGACCATCGGCAGCAAGATCGACAACCTGGTAATGCTTGTGCTTTTCCTGTTTTGTGCCATGGTTCAGGTCTTCATGATTGCCACCCATGCTCAGAGGCTCGTTGATGCGAGTGAACAGATTGGTCAAGCGGTCTATAATCACGACTGGTTCCGTGCTGATCTGCGGTATCGTAAAATGCTGATCCTGATTATTAAGAGGGCCCAACAGCCGAGTCGACTCAAGGCCACAATGTTCCTGAACATCTCACTGGTCACCGTGTCGGATCTCTTGCAACTCTCGTACAAATTCTTTGCCCTTCTGCGCACAATGTACGTGAAT

[0194] DOR115

[0195] MEKLMKYASFFYTAVGIRPYTNGEESKMNKLIFHIVFWSNVINLSFVGLFESIYVYSAFMDNKFLEAVTALSYIGFVTVGMSKMFFIRWKKTAITELINELKEIYPNGLIREERYNLPMYLGTCSRISLIYSLLYSVLIWTFNLFCVMEYWVYDKWLNIRVVGKQLPYLMYIPWKWQDNWSYYPLLFSQNFAGYTSAAGQISTDVLLCAVATQLVMHFDFLSNSMERHELSGDWKKDSRFLVDIVRYHERILRLSDAVNDIFGIPLLLNFMVSSFVICFVGFQMTVGVPPDIVVKLFLFLVSSMSQVYLICHYGQLVADASYGFSVATYNQKWYKADVRYKRALVIIIARSQKVTFLKATIFLDITRSTMTDVRNCVLSV

[0196] DOR115nt

[0197] ATGGAGAAGCTAATGAAGTACGCTAGCTTCTTCTACACAGCAGTGGGCATACGGCCATATACCAATGGTGAAGAATCCAAAATGAACAAACTTATATTTCACATAGTTTTTTGGTCCAATGTGATTAACCTCAGCTTCGTTGGATTATTTGAGAGCATTTACGTTTACAGTGCCTTCATGGATAATAAGTTCCTGGAAGCAGTCACTGCGTTGTCCTACATTGGCTTCGTAACCGTAGGCATGAGCAAGATGTTCTTCATCCGGTGGAAGAAAACGGCTATAACTGAACTGATTAATGAATTGAAGGAGATCTATCCGAATGGTTTGATCCGAGAGGAAAGATACAATCTGCCGATGTATCTGGGCACCTGCTCCAGAATCAGCCTTATATATTCCTTGCTCTACTCTGTTCTCATCTGGACATTCAACTTGTTTTGTGTAATGGAGTATTGGGTCTATGACAAGTGGCTCAACATTCGAGTGGTGGGCAAACAGTTGCCGTACCTCATGTACATTCCTTGGAAATGGCAGGATAACTGGTCGTACTATCCACTGTTATTCTCCCAGAATTTTGCAGGATACACATCTGCAGCTGGTCAAATTTCAACCGATGTCTTGCTCTGCGCGGTGGCCACTCAGTTGGTAATGCACTTCGACTTTCTCTCAAATAGTATGGAACGCCACGAATTGAGTGGAGATTGGAAGAAGGACTCCCGATTTCTGGTGGACATTGTTAGGTATCACGAACGTATACTCCGCCTTTCAGATGCAGTGAACGATATATTTGGAATTCCACTACTACTCAACTTCATGGTATCCTCGTTCGTCATCTGCTTCGTGGGATTCCAGATGACTGTTGGAGTTCCGCCGGATATAGTTGTGAAGCTCTTCCTCTTCCTTGTCTCTTCGATGAGTCAGGTCTATTTGATTTGTCACTATGGTCAACTGGTGGCCGATGCTAGCTACGGATTTTCGGTTGCCACCTACAATCAGAAGTGGTATAAAGCCGATGTGCGCTATAAACGAGCCTTGGTTATTATTATAGCTAGATCGCAGAAGGTAACTTTTCTAAAGGCCACTATATTCTTGGATATTACCAGGTCCACTATGACAGATGTACGCAACTGTGTATTGTCAGTG

[0198] DOR116

[0199] MELLPLAMLMYDGTRVTAMQYLIPGLPLENNYCYVVTYMIQTVTMLVQGVGFYSGDLFVFLGLTQILTFADMLQVKVKELNDALEQKAEYRALVRVGASIDGAENRQRLLLDVIRWHQLFTDYCRAINALYYELIATQVLSMALAMMLSFCINLSSFHMPSAIFFVVSAYSMSIYCILGTILEFAYDQVYESICNVTWYELSGEQRKLFGFLLRESQYPHNIQILGVMSLSVRTALQIVKLIYSVSMMMMNRA

[0200] DOR116nt

[0201] ATGGAACTCCTGCCATTGGCCATGCTAATGTACGATGGAACCCGGGTTACTGCGATGCAGTATTTAATTCCGGGTCTACCGCTTGAGAACAATTATTGCTACGTAGTCACGTACATGATTCAGACGGTGACAATGCTCGTGCAAGGAGTCGGATTCTACTCCGGTGATTTGTTCGTATTTCTCGGCTTAACGCAGATCCTAACTTTCGCCGATATGCTGCAGGTGAAGGTGAAAGAGCTAAACGATGCCCTGGAACAAAAAGCGGAATACAGAGCTCTAGTCCGAGTTGGAGCTTCTATTGATGGAGCGGAAAATCGTCAACGCCTTCTCTTGGATGTTATAAGATGGCATCAATTATTCACGGACTACTGTCGCGCCATAAATGCCCTCTACTACGAATTGATCGCCACTCAGGTTCTTTCGATGGCTTTGGCCATGATGCTCAGCTTCTGCATTAATTTGAGCAGCTTTCACATGCCTTCGGCTATCTTTTTCGTGGTTTCTGCCTACAGCATGTCCATCTATTGCATTCTGGGCACCATTCTTGAGTTTGCATATGACCAGGTGTACGAGAGCATCTGTAATGTGACCTGGTATGAGTTGAGTGGCGAACAGCGAAAGCTTTTTGGTTTTTTGTTGCGGGAATCCCAGTATCCGCACAATATTCAGATACTTGGAGTTATGTCGCTTTCCGTGAGAACGGCTCTGCAGATTGTTAAACTAATTTATAGCGTATCCATGATGATGATGAATC GGGCG

[0202] DOR117

[0203] MDLRRWFPTLYTQSKDSPVRSRDATLYLLRCVFLMGVRKPPAKFFVAYVLWSFALNFCSTFYQPIGFLTGYISHLSEFSPGEFLTSLQVAFNAWSCSTKVLIVWALVKRFDEANNLLDEMDRRITDPGERLQIHRAVSLSNRIFFFFMAVYMVYATNTFLSAIFIGRPPYQNYYPFLDWRSSTLHLALQAGLEYFAMAGACFQDVCVDCYPVNFVLVLRAHMSIFAERLRRLGTYPYESQEQKYERLVQCIQDHKVILRFVDCLRPVISGTIFVQFLVVGLVLGFTLINIVLFANLGSAIAALSFMAAVLLETTPFCILCNYLTEDCYKLADALFQSNWIDEEKRYQKTLMYFLQKLQQPITFMAMNVFPISVGTNISVSRCAL

[0204] DOR117nt

[0205] ATGGATCTGCGAAGGTGGTTTCCGACCTTGTACACCCAGTCGAAGGATTCGCCAGTTCGCTCCCGAGACGCGACCCTGTACCTCCTACGCTGCGTCTTCTTAATGGGCGTCCGCAAGCCACCTGCCAAGTTTTTCGTGGCCTACGTGCTCTGGTCCTTCGCACTGAATTTCTGCTCAACATTTTATCAGCCAATTGGCTTTCTCACAGGCTATATAAGCCATTTATCAGAGTTCTCCCCGGGAGAGTTTCTAACTTCGCTGCAGGTGGCCTTTAATGCTTGGTCCTGCTCTACAAAAGTCCTGATAGTGTGGGCACTAGTTAAGCGCTTTGACGAGGCTAATAACCTTCTCGACGAGATGGATAGGCGTATCACAGACCCCGGAGAGCGTCTTCAGATTCATCGCGCTGTCTCCCTCAGTAACCGTATATTCTTCTTTTTCATGGCAGTCTACATGGTTTATGCCACTAATACGTTTCTGTCGGCGATCTTCATTGGAAGGCCACCGTACCAAAATTACTACCCTTTTCTGGACTGGCGATCTAGCACTCTGCATCTAGCTCTGCAGGCCGGTCTGGAATACTTCGCCATGGCTGGCGCCTGCTTCCAGGACGTTTGCGTTGATTGCTACCCAGTCAATTTCGTTTTGGTCCTGCGTGCCCACATGTCGATCTTCGCGGAGCGCCTTCGACGTTTGGGAACTTATCCTTATGAAAGCCAGGAGCAGAAATATGAACGATTGGTTCAGTGCATACAAGATCACAAAGTAATTTTGCGATTTGTTGACTGCCTGCGTCCTGTTATTTCTGGTACCATCTTCGTGCAATTCTTGGTTGTGGGGTTGGTGCTGGGCTTTACCCTAATTAACATTCTCCTGTTCGCCAACTTGGGATCGGCCATCGCAGCGCTCTCGTTTATGGCCGCAGTGCTTCTAGAGACGACTCCCTTCTGCATATTGTGCAATTATCTCACAGAAGACTGCTACAAGCTGGCCGATGCCCTGTTTCAGTCAAACTGGATTGATGAGGAGAAACGATACCAAAAGACACTCATGTACTTCCTACAGAAACTGCAGCAGCCTATAACCTTCATGGCTATGAACGTGTTTCCAATATCTGTGGGAACTAACATCAGTGTAAGCAGATGTGCCCTT

[0206] DOR118

[0207] MKFIGWLPPKQGVLRYVYLTWTLMTFVWCTTYLPLGFLGSYMTQIKSFSPGEFLTSLQVCINAYGSSVKVAITYSMLWRLIKAKNILDQLDLRCTAMEEREKIHLVVARSNHAFLIFTFVYCGYAGSTYLSSVLSGRPPWQLYNPFIDWHDGTLKLWVASTLEYMVMSGAVLQDQLSDSYPLIYTLILRAHLDMLRERIRRLRSDENLSEAESYEELVKCVMDHKLILRYCAIIKPVIQGTIFTQFLLIGLVLGFTLINVFFFSDIWTGIASFMFVITILLQTFPFCYTCNLIMEDCESLTHAIFQSNWVDASRRYKTTLLYFLQNVQQPIVFIAGGIFQISMSSNISVAKFAFSVITITKQMNIADKFKTD

[0208] DOR118nt

[0209] ATGAAGTTTATTGGATGGCTGCCCCCCAAGCAGGGTGTGCTCCGGTATGTGTACCTCACCTGGACGCTAATGACGTTCGTGTGGTGTACAACGTACCTGCCGCTTGGCTTCCTTGGTAGCTACATGACGCAGATCAAGTCCTTCTCCCCTGGAGAGTTTCTCACTTCACTCCAGGTGTGCATTAATGCCTACGGCTCATCGGTAAAAGTTGCAATCACATACTCCATGCTCTGGCGCCTTATCAAGGCCAAGAACATTTTGGACCAGCTGGACCTGCGCTGCACCGCCATGGAGGAGCGCGAAAAGATCCACCTAGTGGTGGCCCGCAGCAACCATGCCTTTCTCATCTTCACCTTTGTCTACTGCGGATATGCCGGCTCCACCTACCTGAGCTCGGTTCTCAGCGGGCGTCCGCCCTGGCAGCTGTACAATCCCTTTATTGATTGGCATGACGGCACACTCAAGCTCTGGGTGGCCTCCACGTTGGAGTACATGGTGATGTCAGGCGCCGTTCTGCAGGATCAACTCTCGGACTCTTACCCATTGATCTATACCCTCATCCTTCGTGCTCACTTGGACATGCTAAGGGAGCGCATCCGACGCCTCCGTTCCGATGAGAACCTGAGCGAGGCCGAGAGCTATGAAGAGCTGGTCAAATGTGTGATGGACCACAAGCTCATTCTAAGATACTGCGCGATTATTAAACCAGTAATCCAGGGGACCATCTTCACACAGTTTCTGCTGATCGGCCTGGTTCTGGGCTTCACGCTGATCAACGTGTTTTTCTTCTCAGACATCTGGACGGGCATCGCATCATTTATGTTTGTTATAACCATTTTGCTGCAGACCTTCCCCTTCTGCTACACATGCAACCTCATCATGGAGGACTGCGAGTCCTTGACCCATGCTATTTTCCAGTCCAACTGGGTGGATGCCAGTCGTCGCTACAAAACAACACTACTGTATTTTCTCCAAAACGTGCAGCAGCCTATCGTTTTCATTGCAGGCGGTATCTTTCAGATATCCATGAGCAGCAACATAAGTGTGGCAAAGTTTGCTTTCTCCGTGATAACCATTACCAAGCAAATGAATATAGCTGACAAATTTAAGACGGAC

[0210] DOR119

[0211] MAVFKLIKPAPLTEKVQSRQGNIYLYRAMWLIGWIPPKEGVLRYVYLFWTCVPFAFGVFYLPVGFIISYVQEFKNFTPGEFLTSLQVCINVYGASVKSTITYLFLWRLRKTEILLDSLDKRLANDSDRERIHNMVARCNYAFLIYSFIYCGYAGSTFLSYALSGRPPWSVYNPFIDWRDGMGSLWIQAIFEYITMSFAVLQDQLSDTYPLMFTIMFRAHMEVLKDHVRSLRMDPERSEADNYQDLVNCVLDHKTILKCCDMIRPMISRTIPVQFALIGSVLGLTLVNVFFFSNFWKGVASLLFVITILLQTFPFCYTCNMLIDDAQDLSNEIFQSNWVDAEPRYKATLVLFMHHVQQPIIFIAGGIFPISMNSNITVAKFAFSIITIVRQMNLAEQFQATGGCGGTGTTCAAGCTAATCAAACCGGCTCCGTTGACCGAGAAGGTGCAGTCCCGCCAGGGGAATATATATCTGTACCGTGCCATGTGGCTCATCGGATGGATTCCGCCGAAGGAGGGAGTCCTGCGCTACGTGTATCTCTTCTGGACCTGCGTGCCCTTCGCCTTCGGGGTGTTTTACCTGCCCGTGGGCTTCATCATCAGCTACGTGCAGGAGTTCAAGAACTTCACGCCGGGCGAGTTCCTTACCTCGCTGCAGGTGTGCATCAATGTGTATGGCGCCTCGGTGAAGTCCACCATCACCTACCTCTTCCTCTGGCGACTGCGCAAGACGGAGATCCTTCTGGACTCCCTGGACAAGAGGCTGGCGAACGACAGCGATCGCGAGAGGATCCACAATATGGTGGCGCGCTGCAACTACGCCTTTCTCATCTACAGCTTCATCTACTGCGGATACGCGGGTTCCACTTTCCTGTCCTACGCCCTCAGTGGTCGTCCTCCGTGGTCCGTCTACAATCCCTTCATCGATTGGCGCGATGGCATGGGCAGCCTGTGGATCCAGGCCATATTCGAGTACATCACCATGTCCTTCGCCGTGCTGCAGGACCAGCTATCCGACACGTATCCCCTGATGTTCACCATTATGTTCCGGGCCCACATGGAGGTCCTCAAGGATCACGTGCGGAGCCTGCGCATGGATCCCGAGCGCAGTGAGGCAGACAACTATCAGGATCTGGTGAACTGCGTGCTGGACCACAAGACTATACTGAAATGCTGTGACATGATTCGCCCCATGATATCCCGCACCATCTTCGTGCAATTCGCGCTGATTGGTTCCGTTTTGGGCCTGACCCTGGTGAACGTGTTCTTCTTCTCGAACTTCTGGAAGGGCGTGGCCTCGCTCCTGTTCGTCATCACCATCCTGCTGCAGACCTTCCCGTTCTGCTACACCTGCAACATGCTGATCGACGATGCCCAGGATCTGTCCAACGAGATTTTCCAGTCCAACTGGGTGGACGCGGAGCCGCGCTACAAGGCGACGCTGGTGCTCTTCATGCACCATGTTCAGCAGCCCATAATCTTCATTGCCGGAGGCATCTTTCCCATCTCTATGAACAGCAACATAACCGTGGCCAAGTTCGCCTTCAGCATCATTACAATAGTGCGACAAATGAATCTGGCCGAGCAGTTCCAG

[0212] DOR120

[0213] MTKFFFKRLQTAPLDQEVSSLDASDYYYRIAFFLGWTPPKGALLRWIYSLWTLTTMWLGIVYLPLGLSLTYVKHFDRFTPTEFLTSLQVDINCIGNVIKSCVTYSQMWRFRRMNELISSLDKRCVTTTQRRIFHKMVARVNLIVILFLSTYLGFCFLTLFTSVFAGKAPWQLYNPLVDWRKGHWQLWIASILEYCVVSIGTMQELMSDTYAIVFISLFRCHLAILRDRIANLRQDPKLSEMEHYEQMVACIQDHRTIIQCSQIIRPILSITIFAQFMLVGIDLGLAAISILFFPNTIWTIMANVSFIVAICTESFPCCMLCEHLIEDSVHVSNALFHSNWITADRSYKSAVLYFLHRAQQPIQFTAGSTFPISVQSNIAVAKFAFTIITIVNQMNLGEKFFSDRSN GDINP

[0214] DOR120nt

[0215] ATGACCAAGTTCTTCTTCAAGCGCCTGCAAACTGCTCCACTTGATCAGGAGGTGAGTTCCCTTGATGCCAGCGACTACTACTACCGCATCGCATTTTTCCTGGGCTGGACCCCGCCCAAGGGGGCTCTGCTCCGATGGATCTACTCCCTGTGGACTCTGACCACGATGTGGCTGGGTATCGTGTACCTGCCGCTCGGACTGAGCCTCACCTATGTGAAGCACTTCGATAGATTCACGCCGACGGAGTTCCTGACCTCCCTGCAGGTGGATATCAACTGCATCGGGAACGTGATCAAGTCATGCGTAACTTATTCCCAGATGTGGCGTTTTCGCCGGATGAATGAGCTTATCTCGTCCCTGGACAAGAGATGTGTGACTACGACACAGCGTCGAATTTTCCATAAGATGGTGGCACGGGTTAATCTCATCGTGATTCTGTTCTTGTCCACGTACTTGGGCTTCTGCTTTCTAACTCTGTTOACTTCGGTTTTCGCTGGCAAAGCTCCTTGGCAGCTGTACAACCCACTGGTGGACTGGCGGAAAGGCCATTGGCAGCTATGGATTGCCTCCATCCTGGAGTACTGTGTGGTCTCCATTGGCACCATGCAGGAGTTGATGTCCGACACCTACGCCATAGTGTTCATCTCCTTGTTCCGCTGCCACCTGGCTATTCTCAGAGATCGCATAGCTAATCTGCGGCAGGATCCGAAACTCAGTGAGATGGAACACTATGAGCAGATGGTGGCCTGCATTCAGGATCATCGAACCATCATACAGTGCTCCCAGATTATTCGACCCATCCTGTCGATCACTATCTTTGCCCAGTTCATGCTGGTTGGCATTGACTTGGGTCTGGCGGCCATCAGCATCCTCTTCTTTCCGAACACCATTTGGACGATCATGGCAAACGTGTCGTTCATCGTGGCCATCTGTACAGAGTCCTTTCCATGCTGCATGCTCTGCGAGCATCTGATCGAGGACTCCGTCCATGTGAGCAACGCCCTGTTCCACTCAAACTGGATAACCGCGGACAGGAGCTACAAGTCGGCGGTTCTGTATTTCCTGCACCGGGCTCAGCAACCCATTCAATTCACGGCCGGCTCCATATTTCCCATTTCGGTGCAGAGCAACATAGCCGTGGCCAAGTTCGCGTTCACAATCATCACAATCGTGAACCAAATGAATCTGGGCGAGAAGTTCTTCAGTGACAGGAGCAATGGCGATATAAATCCT

[0216] DOR121

[0217] MLTDKFLRLQSALFRLLGLELLHEQDVGHRYPWRSICCILSVASFMPLTIAFGLQNVQNVEQLTDSLCSVLVDLLALCKIGLFLWLYKDFKFLIGQFYCVLQTETHTAVAEMIVTRESRRDQFISAMYAYCFITAGLSACLMSPLSMLISYHEQVNCSRNFHFPVCKKKYCLISRILRYSFCRYPWDNMKLSNYIISYFWNVCAALGVALPTVCVDTLFCSLSHNLCALFQIARHKMMHFEGRNTKETHENLKHVFQLYALCLNLGHFLNEYFRPLICQFVAASLHLCVLCYQLSANILQPALLFYAAFTAAVVGQVSIYCFCGSSIHSECQLFGQAIYESSWPHLLQENLQLVSSLKIAMMRSSLGCPIDGYFFEANRETLITVSKAFIKVSKKTPQVND

[0218] DOR121

[0219] ATGCTGACGGACAAGTTCCTCCGACTGCAGTCCGCTTTATTTCGCCTTCTCGGACTCGAATTGTTGCACGAGCAGGATGTTGGCCATCGATATCCTTGGCGCAGCATCTGCTGCATTCTCTCGGTGGCCAGTTTCATGCCCCTGACCATTGCGTTTGGCCTGCAAAACGTCCAAAATGTGGAGCAATTAACCGACTCACTCTGCTCGGTTCTCGTGGATTTGCTGGCCCTGTGCAAAATCGGGCTTTTCCTTTGGCTTTACAAGGACTTCAAGTTCCTAATAGGGCAGTTCTATTGTGTTTTGCAAACGGAAACCCACACCGCTGTCGCTGAAATGATAGTGACCAGGGAAAGTCGTCGGGATCAGTTCATCAGTGCTATGTATGCCTACTGTTTCATTACGGCTGGCCTTTCGGCCTGCCTGATGTCCCCTCTATCCATGCTGATTAGCTACCACGAACAGGTGAATTGCAGCCGAAATTTCCATTTCCCAGTGTGTAAGAAAAAGTACTGCTTAATATCCAGAATATTAAGATACAGTTTCTGCAGATATCCCTGGGACAATATGAAGCTGTCCAACTACATCATTTCCTATTTCTGGAATGTGTGTGCTGCATTGGGCGTGGCACTGCCCACCGTTTGTGTGGACACACTGTTCTGTTCTCTGAGCCATAATCTCTGTGCCCTATTCCAGATTGCCAGGCACAAAATGATGCACTTTGAGGGCAGAAATACCAAAGAGACTCATGACAACTTAAAGCACGTGTTTCAACTATATGCGTTGTGTTTGAACCTGGGCCATTTCTTAAACGAATATTTCAGACCGCTCATCTGCCAGTTTGTGGCAGCCTCACTGCACTTGTGTGTCCTGTGCTACCAACTGTCTGCCAATATCCTGCAGCCAGCGTTACTCTTCTATGCCGCATTTACGGCAGCAGTTGTTGGCCAGGTGTCTATATACTGCTTCTGCGGATCGAGCATCCATTCGGAGTGTCAGCTATTTGGCCAGGCCATCTACGAGTCCAGCTGGCCCCATCTGCTGCAGGAAAACCTGCAGCTTGTAAGCTCCTTAAAAATTGCCATGATGCGATCGAGTTTGGGATGTCCCATCGATGGTTACTTCTTCGAGGCCAATCGGGAGACGCTCATCACGGTGAGTAAAGCGTTTATAAAAGTGTCCAAAAAGACACCTCAAGTGAATGAT

[0220] DOR14

[0221] MDYDRIRPVRFLTGVLKWWRLWPRKESVSTPDWTNWQAYALHVPFTFLFVLLLWLEAIKSRDIQHTADVLLICLTTTALGGKVINIWKYAHVAQGILSEWSTWDLFELRSKQEVDMWRFEHRRFNRVFMFYCLCSAGVIPFIVIQPLFDIPNRLPFWMWTPFDWQQPVLFWYAFIYQATTIPIACACNVTMDAVNWYLMLHLSLCLRMLGQRLSKLQHDDKDLREKFLELIHLHQRLKQQALSIEIFISKSTFTQILVSSLIICFTIYSMQMDLPGFAAMMQYLVAMIMQVMLPTIYGNAVIDSANMLTDSMYNSDWPDMNCRMRRLVLMFMVYLNRPVTLKAGGFFHIGLPLFTKVVFSTLENPCISYLYFRP

[0222] DOR14nt

[0223] ATGGACTACGATCGAATTCGACCGGTGCGATTTTTGACGGGAGTGCTGAAATGGTGGCGTCTCTGGCCGAGGAAGGAATCGGTGTCCACACCGGACTGGACTAACTGGCAGGCATATGCCTTGCACGTTCCATTTACATTCTTGTTTGTGTTGCTTTTGTGGTTGGAGGCAATCAAGAGCAGGGATATACAGCATACCGCCGATGTCCTTTTGATTTGCCTAACCACCACTGCCTTGGGAGGTAAAGTTATCAATATCTGGAAGTATGCCCATGTGGCCCAAGGCATTTTGTCCGAGTGGAGCACGTGGGATCTTTTCGAGCTGAGGAGCAAACAGGAAGTGGATATGTGGCGATTCGAGCATCGACGTTTCAATCGTGTTTTTATGTTTTACTGTTTGTGCAGTGCTGGTGTAATCCCATTTATTGTGATTCAACCGTTGTTTGATATCCCAAATCGATTGCCCTTCTGGATGTGGACACCATTCGATTGGCAGCAGCCTGTTCTCTTCTGGTATGCATTCATCTATCAGGCCACAACCATTCCTATTGCCTGTGCTTGCAACGTAACCATGGACGCTGTTAATTGGTACTTGATGCTGCATCTGTCCTTGTGTTTGCGTATGTTGGGCCAGCGATTGAGTAAGCTTCAGCATGATGACAAGGATCTGAGGGAGAAGTTCCTGGAACTGATCCATCTGCACCAGCGACTCAAGCAACAGGCCTTGAGCATTGAAATCTTTATTTCGAAGAGCACGTTCACCCAAATTCTGGTCAGTTCCCTTATCATTTGCTTCACCATTTACAGCATGCAGATGGACTTGCCAGGATTTGCCGCCATGATGCAGTACCTAGTGGCCATGATCATGCAGGTCATGCTGCCCACCATATATGGTAACGCCGTCATCGATTCTGCAAATATGTTGACCGATTCCATGTACAATTCGGATTGGCCGGATATGAATTGCCGAATGCGTCGCCTAGTTTTAATGTTTATGGTGTACTTAAATCGACCGGTGACCTTAAAAGCCGGTGGCTTTTTTCATATTGGTTTACCTCTGTTTACCAAGGTTGTATTTTCTACTCTGGAAAATCCTTGTATAAGTTATCTTTATTTCAGACCA

[0224] DOR16

[0225] MTDSGQPAIADHFYRIPRISGLIVGLWPQRIRGGGGRPWHAHLLFVFAFAMVVVGAVGEVSYGCVHLDNLVVALEAFCPGTTKAVCVLKLWVFFRSNRRWAELVQRLRAILWESRRQEAQRMLVGLATTANRLSLLLLSSGTATNAAFTLQPLIMGLYRWIVQLPGQTELPFNIILPSFAVQPGVFPLTYVLLTASGACTVFAFSFVDGFFICSCLYICGAFRLVQQDIRRIFADLHGDSVDVFTEEMNAEVRHRLAQVVERHNAIIDFCTDLTRQFTVIVLMHFLSAAFVLCSTILDIMLVSPFSEAFLWGGYPWVCRATGFSHRLHSAAVLKVFPCFHCLLFFPGFSSRSVLIRFSRFVCLLCGCGCGSLRWQFISA

[0226] DOR16nt

[0227] ATGACTGACAGCGGGCAGCCTGCCATTGCCGACCACTTTTATCGGATTCCCCGCATCTCCGGCCTCATTGTCGGCCTCTGGCCGCAAAGGATAAGGGGCGGGGGCGGTCGTCCTTGGCACGCCCATCTGCTCTTCGTGTTCGCCTTCGCCATGGTGGTGGTGGGTGCGGTGGGCGAGGTGTCGTACGGCTGTGTCCACCTGGACAACCTGGTGGTGGCGCTGGAGGCCTTCTGCCCCGGAACCACCAAGGCGGTCTGCGTTTTGAAGCTGTGGGTCTTCTTCCGCTCCAATCGCCGGTGGGCGGAGTTGCTCCAGCGCCTGCGGGCTATTTTGTGGGAATCGCGGCGGCAGGAGGCCCAGAGGATGCTGGTCGGACTGGCCACCACGGCCAACAGGCTCAGCCTGTTGTTGCTCAGCTCTGGCACGGCGACAAATGCCGCCTTCACCTTGCAACCGCTGATTATGGGTCTCTACCGCTGGATTGTGCAGCTGCCAGGTCAAACCGAGCTGCCCTTTAATATCATACTGCCCTCGTTTGCCGTGCAGCCAGGAGTCTTTCCGCTCACCTACGTGCTGCTGACCGCTTCCGGTGCCTGCACCGTTTTCGCCTTCAGCTTCGTGGACGGATTCTTCATTTGCTCGTGCCTCTACATCTGCGGCGCTTTCCGGCTGGTGCAGCAGGACATTCGCAGGATATTTGCCGATTTGCATGGCGACTCAGTGGATGTGTTCACCGAGGAGATGAACGCGGAGGTGCGGCACAGACTGGCCCAAGTTGTCGAGCGGCACAATGCGATTATCGATTTCTGCACGGACCTAACACGCCAGTTCACCGTTATCGTTTTAATGCATTTCCTGTCCGCCGCCTTCGTCCTCTGCTCGACCATCCTGGACATCATGTTGGTGAGCCCCTTTTCAGAGGCCTTCCTTTGGGGCGGGTATCCTTGGGTTTGTCGCGCCACTGGCTTTTCGCATCGCCTGCATTCGGCGGCTGTTTTAAAAGTTTTTCCCTGTTTTCACTGTTTGCTGTTTTTCCCTGGCTTTTCCAGCCGCTCCGTTCTGATTCGGTTTTCCCGATTTGTTTGTTTGCTTTGTGGCTGCGGCTGCGGCTCTCTCCGGTGGCAATTTATAAGCCCATGA

[0228] DOR19

[0229] MVTEDFYKYQVWYFQILGVWQLPTWAADHQRRFQSMRFGFILVILFIMLLLFSFEMLNNISQVREILKVFFMFATEISCMAKLLHLKLKSRKLAGLVDAMLSPEFGVKSEQEMQMLELDRVAVVRMRNSYGIMSLGAASLILIVPCFDNFGELPLAMLEVCSIEGWICYWSQYLFHSICLLPTCVLNITYDSVAYSLLCFLKVQLQMLVLRLEKLGPVIEPQDNEKIAMELRECAAYYNRIVRFKDLVELFIKGPGSVQLMCSVLVLVSNLYDMSTMSIANGDAIFMLKTCIYQLVMLWQIFIICYASNEVTVQSSRLCHSIYSSQWTGWNRANRRIVLLMMQRFNSPMLLSTFNPTFAFSLEAFGSVGQQKFLYISFITGYALLLSDRQLLLQLLRTAEARQQLNFETPQHLKIFKPIFKSTQNVMHVH

[0230] DOR19nt

[0231] ATGGTTACGGAGGACTTTTATAAGTACCAGGTGTGGTACTTCCAAATCCTTGGTGTTTGGCAGCTCCCCACTTGGGCCGCAGACCACCAGCGTCGTTTTCAGTCCATGAGGTTTGGCTTCATCCTGGTCATCCTGTTCATCATGCTGCTGCTTTTCTCCTTCGAAATGTTGAACAACATTTCCCAAGTTAGGGAGATCCTAAAGGTATTCTTCATGTTCGCCACGGAAATATCCTGCATGGCCAAATTATTGCATTTGAAGTTGAAGAGCCGCAAACTCGCTGGCTTGGTTGATGCGATGTTGTCCCCAGAGTTCGGCGTTAAAAGTGAACAGGAAATGCAGATGCTGGAATTGGATAGAGTGGCGGTTGTCCGCATGAGGAACTCCTACGGCATCATGTCCCTGGGCGCGGCTTCCCTGATCCTTATAGTTCCCTGTTTCGACAACTTTGGCGAGCTACCACTGGCCATGTTGGAGGTATGCAGCATCGAGGGATGGATCTGCTATTGGTCGCAGTACCTTTTCCACTCGATTTGCCTGCTGCCCACTTGTGTGCTGAATATAACCTACGACTCGGTGGCCTACTCGTTGCTCTGTTTCTTGAAGGTTCAGCTACAAATGCTGGTCCTGCGATTAGAAAAGTTGGGTCCTGTGATCGAACCCCAGGATAATGAGAAAATCGCAATGGAACTGCGTGAGTGTGCCGCCTACTACAACAGGATTGTTCGTTTCAAGGACCTGGTGGAGCTGTTCATAAAGGGGCCAGGATCTGTGCAGCTCATGTGTTCTGTTCTGGTGCTGGTGTCCAACCTGTACGACATGTCCACCATGTCCATTGCAAACGGCGATGCCATCTTTATGCTCAAGACCTGTATCTATCAGCTGGTGATGCTCTGGCAGATCTTCATCATTTGCTACGCCTCCAACGAGGTAACTGTCCAGAGCTCTAGGTTGTGTCACAGCATCTACAGCTCCCAATGGACGGGATGGAACAGGGCAAACCGCCGGATTGTCCTTCTCATGATGCAGCGCTTTAATTCCCCGATGCTCCTGAGCACCTTTAACCCCACCTTTGCTTTCAGCTTGGAGGCCTTTGGTTCTGTAGGGCAGCAGAAATTCCTTTATATATCATTTATTACTGGTTATGCTCTTCTCCTTTCAGATCGTCAACTGCTCCTACAGCTACTTCGCACTGCTGAAGCGCGTCAACAGTTAAATTTCGAAACACCGCAGCACCTAAAGATTTTCAAGCCGATTTTTAAAAGCACTCAAAACGTTATGCACGTACAT

[0232] DOR20

[0233] MSKGVEIFYKGQKAFLNILSLWPQIERRWRIIHQVNYVHVIVFWVLLFDLLLVLHVMANLSYMSEVVKAIFILATSAGHTTKLLSIKANNVQMEELFRRLDNEEFRPRGANEELIFAAACERSRKLRDFYGALSFAALSMILIPQFALDWSHLPLKTYNPLGENTGSPAYWLLYCYQCLALSVSCITNIGFDSLCSSLFIFLKCQLDILAVRLDKIGRLITTSGGTVEQQLKENIRYHMTIVELSKTVERLLCKPISVQIFCSVLVLTANFYAIAVWSCEFATRRLSVCDLSGVHVDSDFYIVLLCRVGIPYPKCLPRPVMNFIVSEVTQRSLDLPHELYKTSWVDWDYRSRRIALLFMQRLHSTLRIRTLNPSLGFDLMLFSSVSSFRVLTFLCTVANFHNEAH

[0234] DOR20nt

[0235] ATGAGCAAAGGAGTAGAAATCTTTTACAAGGGCCAGAAGGCATTCTTGAACATCCTCTCGTTGTGGCCTCAGATAGAACGCCGGTGGAGAATCATCCACCAGGTGAACTATGTCCACGTAATTGTGTTTTGGGTGCTGCTCTTTGATCTCCTCTTGGTGCTCCATGTGATGGCTAATTTGAGCTACATGTCCGAGGTTGTGAAAGCCATCTTTATCCTGGCCACCAGTGCAGGGCACACCACCAAGCTGCTGTCCATAAAGGCGAACAATGTGCAGATGGAGGAGCTCTTTAGGAGATTGGATAACGAAGAGTTCCGTCCTAGAGGCGCCAACGAAGAGTTGATCTTTGCAGCAGCCTGTGAAAGAAGTAGGAAGCTTCGGGACTTCTATGGAGCGCTTTCGTTTGCCGCCTTGAGCATGATTCTCATACCCCAGTTCGCCTTGGACTGGTCCCACCTTCCGCTCAAAACATACAATCCGCTTGGCGAGAATACCGGCTCACCTGCTTATTGGCTCCTCTACTGCTATCAGTGTCTGGCCTTGTCCGTATCCTGCATCACCAACATAGGATTCGACTCACTCTGCTCCTCACTGTTCATCTTCCTCAAGTGCCAGCTGGACATTCTGGCCGTGCGACTGGACAAGATCGGTCGGTTAATCACTACTTCTGGTGGCACTGTGGAACAGCAACTTAAGGAAAATATCCGCTATCACATGACCATCGTTGAACTGTCGAAAACCGTGGAGCGTCTACTTTGCAAGCCGATTTCGGTGCAGATCTTCTGCTCGGTTTTGGTGCTGACTGCCAATTTCTATGCCATTGCTGTGGTGAGCTGTGAATTCGCAACAAGAAGACTATCAGTATGTGACCTATCAGGCGTGCATGTTGATTCAGATTTTTATATTGTGCTACTATGCCGGGTGGGTATTCCATATCCGAAATGCCTCCCCAGGCCAGTAATGAATTTCATCGTCAGTGAGGTAACCCAGCGCAGCCTGGACCTTCCGCACGAGCTGTACAAGACCTCCTGGGTGGACTGGGACTACAGGAGCCGAAGGATTGCGCTCCTCTTTATGCAACGCCTTCACTCGACCTTGAGGATTAGGACACTTAATCCAAGTCTTGGTTTTGACTTAATGCTCTTCAGCTCGGTGAGTTCTTTCCGTGTTTTGACTTTTTTGTGCACTGTAGCCAATTTCCATAATGAGGCTCAT

[0236] DOR24

[0237] MDSFLQVQKSTIALLGFDLFSENREMWKRPYRAMNVFSIAAIFPFILAAVLHNWKNVLLLADAMVALLITILGLFKFSMILYLRRDFKRLIDKFRLLMSNEAEQGEEYAEILNAANKQDQRMCTLFRTCFLLAWALNSVLPLVRMGLSYWLAGHAEPELPFPCLFPWNIHIIRNYVLSFIWSAFASTGVVLPAVSLDTIFCSFTSNLCAFFKIAQYKVVRFKGGSLKESQATLNKVFALYQTSLDMCNDLNQCYQPIICAQFFISSLQLCMLGYLFSITFAQTEGVYYASFIATIIIQAYIYCYCGENLKTESASFEWAIYDSPWHESLGAGGASTSICRSLLISMMRAHRGFRITGYFFEANMEAFSSIVRTAMSYITMLRSFS

[0238] DOR24nt

[0239] GGCACGAGCCTTGTCGACATGGACAGTTTTCTGCAAGTACAGAAGAGCACCATTGCTCTTCTGGGCTTTGATCTCTTTAGTGAAAATCGAGAAATGTGGAAACGCCCCTATAGAGCAATGAATGTGTTTAGCATAGCTGCCATTTTTCCCTTTATCCTGGCAGCTGTGCTCCATAATTGGAAGAATGTATTGCTGCTGGCCGATGCCATGGTGGCCCTACTAATAACCATTCTGGGCCTATTCAAGTTTAGCATGATACTTTACTTACGTCGCGATTTCAAGCGACTGATTGACAAATTTCGTTTGCTCATGTCGAATGAGGCGGAACAGGGCGAGGAATACGCCGAGATTCTCAACGCAGCAAACAAGCAGGATCAACGAATGTGCACTCTGTTTAGGACTTGTTTCCTCCTCGCCTGGGCCTTGAATAGTGTTCTGCCCCTCGTGAGAATGGGTCTCAGCTATTGGTTAGCAGGTCATGCAGAGCCCGAGTTGCCTTTTCCCTGTCTTTTTCCCTGGAATATCCACATCATTCGCAATTATGTTTTGAGCTTCATCTGGAGCGCTTTCGCCTCGACAGGTGTGGTTTTACCTGCTGTCAGCTTGGATACCATATTCTGTTCCTTCACCAGCAACCTGTGCGCCTTCTTCAAAATTGCGCAGTACAAGGTGGTTAGATTTAAGGGCGGATCCCTTAAAGAATCACAGGCCACATTGAACAAAGTCTTTGCCCTGTACCAGACCAGCTTGGATATGTGCAACGATCTGAATCAGTGCTACCAACCGATTATCTGCGCCCAGTTCTTCATTTCATCTCTGCAACTCTGCATGCTGGGATATCTGTTCTCCATTACTTTTGCCCAGACAGAGGGCGTGTACTATGCCTCTTTCATAGCCACCATCATTATACAAGCCTATATCTACTGCTACTGCGGGGAGAACCTGAAGACGGAGAGTGCCAGCTTCGAGTGGGCCATCTACGACAGTCCGTGGCACGAGAGTTTGGGTGCTGGTGGAGCCTCTACCTCGATCTGCCGATCCTTGCTGATCAGCATGATGCGGGCTCATCGGGGATTCCGCATTACGGGATACTTCTTCGAGGCAAACATGGAGGCCTTCTCATCGATTGTTCGCACGGCTATGTCCTACATCACAATGCTGAGATCATTCTCCTAAATGTGGTTTGACCACAAGGCTTTGGATTGATTTTTGTGCAATTTTTGTTTTATTGCTGAGCATGCGTTGCCGTACGACATTTAACAATCGATCTTACGTAATTTACATATGATAATCTCACATATTGTTCGTTAAGCACTAAGTAGAATGTAGAATGTGAATTGGCTGTAGAAATGCACAGATGAAGCACGAAAAAAAAAAAAAAAAAAAAAAAA

[0240] DOR25

[0241] MNDSGYQSNLSLLRVFLDEFRSVLRQESPGLIPRLAFYYVRAFLSLPLYRWINLFIMCNVMTIFWTMFVALPESKNVIEMGDDLVWISGMALVFTKIFYMHLRCDEIDELISDFEYYNRELRPHNIDEEVLGWQRLCYVIESGLYINCFCLVNFFSAAIFLQPLLGEGKLPFHSVYPFQWHRLDLHPYTFWFLYIWQSLTSQHNLMSILMVDMVGISTFLQTALNLKLLCIEIRKLGDMEVSDKRFHEEFCRVVRFHQHIIKLVGKANRAFNGAFNAQLMASFSLISISTFETMAAAAvDPKMAAKFVLLMLVAFIQLSLWCVSGTLVYTQSVEVAQAAFDINDWHTKSPGIQRDISFVILRAQKPLMYVAEPFLPFTLGTYMLVLKNCYRLLALMQESM

DOR25nt

[0242] ATGAACGACTCGGGTTATCAATCAAATCTCAGCCTTCTGCGGGTTTTTCTCGACGAGTTCCGATCGGTTCTGCGGCAGGAAAGTCCCGGTCTCATCCCACGCCTGGCTTTTTACTATGTTCGCGCCTTTCTGAGCTTGCCCCTGTACCGATGGATCAACTTGTTCATCATGTGCAATGTGATGACCATTTTCTGGACCATGTTCGTGGCCCTGCCCGAGTCGAAGAACGTGATCGAAATGGGCGACGACTTGGTTTGGATTTCGGGGATGGCACTGGTGTTCACCAAGATCTTTTACATGCATTTGCGTTGCGACGAGATCGATGAACTTATTTCGGATTTTGAATACTACAACCGGGAGCTGAGACCCCATAATATCGATGAGGAGGTGTTGGGTTGGCAGAGACTGTGCTACGTGATAGAATCGGGTCTATATATCAACTGCTTTTGCCTGGTCAACTTCTTCAGTGCCGCTATTTTCCTGCAACCTCTGTTGGGCGAGGGAAAGCTGCCCTTCCACAGCGTCTATCCGTTTCAATGGCATCGCTTGGATCTGCATCCCTACACGTTCTGGTTCCTCTACATCTGGCAGAGTCTGACCTCGCAGCACAACCTAATGAGCATTCTAATGGTGGATATGGTAGGCATTTCCACGTTCCTCCAGACGGCGCTCAATCTCAAGTTGCTTTGCATCGAGATAAGGAAACTGGGGGACATGGAGGTCAGTGATAAGAGGTTCCACGAGGAGTTTTGTCGTGTGGTTCGCTTCCACCAGCACATTATCAAGTTGGTGGGGAAAGCCAATAGAGCTTTCAATGGCGCCTTCAATGCACAATTAATGGCCAGTTTCTCCCTGATTTCCATATCCACTTTCGAGACCATGGCTGCAGCGGCTGTGGATCCCAAAATGGCCGCCAAGTTCGTGCTTCTCATGCTGGTGGCATTCATTCAACTGTCGCTTTGGTGCGTCTCTGGAACTTTGGTTTATACTCAGTCAGTGGAGGTGGCTCAGGCTGCTTTTGATATCAACGATTGGCACACCAAATCGCCAGGCATCCAGAGGGATATATCCTTTGTGATACTACGAGCCCAGAAACCCCTGATGTATGTGGCCGAACCATTTCTGCCCTTCACCCTGGGAACCTATATGCTTGTACTGAAGAACTGCTATCGTTTGCTGGCCCTGATGCAAGAATCGATGTAG

[0243] DOR28

[0244] MYSPEEAAELKRRNYRSIREMIRLSYTVGFNLLDPSRCGQVLRIWTIVLSVSSLASLYGHWQMLARYIHDIPRIGETAGTALQFLTSIAKMWYFLFAHRQIYELLRKARCHELLQKCELFERMSDLPVIKEIRQQVESTMNRYWASTRRQILIYLYSCICITTNYFINSFVINLYRYFTKPKGSYDIMLPLPSLYPAWEHKGLEFPYYHIQMYLETCSLYICGMCAVSFDGVFIVLCLHSVGLMRSLNQMVEQATSELVPPDRRVEYLRCCIYQYQRVANFATEVNNCFRHITFTQFLLSLFNWGLALFQMSVGLGNNSSITMIRMTMYLVAAGYQIVVYCYNGQRFATASEEIANAFYQVRWYGESREFRHLIRMMLMRTNRGFPRLDVSFMQMSLPTLMAVSSGAEQSRGPAGPAGPAGPPPRVPSYSQFHLIDSQMVRTSGQYFLLLQNVNQK

[0245] DOR28nt

[0246] ATGTACTCACCGGAAGAGGCGGCCGAACTGAAGAGGCGCAACTATCGCAGCATCAGGGAGATGATCCGACTCTCCTATACGGTGGGCTTCAACCTGTTGGATCCTTCCCGATGCGGACAGGTGCTCAGAATCTGGACAATTGTCCTTAGCGTGAGTAGCTTGGCATCGCTTTATGGGCACTGGCAAATGTTAGCCAGGTACATTCATGATATTCCACGCATTGGAGAGACCGCTGGAACTGCCCTGCAGTTCCTAACATCGATAGCAAAGATGTGGTACTTTCTGTTTGCCCATAGACAGATATACGAATTGCTACGAAAGGCGCGCTGCCATGAATTACTCCAAAAGTGTGAGCTCTTTGAAAGGATGTCAGATCTACCTGTTATCAAAGAGATTCGCCAGCAGGTTGAGTCCACGATGAATCGGTACTGGGCCAGCACTCGTCGGCAAATTCTTATCTATTTGTACAGCTGTATTTGTATTACTACAAACTACTTTATCAACTCCTTCGTAATCAACCTCTATCGCTATTTCACTAAACCGAAAGGATCCTACGACATAATGTTACCTCTGCCATCTCTGTATCCCGCCTGGGAGCACAAGGGATTAGAGTTTCCCTACTATCATATACAGATGTACCTGGAAACCTGTTCTCTGTATATCTGCGGCATGTGTGCCGTTAGCTTTGATGGAGTCTTTATTGTCCTGTGCCTTCATAGCGTGGGACTTATGAGGTCACTTAACCAAATGGTGGAACAAGCCACATCTGAGTTGGTTCCTCCAGATCGCAGGGTTGAATACTTGCGATGCTGTATTTATCAGTACCAACGAGTGGCGAACTTTGCAACCGAGGTTAACAACTGCTTTCGGCACATCACTTTCACGCAGTTCCTGCTTAGCCTTTTCAACTGGGGCCTGGCCTTGTTCCAAATGAGCGTCGGATTGGGCAACAACAGCAGCATCACCATGATCCGGATGACCATGTACCTGGTGGCAGCCGGCTATCAGATAGTTGTGTACTGCTACAATGGCCAGCGATTTGCGACTGCTAGCGAGGAGATTGCCAACGCCTTTTACCAGGTGCGATGGTACGGAGAGTCCAGGGAGTTCCGCCACCTCATCCGCATGATGCTGATGCGCACGAACCGGGGATTCAGGCTGGACGTGTCCTGGTTCATGCAAATGTCCTTGCCCACACTCATGGCGGTGAGTAGCGGAGCAGAGCAGAGCAGGGGTCCTGCAGGTCCTGCAGGTCCTGCAGGTCCACCCCCAAGGGTCCCCTCCTACAGCCAGTTCCACTTGATTGATTCGCAGATGGTCCGGACAAGTGGACAGTACTTCCTGCTGCTGCAGAACGTCAACCAGAAA

[0247] DOR30

[0248] MAVSTRVATKQEVPESRRAFRNLFNCFYALGMQAPDGSRPTTSSTWQRIYACFSVVMYVWQLLLVPTFFVISYRYMGGMEITQVLTSAQVAIDAVILPAKIVALAWNLPLLRRAEHHLAALDARCREQEEFQLILDAVRFCNYLVWFYQICYAIYSSSTFVCAFLLGQPPYALYLPGLDWQRSQMQFCIQAWIEFLIMNWTCLHQASDDVYAVIYLYVVRIQVQLLARRVEKLGTDDSGQVEIYPDERRQEEHCAELQRCIVDHQTMLQLLDCISPVISRTIFVQFLITAAIMGTTMINIFIFANTNTKIASIIYLLAVTLQTAPCCYQATSLMLDNERLALAIFQCQWLGQSARFRKMLLYYLHRAQQPITLTAMKLFPINLATYFSIAKFSFSLYTLIKGMNLG ERFNRTN

[0249] DOR30nt

[0250] ATGGCGGTGAGCACTCGTGTGGCCACAAAGCAGGAAGTGCCCGAATCCCGGCGAGCGTTTAGGAATCTCTTCAATTGCTTCTATGCCCTTGGCATGCAGGCACCGGATGGCAGTCGACCGACCACGAGCAGCACATGGCAACGCATCTACGCCTGCTTCTCGGTGGTCATGTACGTGTGGCAACTGCTGCTGGTGCCCACATTCTTTGTGATCAGCTATCGGTACATGGGCGGCATGGAGATTACCCAGGTGCTGACCTCCGCCCAGGTGGCCATCGATGCGGTCATTCTGCCGGCCAAGATTGTGGCACTGGCGTGGAATTTGCCATTGCTGCGCAGAGCAGAGCATCATCTGGCCGCCTTGGATGCGCGGTGCAGGGAACAGGAGGAGTTCCAATTGATCCTCGATGCGGTGAGGTTTTGCAACTATCTGGTATGGTTCTACCAGATCTGCTATGCCATCTACTCCTCGTCGACATTTGTGTGCGCCTTCCTGCTGGGCCAACCGCCATATGCCCTCTATTTGCCTGGCCTCGATTGGCAGCGTTCCCAGATGCAGTTCTGCATCCAGGCCTGGATTGAGTTCCTTATCATGAACTGGACGTGCCTGCACCAAGCTAGCGATGATGTGTACGCCGTTATCTATCTGTATGTGGTCCGGATTCAAGTGCAATTGCTGGCCAGGCGGGTGGAGAAGCTGGGCACGGATGATAGTGGCCAGGTGGAGATCTATCCCGATGAGCGGCGGCAGGAGGAGCATTGCGCGGAACTGCAGCGCTGCATTGTAGATCACCAGACGATGCTGCAGCTGCTCGACTGCATTAGTCCCGTCATCTCGCGTACCATATTCGTTCAGTTCCTGATCACCGCCGCCATCATGGGCACCACCATGATCAACATTTTCATTTTCGCCAATACGAACACGAAGATCGCATCGATCATTTACCTGCTGGCGGTGACCCTGCAGACGGCTCCATGTTGCTATCAGGCCACCTCGCTGATGTTGCACAACGAGAGGCTGGCCCTGGCCATCTTCCAGTGCCAGTGGCTGGGCCAGAGTGCCCGGTTCCGTAAGATGCTGCTCTACTATCTTCATCGCGCCCAGCAGCCCATCACGCTGACCGCCATGAAGCTGTTTCCCATCAATCTGGCCACGTACTTCAGTATAGCCAAGTTCTCGTTTTCGCTCTACACGCTCATCAAGGGGATGAATCTCGGCGAGCGATTCAACAGGACAAAT

[0251] DOR31

[0252] MIFKYIQEPVLGSLFRSRDSLIYLNRSIDQMGWRLPPRTKPYWWLYYIWTLVVIVLVFIFIPYGLIMTGIKEFKNFTTTDLFTYVQVPVNTNASIMKGIIVLFMRRRFSRAQKMMDAMDIRCTKMEEKVQVHRAAALCNRVVVIYHCIYFGYLSMALTGALVIGKTPFCLYNPLVNPDDHFYLATAIESVTMAGIILANLILDVYPIIYVVVLRIHMELLSERIKTLRTDVEKGDDQHYAELVECVKDHKLIVEYGNTLRPMISATMFIQLLSVGLLLGLAAVSMQFYNTVMERVVSGVYTIAILSQTFPFCYVCEQLSSDCESLTNTLFHSKWIGAERRYRTTMLYFIHNVQQSILFTAGGIFPICLNTNIKMAKFAFSVVTIVNEMDLAEKLRRE

[0253] DOR31nt

[0254] ATGATTTTTAAGTACATTCAAGAGCCAGTCCTTGGATCCTTATTTCGATCCCGGGATTCGCTGATCTACTTAAACAGATCCATAGATCAAATGGGATGGAGACTGCCGCCACGAACTAAGCCGTACTGGTGGCTCTATTACATTTGGACATTGGTGGTCATAGTACTCGTCTTTATCTTTATACCCTATGGACTGATAATGACTGGAATAAAGGAGTTCAAGAACTTCACGACCACGGATCTGTTTACGTATGTCCAGGTGCCGGTTAACACCAATGCTTCGATCATGAAGGGCATTATAGTGTTGTTTATGCGGCGGCGATTTTCAAGGGCTCAGAAGATGATGGACGCCATGGACATTCGATGCACCAAGATGGAGGAGAAAGTCCAGGTGCACCGAGCAGCAGCCTTATGCAATCGTGTTGTTGTGATTTACCATTGCATATACTTCGGCTATCTATCCATGGCCTTAACCGGAGCTCTGGTGATTGGGAAGACTCCATTCTGTTTGTACAATCCACTGGTTAACCCCGACGATCATTTCTATCTGGCCACTGCCATTGAATCGGTCACCATGGCTGGCATTATTCTGGCCAATCTCATTTTGGACGTATATCCCATCATATATGTGGTCGTTCTGCGGATCCACATGGAGCTCTTGAGTGAGCGAATCAAGACGCTGCGTACTGATGTGGAAAAAGGCGACGATCAACATTATGCCGAGCTGGTGGAGTGTGTAAAGGATCACAAGCTAATTGTCGAATATGGAAACACTCTGCGTCCCATGATATCCGCCACGATGTTCATCCAACTACTATCCGTTGGCTTACTTTTGGGTCTGGCAGCGGTGTCCATGCAGTTCTATAACACCGTAATGGAGCGTGTTGTCTCCGGGGTCTACACCATAGCCATTCTATCCCAGACCTTTCCATTTTGCTATGTCTGTGAGCAGCTGAGCAGCGATTGCGAATCCCTGACCAACACACTGTTCCATTCCAAGTGGATTGGAGCTGAGCCACGATACAGAACCACGATGTTGTACTTCATTCACAATGTTCAGCAGTCGATTTTGTTCACTGCGGGCGGAATTTTCCCCATATGTCTAAACACCAATATAAAGATGGCCAAGTTCGCTTTCTCAGTGGTGACCATTGTAAATGAGATGGACTTGGCCGAGAAATTGAGAAGGGAG

[0255] DOR32

[0256] MEPVQYSYEDFARLPTTVFWIMGYDMLGVPKTRSRRILYWIYRFLCLASHGVCVGVMVFRMVEAKTIDNVSLIMRYATLVTYIINSDTKFATVLQRSAIQSLNSKLAELYPKrTLDRIYHRVNDHYWTKSFVYLVIIYIGSSIMVVIGPIITSIIAYFTHNVFTYMHCYPYFLYDPEKDPVWIYISIYALEWLHSTQMVISNIGADIWLLYFQVQINLHFRGIIRSLADHKPSVKHDQEDRKFIAKIVDKQVHLVSLQNDLNGIFGKSLLLSLLTTAAVICTVAVYTLIQGPTLEGFTYVIFIGTSVMQVYLVCYYGQQVLDLSGEVAHAVYNHDFHDASIAYKRYLLIIIIRAQQPVELNAMGYLSISLDTFKQLMSVSYRVITMLMQMIQ

[0257] DOR32nt

[0258] ATGGAACCTGTGCAGTACAGCTACGAGGATTTCGCTCGATTGCCCACGACGGTGTTCTGGATCATGGGCTACGACATGCTGGGCGTTCCGAAGACCCGCTCTCGCAGGATACTATACTGGATATATCGTTTCCTCTGTCTCGCCAGCCATGGGGTCTGTGTAGGAGTCATGGTATTTCGTATGGTGGAGGCAAAGACCATTGACAATGTTTCGCTGATCATGCGGTATGCCACTCTGGTCACCTATATCATCAACTCGGATACGAAATTCGCAACTGTCTTACAAAGGAGTGCAATTCAAACTCTAAACTCAAAACTGGCCGAACTATATCCGAAGACCACGCTGGACAGGATCTATCACCGGGTGAATGATCACTATTGGACCAAGTCATTTGTATATTTGGTTATTATCTACATTGGTTCGTCGATTATGGTTGTTATTGGACCGATTATTACGTCGATTATAGCTTACTTCACGCACAACGTTTTCACCTACATGCACTGCTATCCGTACTTTTTGTATGATCCTGAGAAGGATCCGGTTTGGATCTACATCAGCATCTATGCTCTGGAATGGTTGCACAGCACACAGATGGTCATTTCGAACATTGGCGCGGATATCTGGCTGCTGTACTTTCAGGTGCAGATAAATCTCCACTTCAGGGGCATTATACGATCACTGGCGGATCACAAGCCCAGTGTGAAGCACGACCAGGAGGACAGGAAATTCATTGCGAAAATTGTCGACAAGCAGGTGCACCTGGTCAGTTTGCAAAACGATCTGAATGGTATCTTTGGAAAATCGCTGCTTCTAAGCCTGCTGACCACCGCAGCGGTTATCTGCACGGTGGCGGTGTACACTCTGATTCAGGGTCCCACCTTGGAGGGCTTCACCTATGTGATCTTCATCGGGACTTCTGTGATGCAGGTCTACCTGGTGTGCTATTACGGTCAGCAAGTTCTCGACTTGAGCGGCGAGGTGGCCCACGCCGTGTACAATCATGATTTTCACGATGCTTCTATAGCGTACAAGAGGTACCTGCTCATAATCATTATCAGGGCGCAGCAGCCCGTGGAACTTAATGCCATGGGCTACCTGTCCATTTCGCTGGACACCTTTAAACAGCTGATGAGCGTCTCCTACCGGGTTATAACCATGCTCATGCAGATGATTCAG

[0259] DOR37

[0260] **protein sequence is incomplete and is in progress**

[0261] KVDSTRALVNHWRIFRIMGIHPPGKRTFWGRHYTAYSMVWNVTFHICIWVSFSVNLLQSNSLETFCESLCVTMPHTLYMLKLINVRRMRGQMISSHWLLRLLDKRLGCDDERQIIMAGIERAEFIFRTIFRGLACTVVLGIIYISASSEPTLMYPTWIPWNwRDsTSAYLATAMLHTTALMANATLVLNLSSYPGTYLILVSVHTKALALRVSKLGYGAPLPAVRMQAILVGYIHDHQIILR*VSGNLISQCKNF*SISGVLTFIERRMYTHFGVPNIFIVIEDYYILFLNYSLFKSLERSLSMTCFLQFFSTACAQCTICYFLLFGNVGIMRFMNMLFLLVILTTETLLLCYTAELPCKEGESLLTAVYSCNWLSQSVNFRRLLLLMLARCQIPMILVSGVIVPI SMKTF

[0262] DOR37nt

[0263] **information on nucleotide sequence is in progress**

[0264] DOR38

[0265] MRLIKISYSALNEVCVWLKLNGSWPLTESSRPWRSQSLLATAYIVWAWYVIASVGITISYQTAFLLNNLSDIIITTENCCTTFMGVLNFVRLIHLRLNQRKFRQLIENFSYEIWIPNSSKNNVAAECRRRMVTFSIMTSLLACLIIMYCVLPLVEIFFGPAFDAQNKPFPYKMIFPYDAQSSWIRYVMTYIFTSYAGICVVTTLFAEDTILGFFITYTCGQFHLLHQRIAGLFAGSNAELAESIQLERLKRIVEKHNNIISANSV

[0266] DOR38nt

[0267] ATGCGTTTGATCAAAATTTCATATTCGGCACTTAATGAGGTGTGCGTTTGGCTGAAACTGAATGGTTCTTGGCCATTAACCGAATCATCGAGGCCATGGAGGAGCCAATCCTTATTGGCCACCGCCTACATCGTGTGGGCGTGGTACGTCATTGCATCTGTGGGCATAACAATCAGCTATCAGACGGCCTTTTTGCTGAACAACCTTTCGGACATTATTATCACCACGGAAAATTGTTGCACCACCTTTATGGGTGTCCTGAACTTTGTCCGACTCATCCATCTTCGCCTCAATCAGAGGAAATTCCGCCAGCTTATTGAGAACTTTTCCTACGAAATTTGGATACCTAATTCTTCCAAAAACAATGTTGCCGCCGAGTGTCGCAGACGCATGGTTACCTTCAGCATAATGACATCCTTGCTAGCGTGCCTGATCATAATGTATTGTGTCCTGCCGCTGGTGGAGATCTTCTTTGGACCCGCCTTCGATGCACAGAACAAGCCGTTTCCCTACAAGATGATCTTTCCGTACGATGCCCAGAGCAGTTGGATCCGATATGTGATGACCTACATCTTCACCTCCTACGCGGGAATCTGTGTGGTCACCACCTTGTTTGCAGAGGACACCATTCTTGGCTTCTTCATAACCTACACTTGTGGCCAATTTCATTTGCTACACCAACGAATCGCAGGTTTATTTGCGGGTTCCAATGCGGAATTGGCCGAGAGCATTCAGCTGGAGCGACTCAAACGTATTGTGGAAAAACACAACAATATTATCAGCGCAAATTCTGTA

[0268] DOR44

[0269] MKSTFKEERIKDDSKRRDLFVFVRQTMCIAAMYPFGYYVNGSGVLAVLVRFCDLTYELFNYFVSVHIAGLYICTIYINYGQGDLDFFVNCLIQTIIYLWTIAMKLYFRRFRPGLLNTILSNINDEYETRSAVGFSFVTMAGSYRMSKLWIKTYVYCCYIGTIFWLALPIAYRDRSLPLACWYPFDYTQPGVYEVVFLLQAMGQIQVAASFASSSGLHMVLCVLISGQYDVLFCSLKNVLASSYVLMGANMTELNQLQAEQSAADVEPGQYAYSVEEETPLQELLKVGSSMDFSSAFRLSFVRCIQHHRYIVAALKKIESFYSPIWFvKIGEVTFLMCLVAFvSTKSTAANSFMRMVSLGQYLLLVLYELFIICYFADIVFQNSQRCGEALWRSPWQRHLKDVRSDYMFFMLNSRRQFQLTAGKISNLNVDRFRGVGILT

[0270] DOR44nt

[0271] ATGAAGAGCACATTCAAGGAAGAAAGGATTAAGGACGACTCCAAGCGTCGCGACCTGTTTGTATTCGTGAGGCAAACCATGTGTATAGCGGCCATGTATCCCTTCGGTTACTACGTGAATGGATCTGGAGTCCTGGCCGTTCTGGTGCGATTCTGTGACTTGACCTACGAGCTCTTTAACTACTTCGTTTCGGTACACATAGCTGGCCTGTACATCTGCACCATCTACATCAACTATGGGCAAGGCGATTTGGACTTCTTCGTGAACTGTTTGATACAAACCATTATTTATCTGTGGACAATAGCGATGAAACTCTACTTTCGGAGCTTCAGACCTGGTTTGTTGAATACCATTCTGTCCAACATCAATGATGAGTACGAGACACGTTCGGCTGTGGGATTCAGTTTCGTCACAATGGCGGGATCCTATCGGATGTCCAAGCTATGGATCAAAACCTATGTGTATTGCTGCTACATAGGCACCATTTTCTGGCTGGCTCTTCCCATTGCCTACCGGGATAGGAGTCTTCCTCTTGCCTGCTGGTATCCCTTTGACTATACACAACCCGGTGTCTATGAGGTAGTGTTCCTTCTCCAGGCGATGGGACAGATCCAAGTGGCCGCATCCTTTGCCTCCTCCAGTGGCCTGCATATGGTGCTTTGTGTGCTGATATCAGGGCAGTACGATGTCCTCTTTTGCAGTCTCAAGAATGTATTAGCCAGCAGCTATGTCCTTATGGGAGCCAATATGACGGAACTGAATCAATTGCAGGCTGAGCAATCTGCGGCCGATGTCGAGCCAGGTCAGTATGCTTACTCCGTGGAGGAGGAGACACCTTTGCAAGAACTTCTAAAAGTTGGGAGCTCAATGGACTTCTCCTCCGCATTCAGGCTGTCTTTTGTGCGGTGCATTCAGCACCATCGATACATAGTGGCGGCACTGAAGAAAATTGAGAGTTTCTACAGTCCCATATGGTTCGTGAAGATTGGCGAAGTCACCTTTCTTATGTGCCTGGTAGCCTTCGTCTCCACGAAGAGCACCGCGGCCAACTCATTCATGCGAATGGTCTCCTTGGGCCAGTACCTGCTCTTAGTTCTCTACGAGCTGTTCATCATCTGCTACTTCGCGGACATCGTTTTTCAGAACAGCCAGCGGTGCGGTGAAGCCCTCTGGCGAAGTCCTTGGCAGCGACATTTGAAGGATGTTCGCAGTGATTACATGTTCTTTATGCTGAATTCCCGCAGGCAGTTCCAACTTACGGCCGGAAAAATAAGCAATCTAAACGTGGATCGTTTCAGAGGGGTGGGTATCCTTACT

[0272] DOR46

[0273] MAEVRVDSLEFFKSHWTAWRYLGVAHFRVENWKNLYVFYSIVSNLLVTLCYPVHLGISLFRNRTITEDILNLTTFATCTACSVKCLLYAYNIKDVLEMERLLRLLDERVVGPEQRSIYGQVRVQLRNVLYVFIGIYMPCALFAELSFLFKEERGLMYPAWFPFDWLHSTRNYYIANAYQIVGISFQLLQNYVSDCFPAVVLCLISSHIKMLYNRFEEVGLDPARDAEKDLEACITDHKHILELFRRIEAFISLPMLIQFTVTALNVCIGLAALVFFVSEPMARMYFIFYSLAMPLQIFPSCFFGTDNEYWFGRLHYAAFSCNWHTQNRSFKRKMMLFVEQSLKKSTAVAGGMMRIHLDTFFSTLKGAYSLFTIIIRMRK

[0274] DOR46nt

[0275] ATGGCAGAGGTCAGAGTGGACAGTCTGGAGTTTTTCAAGAGCCATTGGACCGCCTGGCGGTACTTGGGAGTGGCTCATTTTCGGGTCGAGAACTGGAAGAACCTTTACGTGTTTTACAGCATTGTGTCGAATCTTCTCGTGACCCTGTGCTACCCCGTTCACCTGGGAATATCCCTCTTTCGCAACCGCACCATCACCGAGGACATCCTCAACCTGACCACCTTTGCGACCTGCACAGCCTGTTCGGTGAAGTGCCTGCTCTACGCCTACAACATCAAGGATGTGCTGGAGATGGAGCGGCTGTTGAGGCTTTTGGATGAACGCGTCGTGGGTCCGGAGCAACGCAGCATCTACGGACAAGTGAGGGTCCAGCTGCGAAATGTGCTATACGTGTTCATCGGCATCTACATGCCGTGTGCCCTGTTCGCCGAGCTATCCTTTCTGTTCAAGGAGGAGCGCGGTCTGATGTATCCCGCCTGGTTTCCCTTCGACTGGCTGCACTCCACCAGGAACTATTACATAGCGAACGCCTATCAGATAGTGGGCATCTCGTTTCAGCTGCTGCAAAACTATGTTAGCGACTGCTTTCCGGCGGTGGTGCTGTGCCTGATCTCATCCCACATCAAAATGTTGTACAACAGATTCGAGGAGGTGGGCCTGGATCCAGCCAGAGATGCGGAGAAGGACCTGGAGGCCTGCATCACCGATCACAAGCATATTCTAGAGTGGGCAGGCGGCTCATTGGTTCGTGTTCTATTCACTTTCCAACTTTTTTCCAGACTATTCCGACGCATCGAGGCCTTCATTTCCCTGCCCATGCTAATTCAGTTCACAGTGACCGCCTTGAATGTGTGCATCGGTTTAGCAGCCCTGGTGTTTTTCGTCAGCGAGCCCATGGCACGGATGTACTTCATCTTCTACTCCCTGGCCATGCCGCTGCAGATCTTTCCGTCCTGCTTTTTCGGCACCGACAACGAGTACTGGTTCGGACGCCTCCACTACGCGGCCTTCAGTTGCAATTGGCACACACAGAACAGGAGCTTTAAGCGGAAAATGATGCTGTTCGTTGAGCAATCGTTGAAGAAGAGCACCGCTGTGGCTGGCGGAATGATGCGTATCCACCTGGACACGTTCTTTTCCACCCTAAAGGGGGCCTACTCCCTCTTTACCATCATTATTCGGATGAGAAAG

[0276] DOR48

[0277] MERHYFMVPKFALSLIGFYPEQKRTVLVKLWSFFNFFILTYGCYAEAYYGIHYIPINIATALDALCPVASSILSLVKKVAIWWYQDELRSLIERRFYTLATQLTFLLLCCGFCTSTSYSVRHLIDNILRRTHGKDWIYETPFKMMFPDLLLRLPLYPITYILVHWHGYITVVCFVGADGFFLGFCLYFTVLLLCLQDDVCDLLEVENIEKSPSEAEEARIVREMEKLVDRHNEVAELTERLSGVMVEITLAHFVTSSLIIGTSVVDILLFSGLGIIVYVVYTCAVGVEIFLYCLGGSHIMEACSNLARSTFSSHWYGHSVRVQKMTLLMVARAQRVLTIKIPFFSPSLETLTSILRFTGSLIALAKSVI

[0278] DOR48nt

[0279] ATGGAGCGCCATTATTTCATGGTGCCAAAGTTTGCATTATCGCTGATTGGTTTTTATCCCGAACAGAAGCGAACGGTTTTGGTGAAACTTTGGAGTTTCTTCAACTTTTTCATCCTCACCTACGGCTGTTATGCAGAGGCTTACTATGGCATACACTATATACCGATTAACATAGCCACTGCATTGGATGCCCTTTGTCCTGTGGCCTCCAGCATTTTGTCGCTGGTGAAAATGGTCGCCATTTGGTGGTATCAAGATGAATTAAGGAGTTTGATAGAGCGGGTAAGATTTTTAACAGAGCAACAGAAGTCCAAGAGGAAACTGGGCTATAAGAAGAGGTTCTATACACTGGCAACGCAACTAACATTCCTGCTACTATGCTGTGGATTTTGCACCAGTACTTCCTATTCCGTCAGACATTTGATTGATAATATCCTGAGACGCACCCATGGCAAGGACTGGATCTACGAGACTCCGTTCAAGATGATGTAAGGAAAGGGAAGAATGGTTTATATATACTTTTGGAACGAAATAATGATGTGATCTAAACAAGATGCACTTTTTTTTAGGTTCCCCGATCTTCTCCTGCGTTTGCCACTCTATCCCATCACCTATATACTCGTGCATTGGCATGGCTACATTACTGTGGTTTGTTTTGTCGGCGCGGATGGTTTCTTCCTGGGGTTCTGTTTGTACTTCACTGTTTTGCTGCTCTGTCTGCAGGACGATGTTTGTGATTTACTAGAGGTTGAAAACATCGAGAAGAGTCCCTCCGAAGCGGAGGAAGCTCGCATAGTTCGGGAAATGGAAAAACTGGTGGACCGGCATAACGAGGTGGCCGAGCTGACAGAAAGATTGTCGGGTGTTATGGTGGAAATAACACTGGCCCACTTTGTTACTTCGAGTTTGATAATCGGAACCAGCGTGGTGGATATTTTATTAGTGGGTATTTACATTTGATTAGATCCTTTCGATATATGTTCTTAAATTCTAGTTTTCCGGCCTGGGAATCATTGTGTATGTGGTCTACACTTGTGCCGTAGGTGTGGAAATATTTCTATACTGTTTAGGAGGATCTCATATTATGGAAGCGGTATATTCATAAGAAACTACTATAAAGTTACTTTTAAATTCATTGCATTTCTTAGTGTTCCAATCTAGCGCGCTCCACATTTTCCAGCCACTGGTATGGCCACAGTGTTCGGGTCCAAAAGATGACCCTTTTGATGGTAGCTCGTGCTCAACGAGTTCTCACAATTAAAATTCCTTTCTTTTCCCCATCATTAGAGACTCTAACTTCGGTAAGCTTATGCGAAAATGTTATGGTACACACAAGTCTACATTTCTATGAGGTCTTGTAGATTTTGCGCTTCACTGGATCTCTGATTGCCCTGGCAAAGTCGGTTATA

[0280] DOR53

[0281] MLSKFFPHIKEKPLSERVKSRDAFIYLDRVMWSFGWTEPENKRWILPYKLWLAFVNIVMLILLPISISIEYLHRFKTFSAGEFLSSLEIGVNMYGSSFKCAFTLIGFKKRQEAKVLLDQLDKRCLSDKERSTVHRYVAMGNFFDILYHIFYSTFVVMNFPYFLLERRHAWRMYFPYIDSDEQFYISSIAECFLMTEAIYMDLCTDVCPLISMLMARCHISLLKQRLRNLRSKPGRTEDEYLEELTECIRDHRLLLDYVDALRPVFSGTIFVQFLLIGTVLGLSMINLMFFSTFWTGVATCLFMFDVSMETFrFCYLCNMIIDDCQEMSNCLFQSDWTSADRRYKSTLVYFLHNLQQPITLTAGGVFPISMQTNLAMVKLAFSVVTVIKQFNLAERFQ

[0282] DOR53nt

[0283] TCAAACAAAGCCACGGACAAGATGTTAAGCAAGTTTTTTCCCCACATAAAAGAAAAGCCATTGAGCGAGCGGGTTAAGTCCCGAGATGCCTTCATTTACTTGGATCGGGTGATGTGGTCCTTTGGCTGGACAGAGCCTGAAAACAAAAGGTGGATCCTTCCTTATAAACTGTGGTTAGCGTTCGTGAACATAGTAATGCTCATCCTTCTGCCGATCTCGATAAGCATCGAGTACCTCCACCGATTTAAAACCTTCTCGGCGGGGGAGTTCCTTAGTTCCCTCGAGATTGGAGTCAACATGTACGGAAGCTCTTTTAAGTGCGCCTTCACCTTGATTGGATTCAAGAAAAGACAGGAAGCTAAGGTTTTACTGGATCAGCTGGACAAGAGATGCCTTAGCGATAAGGAGAGGTCCACTGTTCATCGCTATGTCGCCATGGGAAACTTTTTCGATATTTTGTATCACATTTTTTACTCCACCTTCGTGGTAATGAACTTCCCGTATTTTCTGCTTGAGAGACGCCATGCTTGGCGCATGTACTTTCCATATATCGATTCCGACGAACAGTTTTACATCTCCAGCATCGCCGAGTGTTTTCTGATGACGGAGGCCATCTACATGGATCTCTGTACGGACGTGTGTCCCTTGATCTCCATGCTTATGGCTCGATGCCACATCAGCCTCCTGAAACAGCGACTGAGAAATCTCCGATCGAAGCCAGGAAGGACCGAAGATGAGTACTTGGAGGAGCTCACCGAGTGCATTCGGGATCATCGATTGCTATTGGACTATGTTGACGCATTGCGACCCGTCTTTTCGGGAACCATTTTTGTGCAGTTCCTCCTGATCGGTACTGTACTGGGTCTCTCAATGATAAATCTAATGTTCTTCTCGACATTTTGGACTGGTGTCGCCACTTGCCTTTTTATGTTCGACGTGTCCATGGAGACGTTCCCCTTTTGCTATTTGTGCAACATGATTATCGATGACTGCCAGGAAATGTCCAATTGCCTCTTTCAATCGGACTGGACCTCTGCCGATCGTCGCTACAAATCCACTTTGGTATACTTTCTTCACAATCTTCAGCAACCCATTACTCTCACGGCTGGTGGAGTGTTTCCTATTTCCATGCAAACAAATTTGGCTATGGTGAAGCTGGCATTTTCTGTGGTTACGGTAATTAAGCAATTTAACTTGGCCGAAAGGTTTCAATAAGTTGAGAGGGACGAGCTCTGCTACTATTATATTATATATTATATTATATTATATATATATTATTTTATATTATATATTGCTGTACCCTAATAAATATTTAGTAATAAAAAAAAAAAAAA AAAA

[0284] DOR56

[0285] MDPVEMPIFGSTLKLMKFWSYLFVHNWRRYVAMTPYIIINCTQYVDIYLSTESLDFIIRNVYLAVLFTNTVVRGVLLCVQRFSYERFINILKSFYIELLVSTERLSQKCILHKWAVLPYGMYLPTIDEYKYASPYYEIFFVIQAIMAPMGCCMYIPYTNMVVTFTLFAILMCRVLQHKLRSLEKLKNEQVRGEIAQTIAQTVIVIAYMVMIFANSVVLYYVANELYFQSFDIAIAAYESNWMDFDVDTQKTLKFLIMRSQKPLASLVGGTYPMNLKMLQSLINAIYSFFT LLRRVYG

[0286] DOR56nt

[0287] ATGGATCCGGTGGAGATGCCCATTTTTGGTAGCACTCTGAAGCTAATGAAGTTCTGGTCATATCTGTTTGTTCACAACTGGCGCCGCTATGTCGCAATGACTCCGTACATCATTATCAACTGTACTCAGTATGTGGATATATATCTGAGCACCGAATCCTTGGACTTTATCATCAGAAATGTATACCTGGCTGTATTGTTTACCAACACGGTGGTCAGAGGTGTATTGTTATGCGTACAGCGGTTTAGCTACGAGCGTTTCATTAATATTTTGAAAAGCTTTTACATTGAGTTGTTGGTGAGTACCGAAAGATTATCTCAAAAATGCATATTGCATAAATGGGCAGTTCTGCCATATGGCATGTATTTGCCCACTATTGATGAATACAAATACGCATCACCTTACTACGAGATTTTCTTTGTGATTCAAGCCATTATGGCTCCAATGGGGTGTTGCATGTACATACCATACACAAACATGGTAGTGACATTTACCCTTTTCGCCATTCTCATGTGTCGAGTGTTGCAACATAAGTTGAGAAGCCTAGAAAAGCTGAAAAATGAACAAGTACGTGGTGAAATCGCTCAAACAATTGCTCAGACCGTCATAGTCATCGCATACATGGTAATGATATTTGCCAACAGTGTAGTCCTTTACTACGTGGCCAATGAGCTATACTTTCAAAGCTTTGATATTGCCATTGCTGCCTATGAGAGCAATTGCATGGACTTTGATGTGGACACACAAAAGACTTTGAAGTTCCTCATCATGCGCTCGCAAAAGCCCTTGGCGAGTCTGGTGGGTGGCACATATCCCATGAACTTGAAAATGCTTCAGTCACTACTAAATGCCATTTACTCCTTCTTCACCCTTCTGCGTCGCGTTTACGGC

[0288] DOR58

[0289] MDASYFAVQRRALEIVGFDPSTPQLSLKHPIWAGILILSLISHNWPMVVYALQDLSDLTRLTDNFAVFMQGSQSTFKFLVMMAKRRRIGSLIHRLHKLNQAASATPNHLEKIERENQLDRYVARSFRNAAYGVICASAIAPMLLGLWGYVETGVFTPTTPMEFNFWLDERKPHFYWPIYVWGVLGVAAAAWLAIATDTLFSWLTHNVVIQFQLLELVLEEKDLNGGDSPLTGFVSRHRIALDLAKELSSIFGEIVFVKYMLSYLQLCMLAFRFSRSGWSAQVPFRATFLVAIIIQLSSYCYGGEYIKQQSLAIAQAVYGQINWPEMTPKKRRLWQMVIMRAQRPAKIFGFMFVVDLPLLLWVIRTAGSFLAMLRTFER

[0290] DOR58nt

[0291] ATGGACGCCAGCTACTTTGCCGTCCAGAGAAGAGCTCTGGAAATAGTTGGATTCGATCCCAGTACTCCGCAACTGAGTCTGAAACATCCCATCTGGGCCGGGATTCTCATCCTGTCCTTGATCTCTCACAACTGGCCCATGGTAGTCTATGCCCTGCAGGATCTCTCCGACTTGACCCGTCTGACGGACAACTTTGCGGTGTTTATGCAAGGATCACAGAGCACCTTCAAGTTCCTGGTCATGATGGCGAAACGAAGGCGCATTGGATCGTTGATTCACCGTTTGCATAAGCTAAACCAGGCGGCCAGTGCCACGCCCAATCACCTGGAGAAGATCGAGAGGGAAAACCAACTGGATAGGTATGTCGCCAGGTCCTTTAGAAATGCCGCCTACGGAGTGATTTGTGCCTCGGCCATAGCGCCCATGTTGCTTGGCCTGTGGGGATATGTGGAGACGGGTGTATTTACCCCCACCACACCCATGGAGTTCAACTTCTGGCTGGACGAGCGAAAGCCTCACTTTTATTGGCCCATCTACGTTTGGGGCGTACTGGGCGTGGCAGCTGCCGCCTGGTTGGCCATTGCAACGGACACCCTGTTCTCCTGGCTGACTCACAATGTGGTGATTCAGTTCCAACTACTGGAGCTTGLTCTCGAAGAGAAGGATCTGAATGGCGGAGACTCTCGCCTGACCGGGTTTGTTAGTCGTCATCGTATAGCTCTGGATTTGGCCAAGGAACTAAGTTCGATTTTCGGGGAGATCGTCTTTGTGAAATACATGCTCAGTTACCTGCAACTCTGCATGTTGGCCTTTCGCTTCAGCCGCAGTGGCTGGAGTGCCCAGGTGCCATTTAGAGCCACCTTCCTAGTGGCCATCATCATCCAACTGAGTTCGTATTGCTATGGAGGCGAGTATATAAAGCAGCAAAGTTTGGCCATCGCACAAGCCGTTTATGGTCAAATCAATTGGCCAGAAATGACGCCAAAGAAAAGAAGACTCTGGCAAATGGTGATCATGAGGGCGCAGCGACCGGCTAAGATTTTTGGATTCATGTTCGTTGTGGACTTGCCACTGCTGCTTTGGGTCATCAGAACTGCGGGCTCATTTCTGGCCATGCTTAGGACTTTCGAGCGT

[0292] DOR59

[0293] MHEADNREMELLVATQAYTRTITLLIWIPSVIAGLMAYSDCIYRSLFLPKSVFNVPAVRRGEEHPILLFQLFPFGELCDNFVVGYLGPWYALGLGITAIPLWHTFITCLMKYVNLKLQILNKRVEEMDITRLNSKLVIGRLTASELTFWQMQLFKEFVKEQLRIRKFVQELQYLICVPVMADFIIFSVLICFLFFALTVGHDELSLAYFSCGWYNFEMPLQKMLVFMMMHAQRPMKMRALLVDLNLRTFIDIGRGAYSYFNLLRSSHLY

[0294] DOR59nt

[0295] ATGCACGAAGCAGATAATCGGGAGATGGAACTTTTGGTCGCCACTCAGGCTTATACACGAACCATTACCCTGTTGATCTGGATACCATCGGTTATTGCTGGCCTAATGGCCTATTCAGACTGCATCTACAGGAGTCTGTTTCTGCCGAAATCGGTTTTCAATGTGCCAGCTGTGCGACGTGGTGAGGAGCATCCCATTCTGCTATTTCAGCTGTTTCCCTTCGGAGAACTTTGCGATAACTTCGTTGTTGGATACTTGGGACCTTGGTATGCTCTGGGCCTGGGAATCACGGCTATCCCATTGTGGCACACCTTTATCACTTGCCTCATGAAGTACGTAAATCTCAAGCTGCAAATACTCAACAAGCGAGTGGAGGAGATGGATATTACCCGACTTAATTCCAAATTGGTAATTGGTCGCCTAACTGCCAGTGAGTTAACCTTCTGGCAAATGCAACTCTTCAAGGAATTTGTAAAGGAACAGCTGAGGATTCGAAAATTTGTCCAGGAACTACAGTATCTGATTTGCGTGCCTGTGATGGCAGATTTCATTATCTTCTCGGTTCTCATTTGCTTTCTCTTTTTTGCCTTGACAGTTGGCCACGATGAACTGAGCCTTGCTTACTTTTCTTGCGGATGGTACAACTTCGAAATGCCTTTGCAGAAAATGCTGGTTTTTATGATGATGCATGCCCAAAGGCCGATGAAGATGCGCGCCCTGCTGGTCGATTTGAATCTGAGGACCTTCATAGACATTGGCCGTGGAGCCTACAGCTACTTCAATTTGCTGCGTAGCTCCCACTTGTAT

[0296] DOR61

[0297] MGHKDDMDSTDSTALSLKHISSLIFVISAQYPLISYVAYNRNDMEKVTACLSVVFTNMLTVIKISTFLANRKDFWEMIHRFRKMHEQCKYREGLDYVAEANKLASFLGRAYCVSCGLTGLYFMLGPIVKIGVCRWHGTTCDKELPMPMKFPFNDLESPGYEVCFLYTVLVTVVVVAYASAVDGLFISFAINLRAHFQTLQRQIENWEFPSSEPDTQIRLKSIVEYHVLLLSLSRKLRSIYTPTVMGQFVITSLQVGVIIYQLVTNMDSVMDLLLYASFFGSIMLQLFIYCYGGEIIKAESLQVDTAVRLSNWHLASPKTRTSLSLIILQSQKEVLIRAGFFVASLANFPYRLITLIKSIDSIC

[0298] DOR61nt

[0299] **information on nucleotide sequence is in progress**

[0300] DOR62

[0301] MEKQEDFKLNTHSAVYYHWRVWELTGLMRPPGVSSLLYVVYSITVNLVVTVLFPLSLLARLLFTTNMAGLCENLTITITDIVANLKFANVYMVRKQLHEIRSLLRLMDARARLVGDPEEISALRKEVNIAQGTFRTFASIFVFGTTLSCVRVVVRPDRELLYPAWFGVDWMHSTRNYVLINIYQLFGLIVQAIQNCASDSYPPAFLCLLTGHMRALELRVRRIGCRTEKSNKGQTYEAWREEVYQELIECIRDLARVHRLREIIQRVLSVPCMAQFVCSAAVQCTVAMHFLYVADDHDHTAMIISIVFFSAVTLEVFVICYFGDRMRTQSEALCDAFYDCNWIEQLPKFKRELLFTLARTQRPSLIYAGNYIALSLETFEQVMRFTYSVFTLLLRAK

[0302] DOR62nt

[0303] ATGGAGAAGCAAGAGGATTTCAAACTGAACACCCACAGTGCTGTGTACTACCACTGGCGCGTTTGGGAGCTCACTGGCCTGATGCGTCCTCCGGGCGTTTCAAGCCTGCTTTACGTGGTATACTCCATTACGGTCAACTTGGTGGTCACCGTGCTGTTTCCCTTGAGCTTGCTGGCCAGGCTGCTGTTCACCACCAACATGGCCGGATTGTGCGAGAACCTGACCATAACTATTACCGATATTGTGGCCAATTTGAAGTTTGCGAATGTGTACATGGTGAGGAAGCAGCTCCATGAGATTCGCTCTCTCCTAAGGCTCATGGACGCTAGAGCCCGGCTGGTGGGCGATCCCGAGGAGATTTCTGCCTTGAGGAAGGAAGTGAATATCGCACAGGGCACTTTCCGCACCTTTGCCAGTATTTTCGTATTTGGCACTACTTTGAGTTGCGTCCGCGTGGTCGTTCGCCCGGATCGAGAGCTCCTGTATCCGGCCTGGTTCGGCGTTGACTGGATGCACTCCACCAGAAACTATGTGCTCATCAATATCTACCAGCTCTTCGGCTTGATAGTGCAGGCTATACAGAACTGCGCTAGTGACTCCTATCCGCCTGCGTTTCTCTGCCTGCTCACGGGTCATATGCGTGCTTTGGAGCTGAGGGTGCGGCGGATTGGCTGCAGGACGGAAAAGTCCAATAAAGGGCAGACATATGAAGCCTGGCGGGAGGAGGTGTACCAGGAACTCATCGAGTGCATCCGCGATCTGGCGCGGGTCCATCGGCTGAGGGAGATCATTCAGCGGGTCCTTTCAGTGCCCTGCATGGCCCAGTTCGTCTGCTCCGCCGCCGTCCAGTGTACCGTCGCCATGCACTTCCTGTACGTAGCGGATGACCACGACCACACCGCCATGATCATCTCGATTGTATTTTTCTCGGCCGTCACCTTGGAGGTGTTTGTAATCTGCTATTTTGGGGACAGGATGCGGACACAGAGCGAGGCGCTGTGCGATGCCTTCTACGATTGCAACTGGATAGAACAGCTGCCCAAGTTCAAGCGCGAACTGCTCTTCACCCTGGCCAGGACGCAGCGGCCTTCTCTTATTTACGCAGGCAACTACATCGCACTCTCGCTGGAGACCTTCGAGCAGGTCATGAGGTTCACATACTCTGTTTTCACACTCTTGCTGAGGGCCAAGTAAGAACTTTATAATCTCTTTTTGGGGAGAAAAATTTTAAAGCACAATAGCAGAAAAATATATCAGATAATATAACAAA

[0304] DOR64

[0305] MKLSETLKIDYFRVQLNAWRICGALDLSEGRYWSWSMLLCILVYLPTPMLLRGVYSFEDPVENNFSLSLTVTSLSNLMKFCMYVAQLTKMVEVQSLIGQLDARVSGESQSERHRNMTEHLLRMSKLFQITYAVWFIIAAVPFVFETELSLPMPMWFPFDWKNSMVAYIGALVFQEIGYVFQIMQCFAADSFPPLVLYLISEQCQLLILRISEIGYGYKTLEENEQDLVNCIRDQNALYRLLDVTKSLVSYPMMVQFMVIGINIAITLFVLIFYVETLYDRIYYLCFLLGITVQTYPLCYYGTMVQESFAELHYAVFCSNWVDQSASYRGHMLILAERTKRMQLLLAGNLVPIHLSTYVACWKGAYSFFTLMADRDGLGS

[0306] DOR64nt

[0307] GGCACGAGCCAAGAATTCAAAATGAAACTCAGCGAAACCCTAAAAATCGACTATTTTCGAGTCCAGTTGAATGCCTGGCGAATTTGTGGTGCCTTGGATCTCAGCGAGGGTAGGTACTGGAGTTGGTCGATGCTATTGTGCATCTTGGTGTACCTGCCGACACCCATGCTACTGAGAGGAGTATACAGTTTCGAGGATCCGGTGGAAAATAATTTCAGCTTGAGCCTGACGGTCACATCGCTGTCCAATCTCATGAAGTTCTGCATGTACGTGGCCCAACTAACAAAGATGGTCGAGGTCCAGAGTCTTATTGGTCAGCTGGATGCCCGGGTTTCTGGCGAGAGCCAGTCTGAGCGTCATAGAAATATGACCGAGCACCTGCTAAGGATGTCCAAGCTGTTCCAGATCACCTACGCTGTAGTCTTCATCATTGCTGCAGTTCCCTTCGTTTTCGAAACTGAGCTAAGCTTACCCATGCCCATGTGGTTTCCCTTCGACTGGAAGAACTCGATGGTGGCCTACATCGGAGCTCTGGTTTTCCAGGAGATTGGCTATGTCTTTCAAATTATGCAATGCTTTGCAGCTGACTCGTTTCCCCCGCTCGTACTGTACCTGATCTCCGAGCAATGTCAATTGCTGATCCTGAGAATCTCTGAAATCGGATATGGTTACAAGACTCTGGAGGAGAACGAACAGGATCTGGTCAACTGCATCAGGGATCAAAACGCGCTGTATAGATTACTCGATGTGACCAAGAGTCTCGTTTCGTATCCCATGATGGTGCAGTTTATGGTTATTGGCATCAACATCGCCATCACCCTATTTGTCCTGATATTTTACGTGGAGACCTTGTACGATCGCATCTATTATCTTTGCTTTCTCTTGGGCATCACCGTGCAGACATATCCATTGTGCTACTATGGAACCATGGTGCAGGAGAGTTTTGCTGAGCTTCACTATGCGGTATTCTGCAGCAACTGGGTGGATCAAAGTGCCAGCTATCGTGGGCACATGCTCATCCTGGCGGAGCGCACTAAGCGGATGCAGCTTCTCCTCGCCGGCAACCTGGTGCCCATCCACCTGAGCACCTACGTGGCCTGTTGGAAGGGAGCCTACTCCTTCTTCACCCTGATGGCCGATCGAGATGGCCTGGGTTCTTAGTAGCCCAGTCATTTCACTCACATTCTACATCAAGTAGTACTACCACTGAACACGAACACGAATATTTCAAAAGTAAACACATAATATTCACAATAGTGTATCACTTTAATAAAATTTTTGGTTACCATGAAAAAAAAAAAAAAAAAA

[0308] DOR67

[0309] MLSQFFPHIKEKPLSERVKSRDAFVYLDRVMWSFGWTVPENKRWDLHYKLWSTFVTLVIFILLPISVSVEYIQRFKTFSAGEFLSSIQIGVNMYGSSFKSYLTMMGYKKRQEAKMSLDELDKRCVCDEERTIVHRHVALGNFCYIFYHIAYTSFLISNFLSFIMKRIHAWRMYFPYVDPEKQFYISSIAEVILRGWAVFMDLCTDVCPLISMVIARCHITLLKQRLRNLRSEPGRTEDEYLKELADCVRDHRLILDYVDALRSVFSGTIFVQFLLIGIVLGLSMINIMFFSTLSTGVAVVLFMSCVSMQTFPFCYLCNMIMDDCQEMADSLFQSDWTSADRRYKSTLVYFLHNLQQPIILTAGGVFPISMQTNLNMVKLAFTVVTIVKQFNLAEKFQ

[0310] DOR67nt

[0311] GGCACGAGGAAATGTTAAGCCAGTTCTTTCCCCACATTAAAGAAAAGCCATTGAGCGAGCGGGTTAAGTCCCGAGATGCCTTCGTTTACTTAGATCGGGTGATGTGGTCCTTTGGCTGGACAGTGCCTGAAAACAAAAGGTGGGATCTACATTACAAACTGTGGTCAACTTTCGTGACATTGGTGATATTTATCCTTCTGCCGATATCGGTAAGCGTTGAGTATATTCAGCGGTTCAAGACCTTCTCGGCGGGTGAGTTTCTTAGCTCAATCCAGATTGGCGTTAACATGTACGGAAGCAGCTTTAAAAGTTATTTGACCATGATGGGATATAAGAAGAGACAGGAGGCTAAGATGTCACTGGATGAGCTGGACAAGAGATGCGTTTGTGATGAGGAGAGGACCATTGTACATCGACATGTCGCCCTGGGAAACTTTTGCTATATTTTCTATCACATTGCGTACACTAGCTTTTTGATTTCAAACTTTTTGTCATTTATAATGAAGAGAATCCATGCCTGGCGCATGTACTTTCCCTACGTCGACCCCGAAAAGCAATTTTACATCTCTAGCATCGCCGAAGTCATTCTTAGGGGGTGGGCCGTCTTCATGGATCTCTGCACGGATGTGTGTCCTTTGATCTCCATGGTAATAGCACGATGCCACATCACCCTTCTGAAACAGCGCCTGCGAAATCTACGATCGGAACCAGGAAGGACGGAAGATGAGTACTTGAAGGAGCTCGCCGACTGCGTTCGAGATCACCGCTTGATATTGGACTATGTCGACGCATTGCGATCCGTCTTTTCGGGGACAATTTTTGTGCAGTTCCTCTTGATCGGTATTGTACTGGGTCTGTCAATGATAAATATAATGTTTTTCTCAACACTTTCGACTGGTGTCGCCGTTGTCCTTTTTATGTCCTGCGTATCTATGCAGACGTTCCCCTTTTGCTATTTGTGTAACATGATTATGGATGACTGCCAAGAGATGGCCGACTCCCTTTTTCAATCGGACTGGACATCTGCCGATCGTCGCTACAAATCCACTTTGGTATACTTTCTTCACAATCTTCAGCAGCCCATTATTCTTACGGCTGGTGGAGTCTTTCCTATTTCCATGCAAACAAATTTAAATATGGTGAAGCTGGCCTTTACTGTGGTTACAATAGTGAAACAATTTAACTTGGCAGAAAAGTTTCAATAAGTTAAGATATGCAAGCTCTGCTATTATAAACCTACACTCGAGAAAATATTTCTTCACATTAATAAACCTTCAGTACTTACTGCTTGTGGCGCCCCCGGAAAAAAAAAAAAAAAAAA

[0312] DOR68

[0313] MSKLIEVFLGNLWTQRFTFARMGLDLQPDKKGNVLRSPLLYCIMCLTTSFELCTVCAFMVQNRNQIVLCSEALMHGLQMVSSLLKMAIFLAKSHDLVDLIQQIQSPFTEEDLVGTEWRSQNQRGOLMAAIYFMMCAGTSVSFLLMPVALTMLKYHSTGEFAPVSSFRVLLPYDVTQPHVYAMDCCLMVFVLSFFCCSTTGVDTLYGWCALGVSLQYRRLGQQLKRIPSCFNPSRSDFGLSGIFVEHARLLKIVQHFNYSFMEIAFVEVVIICGLYCSVICQYIMPHTNQNFAFLGFFSLVVTTQLCIYLFGAEQVRLEAERFSRLLYEVIPWQNLPPKHRKLFLFPIERAQRETVLGAYFFELGRPLLVWVSIFLFIVLLF

[0314] DOR68nt

[0315] ATGTCAAAGCTAATCGAGGTGTTTCTGGGTAATCTGTGGACCCAGCGTTTTACCTTCGCCCGAATGGGTTTGGATTTGCAGCCCGATAAAAAGGGCAATGTTTTGCGATCTCCGCTTCTTTATTGTATTATGTGTCTGACAACAAGCTTTGAGCTCTGCACCGTGTGCGCCTTTATGGTCCAAAATCGCAACCAAATCGTGCTTTGTTCCGAGGCCCTGATGCACGGACTACAGATGGTCTCCTCGCTACTGAAGATGGCTATATTCTTGGCCAAATCTCACGACCTGGTGGACCTAATTCAACAGATTCAGTCGCCTTTTACAGAGGAGGATCTTGTAGGTACAGAGTGGAGATCCCAAAATCAAAGGGGACAACTAATGGCTGCCATTTACTTTATGATGTGTGCCGGTACGAGTGTGTCATTTCTGTTGATGCCAGTGGCTTTGACCATGCTTAAGTACCATTCCACTGGGGAATTCGCGCCTGTCAGCTCGTTCCGGGTTCTGCTTCCATACGATGTGACACAACCGCATGTTTATGCCATGGACTGCTGCTTGATGGTATTTGTGTTAAGTTTTTTTTGCTGCTCCACCACCGGAGTGGATACCTTATATGGATGGTGTGCTTTAGGCGTGAGTTTACAATACCGTCGCCTCGGTCAACAACTTAAAAGGATACCCTCCTGTTTCAATCCATCTCGGTCTGACTTTGGATTAAGTGGGATTTTTGTGGAGCATGCTCGTCTGCTTAAAATAGTCcAACATTTTAATTATAGTTTTATGGAGATCGCATTTGTGGAGGTTGTTATAATCTGTGGACTCTATTGCTCAGTAATTTGTCAGTATATAATGCCACACACCAACCAAAACTTCGCCTTTCTGGGTTTCTTTTCATTGGTAGTTACCACACAGCTGTGCATCTATCTTTTCGGTGCCGAACAGGTCCGTTTGGAGGCTGAGCGATTTTCCCGGCTGCTATACGAAGTAATTCCTTGGCAAAACCTTCCTCCTAAACACCGGAAACTTTTCCTTTTTCCAATTGAGCGCGCCCAACGAGAAACTGTTCTCGGTGCTTATTTCTTCGAACTAGGCAGACCTCTTCTTGTTTGGGTAAGCATATTCCTTTTTATTGTATTATTATTT

[0316] DOR71

[0317] MVIIDSLSFYRPFWICMRLLVPTFFKDSSRPVQLYVVLLHILVTLWFPLHLLLHLLLLPSTAEFFKNLTMSLTCVACSLKHVAHLYHLPQIVEIESLIEQLDTFIASEQEHRYYRDHVHCHARRFTRCLYISFGMIYALFLFGVFVQVISGNWELLYPAYFPFDLESNRFLGAVALGYQVFSMLVEGFQGLGNDTYTPLTLCLLAGHVHLWSIRMGQLGYFDDETVVNHQRLLDYIEQHKLLVRFHNLVSRTISEVQLVQLGGCGATLCIIVSYMLFFVGDTISLVYYLVFFGVVCVQLFPSCYFASEVAEELERLPYAIFSSRWYDQSRDHRFDLLIFTQLTLGNRGWIIKAGGLIELNLNAFFATLKMAYSLFAVVHRETGNPLQREH

[0318] DOR71nt

[0319] ATGGTCATTATCGACAGTCTTAGTTTTTATCGTCCATTCTGGATCTGCATGCGATTGCTGGTACCGACTTTCTTCAAGGATTCCTCACGTCCTGTCCAGCTGTACGTGGTGTTGCTGCACATCCTGGTCACCTTGTGGTTTCCACTGCATCTGCTGCTGCATCTTCTGCTACTTCCATCTACCGCTGAGTTCTTTAAGAACCTGACCATGTCTCTGACTTGTGTGGCCTGCAGTCTGAAGCATGTGGCCCACTTGTATCACTTGCCGCAGATTGTGGAAATCGAATCACTGATCGAGCAATTAGACACATTTATTGCCAGCGAACAGGAGCATCGTTACTATCGGGATCACGTACATTGCCATGCTAGGCGCTTTACAAGATGTCTCTATATTAGCTTTGGCATGATCTATGCGCTTTTCCTGTTCGGCGTCTTCGTTCAGGTTATTAGCGGAAATTGGGAACTTCTCTATCCAGCCTATTTCCCATTCGACTTGGAGAGCAATCGCTTTCTCGGCGCAGTAGCCTTGGGCTATCAGGTATTCAGCATGTTAGTTGAAGGCTTCCAGGGGCTGGGCAACGATACCTATACCCCACTGACCCTATGCCTTCTGGCCGGACATGTCCATTTGTGGTCCATACGAATGGGTCAACTGGGATACTTCGATGACGAGACGGTGGTGAATCATCAGCGTTTGCTGGATTACATTGAGCAGCATAAACTCTTGGTGCGGTTCCACAACCTGGTGAGCCGGACCATCAGCGAAGTGCAACTGGTGCAGCTGGGCGGATGTGGAGCCACTCTGTGCATCATTGTCTCCTACATGCTCTTCTTTGTGGGCGACACAATCTCGCTGGTCTACTACTTGGTGTTCTTTGGAGTGGTCTGCGTGCAGCTCTTTCCCAGCTGCTATTTTGCCAGCGAAGTAGCCGAGGAGTTGGAACGGCTGCCATATGCGATCTTCTCCAGCAGATGGTACGATCAATCGCGGGATCATCGATTCGATTTGCTCATCTTTACACAATTAACACTGGGAAACCGGGGGTGGATCATCAAGGCAGGAGGTCTTATCGAGCTGAATTTGAATGCCTTTTTCGCCACCCTGAAGATGGCCTATTCCCTTTTTGCAGTTGTGGTGCGGGCAAAGGGTATA

[0320] DOR72

[0321] MDLKPRVIRSEDIYRTYWLYWHLLGLESNFFLNRLLDLVITIFVTIWYPIHLILGLFMERSLGDVCKGLPITAACFFASFKFICFRFKLSEIKEIEILFKELDQRALSREECEFFNQNTRREANFIWKSFIVAYGLSNISAIASVLFGGGHKLLYPAWFPYDVQATELIFWLSVTYQIAGVSLAILQNLANDBYPPMTFCVVAGHVRLLAMRLSRIGQGPEETIYLTGKQLIESIEDHRKLMKIVELLRSTMNISQLGQFISSGVNISITLVNILFFADNNFAITYYGVYFLSMVLELFPCCYYGTLISVEMNQLTYAIYSSNWMSMNRSYSRILLIFMQLTLAEVQIKAGGMIGIGMNAFFATVRLAYSFFTLAMSLR

[0322] DOR72nt

[0323] ATGGACTTAAAACCGCGAGTCATTCGAAGTGAAGATATCTACAGAACCTATTGGTTATATTGGCATCTTTTGGGCCTGGAAAGCAATTTCTTTCTGAATCGCTTGTTGGATTTGGTGATTACAATTTTCGTAACCATTTGGTATCCAATTCACCTGATTCTGGGACTGTTTATGGAAAGATCTTTGGGGGATGTCTGCAAGGGTCTACCAATTACGGCAGCATGCTTTTTCGCCAGCTTTAAATTTATTTGTTTTCGCTTCAAGCTATCTGAAATTAAAGAAATCGAAATATTATTTAAAGAGCTGGATCAGCGAGCTTTAAGTCGAGAGGAATGCGAGTTTTTCAATCAAAATACGAGACGTGAGGCGAATTTCATTTGGAAAAGTTTCATTGTGGCCTATGGACTGTCGAATATCTCGGCTATTGCATCAGTTCTTTTCGGCGGTGGACATAAGCTATTATATCCCGCCTGGTTTCCATACGATGTGCAGGCCACGGAACTAATATTTTGGCTAAGTGTAACATACCAAATTGCCGGAGTAAGTTTGGCCATACTTCAGAATTTGGCCAATGATTCCTATCCACCGATGACATTTTGCGTGGTTGCCGGTCATGTAAGACTTTTGGCGATGCGCTTGAGTAGAATTGGCCAAGGTCCAGAGGAAACAATATACTTAACCGGAAAGCAATTAATCGAAAGCATCGAGGATCACCGAAAACTAATGAAGATAGTGGAATTACTGCGCAGCACCATGAATATTTCGCAGCTCGGCCAGTTTATTTCAAGTGGTGTTAATATTTCCATAACACTAGTCAACATTCTCTTCTTTGCGGATAATAATTTCGCTATAACCTACTACGGAGTGTACTTCCTATCGATGGTGTTGGAATTATTCCCGTGCTGCTATTACGGCACCCTGATATCCGTGGAGATGAACCAGCTGACCTATGCGATTTACTCAAGTAACTGGATGAGTATGAATCGGAGCTACAGCCGCATCCTACTGATCTTCATGCAACTCACCCTGGCGGAAGTGCAGATCAAGGCCGGTGGGATGATTGGCATCGGAATGAACGCCTTCTTTGCCACCGTGCGATTGGCCTACTCCTTCTTCACTTTGGCCATGTCGCTGCGT

[0324] DOR73

[0325] MDSRRKVRSENLYKTYWLYWRLLGVEGDYPFRRLVDFTITSFITILFPVHLILGMYKKPQIQVFRSLHFTSECLFCSYKFFCFRWKLKEIKTIEGLLQDLDSRVESEEERNYFNQNPSRVARMLSKSYLVAAISAIITATVAGLFSTGRNLMYLGWFPYDFQATAAIYWISFSYQAIGSSLLILENLANDSYPPITFCVWSGHVRLLIMRLSRIGHDVKLSSSENTRKLIEGIQDHRKLMKIIRLLRSTLHLSQLGQFLSSGINISITLINILFFAENNFAMLYYAVFFAAMLIELFPSCYYGILMTMEFDKLPYAIFSSNWLKMDKRYNRSLIILMQLTLVPVNIKAGGIVGIDMSAFFATVRMAYSFYTLALSFRV

[0326] DOR73nt

[0327] ATGGATTCAAGAAGGAAAGTCCGAAGTGAAAATCTTTACAAAACCTATTGGCTTTACTGGCGACTTCTGGGAGTCGAGGGCGATTATCCTTTTCGACGGCTAGTGGATTTTACAATCACGTCTTTCATTACGATTTTATTTCCCGTGCATCTTATACTGGGAATGTATAAAAAGCCCCAGATTCAAGTCTTCAGGAGTCTGCATTTCACATCGGAATGCCTTTTCTGCAGCTATAAGTTTTTCTGTTTTCGTTGGAAACTTAAAGAAATAAAGACCATCGAAGGATTGCTCCAGGATCTCGATAGTCGAGTTGAAAGTGAAGAAGAACGCAACTACTTTAATCAAAATCCAAGTCGTGTGGCTCGAATGCTTTCGAAAAGTTACTTGGTAGCTGCTATATCGGCCATAATCACTGCAACTGTAGCTGGTTTATTTAGTACTGGTCGAAATTTAATGTATCTGGGTTGGTTTCCCTACGATTTTCAAGCAACCGCCGCAATCTATTGGATTAGTTTTTCCTATCAGGCGATTGGCTCTAGTCTGTTGATTCTGGAAAATCTGGCCAACGATTCATATCCGCCGATTACATTTTGTGTGGTCTCTGGACATGTGAGACTATTGATAATGCGTTTAAGTCGAATTGGTCACGATGTAAAATTATCAAGTTCGGAAAATACCAGAAAACTCATCGAAGGTATCCAGGATCACAGGAAACTAATGAAGATAATACGCCTACTTCGCAGCACTTTACATCTTAGCCAACTGGGCCAGTTCCTTTCTAGTGGAATCAACATTTCCATAACACTCATCAACATCCTGTTCTTTGCGGAAAACAACTTTGCAATGCTTTATTATGCGGTGTTCTTTGCTGCAATGTTAATAGAACTATTTCCAAGTTGTTACTATGGAATTCTGATGACAATGGAGTTTGATAAGCTACCATATGCCATCTTCTCCAGCAACTGGCTTAAAATGGATAAAAGATACAATCGATCCTTGATAATTCTGATGCAACTAACACTGGTTCCAGTGAATATAAAAGCAGGTGGTATTGTTGGCATCGATATGAGTGCATTTTTTGCCACAGTTCGGATGGCATATTCCTTTTACACTTTAGCCTTGTCATTTCGAGTA

[0328] DOR77

[0329] MELMRVPVQFYRTIGEDIYAHRSTNPLKSLLFKIYLYAGFINFNLLVIGELVFFYNSIQDFETIRLAIAVAPCIGFSLVADFKQAAMIRGKKTLIMLLDDLENMHPKTLAKQMEYKLPDFEKTMKRVINIFTFLCLAYTTTFSFYPAIKASVKFNFLGYDTFDRNFGFLIWFPFDATRNNLIYWIMYWDIAHGAYLAAFQVTESTVEVIIIYCIFLMTSMVQVFMVCYYGDTLIAASLKVGDAAYNQKWFQCSKSYCTMLKLLIMRSQKPASIRPPTFPPISLVTYMKNPFNNLPKHSSSLQINANRYI

[0330] DOR77nt

[0331] ATGGAATTGATGCGAGTGCCAGTACAGTTTTACAGAACGATTGGAGAGGATATCTACGCCCATCGATCCACGAATCCCCTAAAATCGCTTCTCTTCAAGATCTATCTATATGCGGGATTCATAAATTTTAATCTGTTGGTAATCGGTGAACTGGTGTTCTTCTACAACTCAATTCAGGACTTTGAAACCATTCGATTGGCCATCGCGGTGGCTCCATGTATCGGATTTTCTCTGGTTGCTGATTTTAAACAAGCTGCCATGATTAGAGGCAAGAAAACACTAATTATGCTACTCGATGATTTGGAGAACATGCATCCGAAAACCCTGGCAAAGCAAATGGAATACAAATTGCCGGACTTTGAAAAGACCATGAAACGTGTGATCAATATATTCACCTTTCTCTGCTTGGCCTATACGACTACGTTCTCCTTTTATCCGGCCATCAAGGCATCCGTGAAATTTAATTTCTTGGGCTACGACACCTTTGATCGAAATTTTGGTTTCCTCATCTGGTTTCCCTTCGATGCAACAAGGAATAATTTGATATACTGGATCATGTACTGGGACATAGCCCATGGGGCCTATCTAGCGGCCTTTCAGGTCACCGAATCAACAGTGGAAGTGATTATTATTTACTGCATTTTTTTGATGACCTCGATGGTTCAGGTATTTATGGTGTGCTACTATGGGGATACTTTAATTGCCGCGAGCTTGAAAGTGGGCGATGCCGCTTACAACCAAAAGTGGTTTCAGTGCAGCAAATCCTATTGCACCATGTTGAAGTTGCTAATCATGAGGAGTCAGAAACCAGCTTCAATAAGACCGCCGACTTTTCCCCCCATATCCTTGGTTACCTATATGAAGAATCCCTTCAACAATCTACCCAAACACAGCTCTTCCCTGCAAATCAACGCCAATCGCTATATC

[0332] DOR78

[0333] MKFMKYAVFFYTSVGIEPYTIDSRSKKASLWSHLLFWANVINLSVIVFGEILYLGVAYSDGKFIDAVTVLSYIGFVIVGMSKMFFIWWKKTDLSDLVKELEHIYPNGKAEEEMYRLDRYLRSCSRISITYALLYSVLIWTFNLFSIMQFLVYEKLLKIRVVGQTLPYLMYFPWNWHENWTYYVLLFCQNFAGHTSASGQISTDLLLCAVATQVVMHFDYLARVVEKQVLDRDWSENSRFLAKTVQYHQRILRLMDVLNDIFGIPLLLNFMVSTFVICFVGFQMTVGVPPDIMIKLFLFLFSSLSQVYLICHYGQLIADAVRDFRSSSLSISAYKQNWQNADIRYRRALVFFIARPQRTTYLKATIFMNITRATMTDVRYNLKCH

[0334] DOR78nt

[0335] ATGAAGTTCATGAAGTACGCAGTTTTCTTTTACACATCGGTGGGCATTGAGCCGTATACGATTGACTCGCGGTCCAAAAAAGCGAGCCTATGGTCACATCTTCTCTTCTGGGCCAATGTGATCAATTTAAGTGTCATTGTTTTCGGAGAGATCCTCTATCTGGGAGTGGCCTATTCCGATGGAAAGTTCATTGATGCCGTCACTGTACTGTCATATATCGGATTCGTAATCGTGGGCATGAGCAAGATGTTCTTCATATGGTGGAAGAAGACCGATCTAAGCGATTTGGTTAAGGAATTGGAGCACATCTATCCAAATGGCAAAGCTGAGGAGGAGATGTATCGGTTGGATAGGTATCTGCGATCTTGTTCACGAATTAGCATTACCTATGCACTACTCTACTCCGTACTCATCTGGACCTTCAATCTGTTCAGTATCATGCAATTCCTTGTCTATGAAAAGTTGCTTAAAATCCGAGTGGTCGGCCAAACGCTGCCATATTTGATGTACTTTCCCTGGAACTGGCATGAAAACTGGACGTATTATGTGCTGCTGTTCTGTCAAAACTTCGCAGGACATACTTCGGCATCGGGACAGATCTCTACGGATCTTTTGCTTTGTGCTGTTGCTACCCAGGTGGTAATGCACTTCGATTACTTGGCCAGAGTGGTGGAAAAACAAGTGTTAGATCGCGATTGGAGCGAAAACTCCAGATTTTTGGCAAAAACTGTACAATATCATCAGCGCATTCTTCGGCTAATGGACGTTCTCAACGATATATTCGGGATACCGCTACTGCTTAACTTTATGGTCTCCACATTTGTCATCTGCTTTGTGGGATTCCAAATGACCGTGGGTGTCCCGCCGGACATCATGATTAAGCTCTTCTTGTTCCTGTTCTCGTCCTTGTCGCAAGTGTACTTGATATGCCACTACGGCCAGCTGATTGCCGATGCGGTAAGAGACTTTCGAAGCTCTAGCTTATCGATTTCTGCATATAAGCAGAATTGGCAAAATGCTGACATTCGCTATCGTCGGGCTCTGGTATTCTTTATAGCTCGACCTCAGAGGACAACTTATCTAAAAGCTACAATTTTCATGAATATAACAAGGGCCACCATGACGGACGTAAGATACAATTTGAAATGTCAT

[0336] DOR81

[0337] MMETLRNSGLNLKNDFGIGRKIWRVFSFTYNMVILPVSFPINYVIHLAEFPPELLLQSLQLCLNTWCFALKFFTLIVYTHRLELANKHFDELDKYCVKPAEKRKVRDMVATITRLYLTFVVVYVLYATSTLLDGLLHHRVPYNTYYPFINWRVDRTQMYIQSFLEYFTVGYAIYVATATDSYPVIYVAALRTHILLLKDRIIYLGDPSNEGSSDPSYMFKSLVDCIKAHRTMLNFCDAIQPIISGTIFAQFIICGSILGIIMINMVLFADQSTRFGIVIYVMAVLLQTFPLCFYCNAIVDDCKELAHALFHSAWWVQDKRYQRTVIQFLQKLQQPMTFTAMNIFNINLATNINVSPLLSVRTGKEAKSELQSLQVAKFAFTVYAIASGMNLDQKLSIKE

[0338] DOR81nt

[0339] ATGATGGAGACGCTGCGAAATTCGGGCTTGAATTTGAAGAACGATTTCGGTATAGGCCGCAAGATTTGGAGGGTGTTTTCGTTCACCTACAATATGGTGATACTTCCCGTAAGTTTCCCAATCAACTATGTGATACATCTGGCGGAGTTCCCGCCGGAGCTGCTGCTGCAATCCCTGCAACTGTGCCTCAACACTTGGTGCTTCGCTCTGAAGTTCTTCACTCTGATCGTCTATACGCACCGCTTGGAGCTGGCCAACAAGCACTTTGACGAATTGGATAAGTACTGCGTGAAGCCGGCGGAGAAGCGCAAGGTTCGCGACATGGTGGCCACTATTACAAGACTGTACCTGACCTTCGTCGTGGTCTACGTCCTCTACGCCACCTCCACGCTACTGGACGGACTACTGCACCACCGTGTTCCCTACAATACGTACTATCCGTTCATAAACTGGCGAGTCGATCGGACCCAGATGTACATCCAGAGTTTTCTGGAGTACTTCACCGTGGGTTATGCCATATATGTGGCCACCGCCACCGATTCCTACCCTGTGATTTACGTGGCAGCCCTGCGAACTCATATTCTCTTGCTCAAGGACCGTATCATTTACTTGGGCGATCCCAGCAACGAGGGTAGCAGCGACCCGAGCTACATGTTTAAATCGTTGGTGGATTGTATCAAGGCACACAGAACCATGCTAAAGTOCAGTTTTTGTGATGCCATTCAACCAATCATCTCTGGCACGATATTTGCCCAATTCATCATATGCGGATCGATCCTGGGCATAATTATGATCAACATGGTATTGTTCGCTGATCAATCGACCCGATTCGGCATAGTCATCTACGTTATGGCCGTCCTTCTGCAGACTTTTCCGCTTTGCTTCTACTGCAACGCCATCGTGGACGACTGCAAAGAACTGGCCCACGCACTTTTCCATTCCGCCTGGTGGGTGCAGGACAAGCGATACCAGCGGACTGTCATCCAGTTCCTGCAGAAACTGCAGCAGCCCATGACCTTCACCGCCATGAACATATTTAACATTAATTTGGCCACTAACATCAATGTAAGTCCACTGCTCTCGGTTAGAACGGGGAAGGAAGCAAAGTCCGAACTTCAATCCTTGCAGGTAGCCAAGTTCGCCTTCACCGTGTACGCCATCGCGAGCGGTATGAACCTGGACCAAAAGTTAAGCATTAAGGAA

[0340] DOR82

[0341] MACIPRYQWKGRPTERQFYASEQRIVFLLGTICQIFQITGVLIYWYCNGRLATETGTPVAQLSEMCSSFCLTFVGFCNVYAISTNRNQIETLLEELHQIYPRYRKNHYRcQHYFDMAMTIMRIEFLFYMILYVYYNSAPLWVLLWEHLHEEYDLSFKTQTNTWFPWKVHGSALGFGMAVLSITVGSFVGVGFSIVTQNLICLLTFQLKLHYDGISSQLVSLDCRRPGAHKELSILIAHHSRILQLGDQVNDIMNFVFGSSLVGATIAICMSSVSIMLLDLASAFKYASGLVAFVLYNFVICYMGTEVTLAVKIGSYMDGRRWIPKDSLLRSQRLQVLVAVGFFNICVLSNRRPKIEILLRYYYHIMFYSFKLYFSLRKGSLWKILSSFTLLRI

[0342] DOR82nt

[0343] ATGGCATGCATACCAAGATATCAATGGAAAGGACGCCCTACTGAAAGACAGTTCTACGCTTCGGAGCAAAGGATAGTGTTCCTTCTTGGAACCATTTGCCAGATATTCCAGATTACTGGAGTGCTTATCTATTGGTATTGCAATGGCCGTCTTGCCACGGAAACGGGCACCTTTGTGGCACAATTATCTGAAATGTGCAGTTCTTTTTGTCTAACATTTGTGGGATTCTGTAACGTTTATGCGATCTCTACAAACCGCAATCAAATTGAAACATTACTCGAGGAGCTTCATCAGATATATCCGAGATACAGGAAAAATCACTATCGCTGCCAGCATTATTTTGACATGGCCATGACAATAATGAGAATTGAGTTTCTTTTCTATATGATCTTGTACGTGTACTACAATAGTGCACCATTATGGGTGCTTCTTTGGGAACACTTGCACGAGGAATATGATCTTAGCTTCAAGACGCAGACCAACACTTGGTTTCCATGGAAAGTCCATGGGTCGGCACTTGGATTTGGTATGGCTGTACTAAGCATAACCGTGGGATCCTTTGTGGGCGTAGGTTTCAGTATTGTCACCCAGAATCTTATCTGTTTGTTAACCTTCCAACTAAAGTTGCACTACGATGGAATATCCAGTCAGTTAGTATCTCTCGATTGCCGTCGTCCTGGAGCTCATAAGGAGTTGAGCATCCTCATCGCCCACCACAGCCGAATCCTTCAGCTGGGCGACUAAGTCAATGACATAATGAACTTTGTATTCGGCTCTAGCCTAGTAGGTGCCACTATTGCCATTTGTATGTCAAGTGTTTCTATAATGCTACTGGACTTAGCATCTGCCTTCAAATATGCCAGTGGTCTAGTGGCATTCGTCCTCTACAACTTTGTCATCTGCTACATGGGAACCGAGGTCACTTTAGCTGTGAAGATTGGTTCATATATGGACGGAAGGCGGTGGATACCCAAAGATTCGTTGCTGAGATCTCAGAGGCTACAGGTGCTCGTCGCAGTTGGATTTTTTAATATATGTGTCCTCTCGAATCGTCGTCCTAAAATTGAAATTTTGCTTAGATATTATTACCATATTATGTTTTATTCATTTAAATTATATTTTTCTTTAAGGAAAGGTAGCCTTTGGAAAATCTTcTCTTCTTTCACCTTATTGAGGATC

[0344] DOR83

[0345] MQLEDFMRYPDLVCQAAQLPRYTWNGRRSLEVKRNLAKRIIFWLGAVNLVYHNIGCVMYGYFGDGRTKDPIAYLAELASVASMLGFTIVGTLNLWKMLSLKTHFENLLNEFEELFQLIKHRAYRIHHYQEKYTRHIRNTFIFHTSAVVYYNSLPILLMIREHFSNSQQLGYRIQSNTWYPWQVQGSIPGFFAAVACQIFSCQTNMCVNMFIQFLINFFGIQLEIHFDGLARQLETIDARNPHAKDQLKYLIVYHTKLLNLADRVNRSFNFTFLISLSVSMISNCFLAFSMTMFDFGTSLKHLLGLLLFITYNFSMCRSGTHLILTSGKVLPAAFYNNWYEGDLVYRRMLLILMMRATKPYMWKTYKLAPVSITTYMAECKTKEAHEQRHFRRHERQKPRVARI

[0346] DOR83nt

[0347] ATGCAGTTGGAGGACTTTATGCGGTACCCGGACCTCGTGTGTCAAGCGGCCCAACTTCCCAGATACACGTGGAATGGCAGACGATCCTTGGAAGTTAAACGCAACTTGGCAAAACGCATTATCTTCTGGCTTGGAGCAGTAAATTTGGTTTATCACAATATTGGCTGCGTCATGTATGGCTATTTCGGTGATGGAAGAACAAAGGATCCAATTGCGTATTTAGCTGAATTGGCATCTGTGGCCAGCATGCTTGGTTTCACCATTGTGGGCACCCTCAACTTGTGGAAGATGCTGAGCCTTAAGACCCATTTTGAGAACCTACTAAATGAATTCGAGGAATTATTTCAACTAATCAAGCACAGGGCGTATCGCATACACCACTATCAAGAAAAGTATACGCGTCATATACGAAATACATTTATTTTCCATACCTCTGCCGTTGTCTACTACAACTCACTACCAATTCTTCTAATGATTCGGGAACATTTCTCGAACTCACAGCAGTTGGGCTATAGAATTCAGAGTAATACCTGGTATCCCTGGCAGGTTCAGGGATCAATTCCTGGATTTTTTGCTGCAGTCGCCTGTCAAATCTTTTCGTGCCAAACCAATATGTGCGTCAATATGTTTATCCAGTTTCTGATCAACTTTTTTGGTATCCAGCTAGAAATACACTTCGATGGTTTGGCCAGGCAGCTGGAGACCATCGATGCCCGCAATCCCCATGCCAAGGATCAATTGAAGTATCTGATTGTATATCACACAAAATTGCTTAATCTAGCCGACAGAGTTAATCGATCGTTTAACTTTACGTTTCTCATAAGTCTGTCGGTATCCATGATATCCAACTGTTTTCTGGCATTTTCCATGACCATGTTCGACTTTGGCACCTCTCTAAAACATTTACTCGGACTTTTGCTATTCATCACATATAATTTTTCAATGTGCCGCAGTGGTACGCACTTGATTTTAACGAGTGGCAAAGTATTGCCAGCGGCCTTTTATAACAATTGGTATGAAGGCGATCTTGTTTATCGAAGGATGCTCCTCATCCTGATGATGCGTGCTACGAAACCTTATATGTGGAAAACCTACAAGCTGGCACCTGTATCCATAACTACATATATGGCAGAATGCAAAACAAAAGAAGCCCATGAACAACGCCATTTTAGACGCCATGAAAGACAAAAACCTCGGGTTGCACGAATA

[0348] DOR84

[0349] MVFSFYAEVATLVDRLRDNENFLESCILLSYVSFVVMGLSKIGAVMKKKPKMTALVRQLETCFPSPSAKVQEEYAVKSWLKRCHIYTKGFGGLFMIMYFAHALIPLFIYFIQRVLLHYPDAKQIMPFYQLEPWEFRDSWLFYPSYFHQSSAGYTATCGSIAGDLMIFAVVLQVIMHYERLAKVLREFKIQAHNAPNGAKEDIRKLQSLVANHIDILRLTDLMNEVFGIPLLLNFIASALLVCLVGVQLTIALSPEYFCKQMLFLISVLLEVYLLCSFSQRLIDAVC

[0350] DOR84nt

[0351] ATGGTGTTTAGTTTTTATGCCGAGGTAGCGACTCTGGTGGACAGGTTACGCGATAATGAAAATTTTCTCGAGAGCTGCATCTTACTGAGCTACGTGTCCTTTGTGGTCATGGGCCTCTCCAAGATAGGTGCTGTAATGAAAAAAAAGCCAAAAATGACAGCTTTGGTCAGGCAATTGGAGACCTGCTTTCCGTCGCCAAGTGCAAAGGTTCAAGAGGAATATGCTGTGAAGTCCTGGCTGAAACGCTGCCATATATACACAAAGGGATTTGGTGGTCTCTTCATGATCATGTATTTCGCTCACGCTCTGATTCCCTTATTCATATACTTCATTCAAAGAGTGCTGCTCCACTATCCGGATGCCAAGCAGATTATGCCGTTTTACCAACTCGAACCTTGGGAATTTCGCGACTCCTGGTTGTTTTATCCAAGCTATTTTCACCAGTCGTCGGCCGGATATACGGCTACATGTGGATCCATTGCCGGTGACCTAATGATCTTCGCTGTGGTCCTGCAGGTCATCATGCACTACCAAAGACTGGCCAAGGTTCTTAGGGAGTTTAAGATTCAAGCCCATAACGCACCCAATGGAGCTAAGGAGGATATAAGGAAGTTGCAGTCCCTAGTCGCCAATCACATTGATATACTTCGACTCACTGATCTGATGAACGAGGTCTTTGGAATTCCCTTGTTGCTAAACTTTATTGCATCTGCGCTGCTGGTCTGCCTGGTGGGAGTTCAATTAACCATCGCTTTAAGTCCAGAGTATTTTTGCAAGCAGATGCTATTTCTGATTTCCGTACTGCTTGAGGTCTATCTCCTTTGCTCCTTCAGCCAGAGGTTAATAGATGCTGTATGT

[0352] DOR87

[0353] MTIEDIGLVGINVRMWRHLAVLYPTPGSSWRKFAFVLPVTAMNLMQFVYLLRMWGDLPAFILNMFFFSAIFNALMRTWLVIIKRRQFEEFLGQLATLFHSILDSTDEWGRGILRRAEREARNLAILNLSASFLDIVGALVSPLFREERAHPFGVALPGVSMTSSPVYEVIYLAQLPTPLLLSMMYMPFVSLFAGLAIFGKAMLQILVHRLGQIGGEEQSEEERFQRLASCIAYHTQVMRYVWQLNKLVANIVAVEAIIFGSIICSLLFCLNIITSPTQVISIVMYILTMLYVLFTYYNRANEICLENNRVAEAVYNVPWYEAGTRFRKTLLIFLMQTQHPMEIRVGNVYPMTLAMFQSLLNASYSYFTMLRGVTGK

[0354] DOR87nt

[0355] GGCACGAGGCTTATAGAAAGTGCCGAGCAATGACAATCGAGGATATCGGCCTGGTGGGCATCAACGTGCGGATGTGGCGACACTTGGCCGTGCTGTACCCCACTCCGGGCTCCAGCTGGCGCAAGTTCGCCTTCGTGCTGCCGGTGACTGCGATGAATCTGATGCAGTTCGTCTACCTGCTGCGGATGTGGGGCGACCTGCCCGCCTTCATTCTGAACATGTTCTTCTTCTCGGCCATTTTCAACGCCCTGATGCGCACGTGGCTGGTCATAATCAAGCGGCGCCAGTTCGAGGAGTTTCTCGGCCAACTGGCCACTCTGTTCCATTCGATTCTCGACTCCACCGACGAGTGGGGGCGTGGCATCCTGCGGAGGGCGGAACGGGAGGCTCGGAACCTGGCCATCCTTAATTTGAGTGCCTCCTTCCTGGACATTGTCGGTGCTCTGGTATCGCCGCTTTTCAGGGAGGAGAGAGCTCATCCCTTCGGCGTAGCTCTACCAGGAGTGAGCATGACCAGTTCACCCGTCTACGAGGTTATCTACTTGGCCCAACTGCCTACGCCCCTGCTGCTGTCCATGATGTACATGCCTTTCGTCAGCCTTTTTGCCGGCCTGGCCATCTTTGGGAAGGCCATGCTGCAGATCCTGGTACACAGGCTGGGCCAGATTGGCGGAGAAGAGCAGTCGGAGGAGGAGCGCTTCCAAAGGCTGGCCTCCTGCATTGCGTACCACACGCAGGTGATGCGCTATGTGTGGCAGCTCAACAAACTGGTGGCCAACATTGTGGCGGTGGAAGCAATTATTTTTGGCTCGATAATCTGCTCACTGCTCTTCTGTCTGAATATTATAACCTCACCCACCCAGGTGATCTCGATAGTGATGTACATTCTGACCATGCTGTACGTTCTCTTCACCTACTACAATCGGGCCAATGAAATATGCCTCGAGAACAACCGGGTGGCGGAGGCTGTTTACAATGTGCCCTGGTACGAGGCAGGAACTCGGTTTCGCAAAACCCTCCTGATCTTCTTGATGCAAACACAACACCCGATGGAGATAAGAGTCGGCAACGTTTACCCCATGACATTGGCCATGTTCCAGAGTCTGTTGAATGCGTCCTACTCCTACTTTACCATGCTGCGTGGCGTCACCGGCAAATGAGCTGAAAGACCGAAAAAACCGGAGTATCCCCTTCCATATTCCCCCTGCTCCTTTATTTTCCTTTCCTTTTCCCTTTCCGTTTTCCCATTCGCTTTTCCAGCAATCCGGGTAATGCAAAAAGTTGTTGCTGGCTGTGGTCCTGGCTGCTTGTTTGGCATTTGCATATGCTTGTCGTTTGAAAGGATTTAATCGGACTGCTGGCACGGAGTCGGCATCCTGGCTCCTGGATCCTGGCATGCAAATAGTTGGCTTCTTAGATTGTTACACAAAATAGATTGTAGATTGCAGCTGAATGTTGTGCTTGGAATAAAGTCAAAAGGATGTGGAGTCGGCCCAAGGCTCTGCCCATTCTGTTTGCTCGGGATGCCCGAAAGTATGAAAAAAAAAAAAAAAAAA

[0356] DOR91

[0357] MVRYVPRFADGQKVKLAWPLAVFRLNHIFWPLDPSTGKWGRYLDKVLAVAMSLVFMQHNDAELRYLRFEASNRNLDAFLTGMPTYLILVEAQFRSLHILLHFEKLQKFLEIFYANIYIDPRKEPEMFRKVDGKMIINRLVSAMYGAVISLYLIAPVFSIINQSKDFLYSMIFPFDSDPLYIFVPLLLTNVWVGIVIDTMMFGETNLLCELIVHLNGSYMLLKRDLQLAIEKILVARDRPHMAKQLKVLITKTLRKNVALNQFGQQLEAQYTVRVFIMFAFAAGLLCALSFKAYTTDSLSTMYYLTHWEQILQYSTNPSENLRLLKLINLAIEMNSKPFYVTGLKYFRVSLQAGLKRQKFLRSASSSTLSTADVLAFAFAFTRWLL

[0358] DOR91nt

[0359] ATGGTTCGTTACGTGCCCCGGTTCGCTGATGGTCAGAAAGTAAAGTTGGCTTGGCCCTTGGCGGTTTTTCGGTTAAATCACATATTCTGGCCATTGGATCCGAGCACAGGGAAATGGGGCCGATATCTGGACAAGGTTCTAGCTGTTGCGATGTCCTTGGTTTTTATGCAACACAACGATGCAGAGCTGAGGTACTTGCGCTTCGAGGCAAGTAATCGGAATTTGGATGCCTTTCTCACAGGAATGCCAACGTATTTAATCCTCGTGGAGGCTCAATTTAGAAGTCTTCACATTCTACTGCACTTCGAGAAGCTTCAGAAGTTTTTAGAAATATTCTACGCAAATATTTATATTGATCCCCGTAAGGAACCCGAAATGTTTCGAAAAGTGGATGGAAAGATGATAATTAACAGATTAGTTTCGGCCATGTACGGTGCAGTTATCTCTCTGTATCTAATCGCACCCGTTTTTTCCATCATTAACCAAAGCAAAGATTTTCTATACTCTATGATCTTTCCGTTCGATTCGGATCCCTTGTACATATTTGTGCCACTGCTTTTGACAAACGTATGGGTTGGCATTGTAATAGATACCATGATGTTCGGGGAGACGAATTTGTTGTGTGAACTAATTGTCCACCTAAATGGTAGTTATATGTTGCTCAAGAGGGACTTGCAGTTGGCCATTGAAAAGATATTAGTTGCAAGGGACCGTCCGCATATGGCCAAACAGCTAAAGGTTTTAATTACAAAAACTCTCCGAAAGAATGTGGCTCTAAATCAGTTTGGCCAGCAGCTGGAGGCTCAGTATACTGTGCGGGTTTTTATTATGTTTGCATTCGCTGCGGGCCTTTTATGTGCTCTTTCTTTTAAGGCTTATACGACGGATTCCCTCAGCACAATGTACTACCTTACCCATTGGGAGCAAATCCTGCAGTACTCTACAAATCCCAGCGAAAATCTGCGATTACTAAAGCTCATTAACTTGGCCATTGAGATGAACAGCAAGCCCTTCTATGTGACAGGGCTAAAATATTTTCGCGTTAGTCTGCAGGCTGGCTTAAAACGTCAAAAGTTTCTGCGGTCTGCCAGCTCATCCACCCTTAGCACCGCTGATGTGTTGGCATTTGCTTTTGCTTTTACTCGCTGGCTGCTT

[0360] DOR92

[0361] MSEWLRFLKRDQQLDVYFFAVPRLSLDIMGYWPGKTGDTWPWRSLIHFAILAIGVATELHAGMCFLDRQQITLALETLCPAGTSAVTLLKMFLMLRFRQDLSIMWNRLRGLLFDPNWERPEQRDIRLKHSAMAARINFWPLSAGFFTCTTYNLKPILIAMILYLQNRYEDFVWFTPFNMTMPKVLLNYPFFPLTYIFIAYTGYVTIFMFGGCDGFYFEFCAHLSALFEVLQAEIESMFRPYTDHLELSPVQLYILEQKMRSVIIRHNAIIDLTRFFRDRYTIITLAHFVSAAMVIGFSMVNLLTLGNNGLGAMLYVAYTVAALSQLLVYCYGGTLVAESSTGLCRAMFSCPWQLFKPKQRRLVQLLILRSQRPVSMAVPFFSPSLATFAAILQTSGSIIALVKSFQ

[0362] DOR92nt

[0363] ATGTCCGAGTGGTTACGCTTTCTGAAACGCGATCAACAGCTGGATGTGTACTTTTTTGCAGTGCCCCGCTTGAGTTTAGACATAATGGGCTATTGGCCGGGCAAAACTGGTGATACATGGCCCTGGAGATCCCTGATTCACTTCGCAATCCTGGCCATTGGCGTGGCCACCGAACTGCATGCTGGCATGTGTTTTCTAGACCGACAGCAGATTACCTTGGCACTGGAGACCCTCTGTCCAGCTGGCACATCGGCGGTCACGCTGCTCAAGATGTTCCTAATGCTGCGCTTTCGTCAGGATCTCTCCATTATGTGGAACCGCCTGAGGGGCCTGCTCTTCGATCCCAACTGGGAGCGACCCGAGCAGCGGGACATCCGGCTAAAGCACTCGGCCATGGCGGCTCGCATCAATTTCTGGCCCCTGTCAGCCGGATTCTTCACATGCACCACCTACAACCTAAAGCCGATACTGATCGCAATGATATTGTATCTCCAGAATCGTTACGAGGACTTCGTTTGGTTTACACCCTTCAATATGACTATGCCCAAAGTTCTGCTAAACTATCCATTTTTTCCCCTGACCTACATATTTATTGCCTATACGGGCTATGTGACCATCTTTATGTTCGGCGGCTGTGATGGTTTTTATTTCGAGTTCTGTGCCCACCTATCAGCTCTTTTCGAAGTGCTCCAGGCGGAGATAGAATCAATGTTTAGACCCTACACTGATCACTTGGAACTGTCGCCAGTGCAGCTTTACATTTTAGAGCAAAAGATGCGATCAGTAATCATTAGGCACAATGCCATCATCGATTTGACCAGATTTTTTCGTGATCGCTATACCATTATTACCCTGGCCCATTTTGTGTCCGCCGCCATGGTGATTGGATTCAGCATGGTTAATCTCCTGACATTGGGCAATAATGGTCTGGGCGCAATGCTCTATGTGGCCTACACGGTTGCCGCTTTGAGCCAACTGCTGGTTTATTGCTATGGCGGAACTCTGGTGGCCGAAAGTAGCACTGGTCTGTGCCGAGCCATGTTCTCCTGTCCGTGGCAGCTTTTTAAGCCTAAACAACGTCGACTCGTTCAGCTTTTGATTCTCAGATCGCAGCGTCCTGTTTCCATGGCAGTGCCATTCTTTTCGCCATCGTTGGCTACCTTTGCTGCGATTCTTCAAACTTCGGGTTCCATAATTGCGCTGGTTAAGTCCTTTCAG

[0364] DOR95

[0365] MSDKVKGKKQEEKDQSLRVQILVYRCMGIDLWSPTMANDRPWLTFVTMGPLFLFMVPMFLAAHEYITQVSLLSDTLGSTFASMLTLVKFLLFCYHRKEFVGLIYHIRAILAKEIEVWPDAREIIEVENQSDQMLSLTYTRCFGLAGIFAALKPFVGIILSSIRGDEIHLELPHNGVYPYDLQVVMFYVPTYLWNVMASYSAVTMALCVDSLLFFFTYNvCAIFKIAKHRMIHLPAVGGKEELEGLVQVLLLHQKGLQIADHIADKYRPLIFLQFFLSALQICFIGFQVADLFPNPQSLYFIAFVGSLLIALFIYSKCGENIKSASLDFGNGLYETNWTDFSPPTKRALLIAAMRAQRPCQMKGYFFEASMATFSTIVRSAVSYIMMLRSFNA

[0366] DOR95nt

[0367] ATGAGCGACAAGGTGAAGGGAAAAAAGCAGGAGGAAAAGGATCAATCCTTGCGGGTG CAAATTCCCAGCTATAGTGCTGTAACCATGGCACTCTGCGTGGACTCGCTGCTCTTCTTTTTCACCTACAACGTGTGCGCCATTTTCAAGATCGCCAAGCACCGGATGATCCATCTGCCGGCGGTGGGCGGAAAGGAGGAGCTGGAGGGGCTCGTCCAGGTGCTGCTGCTGCACCAGAAGGGCCTCCAGATCGCCGATCACATTGCGGACAAGTACCGGCCGCTGATCTTTTTGCAGTTCTTTCTGTCCGCCTTGCAGATCTGCTTCATTGGATTCCAGGTGGCTGATCTGTTTCCCAATCCGCAGAGTCTCTACTTTATCGCCTTTGTGGGCTCGCTGCTCATCGCACTGTTCATCTACTCGAAGTGCGGCGAAAATATCAAGAGTGCCAGCCTGGATTTCGGAAACGGGCTGTACGAGACCAACTGGACCGACTTCTCGCCACCCACTAAAAGAGCCCTCCTCATTGCCGCCATGCGCGCCCAGCGACCTTGCCAGATGAAGGGCTACTTTTTCGAGGCCAGCATGGCCACCTTCTCGACGATTGTTCGCTCTGCCGTGTCGTACATCATGATGTTGCGCTCCTT TAATGCC

[0368] DOR99

[0369] MEEFLRPQMFQEVAQMVHFQWRRNPVDNSMVNASMVPFCLSAFLNVLFFGCNGWDIIGHFWLGHPANQNPPVLSITIYFSIRGLMLYLKRKEIVEFVNDLDRECPRDLVSQLDMQMDETYRNFWQRYRFIRIYSHLGGPMFCVVPLALFLLTHEGKDTPVAQHEQLLGGWLPCGVRKDPNFYLLVWSFDLMCTTCGVSFFVTFDNLFNVMQGHLVMHLGHLARQFSAIDPRQSLTDEKRFFVDLRLLVQRQQLLNGLCRKYNDIFKVAFLVSNFVGAGSLCFYLFMLSETSDVLIIAQYILPTLVLVGFTFEICLRGTQLEKASEGLESSLRSQEWYLGSRRYRKFYLLWTQYCQRTQQLGAFGLIQVNMVHFTEIMQLAYRLFTFLKSH

[0370] DOR99nt

[0371] ATGGAGGAGTTTCTGCGTCCGCAGATGTTCCAGGAGGTGGCTCAGATGGTGCATTTCCAGTGGCGGAGAAATCCGGTGGACAACAGCATGGTGAACGCATCCATGGTCCCCTTCTGCTTGTCGGCGTTTCTTAATGTCCTGTTTTTCGGCTGCAATGGTTGGGACATCATAGGACATTTTTGGCTGGGACATCCTGCCAACCAGAATCCGCCCGTGCTTAGCATCACCATTTACTTCTCGATCAGGGGATTGATGCTATACCTGAAACGAAAGGAAATCGTTGAGTTTGTTAACGACTTGGATCGGGAGTGTCCGCGGGACTTGGTCAGCCAGTTGGACATGCAAATGGATGAGACGTACCGAAACTTTTGGCAGCGCTATCGCTTCATCCGTATCTACTCCCATTTGGGTGGTCCGATGTTCTGCGTTGTGCCATTAGCTCTATTCCTCCTGACCCACGAGGGTAAAGATACTCCTGTTGCCCAGCACGAGCAGCTCCTTGGAGGATGGCTGCCATGCGGTGTGCGAAAGGACCCAAATTTCTACCTTTTAGTCTGGTCCTTCGACCTGATGTGCACCACTTGCGGCGTCTCCTTTTTCGTTACCTTCGACAACCTATTCAATGTGATGCAGGGACATTTGGTCATGCATTTGGGCCATCTTGCTCGCCAGTTTTCGGCCATCGATCCTCGACAGAGTTTGACCGATGAGAAGCGATTCTTTGTGGATCTTAGGTTATTAGTTCAGAGGCAGCAGCTTCTTAATGGATTGTGCAGAAAATACAACGACATCTTTAAAGTGGCCTTCCTGGTGAGCAATTTTGTAGGCGCCGGTTCCCTCTGCTTCTACCTCTTTATGCTCTCGGAGACATCAGATGTCCTTATCATCGCCCAGTATATATTACCCACTTTGGTCCTGGTGGGCTTCACATTTGAGATTTGTCTACGGGGAACCCAACTGGAAAAGGCGTCGGAGGGACTGGAATCGTCGTTGCGAAGCCAGGAATGGTATTTGGGAAGTAGGCGGTACCGGAAGTTCTATTTGCTCTGGACGCAATATTGCCAGCGAACACAGCAACTGGGCGCCTTTGGGCTAATCCAAGTCAATATGGTGCACTTCACTGAAATAATGCAGCTGGCCTATAGACTCTTCACTTTTCT CAAATCTCAT

[0372] DORA45

[0373] MTTSMQPSKYTGLVADLMPNIRAMKYSGLFMHNFTGGSAFMKKVYSSVHLVFLLMQFTFILVNMALNAEEVNELSGNTITTLFFTHCITKFIYLAVNQKNFYRTLNIWNQVNTHPLFAESDARYHSIALAKMRKLFFLVMLTTVASATAWTTITFFGDSVKMVVDHETNSSIPVEIPRLPIKSFYPWNASHGMFYMISFAFQIYYVLFSMIHSNLCDVMFCSWLIFACEQLQHLKGIMKPLMELSASLDTYRPNSAALFRSLSANSKSELIHNEEKDPGTDMDMSGIYSSKADWGAQFRAPSTLQSFGGNGGGGNGLVNGANPNGLTKKQEMMVRSAIKYWVERHKHVVRLVAAIGDTYGAALLLHMLTSTIKLTLLAYQATKINGVNVYAFTVVGYLGYALAQVFHFCIFGNRLIEESSSVMEAAYSCHWYDGSEEAKTFVQIVCQQCQKAMSISGAKFFTVSLDLFASVLGAVVTYFMVLVQLK

[0374] DORA45nt

[0375] GGCACGAGCTGGTTCCGGAAAGCCTCATATCTCGTATCTTAAAGTATCCCGGTTAAGCCTTAAAGAGTGAAATGATTGCCTAGACGATTGCTGCATTACTGGCACTCAATTAACCCAAGTGTACCAGACAACAATTACATTTGTATTTTTAAAGTTCAATAGCAAGGATGACAACCTCGATGCAGCCGAGCAAGTACACGGGCCTGGTCGCCGACCTGATGCCCAACATCCGGGCGATGAAGTACTCCGGCCTGTTCATGCACAACTTCACGGGCGGCAGTGCCTTCATGAAGAAGGTGTACTCCTCCGTGCACCTGGTGTTCCTCCTCATGCAGTTCACCTTCATCCTGGTCAACATGGCCCTGAACGCCGAGGAGGTCAACGAGCTGTCGGGCAACACGATCACGACCCTCTTCTTCACCCACTGCATCACGAAGTTTATCTACCTGGCTGTTAACCAGAAGAATTTCTACAGAACATTGAATATATGGAACCAGGTGAACACGCATCCCTTGTTCGCCGAGTCGGATGCTCGTTACCATTCGATCGCACTGGCGAAGATGAGGAAGCTGTTCTTTCTGGTGATGCTGACCACAGTCGCCTCGGCCACCGCCTGGACCACGATCACCTTCTTTGGCGACAGCGTAAAAATGGTGGTGGACCATGAGACGAACTCCAGCATCCCGGTGGAGATACCCCGGCTGCCGATTAAGTCCTTCTACCCGTGGAACGCCAGCCACGGCATGTTCTACATGATCAGCTTTGCCTTTCAGATCTACTACGTGCTCTTCTCGATGATCCACTCCAATCTATGCGACGTGATGTTCTGCTCTTGGCTGATATTCGCCTGCGAGCAGCTGCAGCACTTGAAGGGCATCATGAAGCCGCTGATGGAGCTGTCCGCCTCGCTGGACACCTACAGGCCCAACTCGGCGGCCCTCTTCAGGTCCCTGTCGGCCAACTCCAAGTCGGAGCTAATTCATAATGAAGAAAAGGATCCCGGCACCGACATGGACATGTCGGGCATCTACAGCTCGAAAGCGGATTGGGGCGCTCAGTTTCGAGCACCCTCGACACTGCAGTCCTTTGGCGGGAACGGGGGCGGAGGCAACGGGTTGGTGAACGGCGCTAATCCCAACGGGCTGACCAAAAAGCAGGAGATGATGGTGCGCAGTGCCATCAAGTACTGGGTCGAGCGGCACAAGCACGTGGTGCGACTGGTGGCTGCCATCGGCGATACTTACGGAGCCGCCCTCCTCCTCCACATGCTGACCTCGACCATCAAGCTGACCCTGCTGGCATACCAGGCCACCAAAATCAACGGAGTGAATGTCTACGCCTTCACAGTCGTCGGATACCTAGGATACGCGCTGGCCCAGGTGTTCCACTTTTGCATCTTTGGCAATCGTCTGATTGAAGAGAGTTCATCCGTCATGGAGGCCGCCTACTCGTGCCACTGGTACGATGGCTCCGAGGAGGCCAAGACCTTCGTCCAGATCGTGTGCCAGCAGTGCCAGAAGGCGATGAGCATATCGGGAGCGAAATTCTTCACCGTCTCCCTGGATTTGTTTGCTTCGGTTCTGGGTGCCGTCGTCACCTACTTTATGGTGCTGGTGCAGCTCAAGTAAGTTGCTGCGAAGCTGATGGATTTTTGTACCAGAAAAGCGAATGCCAAGAAGCCACCTACCGCCCCTTGCCCCCTCCGCACTGTGCAACCAGCAATATCACAGAGCAATTATAACGCAAATTATATATTTTATACCTGCGACGAGCGAGCCTCGTGGGGCATAATGGAGACATTCTGGGGCACATAGAAGCCTGCAAATACTTATCGATTTTGTACACGCGTAGAGCTTTTAATGTAAACTCAAGATGCAAACTAAATAAATGTGTAGTGAAAAAAAAAAAAAAAAA AAA

[0376] Genbank Accession Numbers

[0377] The accession numbers for the sequences reported in this paperare AF127921-AF127926.

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1 108 1 1285 DNA DROSOPHILA MELANOGASTER DOR62 1 atggagaagc aagaggatttcaaactgaac acccacagtg ctgtgtacta ccactggcgc 60 gtttgggagc tcactggcctgatgcgtcct ccgggcgttt caagcctgct ttacgtggta 120 tactccatta cggtcaacttggtggtcacc gtgctgtttc ccttgagctt gctggccagg 180 ctgctgttca ccaccaacatggccggattg tgcgagaacc tgaccataac tattaccgat 240 attgtggcca atttgaagtttgcgaatgtg tacatggtga ggaagcagct ccatgagatt 300 cgctctctcc taaggctcatggacgctaga gcccggctgg tgggcgatcc cgaggagatt 360 tctgccttga ggaaggaagtgaatatcgca cagggcactt tccgcacctt tgccagtatt 420 ttcgtatttg gcactactttgagttgcgtc cgcgtggtcg ttcgcccgga tcgagagctc 480 ctgtatccgg cctggttcggcgttgactgg atgcactcca ccagaaacta tgtgctcatc 540 aatatctacc agctcttcggcttgatagtg caggctatac agaactgcgc tagtgactcc 600 tatccgcctg cgtttctctgcctgctcacg ggtcatatgc gtgctttgga gctgagggtg 660 cggcggattg gctgcaggacggaaaagtcc aataaagggc agacatatga agcctggcgg 720 gaggaggtgt accaggaactcatcgagtgc atccgcgatc tggcgcgggt ccatcggctg 780 agggagatca ttcagcgggtcctttcagtg ccctgcatgg cccagttcgt ctgctccgcc 840 gccgtccagt gtaccgtcgccatgcacttc ctgtacgtag cggatgacca cgaccacacc 900 gccatgatca tctcgattgtatttttctcg gccgtcacct tggaggtgtt tgtaatctgc 960 tattttgggg acaggatgcggacacagagc gaggcgctgt gcgatgcctt ctacgattgc 1020 aactggatag aacagctgcccaagttcaag cgcgaactgc tcttcaccct ggccaggacg 1080 cagcggcctt ctcttatttacgcaggcaac tacatcgcac tctcgctgga gaccttcgag 1140 caggtcatga ggttcacatactctgttttc acactcttgc tgagggccaa gtaagaactt 1200 tataatctct ttttggggagaaaaatttta aagcacaata gcagaaaaat atatcagata 1260 atataacaaa aaaaaaaaaaaaaaa 1285 2 397 PRT DROSOPHILA MELANOGASTER DOR62 2 Met Glu Lys Gln GluAsp Phe Lys Leu Asn Thr His Ser Ala Val Tyr 1 5 10 15 Tyr His Trp ArgVal Trp Glu Leu Thr Gly Leu Met Arg Pro Pro Gly 20 25 30 Val Ser Ser LeuLeu Tyr Val Val Tyr Ser Ile Thr Val Asn Leu Val 35 40 45 Val Thr Val LeuPhe Pro Leu Ser Leu Leu Ala Arg Leu Leu Phe Thr 50 55 60 Thr Asn Met AlaGly Leu Cys Glu Asn Leu Thr Ile Thr Ile Thr Asp 65 70 75 80 Ile Val AlaAsn Leu Lys Phe Ala Asn Val Tyr Met Val Arg Lys Gln 85 90 95 Leu His GluIle Arg Ser Leu Leu Arg Leu Met Asp Ala Arg Ala Arg 100 105 110 Leu ValGly Asp Pro Glu Glu Ile Ser Ala Leu Arg Lys Glu Val Asn 115 120 125 IleAla Gln Gly Thr Phe Arg Thr Phe Ala Ser Ile Phe Val Phe Gly 130 135 140Thr Thr Leu Ser Cys Val Arg Val Val Val Arg Pro Asp Arg Glu Leu 145 150155 160 Leu Tyr Pro Ala Trp Phe Gly Val Asp Trp Met His Ser Thr Arg Asn165 170 175 Tyr Val Leu Ile Asn Ile Tyr Gln Leu Phe Gly Leu Ile Val GlnAla 180 185 190 Ile Gln Asn Cys Ala Ser Asp Ser Tyr Pro Pro Ala Phe LeuCys Leu 195 200 205 Leu Thr Gly His Met Arg Ala Leu Glu Leu Arg Val ArgArg Ile Gly 210 215 220 Cys Arg Thr Glu Lys Ser Asn Lys Gly Gln Thr TyrGlu Ala Trp Arg 225 230 235 240 Glu Glu Val Tyr Gln Glu Leu Ile Glu CysIle Arg Asp Leu Ala Arg 245 250 255 Val His Arg Leu Arg Glu Ile Ile GlnArg Val Leu Ser Val Pro Cys 260 265 270 Met Ala Gln Phe Val Cys Ser AlaAla Val Gln Cys Thr Val Ala Met 275 280 285 His Phe Leu Tyr Val Ala AspAsp His Asp His Thr Ala Met Ile Ile 290 295 300 Ser Ile Val Phe Phe SerAla Val Thr Leu Glu Val Phe Val Ile Cys 305 310 315 320 Tyr Phe Gly AspArg Met Arg Thr Gln Ser Glu Ala Leu Cys Asp Ala 325 330 335 Phe Tyr AspCys Asn Trp Ile Glu Gln Leu Pro Lys Phe Lys Arg Glu 340 345 350 Leu LeuPhe Thr Leu Ala Arg Thr Gln Arg Pro Ser Leu Ile Tyr Ala 355 360 365 GlyAsn Tyr Ile Ala Leu Ser Leu Glu Thr Phe Glu Gln Val Met Arg 370 375 380Phe Thr Tyr Ser Val Phe Thr Leu Leu Leu Arg Ala Lys 385 390 395 3 1499DNA DROSOPHILA MELANOGASTER DOR104 3 gaattcggca cgagcagtcg atggccagtcttcagttcca cggcaacgtc gatgcggaca 60 tcaggtatga tattagcctg gatccggctagggaatcgaa tctcttccgt ctgctaatgg 120 gactccagtt ggcgaatggc acgaagccatcgccgcggtt acccaaatgg tggccaaagc 180 ggctggaaat gattggtaaa gtgctgcccaaagcctattg ttccatggtg attttcacct 240 ccctgcattt gggtgtcctg ttcacgaaaaccacactgga tgtcctgccg acgggggagc 300 tgcaggccat aacggatgcc ctcaccatgaccataatata ctttttcacg ggctacggca 360 ccatctactg gtgcctgcgc tcccggcgcctcttggccta catggagcac atgaaccggg 420 agtatcgcca tcattcgctg gccggggtgacctttgtgag tagccatgcg gcctttagga 480 tgtccagaaa cttcacggtg gtgtggataatgtcctgcct gctgggcgtg atttcctggg 540 gcgtttcgcc actgatgctg ggcatccggatgctgccgct ccaatgttgg tatcccttcg 600 acgccctggg tcccggcaca tatacggcggtctatgctac acaacttttc ggtcagatca 660 tggtgggcat gacctttgga ttcgggggatcactgtttgt caccctgagc ctgctactcc 720 tgggacaatt cgatgtgctc tactgcagcctgaagaacct ggatgcccat accaagttgc 780 tgggcgggga gtctgtaaat ggcctgagttcgctgcaaga ggagttgctg ctgggggact 840 cgaagaggga attaaatcag tacgttttgctccaggagca tccgacggat ctgctgagat 900 tgtcggcagg acgaaaatgt cctgaccaaggaaatgcgtt tcacaacgcc ttggtggaat 960 gcattcgctt gcatcgcttc attctgcactgctcacagga gttggagaat ctattcagtc 1020 catattgtct ggtcaagtca ctgcagatcacctttcagct ttgcctgctg gtctttgtgg 1080 gcgtttcggg tactcgagag gtcctgcggattgtcaacca gctacagtac ttgggactga 1140 ccatcttcga gctcctaatg ttcacctattgtggcgaact cctcagtcgg catagtattc 1200 gatctggcga cgccttttgg aggggtgcgtggtggaagca cgcccatttc atccgccagg 1260 acatcctcat ctttctggtc aatagtagacgtgcagttca cgtgactgcc ggcaagtttt 1320 atgtgatgga tgtgaatcgt ctaagatcggttataacgca ggcgttcagc ttcttgactt 1380 tgctgcaaaa gttggctgcc aagaagacggaatcggagct ctaaactggt accacgcatc 1440 gatatttatt tagcgcatta aaaaaaagtcgagtaaaagc aaaaaaaaaa aaaaaaaaa 1499 4 467 PRT DROSOPHILA MELANOGASTERDOR104 4 Met Ala Ser Leu Gln Phe His Gly Asn Val Asp Ala Asp Ile Arg Tyr1 5 10 15 Asp Ile Ser Leu Asp Pro Ala Arg Glu Ser Asn Leu Phe Arg LeuLeu 20 25 30 Met Gly Leu Gln Leu Ala Asn Gly Thr Lys Pro Ser Pro Arg LeuPro 35 40 45 Lys Trp Trp Pro Lys Arg Leu Glu Met Ile Gly Lys Val Leu ProLys 50 55 60 Ala Tyr Cys Ser Met Val Ile Phe Thr Ser Leu His Leu Gly ValLeu 65 70 75 80 Phe Thr Lys Thr Thr Leu Asp Val Leu Pro Thr Gly Glu LeuGln Ala 85 90 95 Ile Thr Asp Ala Leu Thr Met Thr Ile Ile Tyr Phe Phe ThrGly Tyr 100 105 110 Gly Thr Ile Tyr Trp Cys Leu Arg Ser Arg Arg Leu LeuAla Tyr Met 115 120 125 Glu His Met Asn Arg Glu Tyr Arg His His Ser LeuAla Gly Val Thr 130 135 140 Phe Val Ser Ser His Ala Ala Phe Arg Met SerArg Asn Phe Thr Val 145 150 155 160 Val Trp Ile Met Ser Cys Leu Leu GlyVal Ile Ser Trp Gly Val Ser 165 170 175 Pro Leu Met Leu Gly Ile Arg MetLeu Pro Leu Gln Cys Trp Tyr Pro 180 185 190 Phe Asp Ala Leu Gly Pro GlyThr Tyr Thr Ala Val Tyr Ala Thr Gln 195 200 205 Leu Phe Gly Gln Ile MetVal Gly Met Thr Phe Gly Phe Gly Gly Ser 210 215 220 Leu Phe Val Thr LeuSer Leu Leu Leu Leu Gly Gln Phe Asp Val Leu 225 230 235 240 Tyr Cys SerLeu Lys Asn Leu Asp Ala His Thr Lys Leu Leu Gly Gly 245 250 255 Glu SerVal Asn Gly Leu Ser Ser Leu Gln Glu Glu Leu Leu Leu Gly 260 265 270 AspSer Lys Arg Glu Leu Asn Gln Tyr Val Leu Leu Gln Glu His Pro 275 280 285Thr Asp Leu Leu Arg Leu Ser Ala Gly Arg Lys Cys Pro Asp Gln Gly 290 295300 Asn Ala Phe His Asn Ala Leu Val Glu Cys Ile Arg Leu His Arg Phe 305310 315 320 Ile Leu His Cys Ser Gln Glu Leu Glu Asn Leu Phe Ser Pro TyrCys 325 330 335 Leu Val Lys Ser Leu Gln Ile Thr Phe Gln Leu Cys Leu LeuVal Phe 340 345 350 Val Gly Val Ser Gly Thr Arg Glu Val Leu Arg Ile ValAsn Gln Leu 355 360 365 Gln Tyr Leu Gly Leu Thr Ile Phe Glu Leu Leu MetPhe Thr Tyr Cys 370 375 380 Gly Glu Leu Leu Ser Arg His Ser Ile Arg SerGly Asp Ala Phe Trp 385 390 395 400 Arg Gly Ala Trp Trp Lys His Ala HisPhe Ile Arg Gln Asp Ile Leu 405 410 415 Ile Phe Leu Val Asn Ser Arg ArgAla Val His Val Thr Ala Gly Lys 420 425 430 Phe Tyr Val Met Asp Val AsnArg Leu Arg Ser Val Ile Thr Gln Ala 435 440 445 Phe Ser Phe Leu Thr LeuLeu Gln Lys Leu Ala Ala Lys Lys Thr Glu 450 455 460 Ser Glu Leu 465 51556 DNA DROSOPHILA MELANOGASTER DOR87 5 ggcacgaggc ttatagaaagtgccgagcaa tgacaatcga ggatatcggc ctggtgggca 60 tcaacgtgcg gatgtggcgacacttggccg tgctgtaccc cactccgggc tccagctggc 120 gcaagttcgc cttcgtgctgccggtgactg cgatgaatct gatgcagttc gtctacctgc 180 tgcggatgtg gggcgacctgcccgccttca ttctgaacat gttcttcttc tcggccattt 240 tcaacgccct gatgcgcacgtggctggtca taatcaagcg gcgccagttc gaggagtttc 300 tcggccaact ggccactctgttccattcga ttctcgactc caccgacgag tgggggcgtg 360 gcatcctgcg gagggcggaacgggaggctc ggaacctggc catccttaat ttgagtgcct 420 ccttcctgga cattgtcggtgctctggtat cgccgctttt cagggaggag agagctcatc 480 ccttcggcgt agctctaccaggagtgagca tgaccagttc acccgtctac gaggttatct 540 acttggccca actgcctacgcccctgctgc tgtccatgat gtacatgcct ttcgtcagcc 600 tttttgccgg cctggccatctttgggaagg ccatgctgca gatcctggta cacaggctgg 660 gccagattgg cggagaagagcagtcggagg aggagcgctt ccaaaggctg gcctcctgca 720 ttgcgtacca cacgcaggtgatgcgctatg tgtggcagct caacaaactg gtggccaaca 780 ttgtggcggt ggaagcaattatttttggct cgataatctg ctcactgctc ttctgtctga 840 atattataac ctcacccacccaggtgatct cgatagtgat gtacattctg accatgctgt 900 acgttctctt cacctactacaatcgggcca atgaaatatg cctcgagaac aaccgggtgg 960 cggaggctgt ttacaatgtgccctggtacg aggcaggaac tcggtttcgc aaaaccctcc 1020 tgatcttctt gatgcaaacacaacacccga tggagataag agtcggcaac gtttacccca 1080 tgacattggc catgttccagagtctgttga atgcgtccta ctcctacttt accatgctgc 1140 gtggcgtcac cggcaaatgagctgaaagac cgaaaaaacc ggagtatccc cttccatatt 1200 ccccctgctc ctttattttcctttcctttt ccctttccgt tttcccattc gcttttccag 1260 caatccgggt aatgcaaaaagttgttgctg gctgtggtcc tggctgcttg tttggcattt 1320 gcatatgctt gtcgtttgaaaggatttaat cggactgctg gcacggagtc ggcatcctgg 1380 ctcctggatc ctggcatgcaaatagttggc ttcttagatt gttacacaaa atagattgta 1440 gattgcagct gaatgttgtgcttggaataa agtcaaaagg atgtggagtc ggcccaaggc 1500 tctgcccatt ctgtttgctcgggatgcccg aaagtatgaa aaaaaaaaaa aaaaaa 1556 6 376 PRT DROSOPHILAMELANOGASTER DOR87 6 Met Thr Ile Glu Asp Ile Gly Leu Val Gly Ile Asn ValArg Met Trp 1 5 10 15 Arg His Leu Ala Val Leu Tyr Pro Thr Pro Gly SerSer Trp Arg Lys 20 25 30 Phe Ala Phe Val Leu Pro Val Thr Ala Met Asn LeuMet Gln Phe Val 35 40 45 Tyr Leu Leu Arg Met Trp Gly Asp Leu Pro Ala PheIle Leu Asn Met 50 55 60 Phe Phe Phe Ser Ala Ile Phe Asn Ala Leu Met ArgThr Trp Leu Val 65 70 75 80 Ile Ile Lys Arg Arg Gln Phe Glu Glu Phe LeuGly Gln Leu Ala Thr 85 90 95 Leu Phe His Ser Ile Leu Asp Ser Thr Asp GluTrp Gly Arg Gly Ile 100 105 110 Leu Arg Arg Ala Glu Arg Glu Ala Arg AsnLeu Ala Ile Leu Asn Leu 115 120 125 Ser Ala Ser Phe Leu Asp Ile Val GlyAla Leu Val Ser Pro Leu Phe 130 135 140 Arg Glu Glu Arg Ala His Pro PheGly Val Ala Leu Pro Gly Val Ser 145 150 155 160 Met Thr Ser Ser Pro ValTyr Glu Val Ile Tyr Leu Ala Gln Leu Pro 165 170 175 Thr Pro Leu Leu LeuSer Met Met Tyr Met Pro Phe Val Ser Leu Phe 180 185 190 Ala Gly Leu AlaIle Phe Gly Lys Ala Met Leu Gln Ile Leu Val His 195 200 205 Arg Leu GlyGln Ile Gly Gly Glu Glu Gln Ser Glu Glu Glu Arg Phe 210 215 220 Gln ArgLeu Ala Ser Cys Ile Ala Tyr His Thr Gln Val Met Arg Tyr 225 230 235 240Val Trp Gln Leu Asn Lys Leu Val Ala Asn Ile Val Ala Val Glu Ala 245 250255 Ile Ile Phe Gly Ser Ile Ile Cys Ser Leu Leu Phe Cys Leu Asn Ile 260265 270 Ile Thr Ser Pro Thr Gln Val Ile Ser Ile Val Met Tyr Ile Leu Thr275 280 285 Met Leu Tyr Val Leu Phe Thr Tyr Tyr Asn Arg Ala Asn Glu IleCys 290 295 300 Leu Glu Asn Asn Arg Val Ala Glu Ala Val Tyr Asn Val ProTrp Tyr 305 310 315 320 Glu Ala Gly Thr Arg Phe Arg Lys Thr Leu Leu IlePhe Leu Met Gln 325 330 335 Thr Gln His Pro Met Glu Ile Arg Val Gly AsnVal Tyr Pro Met Thr 340 345 350 Leu Ala Met Phe Gln Ser Leu Leu Asn AlaSer Tyr Ser Tyr Phe Thr 355 360 365 Met Leu Arg Gly Val Thr Gly Lys 370375 7 1338 DNA DROSOPHILA MELANOGASTER DOR53 7 tcaaacaaag ccacggacaagatgttaagc aagttttttc cccacataaa agaaaagcca 60 ttgagcgagc gggttaagtcccgagatgcc ttcatttact tggatcgggt gatgtggtcc 120 tttggctgga cagagcctgaaaacaaaagg tggatccttc cttataaact gtggttagcg 180 ttcgtgaaca tagtaatgctcatccttctg ccgatctcga taagcatcga gtacctccac 240 cgatttaaaa ccttctcggcgggggagttc cttagttccc tcgagattgg agtcaacatg 300 tacggaagct cttttaagtgcgccttcacc ttgattggat tcaagaaaag acaggaagct 360 aaggttttac tggatcagctggacaagaga tgccttagcg ataaggagag gtccactgtt 420 catcgctatg tcgccatgggaaactttttc gatattttgt atcacatttt ttactccacc 480 ttcgtggtaa tgaacttcccgtattttctg cttgagagac gccatgcttg gcgcatgtac 540 tttccatata tcgattccgacgaacagttt tacatctcca gcatcgccga gtgttttctg 600 atgacggagg ccatctacatggatctctgt acggacgtgt gtcccttgat ctccatgctt 660 atggctcgat gccacatcagcctcctgaaa cagcgactga gaaatctccg atcgaagcca 720 ggaaggaccg aagatgagtacttggaggag ctcaccgagt gcattcggga tcatcgattg 780 ctattggact atgttgacgcattgcgaccc gtcttttcgg gaaccatttt tgtgcagttc 840 ctcctgatcg gtactgtactgggtctctca atgataaatc taatgttctt ctcgacattt 900 tggactggtg tcgccacttgcctttttatg ttcgacgtgt ccatggagac gttccccttt 960 tgctatttgt gcaacatgattatcgatgac tgccaggaaa tgtccaattg cctctttcaa 1020 tcggactgga cctctgccgatcgtcgctac aaatccactt tggtatactt tcttcacaat 1080 cttcagcaac ccattactctcacggctggt ggagtgtttc ctatttccat gcaaacaaat 1140 ttggctatgg tgaagctggcattttctgtg gttacggtaa ttaagcaatt taacttggcc 1200 gaaaggtttc aataagttgagagggacgag ctctgctact attatattat atattatatt 1260 atattatata tatattattttatattatat attgctgtac cctaataaat atttagtaat 1320 aaaaaaaaaa aaaaaaaa1338 8 397 PRT DROSOPHILA MELANOGASTER DOR53 8 Met Leu Ser Lys Phe PhePro His Ile Lys Glu Lys Pro Leu Ser Glu 1 5 10 15 Arg Val Lys Ser ArgAsp Ala Phe Ile Tyr Leu Asp Arg Val Met Trp 20 25 30 Ser Phe Gly Trp ThrGlu Pro Glu Asn Lys Arg Trp Ile Leu Pro Tyr 35 40 45 Lys Leu Trp Leu AlaPhe Val Asn Ile Val Met Leu Ile Leu Leu Pro 50 55 60 Ile Ser Ile Ser IleGlu Tyr Leu His Arg Phe Lys Thr Phe Ser Ala 65 70 75 80 Gly Glu Phe LeuSer Ser Leu Glu Ile Gly Val Asn Met Tyr Gly Ser 85 90 95 Ser Phe Lys CysAla Phe Thr Leu Ile Gly Phe Lys Lys Arg Gln Glu 100 105 110 Ala Lys ValLeu Leu Asp Gln Leu Asp Lys Arg Cys Leu Ser Asp Lys 115 120 125 Glu ArgSer Thr Val His Arg Tyr Val Ala Met Gly Asn Phe Phe Asp 130 135 140 IleLeu Tyr His Ile Phe Tyr Ser Thr Phe Val Val Met Asn Phe Pro 145 150 155160 Tyr Phe Leu Leu Glu Arg Arg His Ala Trp Arg Met Tyr Phe Pro Tyr 165170 175 Ile Asp Ser Asp Glu Gln Phe Tyr Ile Ser Ser Ile Ala Glu Cys Phe180 185 190 Leu Met Thr Glu Ala Ile Tyr Met Asp Leu Cys Thr Asp Val CysPro 195 200 205 Leu Ile Ser Met Leu Met Ala Arg Cys His Ile Ser Leu LeuLys Gln 210 215 220 Arg Leu Arg Asn Leu Arg Ser Lys Pro Gly Arg Thr GluAsp Glu Tyr 225 230 235 240 Leu Glu Glu Leu Thr Glu Cys Ile Arg Asp HisArg Leu Leu Leu Asp 245 250 255 Tyr Val Asp Ala Leu Arg Pro Val Phe SerGly Thr Ile Phe Val Gln 260 265 270 Phe Leu Leu Ile Gly Thr Val Leu GlyLeu Ser Met Ile Asn Leu Met 275 280 285 Phe Phe Ser Thr Phe Trp Thr GlyVal Ala Thr Cys Leu Phe Met Phe 290 295 300 Asp Val Ser Met Glu Thr PhePro Phe Cys Tyr Leu Cys Asn Met Ile 305 310 315 320 Ile Asp Asp Cys GlnGlu Met Ser Asn Cys Leu Phe Gln Ser Asp Trp 325 330 335 Thr Ser Ala AspArg Arg Tyr Lys Ser Thr Leu Val Tyr Phe Leu His 340 345 350 Asn Leu GlnGln Pro Ile Thr Leu Thr Ala Gly Gly Val Phe Pro Ile 355 360 365 Ser MetGln Thr Asn Leu Ala Met Val Lys Leu Ala Phe Ser Val Val 370 375 380 ThrVal Ile Lys Gln Phe Asn Leu Ala Glu Arg Phe Gln 385 390 395 9 1321 DNADROSOPHILA MELANOGASTER DOR67 9 ggcacgagga aatgttaagc cagttctttccccacattaa agaaaagcca ttgagcgagc 60 gggttaagtc ccgagatgcc ttcgtttacttagatcgggt gatgtggtcc tttggctgga 120 cagtgcctga aaacaaaagg tgggatctacattacaaact gtggtcaact ttcgtgacat 180 tggtgatatt tatccttctg ccgatatcggtaagcgttga gtatattcag cggttcaaga 240 ccttctcggc gggtgagttt cttagctcaatccagattgg cgttaacatg tacggaagca 300 gctttaaaag ttatttgacc atgatgggatataagaagag acaggaggct aagatgtcac 360 tggatgagct ggacaagaga tgcgtttgtgatgaggagag gaccattgta catcgacatg 420 tcgccctggg aaacttttgc tatattttctatcacattgc gtacactagc tttttgattt 480 caaacttttt gtcatttata atgaagagaatccatgcctg gcgcatgtac tttccctacg 540 tcgaccccga aaagcaattt tacatctctagcatcgccga agtcattctt agggggtggg 600 ccgtcttcat ggatctctgc acggatgtgtgtcctttgat ctccatggta atagcacgat 660 gccacatcac ccttctgaaa cagcgcctgcgaaatctacg atcggaacca ggaaggacgg 720 aagatgagta cttgaaggag ctcgccgactgcgttcgaga tcaccgcttg atattggact 780 atgtcgacgc attgcgatcc gtcttttcggggacaatttt tgtgcagttc ctcttgatcg 840 gtattgtact gggtctgtca atgataaatataatgttttt ctcaacactt tcgactggtg 900 tcgccgttgt cctttttatg tcctgcgtatctatgcagac gttccccttt tgctatttgt 960 gtaacatgat tatggatgac tgccaagagatggccgactc cctttttcaa tcggactgga 1020 catctgccga tcgtcgctac aaatccactttggtatactt tcttcacaat cttcagcagc 1080 ccattattct tacggctggt ggagtctttcctatttccat gcaaacaaat ttaaatatgg 1140 tgaagctggc ctttactgtg gttacaatagtgaaacaatt taacttggca gaaaagtttc 1200 aataagttaa gatatgcaag ctctgctattataaacctac actcgagaaa atatttcttc 1260 acattaataa accttcagta cttactgcttgtggcgcccc cggaaaaaaa aaaaaaaaaa 1320 a 1321 10 397 PRT DROSOPHILAMELANOGASTER DOR67 10 Met Leu Ser Gln Phe Phe Pro His Ile Lys Glu LysPro Leu Ser Glu 1 5 10 15 Arg Val Lys Ser Arg Asp Ala Phe Val Tyr LeuAsp Arg Val Met Trp 20 25 30 Ser Phe Gly Trp Thr Val Pro Glu Asn Lys ArgTrp Asp Leu His Tyr 35 40 45 Lys Leu Trp Ser Thr Phe Val Thr Leu Val IlePhe Ile Leu Leu Pro 50 55 60 Ile Ser Val Ser Val Glu Tyr Ile Gln Arg PheLys Thr Phe Ser Ala 65 70 75 80 Gly Glu Phe Leu Ser Ser Ile Gln Ile GlyVal Asn Met Tyr Gly Ser 85 90 95 Ser Phe Lys Ser Tyr Leu Thr Met Met GlyTyr Lys Lys Arg Gln Glu 100 105 110 Ala Lys Met Ser Leu Asp Glu Leu AspLys Arg Cys Val Cys Asp Glu 115 120 125 Glu Arg Thr Ile Val His Arg HisVal Ala Leu Gly Asn Phe Cys Tyr 130 135 140 Ile Phe Tyr His Ile Ala TyrThr Ser Phe Leu Ile Ser Asn Phe Leu 145 150 155 160 Ser Phe Ile Met LysArg Ile His Ala Trp Arg Met Tyr Phe Pro Tyr 165 170 175 Val Asp Pro GluLys Gln Phe Tyr Ile Ser Ser Ile Ala Glu Val Ile 180 185 190 Leu Arg GlyTrp Ala Val Phe Met Asp Leu Cys Thr Asp Val Cys Pro 195 200 205 Leu IleSer Met Val Ile Ala Arg Cys His Ile Thr Leu Leu Lys Gln 210 215 220 ArgLeu Arg Asn Leu Arg Ser Glu Pro Gly Arg Thr Glu Asp Glu Tyr 225 230 235240 Leu Lys Glu Leu Ala Asp Cys Val Arg Asp His Arg Leu Ile Leu Asp 245250 255 Tyr Val Asp Ala Leu Arg Ser Val Phe Ser Gly Thr Ile Phe Val Gln260 265 270 Phe Leu Leu Ile Gly Ile Val Leu Gly Leu Ser Met Ile Asn IleMet 275 280 285 Phe Phe Ser Thr Leu Ser Thr Gly Val Ala Val Val Leu PheMet Ser 290 295 300 Cys Val Ser Met Gln Thr Phe Pro Phe Cys Tyr Leu CysAsn Met Ile 305 310 315 320 Met Asp Asp Cys Gln Glu Met Ala Asp Ser LeuPhe Gln Ser Asp Trp 325 330 335 Thr Ser Ala Asp Arg Arg Tyr Lys Ser ThrLeu Val Tyr Phe Leu His 340 345 350 Asn Leu Gln Gln Pro Ile Ile Leu ThrAla Gly Gly Val Phe Pro Ile 355 360 365 Ser Met Gln Thr Asn Leu Asn MetVal Lys Leu Ala Phe Thr Val Val 370 375 380 Thr Ile Val Lys Gln Phe AsnLeu Ala Glu Lys Phe Gln 385 390 395 11 1308 DNA DROSOPHILA MELANOGASTERDOR64 11 ggcacgagcc aagaattcaa aatgaaactc agcgaaaccc taaaaatcgactattttcga 60 gtccagttga atgcctggcg aatttgtggt gccttggatc tcagcgagggtaggtactgg 120 agttggtcga tgctattgtg catcttggtg tacctgccga cacccatgctactgagagga 180 gtatacagtt tcgaggatcc ggtggaaaat aatttcagct tgagcctgacggtcacatcg 240 ctgtccaatc tcatgaagtt ctgcatgtac gtggcccaac taacaaagatggtcgaggtc 300 cagagtctta ttggtcagct ggatgcccgg gtttctggcg agagccagtctgagcgtcat 360 agaaatatga ccgagcacct gctaaggatg tccaagctgt tccagatcacctacgctgta 420 gtcttcatca ttgctgcagt tcccttcgtt ttcgaaactg agctaagcttacccatgccc 480 atgtggtttc ccttcgactg gaagaactcg atggtggcct acatcggagctctggttttc 540 caggagattg gctatgtctt tcaaattatg caatgctttg cagctgactcgtttcccccg 600 ctcgtactgt acctgatctc cgagcaatgt caattgctga tcctgagaatctctgaaatc 660 ggatatggtt acaagactct ggaggagaac gaacaggatc tggtcaactgcatcagggat 720 caaaacgcgc tgtatagatt actcgatgtg accaagagtc tcgtttcgtatcccatgatg 780 gtgcagttta tggttattgg catcaacatc gccatcaccc tatttgtcctgatattttac 840 gtggagacct tgtacgatcg catctattat ctttgctttc tcttgggcatcaccgtgcag 900 acatatccat tgtgctacta tggaaccatg gtgcaggaga gttttgctgagcttcactat 960 gcggtattct gcagcaactg ggtggatcaa agtgccagct atcgtgggcacatgctcatc 1020 ctggcggagc gcactaagcg gatgcagctt ctcctcgccg gcaacctggtgcccatccac 1080 ctgagcacct acgtggcctg ttggaaggga gcctactcct tcttcaccctgatggccgat 1140 cgagatggcc tgggttctta gtagcccagt catttcactc acattctacatcaagtagta 1200 ctaccactga acacgaacac gaatatttca aaagtaaaca cataatattcacaatagtgt 1260 atcactttaa taaaattttt ggttaccatg aaaaaaaaaa aaaaaaaa1308 12 379 PRT DROSOPHILA MELANOGASTER DOR64 12 Met Lys Leu Ser Glu ThrLeu Lys Ile Asp Tyr Phe Arg Val Gln Leu 1 5 10 15 Asn Ala Trp Arg IleCys Gly Ala Leu Asp Leu Ser Glu Gly Arg Tyr 20 25 30 Trp Ser Trp Ser MetLeu Leu Cys Ile Leu Val Tyr Leu Pro Thr Pro 35 40 45 Met Leu Leu Arg GlyVal Tyr Ser Phe Glu Asp Pro Val Glu Asn Asn 50 55 60 Phe Ser Leu Ser LeuThr Val Thr Ser Leu Ser Asn Leu Met Lys Phe 65 70 75 80 Cys Met Tyr ValAla Gln Leu Thr Lys Met Val Glu Val Gln Ser Leu 85 90 95 Ile Gly Gln LeuAsp Ala Arg Val Ser Gly Glu Ser Gln Ser Glu Arg 100 105 110 His Arg AsnMet Thr Glu His Leu Leu Arg Met Ser Lys Leu Phe Gln 115 120 125 Ile ThrTyr Ala Val Val Phe Ile Ile Ala Ala Val Pro Phe Val Phe 130 135 140 GluThr Glu Leu Ser Leu Pro Met Pro Met Trp Phe Pro Phe Asp Trp 145 150 155160 Lys Asn Ser Met Val Ala Tyr Ile Gly Ala Leu Val Phe Gln Glu Ile 165170 175 Gly Tyr Val Phe Gln Ile Met Gln Cys Phe Ala Ala Asp Ser Phe Pro180 185 190 Pro Leu Val Leu Tyr Leu Ile Ser Glu Gln Cys Gln Leu Leu IleLeu 195 200 205 Arg Ile Ser Glu Ile Gly Tyr Gly Tyr Lys Thr Leu Glu GluAsn Glu 210 215 220 Gln Asp Leu Val Asn Cys Ile Arg Asp Gln Asn Ala LeuTyr Arg Leu 225 230 235 240 Leu Asp Val Thr Lys Ser Leu Val Ser Tyr ProMet Met Val Gln Phe 245 250 255 Met Val Ile Gly Ile Asn Ile Ala Ile ThrLeu Phe Val Leu Ile Phe 260 265 270 Tyr Val Glu Thr Leu Tyr Asp Arg IleTyr Tyr Leu Cys Phe Leu Leu 275 280 285 Gly Ile Thr Val Gln Thr Tyr ProLeu Cys Tyr Tyr Gly Thr Met Val 290 295 300 Gln Glu Ser Phe Ala Glu LeuHis Tyr Ala Val Phe Cys Ser Asn Trp 305 310 315 320 Val Asp Gln Ser AlaSer Tyr Arg Gly His Met Leu Ile Leu Ala Glu 325 330 335 Arg Thr Lys ArgMet Gln Leu Leu Leu Ala Gly Asn Leu Val Pro Ile 340 345 350 His Leu SerThr Tyr Val Ala Cys Trp Lys Gly Ala Tyr Ser Phe Phe 355 360 365 Thr LeuMet Ala Asp Arg Asp Gly Leu Gly Ser 370 375 13 1152 DNA DROSOPHILAMELANOGASTER DOR71g 13 atggtcatta tcgacagtct tagtttttat cgtccattctggatctgcat gcgattgctg 60 gtaccgactt tcttcaagga ttcctcacgt cctgtccagctgtacgtggt gttgctgcac 120 atcctggtca ccttgtggtt tccactgcat ctgctgctgcatcttctgct acttccatct 180 accgctgagt tctttaagaa cctgaccatg tctctgacttgtgtggcctg cagtctgaag 240 catgtggccc acttgtatca cttgccgcag attgtggaaatcgaatcact gatcgagcaa 300 ttagacacat ttattgccag cgaacaggag catcgttactatcgggatca cgtacattgc 360 catgctaggc gctttacaag atgtctctat attagctttggcatgatcta tgcgcttttc 420 ctgttcggcg tcttcgttca ggttattagc ggaaattgggaacttctcta tccagcctat 480 ttcccattcg acttggagag caatcgcttt ctcggcgcagtagccttggg ctatcaggta 540 ttcagcatgt tagttgaagg cttccagggg ctgggcaacgatacctatac cccactgacc 600 ctatgccttc tggccggaca tgtccatttg tggtccatacgaatgggtca actgggatac 660 ttcgatgacg agacggtggt gaatcatcag cgtttgctggattacattga gcagcataaa 720 ctcttggtgc ggttccacaa cctggtgagc cggaccatcagcgaagtgca actggtgcag 780 ctgggcggat gtggagccac tctgtgcatc attgtctcctacatgctctt ctttgtgggc 840 gacacaatct cgctggtcta ctacttggtg ttctttggagtggtctgcgt gcagctcttt 900 cccagctgct attttgccag cgaagtagcc gaggagttggaacggctgcc atatgcgatc 960 ttctccagca gatggtacga tcaatcgcgg gatcatcgattcgatttgct catctttaca 1020 caattaacac tgggaaaccg ggggtggatc atcaaggcaggaggtcttat cgagctgaat 1080 ttgaatgcct ttttcgccac cctgaagatg gcctattccctttttgcagt tgtggtgcgg 1140 gcaaagggta ta 1152 14 390 PRT DROSOPHILAMELANOGASTER DOR71g 14 Met Val Ile Ile Asp Ser Leu Ser Phe Tyr Arg ProPhe Trp Ile Cys 1 5 10 15 Met Arg Leu Leu Val Pro Thr Phe Phe Lys AspSer Ser Arg Pro Val 20 25 30 Gln Leu Tyr Val Val Leu Leu His Ile Leu ValThr Leu Trp Phe Pro 35 40 45 Leu His Leu Leu Leu His Leu Leu Leu Leu ProSer Thr Ala Glu Phe 50 55 60 Phe Lys Asn Leu Thr Met Ser Leu Thr Cys ValAla Cys Ser Leu Lys 65 70 75 80 His Val Ala His Leu Tyr His Leu Pro GlnIle Val Glu Ile Glu Ser 85 90 95 Leu Ile Glu Gln Leu Asp Thr Phe Ile AlaSer Glu Gln Glu His Arg 100 105 110 Tyr Tyr Arg Asp His Val His Cys HisAla Arg Arg Phe Thr Arg Cys 115 120 125 Leu Tyr Ile Ser Phe Gly Met IleTyr Ala Leu Phe Leu Phe Gly Val 130 135 140 Phe Val Gln Val Ile Ser GlyAsn Trp Glu Leu Leu Tyr Pro Ala Tyr 145 150 155 160 Phe Pro Phe Asp LeuGlu Ser Asn Arg Phe Leu Gly Ala Val Ala Leu 165 170 175 Gly Tyr Gln ValPhe Ser Met Leu Val Glu Gly Phe Gln Gly Leu Gly 180 185 190 Asn Asp ThrTyr Thr Pro Leu Thr Leu Cys Leu Leu Ala Gly His Val 195 200 205 His LeuTrp Ser Ile Arg Met Gly Gln Leu Gly Tyr Phe Asp Asp Glu 210 215 220 ThrVal Val Asn His Gln Arg Leu Leu Asp Tyr Ile Glu Gln His Lys 225 230 235240 Leu Leu Val Arg Phe His Asn Leu Val Ser Arg Thr Ile Ser Glu Val 245250 255 Gln Leu Val Gln Leu Gly Gly Cys Gly Ala Thr Leu Cys Ile Ile Val260 265 270 Ser Tyr Met Leu Phe Phe Val Gly Asp Thr Ile Ser Leu Val TyrTyr 275 280 285 Leu Val Phe Phe Gly Val Val Cys Val Gln Leu Phe Pro SerCys Tyr 290 295 300 Phe Ala Ser Glu Val Ala Glu Glu Leu Glu Arg Leu ProTyr Ala Ile 305 310 315 320 Phe Ser Ser Arg Trp Tyr Asp Gln Ser Arg AspHis Arg Phe Asp Leu 325 330 335 Leu Ile Phe Thr Gln Leu Thr Leu Gly AsnArg Gly Trp Ile Ile Lys 340 345 350 Ala Gly Gly Leu Ile Glu Leu Asn LeuAsn Ala Phe Phe Ala Thr Leu 355 360 365 Lys Met Ala Tyr Ser Leu Phe AlaVal Val His Arg Glu Thr Gly Asn 370 375 380 Pro Leu Gln Arg Glu His 385390 15 1137 DNA DROSOPHILA MELANOGASTER DOR72g 15 atggacttaa aaccgcgagtcattcgaagt gaagatatct acagaaccta ttggttatat 60 tggcatcttt tgggcctggaaagcaatttc tttctgaatc gcttgttgga tttggtgatt 120 acaattttcg taaccatttggtatccaatt cacctgattc tgggactgtt tatggaaaga 180 tctttggggg atgtctgcaagggtctacca attacggcag catgcttttt cgccagcttt 240 aaatttattt gttttcgcttcaagctatct gaaattaaag aaatcgaaat attatttaaa 300 gagctggatc agcgagctttaagtcgagag gaatgcgagt ttttcaatca aaatacgaga 360 cgtgaggcga atttcatttggaaaagtttc attgtggcct atggactgtc gaatatctcg 420 gctattgcat cagttcttttcggcggtgga cataagctat tatatcccgc ctggtttcca 480 tacgatgtgc aggccacggaactaatattt tggctaagtg taacatacca aattgccgga 540 gtaagtttgg ccatacttcagaatttggcc aatgattcct atccaccgat gacattttgc 600 gtggttgccg gtcatgtaagacttttggcg atgcgcttga gtagaattgg ccaaggtcca 660 gaggaaacaa tatacttaaccggaaagcaa ttaatcgaaa gcatcgagga tcaccgaaaa 720 ctaatgaaga tagtggaattactgcgcagc accatgaata tttcgcagct cggccagttt 780 atttcaagtg gtgttaatatttccataaca ctagtcaaca ttctcttctt tgcggataat 840 aatttcgcta taacctactacggagtgtac ttcctatcga tggtgttgga attattcccg 900 tgctgctatt acggcaccctgatatccgtg gagatgaacc agctgaccta tgcgatttac 960 tcaagtaact ggatgagtatgaatcggagc tacagccgca tcctactgat cttcatgcaa 1020 ctcaccctgg cggaagtgcagatcaaggcc ggtgggatga ttggcatcgg aatgaacgcc 1080 ttctttgcca ccgtgcgattggcctactcc ttcttcactt tggccatgtc gctgcgt 1137 16 379 PRT DROSOPHILAMELANOGASTER DOR72g 16 Met Asp Leu Lys Pro Arg Val Ile Arg Ser Glu AspIle Tyr Arg Thr 1 5 10 15 Tyr Trp Leu Tyr Trp His Leu Leu Gly Leu GluSer Asn Phe Phe Leu 20 25 30 Asn Arg Leu Leu Asp Leu Val Ile Thr Ile PheVal Thr Ile Trp Tyr 35 40 45 Pro Ile His Leu Ile Leu Gly Leu Phe Met GluArg Ser Leu Gly Asp 50 55 60 Val Cys Lys Gly Leu Pro Ile Thr Ala Ala CysPhe Phe Ala Ser Phe 65 70 75 80 Lys Phe Ile Cys Phe Arg Phe Lys Leu SerGlu Ile Lys Glu Ile Glu 85 90 95 Ile Leu Phe Lys Glu Leu Asp Gln Arg AlaLeu Ser Arg Glu Glu Cys 100 105 110 Glu Phe Phe Asn Gln Asn Thr Arg ArgGlu Ala Asn Phe Ile Trp Lys 115 120 125 Ser Phe Ile Val Ala Tyr Gly LeuSer Asn Ile Ser Ala Ile Ala Ser 130 135 140 Val Leu Phe Gly Gly Gly HisLys Leu Leu Tyr Pro Ala Trp Phe Pro 145 150 155 160 Tyr Asp Val Gln AlaThr Glu Leu Ile Phe Trp Leu Ser Val Thr Tyr 165 170 175 Gln Ile Ala GlyVal Ser Leu Ala Ile Leu Gln Asn Leu Ala Asn Asp 180 185 190 Ser Tyr ProPro Met Thr Phe Cys Val Val Ala Gly His Val Arg Leu 195 200 205 Leu AlaMet Arg Leu Ser Arg Ile Gly Gln Gly Pro Glu Glu Thr Ile 210 215 220 TyrLeu Thr Gly Lys Gln Leu Ile Glu Ser Ile Glu Asp His Arg Lys 225 230 235240 Leu Met Lys Ile Val Glu Leu Leu Arg Ser Thr Met Asn Ile Ser Gln 245250 255 Leu Gly Gln Phe Ile Ser Ser Gly Val Asn Ile Ser Ile Thr Leu Val260 265 270 Asn Ile Leu Phe Phe Ala Asp Asn Asn Phe Ala Ile Thr Tyr TyrGly 275 280 285 Val Tyr Phe Leu Ser Met Val Leu Glu Leu Phe Pro Cys CysTyr Tyr 290 295 300 Gly Thr Leu Ile Ser Val Glu Met Asn Gln Leu Thr TyrAla Ile Tyr 305 310 315 320 Ser Ser Asn Trp Met Ser Met Asn Arg Ser TyrSer Arg Ile Leu Leu 325 330 335 Ile Phe Met Gln Leu Thr Leu Ala Glu ValGln Ile Lys Ala Gly Gly 340 345 350 Met Ile Gly Ile Gly Met Asn Ala PhePhe Ala Thr Val Arg Leu Ala 355 360 365 Tyr Ser Phe Phe Thr Leu Ala MetSer Leu Arg 370 375 17 1134 DNA DROSOPHILA MELANOGASTER DOR73g 17atggattcaa gaaggaaagt ccgaagtgaa aatctttaca aaacctattg gctttactgg 60cgacttctgg gagtcgaggg cgattatcct tttcgacggc tagtggattt tacaatcacg 120tctttcatta cgattttatt tcccgtgcat cttatactgg gaatgtataa aaagccccag 180attcaagtct tcaggagtct gcatttcaca tcggaatgcc ttttctgcag ctataagttt 240ttctgttttc gttggaaact taaagaaata aagaccatcg aaggattgct ccaggatctc 300gatagtcgag ttgaaagtga agaagaacgc aactacttta atcaaaatcc aagtcgtgtg 360gctcgaatgc tttcgaaaag ttacttggta gctgctatat cggccataat cactgcaact 420gtagctggtt tatttagtac tggtcgaaat ttaatgtatc tgggttggtt tccctacgat 480tttcaagcaa ccgccgcaat ctattggatt agtttttcct atcaggcgat tggctctagt 540ctgttgattc tggaaaatct ggccaacgat tcatatccgc cgattacatt ttgtgtggtc 600tctggacatg tgagactatt gataatgcgt ttaagtcgaa ttggtcacga tgtaaaatta 660tcaagttcgg aaaataccag aaaactcatc gaaggtatcc aggatcacag gaaactaatg 720aagataatac gcctacttcg cagcacttta catcttagcc aactgggcca gttcctttct 780agtggaatca acatttccat aacactcatc aacatcctgt tctttgcgga aaacaacttt 840gcaatgcttt attatgcggt gttctttgct gcaatgttaa tagaactatt tccaagttgt 900tactatggaa ttctgatgac aatggagttt gataagctac catatgccat cttctccagc 960aactggctta aaatggataa aagatacaat cgatccttga taattctgat gcaactaaca 1020ctggttccag tgaatataaa agcaggtggt attgttggca tcgatatgag tgcatttttt 1080gccacagttc ggatggcata ttccttttac actttagcct tgtcatttcg agta 1134 18 378PRT Drosophila Melanogaster DOR73g 18 Met Asp Ser Arg Arg Lys Val ArgSer Glu Asn Leu Tyr Lys Thr Tyr 1 5 10 15 Trp Leu Tyr Trp Arg Leu LeuGly Val Glu Gly Asp Tyr Pro Phe Arg 20 25 30 Arg Leu Val Asp Phe Thr IleThr Ser Phe Ile Thr Ile Leu Phe Pro 35 40 45 Val His Leu Ile Leu Gly MetTyr Lys Lys Pro Gln Ile Gln Val Phe 50 55 60 Arg Ser Leu His Phe Thr SerGlu Cys Leu Phe Cys Ser Tyr Lys Phe 65 70 75 80 Phe Cys Phe Arg Trp LysLeu Lys Glu Ile Lys Thr Ile Glu Gly Leu 85 90 95 Leu Gln Asp Leu Asp SerArg Val Glu Ser Glu Glu Glu Arg Asn Tyr 100 105 110 Phe Asn Gln Asn ProSer Arg Val Ala Arg Met Leu Ser Lys Ser Tyr 115 120 125 Leu Val Ala AlaIle Ser Ala Ile Ile Thr Ala Thr Val Ala Gly Leu 130 135 140 Phe Ser ThrGly Arg Asn Leu Met Tyr Leu Gly Trp Phe Pro Tyr Asp 145 150 155 160 PheGln Ala Thr Ala Ala Ile Tyr Trp Ile Ser Phe Ser Tyr Gln Ala 165 170 175Ile Gly Ser Ser Leu Leu Ile Leu Glu Asn Leu Ala Asn Asp Ser Tyr 180 185190 Pro Pro Ile Thr Phe Cys Val Val Ser Gly His Val Arg Leu Leu Ile 195200 205 Met Arg Leu Ser Arg Ile Gly His Asp Val Lys Leu Ser Ser Ser Glu210 215 220 Asn Thr Arg Lys Leu Ile Glu Gly Ile Gln Asp His Arg Lys LeuMet 225 230 235 240 Lys Ile Ile Arg Leu Leu Arg Ser Thr Leu His Leu SerGln Leu Gly 245 250 255 Gln Phe Leu Ser Ser Gly Ile Asn Ile Ser Ile ThrLeu Ile Asn Ile 260 265 270 Leu Phe Phe Ala Glu Asn Asn Phe Ala Met LeuTyr Tyr Ala Val Phe 275 280 285 Phe Ala Ala Met Leu Ile Glu Leu Phe ProSer Cys Tyr Tyr Gly Ile 290 295 300 Leu Met Thr Met Glu Phe Asp Lys LeuPro Tyr Ala Ile Phe Ser Ser 305 310 315 320 Asn Trp Leu Lys Met Asp LysArg Tyr Asn Arg Ser Leu Ile Ile Leu 325 330 335 Met Gln Leu Thr Leu ValPro Val Asn Ile Lys Ala Gly Gly Ile Val 340 345 350 Gly Ile Asp Met SerAla Phe Phe Ala Thr Val Arg Met Ala Tyr Ser 355 360 365 Phe Tyr Thr LeuAla Leu Ser Phe Arg Val 370 375 19 1191 DNA DROSOPHILA MELANOGASTERDOR46 19 atggcagagg tcagagtgga cagtctggag tttttcaaga gccattggaccgcctggcgg 60 tacttgggag tggctcattt tcgggtcgag aactggaaga acctttacgtgttttacagc 120 attgtgtcga atcttctcgt gaccctgtgc taccccgttc acctgggaatatccctcttt 180 cgcaaccgca ccatcaccga ggacatcctc aacctgacca cctttgcgacctgcacagcc 240 tgttcggtga agtgcctgct ctacgcctac aacatcaagg atgtgctggagatggagcgg 300 ctgttgaggc ttttggatga acgcgtcgtg ggtccggagc aacgcagcatctacggacaa 360 gtgagggtcc agctgcgaaa tgtgctatac gtgttcatcg gcatctacatgccgtgtgcc 420 ctgttcgccg agctatcctt tctgttcaag gaggagcgcg gtctgatgtatcccgcctgg 480 tttcccttcg actggctgca ctccaccagg aactattaca tagcgaacgcctatcagata 540 gtgggcatct cgtttcagct gctgcaaaac tatgttagcg actgctttccggcggtggtg 600 ctgtgcctga tctcatccca catcaaaatg ttgtacaaca gattcgaggaggtgggcctg 660 gatccagcca gagatgcgga gaaggacctg gaggcctgca tcaccgatcacaagcatatt 720 ctagagtggg caggcggctc attggttcgt gttctattca ctttccaacttttttccaga 780 ctattccgac gcatcgaggc cttcatttcc ctgcccatgc taattcagttcacagtgacc 840 gccttgaatg tgtgcatcgg tttagcagcc ctggtgtttt tcgtcagcgagcccatggca 900 cggatgtact tcatcttcta ctccctggcc atgccgctgc agatctttccgtcctgcttt 960 ttcggcaccg acaacgagta ctggttcgga cgcctccact acgcggccttcagttgcaat 1020 tggcacacac agaacaggag ctttaagcgg aaaatgatgc tgttcgttgagcaatcgttg 1080 aagaagagca ccgctgtggc tggcggaatg atgcgtatcc acctggacacgttcttttcc 1140 accctaaagg gggcctactc cctctttacc atcattattc ggatgagaaa g1191 20 379 PRT DROSOPHILA MELANOGASTER DOR46 20 Met Ala Glu Val Arg ValAsp Ser Leu Glu Phe Phe Lys Ser His Trp 1 5 10 15 Thr Ala Trp Arg TyrLeu Gly Val Ala His Phe Arg Val Glu Asn Trp 20 25 30 Lys Asn Leu Tyr ValPhe Tyr Ser Ile Val Ser Asn Leu Leu Val Thr 35 40 45 Leu Cys Tyr Pro ValHis Leu Gly Ile Ser Leu Phe Arg Asn Arg Thr 50 55 60 Ile Thr Glu Asp IleLeu Asn Leu Thr Thr Phe Ala Thr Cys Thr Ala 65 70 75 80 Cys Ser Val LysCys Leu Leu Tyr Ala Tyr Asn Ile Lys Asp Val Leu 85 90 95 Glu Met Glu ArgLeu Leu Arg Leu Leu Asp Glu Arg Val Val Gly Pro 100 105 110 Glu Gln ArgSer Ile Tyr Gly Gln Val Arg Val Gln Leu Arg Asn Val 115 120 125 Leu TyrVal Phe Ile Gly Ile Tyr Met Pro Cys Ala Leu Phe Ala Glu 130 135 140 LeuSer Phe Leu Phe Lys Glu Glu Arg Gly Leu Met Tyr Pro Ala Trp 145 150 155160 Phe Pro Phe Asp Trp Leu His Ser Thr Arg Asn Tyr Tyr Ile Ala Asn 165170 175 Ala Tyr Gln Ile Val Gly Ile Ser Phe Gln Leu Leu Gln Asn Tyr Val180 185 190 Ser Asp Cys Phe Pro Ala Val Val Leu Cys Leu Ile Ser Ser HisIle 195 200 205 Lys Met Leu Tyr Asn Arg Phe Glu Glu Val Gly Leu Asp ProAla Arg 210 215 220 Asp Ala Glu Lys Asp Leu Glu Ala Cys Ile Thr Asp HisLys His Ile 225 230 235 240 Leu Glu Leu Phe Arg Arg Ile Glu Ala Phe IleSer Leu Pro Met Leu 245 250 255 Ile Gln Phe Thr Val Thr Ala Leu Asn ValCys Ile Gly Leu Ala Ala 260 265 270 Leu Val Phe Phe Val Ser Glu Pro MetAla Arg Met Tyr Phe Ile Phe 275 280 285 Tyr Ser Leu Ala Met Pro Leu GlnIle Phe Pro Ser Cys Phe Phe Gly 290 295 300 Thr Asp Asn Glu Tyr Trp PheGly Arg Leu His Tyr Ala Ala Phe Ser 305 310 315 320 Cys Asn Trp His ThrGln Asn Arg Ser Phe Lys Arg Lys Met Met Leu 325 330 335 Phe Val Glu GlnSer Leu Lys Lys Ser Thr Ala Val Ala Gly Gly Met 340 345 350 Met Arg IleHis Leu Asp Thr Phe Phe Ser Thr Leu Lys Gly Ala Tyr 355 360 365 Ser LeuPhe Thr Ile Ile Ile Arg Met Arg Lys 370 375 21 1290 DNA DROSOPHILAMELANOGASTER DOR19g 21 atggttacgg aggactttta taagtaccag gtgtggtacttccaaatcct tggtgtttgg 60 cagctcccca cttgggccgc agaccaccag cgtcgttttcagtccatgag gtttggcttc 120 atcctggtca tcctgttcat catgctgctg cttttctccttcgaaatgtt gaacaacatt 180 tcccaagtta gggagatcct aaaggtattc ttcatgttcgccacggaaat atcctgcatg 240 gccaaattat tgcatttgaa gttgaagagc cgcaaactcgctggcttggt tgatgcgatg 300 ttgtccccag agttcggcgt taaaagtgaa caggaaatgcagatgctgga attggataga 360 gtggcggttg tccgcatgag gaactcctac ggcatcatgtccctgggcgc ggcttccctg 420 atccttatag ttccctgttt cgacaacttt ggcgagctaccactggccat gttggaggta 480 tgcagcatcg agggatggat ctgctattgg tcgcagtaccttttccactc gatttgcctg 540 ctgcccactt gtgtgctgaa tataacctac gactcggtggcctactcgtt gctctgtttc 600 ttgaaggttc agctacaaat gctggtcctg cgattagaaaagttgggtcc tgtgatcgaa 660 ccccaggata atgagaaaat cgcaatggaa ctgcgtgagtgtgccgccta ctacaacagg 720 attgttcgtt tcaaggacct ggtggagctg ttcataaaggggccaggatc tgtgcagctc 780 atgtgttctg ttctggtgct ggtgtccaac ctgtacgacatgtccaccat gtccattgca 840 aacggcgatg ccatctttat gctcaagacc tgtatctatcagctggtgat gctctggcag 900 atcttcatca tttgctacgc ctccaacgag gtaactgtccagagctctag gttgtgtcac 960 agcatctaca gctcccaatg gacgggatgg aacagggcaaaccgccggat tgtccttctc 1020 atgatgcagc gctttaattc cccgatgctc ctgagcacctttaaccccac ctttgctttc 1080 agcttggagg cctttggttc tgtagggcag cagaaattcctttatatatc atttattact 1140 ggttatgctc ttctcctttc agatcgtcaa ctgctcctacagctacttcg cactgctgaa 1200 gcgcgtcaac agttaaattt cgaaacaccg cagcacctaaagattttcaa gccgattttt 1260 aaaagcactc aaaacgttat gcacgtacat 1290 22 430PRT DROSOPHILA MELANOGASTER DOR19g 22 Met Val Thr Glu Asp Phe Tyr LysTyr Gln Val Trp Tyr Phe Gln Ile 1 5 10 15 Leu Gly Val Trp Gln Leu ProThr Trp Ala Ala Asp His Gln Arg Arg 20 25 30 Phe Gln Ser Met Arg Phe GlyPhe Ile Leu Val Ile Leu Phe Ile Met 35 40 45 Leu Leu Leu Phe Ser Phe GluMet Leu Asn Asn Ile Ser Gln Val Arg 50 55 60 Glu Ile Leu Lys Val Phe PheMet Phe Ala Thr Glu Ile Ser Cys Met 65 70 75 80 Ala Lys Leu Leu His LeuLys Leu Lys Ser Arg Lys Leu Ala Gly Leu 85 90 95 Val Asp Ala Met Leu SerPro Glu Phe Gly Val Lys Ser Glu Gln Glu 100 105 110 Met Gln Met Leu GluLeu Asp Arg Val Ala Val Val Arg Met Arg Asn 115 120 125 Ser Tyr Gly IleMet Ser Leu Gly Ala Ala Ser Leu Ile Leu Ile Val 130 135 140 Pro Cys PheAsp Asn Phe Gly Glu Leu Pro Leu Ala Met Leu Glu Val 145 150 155 160 CysSer Ile Glu Gly Trp Ile Cys Tyr Trp Ser Gln Tyr Leu Phe His 165 170 175Ser Ile Cys Leu Leu Pro Thr Cys Val Leu Asn Ile Thr Tyr Asp Ser 180 185190 Val Ala Tyr Ser Leu Leu Cys Phe Leu Lys Val Gln Leu Gln Met Leu 195200 205 Val Leu Arg Leu Glu Lys Leu Gly Pro Val Ile Glu Pro Gln Asp Asn210 215 220 Glu Lys Ile Ala Met Glu Leu Arg Glu Cys Ala Ala Tyr Tyr AsnArg 225 230 235 240 Ile Val Arg Phe Lys Asp Leu Val Glu Leu Phe Ile LysGly Pro Gly 245 250 255 Ser Val Gln Leu Met Cys Ser Val Leu Val Leu ValSer Asn Leu Tyr 260 265 270 Asp Met Ser Thr Met Ser Ile Ala Asn Gly AspAla Ile Phe Met Leu 275 280 285 Lys Thr Cys Ile Tyr Gln Leu Val Met LeuTrp Gln Ile Phe Ile Ile 290 295 300 Cys Tyr Ala Ser Asn Glu Val Thr ValGln Ser Ser Arg Leu Cys His 305 310 315 320 Ser Ile Tyr Ser Ser Gln TrpThr Gly Trp Asn Arg Ala Asn Arg Arg 325 330 335 Ile Val Leu Leu Met MetGln Arg Phe Asn Ser Pro Met Leu Leu Ser 340 345 350 Thr Phe Asn Pro ThrPhe Ala Phe Ser Leu Glu Ala Phe Gly Ser Val 355 360 365 Gly Gln Gln LysPhe Leu Tyr Ile Ser Phe Ile Thr Gly Tyr Ala Leu 370 375 380 Leu Leu SerAsp Arg Gln Leu Leu Leu Gln Leu Leu Arg Thr Ala Glu 385 390 395 400 AlaArg Gln Gln Leu Asn Phe Glu Thr Pro Gln His Leu Lys Ile Phe 405 410 415Lys Pro Ile Phe Lys Ser Thr Gln Asn Val Met His Val His 420 425 430 231391 DNA DROSOPHILA MELANOGASTER DOR24 23 ggcacgagcc ttgtcgacatggacagtttt ctgcaagtac agaagagcac cattgctctt 60 ctgggctttg atctctttagtgaaaatcga gaaatgtgga aacgccccta tagagcaatg 120 aatgtgttta gcatagctgccatttttccc tttatcctgg cagctgtgct ccataattgg 180 aagaatgtat tgctgctggccgatgccatg gtggccctac taataaccat tctgggccta 240 ttcaagttta gcatgatactttacttacgt cgcgatttca agcgactgat tgacaaattt 300 cgtttgctca tgtcgaatgaggcggaacag ggcgaggaat acgccgagat tctcaacgca 360 gcaaacaagc aggatcaacgaatgtgcact ctgtttagga cttgtttcct cctcgcctgg 420 gccttgaata gtgttctgcccctcgtgaga atgggtctca gctattggtt agcaggtcat 480 gcagagcccg agttgccttttccctgtctt tttccctgga atatccacat cattcgcaat 540 tatgttttga gcttcatctggagcgctttc gcctcgacag gtgtggtttt acctgctgtc 600 agcttggata ccatattctgttccttcacc agcaacctgt gcgccttctt caaaattgcg 660 cagtacaagg tggttagatttaagggcgga tcccttaaag aatcacaggc cacattgaac 720 aaagtctttg ccctgtaccagaccagcttg gatatgtgca acgatctgaa tcagtgctac 780 caaccgatta tctgcgcccagttcttcatt tcatctctgc aactctgcat gctgggatat 840 ctgttctcca ttacttttgcccagacagag ggcgtgtact atgcctcttt catagccacc 900 atcattatac aagcctatatctactgctac tgcggggaga acctgaagac ggagagtgcc 960 agcttcgagt gggccatctacgacagtccg tggcacgaga gtttgggtgc tggtggagcc 1020 tctacctcga tctgccgatccttgctgatc agcatgatgc gggctcatcg gggattccgc 1080 attacgggat acttcttcgaggcaaacatg gaggccttct catcgattgt tcgcacggct 1140 atgtcctaca tcacaatgctgagatcattc tcctaaatgt ggtttgacca caaggctttg 1200 gattgatttt tgtgcaatttttgttttatt gctgagcatg cgttgccgta cgacatttaa 1260 caatcgatct tacgtaatttacatatgata atctcacata ttgttcgtta agcactaagt 1320 agaatgtaga atgtgaattggctgtagaaa tgcacagatg aagcacgaaa aaaaaaaaaa 1380 aaaaaaaaaa a 1391 24385 PRT DROSOPHILA MELANOGASTER DOR24 24 Met Asp Ser Phe Leu Gln Val GlnLys Ser Thr Ile Ala Leu Leu Gly 1 5 10 15 Phe Asp Leu Phe Ser Glu AsnArg Glu Met Trp Lys Arg Pro Tyr Arg 20 25 30 Ala Met Asn Val Phe Ser IleAla Ala Ile Phe Pro Phe Ile Leu Ala 35 40 45 Ala Val Leu His Asn Trp LysAsn Val Leu Leu Leu Ala Asp Ala Met 50 55 60 Val Ala Leu Leu Ile Thr IleLeu Gly Leu Phe Lys Phe Ser Met Ile 65 70 75 80 Leu Tyr Leu Arg Arg AspPhe Lys Arg Leu Ile Asp Lys Phe Arg Leu 85 90 95 Leu Met Ser Asn Glu AlaGlu Gln Gly Glu Glu Tyr Ala Glu Ile Leu 100 105 110 Asn Ala Ala Asn LysGln Asp Gln Arg Met Cys Thr Leu Phe Arg Thr 115 120 125 Cys Phe Leu LeuAla Trp Ala Leu Asn Ser Val Leu Pro Leu Val Arg 130 135 140 Met Gly LeuSer Tyr Trp Leu Ala Gly His Ala Glu Pro Glu Leu Pro 145 150 155 160 PhePro Cys Leu Phe Pro Trp Asn Ile His Ile Ile Arg Asn Tyr Val 165 170 175Leu Ser Phe Ile Trp Ser Ala Phe Ala Ser Thr Gly Val Val Leu Pro 180 185190 Ala Val Ser Leu Asp Thr Ile Phe Cys Ser Phe Thr Ser Asn Leu Cys 195200 205 Ala Phe Phe Lys Ile Ala Gln Tyr Lys Val Val Arg Phe Lys Gly Gly210 215 220 Ser Leu Lys Glu Ser Gln Ala Thr Leu Asn Lys Val Phe Ala LeuTyr 225 230 235 240 Gln Thr Ser Leu Asp Met Cys Asn Asp Leu Asn Gln CysTyr Gln Pro 245 250 255 Ile Ile Cys Ala Gln Phe Phe Ile Ser Ser Leu GlnLeu Cys Met Leu 260 265 270 Gly Tyr Leu Phe Ser Ile Thr Phe Ala Gln ThrGlu Gly Val Tyr Tyr 275 280 285 Ala Ser Phe Ile Ala Thr Ile Ile Ile GlnAla Tyr Ile Tyr Cys Tyr 290 295 300 Cys Gly Glu Asn Leu Lys Thr Glu SerAla Ser Phe Glu Trp Ala Ile 305 310 315 320 Tyr Asp Ser Pro Trp His GluSer Leu Gly Ala Gly Gly Ala Ser Thr 325 330 335 Ser Ile Cys Arg Ser LeuLeu Ile Ser Met Met Arg Ala His Arg Gly 340 345 350 Phe Arg Ile Thr GlyTyr Phe Phe Glu Ala Asn Met Glu Ala Phe Ser 355 360 365 Ser Ile Val ArgThr Ala Met Ser Tyr Ile Thr Met Leu Arg Ser Phe 370 375 380 Ser 385 25900 DNA Drosophila Melanogaster DOR10 25 atggaaaaac tacgttcctatgaggatttc atcttcatgg ccaacatgat gttcaagacc 60 cttggctacg atctattccatacacccaaa ccctggtggc gctatctgct tgtgcgagga 120 tacttcgttt tgtgcacgatcagcaacttt tacgaggctt ccatggtgac gacaaggata 180 attgagtggg aatccttggccggaagtccc tccaaaataa tgcgacaggg tctgcacttc 240 ttttacatgt tgagtagccaattgaaattt atcacattca tgataaatcg caaacgccta 300 ctgcagctga gccatcgtttgaaagagttg tatcctcata aagagcaaaa tcaaaggaag 360 tacgaggtga ataaatactacctatcctgt tccacgcgca atgttttgta cgtgtactac 420 tttgtaatgg tcgtcatggcactggaaccc ctcgttcagt cccagttcat agtgaatgtg 480 agcctgggca cagatctgtggatgatgtgc gtctcaagcc aaatatcgat gcacttgggc 540 tatctggcca atatgttggcctccattcga ccaagtccag aaacggaaca acaagactgt 600 gacttcttgg ccagcattataaagagacat caactaatga tcaggcttca aaaggacgtg 660 aactatgttt ttggactcttattggcatct aatctgttta ccacatcctg tttactttgc 720 tgcatggcgt actataccgtcgtcgaaggt ttcaattggg agggcatttc ctatatgatg 780 ctctttgcta gtgtagctgcccagttctac gttgtcagct cacacggaca aatgttaata 840 gatttgttga tgaccatcacatacagattt ttcgcggtta tacgacaaac tgtagaaaag 900 26 300 PRT DrosophilaMelanogaster DOR10 26 Met Glu Lys Leu Arg Ser Tyr Glu Asp Phe Ile PheMet Ala Asn Met 1 5 10 15 Met Phe Lys Thr Leu Gly Tyr Asp Leu Phe HisThr Pro Lys Pro Trp 20 25 30 Trp Arg Tyr Leu Leu Val Arg Gly Tyr Phe ValLeu Cys Thr Ile Ser 35 40 45 Asn Phe Tyr Glu Ala Ser Met Val Thr Thr ArgIle Ile Glu Trp Glu 50 55 60 Ser Leu Ala Gly Ser Pro Ser Lys Ile Met ArgGln Gly Leu His Phe 65 70 75 80 Phe Tyr Met Leu Ser Ser Gln Leu Lys PheIle Thr Phe Met Ile Asn 85 90 95 Arg Lys Arg Leu Leu Gln Leu Ser His ArgLeu Lys Glu Leu Tyr Pro 100 105 110 His Lys Glu Gln Asn Gln Arg Lys TyrGlu Val Asn Lys Tyr Tyr Leu 115 120 125 Ser Cys Ser Thr Arg Asn Val LeuTyr Val Tyr Tyr Phe Val Met Val 130 135 140 Val Met Ala Leu Glu Pro LeuVal Gln Ser Gln Phe Ile Val Asn Val 145 150 155 160 Ser Leu Gly Thr AspLeu Trp Met Met Cys Val Ser Ser Gln Ile Ser 165 170 175 Met His Leu GlyTyr Leu Ala Asn Met Leu Ala Ser Ile Arg Pro Ser 180 185 190 Pro Glu ThrGlu Gln Gln Asp Cys Asp Phe Leu Ala Ser Ile Ile Lys 195 200 205 Arg HisGln Leu Met Ile Arg Leu Gln Lys Asp Val Asn Tyr Val Phe 210 215 220 GlyLeu Leu Leu Ala Ser Asn Leu Phe Thr Thr Ser Cys Leu Leu Cys 225 230 235240 Cys Met Ala Tyr Tyr Thr Val Val Glu Gly Phe Asn Trp Glu Gly Ile 245250 255 Ser Tyr Met Met Leu Phe Ala Ser Val Ala Ala Gln Phe Tyr Val Val260 265 270 Ser Ser His Gly Gln Met Leu Ile Asp Leu Leu Met Thr Ile ThrTyr 275 280 285 Arg Phe Phe Ala Val Ile Arg Gln Thr Val Glu Lys 290 295300 27 1125 DNA Drosophila Melanogaster DOR105 27 atgtttgaag acattcagctaatctacatg aatatcaaga tattgcgatt ctgggccctg 60 ctctatgaca aaaacttgaggcgttatgtg tgcattggac tggcctcatt ccacatcttc 120 acccaaatcg tctacatgatgagtaccaat gaaggactaa ccgggataat tcgtaactca 180 tatatgctcg tcctttggattaatacggtg ctgcgagctt atctcttgct ggcggatcac 240 gacagatatt tggctttgatccaaaaacta actgaggcct attacgattt actgaatctg 300 aacgattcgt atatatcggaaatattggac caggtgaaca aggtgggaaa gttgatggct 360 aggggcaatc tgttctttggcatgctcaca tccatgggat tcggtctgta cccattgtcc 420 tccagcgaaa gagtcctgccatttggcagc aaaattcctg gtctaaatga gtacgagagt 480 ccgtactatg agatgtggtacatctttcag atgctcatca ccccgatggg ctgttgcatg 540 tacattccgt acaccagtctgattgtgggc ttgataatgt tcggcattgt gaggtgcaag 600 gctttgcagc atcgcctccgccaggtggcg cttaagcatc cgtacggaga tcgcgatccc 660 cgtgaactga gggaggagatcatagcctgc atacgttacc agcagagcat tatcgagtac 720 atggatcaca taaacgagctgaccaccatg atgttcctat tcgaactgat ggccttttcg 780 gcgctgctct gtgcgctgctctttatgctg attatcgtca gcggcaccag tcagctgata 840 attgtttgca tgtacattaacatgattctg gcccaaatac tggccctcta ttggtatgca 900 aatgagttaa gggaacagaatctggcggtg gccaccgcag cctacgaaac ggagtggttc 960 accttcgacg ttccactgcgcaaaaacatc ctgttcatga tgatgagggc acagcggcca 1020 gctgcaatac tactgggcaatatacgcccc atcactttgg aactgttcca aaacctactg 1080 aacacaacct atacattttttacggttctc aagcgagtct acgga 1125 28 375 PRT Drosophila MelanogasterDOR105 28 Met Phe Glu Asp Ile Gln Leu Ile Tyr Met Asn Ile Lys Ile LeuArg 1 5 10 15 Phe Trp Ala Leu Leu Tyr Asp Lys Asn Leu Arg Arg Tyr ValCys Ile 20 25 30 Gly Leu Ala Ser Phe His Ile Phe Thr Gln Ile Val Tyr MetMet Ser 35 40 45 Thr Asn Glu Gly Leu Thr Gly Ile Ile Arg Asn Ser Tyr MetLeu Val 50 55 60 Leu Trp Ile Asn Thr Val Leu Arg Ala Tyr Leu Leu Leu AlaAsp His 65 70 75 80 Asp Arg Tyr Leu Ala Leu Ile Gln Lys Leu Thr Glu AlaTyr Tyr Asp 85 90 95 Leu Leu Asn Leu Asn Asp Ser Tyr Ile Ser Glu Ile LeuAsp Gln Val 100 105 110 Asn Lys Val Gly Lys Leu Met Ala Arg Gly Asn LeuPhe Phe Gly Met 115 120 125 Leu Thr Ser Met Gly Phe Gly Leu Tyr Pro LeuSer Ser Ser Glu Arg 130 135 140 Val Leu Pro Phe Gly Ser Lys Ile Pro GlyLeu Asn Glu Tyr Glu Ser 145 150 155 160 Pro Tyr Tyr Glu Met Trp Tyr IlePhe Gln Met Leu Ile Thr Pro Met 165 170 175 Gly Cys Cys Met Tyr Ile ProTyr Thr Ser Leu Ile Val Gly Leu Ile 180 185 190 Met Phe Gly Ile Val ArgCys Lys Ala Leu Gln His Arg Leu Arg Gln 195 200 205 Val Ala Leu Lys HisPro Tyr Gly Asp Arg Asp Pro Arg Glu Leu Arg 210 215 220 Glu Glu Ile IleAla Cys Ile Arg Tyr Gln Gln Ser Ile Ile Glu Tyr 225 230 235 240 Met AspHis Ile Asn Glu Leu Thr Thr Met Met Phe Leu Phe Glu Leu 245 250 255 MetAla Phe Ser Ala Leu Leu Cys Ala Leu Leu Phe Met Leu Ile Ile 260 265 270Val Ser Gly Thr Ser Gln Leu Ile Ile Val Cys Met Tyr Ile Asn Met 275 280285 Ile Leu Ala Gln Ile Leu Ala Leu Tyr Trp Tyr Ala Asn Glu Leu Arg 290295 300 Glu Gln Asn Leu Ala Val Ala Thr Ala Ala Tyr Glu Thr Glu Trp Phe305 310 315 320 Thr Phe Asp Val Pro Leu Arg Lys Asn Ile Leu Phe Met MetMet Arg 325 330 335 Ala Gln Arg Pro Ala Ala Ile Leu Leu Gly Asn Ile ArgPro Ile Thr 340 345 350 Leu Glu Leu Phe Gln Asn Leu Leu Asn Thr Thr TyrThr Phe Phe Thr 355 360 365 Val Leu Lys Arg Val Tyr Gly 370 375 29 1188DNA Drosophila Melanogaster DOR107 29 atgtatccgc gattcctcag ccgtaactatccgctggcca agcatttgtt cttcgtcacc 60 agatactcct ttggcctgct gggcctgagatttggcaaag agcaatcgtg gcttcacctc 120 ttgtggctgg tgttcaattt cgttaacctggcgcactgct gccaggcgga gttcgtcttc 180 ggctggagtc acttgcgcac cagtcccgtggatgccatgg acgccttttg tcctctggcc 240 tgcagtttca ccacgctctt caagctgggatggatgtggt ggcgtcgcca ggaagtagct 300 gatctaatgg accgcatccg cttgctcatcggggagcagg agaagaggga ggactcccgg 360 agaaaggtgg ctcaaaggag ctactatctcatggtcacca ggtgcggtat gctggtcttc 420 accctgggca gcattaccac tggagccttcgttctgcgtt ccctttggga aatgtgggtg 480 cgtcgtcatc aggagttcaa attcgatatgccctttcgca tgctgttcca cgactttgcg 540 catcgcatgc cctggtttcc agttttctatctctactcca catggagtgg ccaggtcact 600 gtgtacgcct ttgctggtac agatggtttcttctttggct ttaccctcta catggccttc 660 ttgctgcagg ccttaagata cgatatccaggatgccctca agccaataag agatccctcg 720 cttagggaat ccaaaatctg ctgtcagcgattggcggaca tcgtggatcg ccacaatgag 780 atagagaaga tagtcaagga attttctggaattatggctg ctccaacttt tgttcacttc 840 gtatcagcca gcttagtgat agccaccagcgtcattgata tactattgta ttccggctat 900 aacatcatcc gttacgtggt gtacaccttcacggtttcct cggccatctt cctctattgc 960 tacggaggca cagaaatgtc aactgagagcctttccttgg gagaagcagc ctacagcagt 1020 gcctggtata cttgggatcg agagacccgcaggcgggtct ttctcattat cctgcgtgct 1080 caacgaccca ttacggtgag ggtgcccttttttgcaccat cgttaccagt cttcacatcg 1140 gtcatcaagt ttacaggttc gattgtggcactggctaaga cgatactg 1188 30 396 PRT Drosophila Melanogaster DOR107 30Met Tyr Pro Arg Phe Leu Ser Arg Asn Tyr Pro Leu Ala Lys His Leu 1 5 1015 Phe Phe Val Thr Arg Tyr Ser Phe Gly Leu Leu Gly Leu Arg Phe Gly 20 2530 Lys Glu Gln Ser Trp Leu His Leu Leu Trp Leu Val Phe Asn Phe Val 35 4045 Asn Leu Ala His Cys Cys Gln Ala Glu Phe Val Phe Gly Trp Ser His 50 5560 Leu Arg Thr Ser Pro Val Asp Ala Met Asp Ala Phe Cys Pro Leu Ala 65 7075 80 Cys Ser Phe Thr Thr Leu Phe Lys Leu Gly Trp Met Trp Trp Arg Arg 8590 95 Gln Glu Val Ala Asp Leu Met Asp Arg Ile Arg Leu Leu Ile Gly Glu100 105 110 Gln Glu Lys Arg Glu Asp Ser Arg Arg Lys Val Ala Gln Arg SerTyr 115 120 125 Tyr Leu Met Val Thr Arg Cys Gly Met Leu Val Phe Thr LeuGly Ser 130 135 140 Ile Thr Thr Gly Ala Phe Val Leu Arg Ser Leu Trp GluMet Trp Val 145 150 155 160 Arg Arg His Gln Glu Phe Lys Phe Asp Met ProPhe Arg Met Leu Phe 165 170 175 His Asp Phe Ala His Arg Met Pro Trp PhePro Val Phe Tyr Leu Tyr 180 185 190 Ser Thr Trp Ser Gly Gln Val Thr ValTyr Ala Phe Ala Gly Thr Asp 195 200 205 Gly Phe Phe Phe Gly Phe Thr LeuTyr Met Ala Phe Leu Leu Gln Ala 210 215 220 Leu Arg Tyr Asp Ile Gln AspAla Leu Lys Pro Ile Arg Asp Pro Ser 225 230 235 240 Leu Arg Glu Ser LysIle Cys Cys Gln Arg Leu Ala Asp Ile Val Asp 245 250 255 Arg His Asn GluIle Glu Lys Ile Val Lys Glu Phe Ser Gly Ile Met 260 265 270 Ala Ala ProThr Phe Val His Phe Val Ser Ala Ser Leu Val Ile Ala 275 280 285 Thr SerVal Ile Asp Ile Leu Leu Tyr Ser Gly Tyr Asn Ile Ile Arg 290 295 300 TyrVal Val Tyr Thr Phe Thr Val Ser Ser Ala Ile Phe Leu Tyr Cys 305 310 315320 Tyr Gly Gly Thr Glu Met Ser Thr Glu Ser Leu Ser Leu Gly Glu Ala 325330 335 Ala Tyr Ser Ser Ala Trp Tyr Thr Trp Asp Arg Glu Thr Arg Arg Arg340 345 350 Val Phe Leu Ile Ile Leu Arg Ala Gln Arg Pro Ile Thr Val ArgVal 355 360 365 Pro Phe Phe Ala Pro Ser Leu Pro Val Phe Thr Ser Val IleLys Phe 370 375 380 Thr Gly Ser Ile Val Ala Leu Ala Lys Thr Ile Leu 385390 395 31 1161 DNA Drosophila Melanogaster DOR108 31 atggataaacacaaggatcg cattgaatcc atgcgcctaa ttcttcaggt catgcaacta 60 tttggcctctggccgtggtc cttgaaatcg gaagaggagt ggactttcac cggttttgta 120 aagcgcaactatcgcttcct gctccatctg cccattacct tcacctttat tggactcatg 180 tggctggaggccttcatctc gagcaatctg gagcaggctg gccaggttct gtacatgtcc 240 atcaccgagatggctttggt ggtgaaaatc ctgagcattt ggcactatcg caccgaagct 300 tggcggctgatgtacgaact ccaacatgct ccggactacc aactccacaa ccaggaggag 360 gtagacttttggcgccggga gcaacgattc ttcaagtggt tcttctacat ctacattctg 420 attagcttgggcgtggtata tagtggctgc actggagtac tttttctgga gggctacgaa 480 ctgccctttgcctactacgt gcccttcgaa tggcagaacg agagaaggta ctggttcgcc 540 tatggttacgatatggcggg catgacgctg acctgcatct caaacattac cctggacacc 600 ctgggttgctatttcctgtt ccatatctct cttttgtacc gactgcttgg tctgcgattg 660 agggaaacgaagaatatgaa gaatgatacc atttttggcc agcagttgcg tgccatcttc 720 attatgcatcagaggattag aagcctaacc ctgacctgcc agagaatcgt atctccctat 780 atcctatctcagatcatttt gagtgccctg atcatctgct ttagtggata ccgcttgcag 840 catgtgggaattcgcgataa tcccggccag tttatatcca tgttgcagtt tgtcagtgtg 900 atgatcctgcagatttactt gccctgctac tatggaaacg agataaccgt gtatgccaat 960 cagctgaccaacgaggttta ccataccaat tggctggaat gtcggccacc gattcgaaag 1020 ttactcaatgcctacatgga gcacctgaag aaaccggtga ccatccgggc tggcaactcc 1080 ttcgccgtgggactaccaat ttttgttaag accatcaaca acgcctacag tttcttggct 1140 ttattactaaatgtatcgaa t 1161 32 387 PRT Drosophila Melanogaster DOR108 32 Met AspLys His Lys Asp Arg Ile Glu Ser Met Arg Leu Ile Leu Gln 1 5 10 15 ValMet Gln Leu Phe Gly Leu Trp Pro Trp Ser Leu Lys Ser Glu Glu 20 25 30 GluTrp Thr Phe Thr Gly Phe Val Lys Arg Asn Tyr Arg Phe Leu Leu 35 40 45 HisLeu Pro Ile Thr Phe Thr Phe Ile Gly Leu Met Trp Leu Glu Ala 50 55 60 PheIle Ser Ser Asn Leu Glu Gln Ala Gly Gln Val Leu Tyr Met Ser 65 70 75 80Ile Thr Glu Met Ala Leu Val Val Lys Ile Leu Ser Ile Trp His Tyr 85 90 95Arg Thr Glu Ala Trp Arg Leu Met Tyr Glu Leu Gln His Ala Pro Asp 100 105110 Tyr Gln Leu His Asn Gln Glu Glu Val Asp Phe Trp Arg Arg Glu Gln 115120 125 Arg Phe Phe Lys Trp Phe Phe Tyr Ile Tyr Ile Leu Ile Ser Leu Gly130 135 140 Val Val Tyr Ser Gly Cys Thr Gly Val Leu Phe Leu Glu Gly TyrGlu 145 150 155 160 Leu Pro Phe Ala Tyr Tyr Val Pro Phe Glu Trp Gln AsnGlu Arg Arg 165 170 175 Tyr Trp Phe Ala Tyr Gly Tyr Asp Met Ala Gly MetThr Leu Thr Cys 180 185 190 Ile Ser Asn Ile Thr Leu Asp Thr Leu Gly CysTyr Phe Leu Phe His 195 200 205 Ile Ser Leu Leu Tyr Arg Leu Leu Gly LeuArg Leu Arg Glu Thr Lys 210 215 220 Asn Met Lys Asn Asp Thr Ile Phe GlyGln Gln Leu Arg Ala Ile Phe 225 230 235 240 Ile Met His Gln Arg Ile ArgSer Leu Thr Leu Thr Cys Gln Arg Ile 245 250 255 Val Ser Pro Tyr Ile LeuSer Gln Ile Ile Leu Ser Ala Leu Ile Ile 260 265 270 Cys Phe Ser Gly TyrArg Leu Gln His Val Gly Ile Arg Asp Asn Pro 275 280 285 Gly Gln Phe IleSer Met Leu Gln Phe Val Ser Val Met Ile Leu Gln 290 295 300 Ile Tyr LeuPro Cys Tyr Tyr Gly Asn Glu Ile Thr Val Tyr Ala Asn 305 310 315 320 GlnLeu Thr Asn Glu Val Tyr His Thr Asn Trp Leu Glu Cys Arg Pro 325 330 335Pro Ile Arg Lys Leu Leu Asn Ala Tyr Met Glu His Leu Lys Lys Pro 340 345350 Val Thr Ile Arg Ala Gly Asn Ser Phe Ala Val Gly Leu Pro Ile Phe 355360 365 Val Lys Thr Ile Asn Asn Ala Tyr Ser Phe Leu Ala Leu Leu Leu Asn370 375 380 Val Ser Asn 385 33 1149 DNA Drosophila Melanogaster DOR10933 atggagtcta caaatcgcct aagtgccatc caaacacttt tagtaatcca acgttggata 60ggacttctta aatgggaaaa cgagggcgag gatggagtat taacctggct aaaacgaata 120tatccttttg tactgcacct tccactgacc ttcacgtata ttgccttaat gtggtatgaa 180gctattacat cgtcagattt tgaggaagct ggtcaagttc tgtacatgtc catcaccgaa 240ctggcattgg tcactaaact gctgaatatt tggtatcgtc gtcatgaagc tgctagtcta 300atccacgaat tgcaacacga tcccgcattt aatctgcgca attcggagga aatcaaattc 360tggcagcaaa atcagaggaa ctttaagaga atattttact ggtacatctg gggcagcctt 420ttcgtggctg taatgggtta tataagcgtg tttttccagg aggattacga gctgcccttt 480ggctactacg tgccattcga gtggcgcacc agggaacgat acttctacgc ttggggctat 540aatgtggtgg ccatgaccct gtgctgtcta tccaacatcc tactggacac actaggctgt 600tatttcatgt tccacatcgc ctcgcttttc aggcttttgg gaatgcgact ggaggccttg 660aaaaatgcag ccgaagagaa agccagaccg gagttgcgcc gcattttcca actgcacact 720aaagtccgcc gattgacgag ggaatgcgaa gtgttagttt caccctatgt tctatcccaa 780gtggtcttca gtgccttcat catctgcttc agtgcctatc gactggtgca catgggcttc 840aagcagcgac ctggactctt cgtgaccacc gtgcaattcg tggccgtcat gatcgtccag 900attttcttgc cctgttacta cggcaatgag ttgacctttc atgccaatgc actcactaat 960agtgtcttcg gtaccaattg gctggagtac tccgtgggca ctcgcaagct gcttaactgc 1020tacatggagt tcctcaagcg accggttaaa gtgcgagctg gggtgttctt tgaaatagga 1080ctacccatct ttgtgaagac catcaacaat gcctacagtt tcttcgccct gctgctaaag 1140atatccaag 1149 34 383 PRT Drosophila Melanogaster DOR109 34 Met Glu SerThr Asn Arg Leu Ser Ala Ile Gln Thr Leu Leu Val Ile 1 5 10 15 Gln ArgTrp Ile Gly Leu Leu Lys Trp Glu Asn Glu Gly Glu Asp Gly 20 25 30 Val LeuThr Trp Leu Lys Arg Ile Tyr Pro Phe Val Leu His Leu Pro 35 40 45 Leu ThrPhe Thr Tyr Ile Ala Leu Met Trp Tyr Glu Ala Ile Thr Ser 50 55 60 Ser AspPhe Glu Glu Ala Gly Gln Val Leu Tyr Met Ser Ile Thr Glu 65 70 75 80 LeuAla Leu Val Thr Lys Leu Leu Asn Ile Trp Tyr Arg Arg His Glu 85 90 95 AlaAla Ser Leu Ile His Glu Leu Gln His Asp Pro Ala Phe Asn Leu 100 105 110Arg Asn Ser Glu Glu Ile Lys Phe Trp Gln Gln Asn Gln Arg Asn Phe 115 120125 Lys Arg Ile Phe Tyr Trp Tyr Ile Trp Gly Ser Leu Phe Val Ala Val 130135 140 Met Gly Tyr Ile Ser Val Phe Phe Gln Glu Asp Tyr Glu Leu Pro Phe145 150 155 160 Gly Tyr Tyr Val Pro Phe Glu Trp Arg Thr Arg Glu Arg TyrPhe Tyr 165 170 175 Ala Trp Gly Tyr Asn Val Val Ala Met Thr Leu Cys CysLeu Ser Asn 180 185 190 Ile Leu Leu Asp Thr Leu Gly Cys Tyr Phe Met PheHis Ile Ala Ser 195 200 205 Leu Phe Arg Leu Leu Gly Met Arg Leu Glu AlaLeu Lys Asn Ala Ala 210 215 220 Glu Glu Lys Ala Arg Pro Glu Leu Arg ArgIle Phe Gln Leu His Thr 225 230 235 240 Lys Val Arg Arg Leu Thr Arg GluCys Glu Val Leu Val Ser Pro Tyr 245 250 255 Val Leu Ser Gln Val Val PheSer Ala Phe Ile Ile Cys Phe Ser Ala 260 265 270 Tyr Arg Leu Val His MetGly Phe Lys Gln Arg Pro Gly Leu Phe Val 275 280 285 Thr Thr Val Gln PheVal Ala Val Met Ile Val Gln Ile Phe Leu Pro 290 295 300 Cys Tyr Tyr GlyAsn Glu Leu Thr Phe His Ala Asn Ala Leu Thr Asn 305 310 315 320 Ser ValPhe Gly Thr Asn Trp Leu Glu Tyr Ser Val Gly Thr Arg Lys 325 330 335 LeuLeu Asn Cys Tyr Met Glu Phe Leu Lys Arg Pro Val Lys Val Arg 340 345 350Ala Gly Val Phe Phe Glu Ile Gly Leu Pro Ile Phe Val Lys Thr Ile 355 360365 Asn Asn Ala Tyr Ser Phe Phe Ala Leu Leu Leu Lys Ile Ser Lys 370 375380 35 1161 DNA Drosophila Melanogaster DOR110 35 atgttgttca actatctgcgaaagccgaat cccacaaacc ttttgacttc tccggactca 60 tttagatact ttgagtatggaatgttttgc atgggatggc acacaccagc aacgcataag 120 ataatctact atataacatcctgtttgatt tttgcttggt gtgccgtata cttgccaatc 180 ggaatcatca ttagtttcaaaacggatatt aacacattca caccgaatga actgttgaca 240 gttatgcaat tatttttcaattcagtggga atgccattca aggttctgtt cttcaatttg 300 tatatttctg gattttacaaggccaaaaag ctccttagcg aaatggacaa acgttgcacc 360 actttgaagg agcgagtggaagtgcaccaa ggtgtggtcc gttgcaacaa ggcctacctc 420 atttaccagt tcatttataccgcgtacact atttcaacat ttctatcggc ggctcttagt 480 ggaaaattgc catggcgcatctataatcct tttgtggatt ttcgagaaag tagatccagt 540 ttttggaaag ctgccctcaacgagacagca cttatgctat ttgctgtgac tcaaacccta 600 atgagtgata tatatccactgctttatggt ttgatcctga gagttcacct caaacttttg 660 cgactaagag tggagagcctgtgcacagat tctggaaaaa gcgatgctga aaacgagcaa 720 gatttgatta actatgctgcagcaatacga ccagcggtta cccgcacaat tttcgttcaa 780 ttcctcttga tcggaatttgccttggcctt tcaatgatca atctactctt ctttgccgac 840 atctggacag gattggccacagtggcttac atcaatggtc taatggtgca gacatttcca 900 ttttgcttcg tttgtgatctactcaaaaag gattgtgaac ttcttgtgtc ggccatattt 960 cattccaact ggattaattcaagccgcagt tacaagtcat ctttgagata ttttctgaag 1020 aacgcccaga aatcaattgcttttacagcc ggctctattt ttcccatttc tactggctcg 1080 aatattaagg tggctaagctggcattttcg gtggttactt ttgtcaatca acttaacata 1140 gctgacagat tgacaaagaa c1161 36 387 PRT Drosophila Melanogaster DOR110 36 Met Leu Phe Asn TyrLeu Arg Lys Pro Asn Pro Thr Asn Leu Leu Thr 1 5 10 15 Ser Pro Asp SerPhe Arg Tyr Phe Glu Tyr Gly Met Phe Cys Met Gly 20 25 30 Trp His Thr ProAla Thr His Lys Ile Ile Tyr Tyr Ile Thr Ser Cys 35 40 45 Leu Ile Phe AlaTrp Cys Ala Val Tyr Leu Pro Ile Gly Ile Ile Ile 50 55 60 Ser Phe Lys ThrAsp Ile Asn Thr Phe Thr Pro Asn Glu Leu Leu Thr 65 70 75 80 Val Met GlnLeu Phe Phe Asn Ser Val Gly Met Pro Phe Lys Val Leu 85 90 95 Phe Phe AsnLeu Tyr Ile Ser Gly Phe Tyr Lys Ala Lys Lys Leu Leu 100 105 110 Ser GluMet Asp Lys Arg Cys Thr Thr Leu Lys Glu Arg Val Glu Val 115 120 125 HisGln Gly Val Val Arg Cys Asn Lys Ala Tyr Leu Ile Tyr Gln Phe 130 135 140Ile Tyr Thr Ala Tyr Thr Ile Ser Thr Phe Leu Ser Ala Ala Leu Ser 145 150155 160 Gly Lys Leu Pro Trp Arg Ile Tyr Asn Pro Phe Val Asp Phe Arg Glu165 170 175 Ser Arg Ser Ser Phe Trp Lys Ala Ala Leu Asn Glu Thr Ala LeuMet 180 185 190 Leu Phe Ala Val Thr Gln Thr Leu Met Ser Asp Ile Tyr ProLeu Leu 195 200 205 Tyr Gly Leu Ile Leu Arg Val His Leu Lys Leu Leu ArgLeu Arg Val 210 215 220 Glu Ser Leu Cys Thr Asp Ser Gly Lys Ser Asp AlaGlu Asn Glu Gln 225 230 235 240 Asp Leu Ile Asn Tyr Ala Ala Ala Ile ArgPro Ala Val Thr Arg Thr 245 250 255 Ile Phe Val Gln Phe Leu Leu Ile GlyIle Cys Leu Gly Leu Ser Met 260 265 270 Ile Asn Leu Leu Phe Phe Ala AspIle Trp Thr Gly Leu Ala Thr Val 275 280 285 Ala Tyr Ile Asn Gly Leu MetVal Gln Thr Phe Pro Phe Cys Phe Val 290 295 300 Cys Asp Leu Leu Lys LysAsp Cys Glu Leu Leu Val Ser Ala Ile Phe 305 310 315 320 His Ser Asn TrpIle Asn Ser Ser Arg Ser Tyr Lys Ser Ser Leu Arg 325 330 335 Tyr Phe LeuLys Asn Ala Gln Lys Ser Ile Ala Phe Thr Ala Gly Ser 340 345 350 Ile PhePro Ile Ser Thr Gly Ser Asn Ile Lys Val Ala Lys Leu Ala 355 360 365 PheSer Val Val Thr Phe Val Asn Gln Leu Asn Ile Ala Asp Arg Leu 370 375 380Thr Lys Asn 385 37 1050 DNA Drosophila Melanogaster DOR111 37 atgctgttccgcaaacgtaa gccaaaaagt gacgatgaag tcatcacctt cgacgaactt 60 acccggtttccgatgacttt ctacaagacc atcggcgagg atctgtactc cgatagggat 120 ccgaatgtgataaggcgtta cctgctacgt ttttatctgg tactcggttt tctcaacttc 180 aatgcctatgtggtgggcga aatcgcgtac tttatagtcc atataatgtc gacgactact 240 cttttggaggccactgcagt ggcaccgtgc attggcttca gcttcatggc cgactttaag 300 cagttcggtctcacagtgaa tagaaagcga ttggtcagat tgctggatga tctcaaggag 360 atatttcctttagatttaga agcgcagcgg aagtataacg tatcgtttta ccggaaacac 420 atgaacagggtcatgaccct attcaccatc ctctgcatga cctacacctc gtcatttagc 480 ttttatccagccatcaagtc gaccataaag tattacctta tgggatcgga aatctttgag 540 cgcaactacggatttcacat tttgtttccc tacgacgcag aaacggatct gacggtctac 600 tggttttcctactggggatt ggctcattgt gcctatgtgg ccggagtttc ctacgtctgc 660 gtggatctcctgctgatcgc gaccataacc cagctgacca tgcacttcaa ctttatagcg 720 aatgatttggaggcctacga aggaggtgat catacggatg aagaaaatat caaatacctg 780 cacaacttggtcgtctatca tgccagggcg ctggatatta acaagaaatg tacatttcag 840 agctctcggattggccattc ggcatttaat cagaactggt tgccatgcag caccaaatac 900 aaacgcatcctgcaatttat tatcgcgcgc agccagaagc ccgcctctat aagaccgcct 960 acctttccacccatatcttt taataccttt atgaaggtaa tcagcatgtc gtatcagttt 1020 tttgcactgctccgcaccac atattatggt 1050 38 350 PRT Drosophila Melanogaster DOR111 38Met Leu Phe Arg Lys Arg Lys Pro Lys Ser Asp Asp Glu Val Ile Thr 1 5 1015 Phe Asp Glu Leu Thr Arg Phe Pro Met Thr Phe Tyr Lys Thr Ile Gly 20 2530 Glu Asp Leu Tyr Ser Asp Arg Asp Pro Asn Val Ile Arg Arg Tyr Leu 35 4045 Leu Arg Phe Tyr Leu Val Leu Gly Phe Leu Asn Phe Asn Ala Tyr Val 50 5560 Val Gly Glu Ile Ala Tyr Phe Ile Val His Ile Met Ser Thr Thr Thr 65 7075 80 Leu Leu Glu Ala Thr Ala Val Ala Pro Cys Ile Gly Phe Ser Phe Met 8590 95 Ala Asp Phe Lys Gln Phe Gly Leu Thr Val Asn Arg Lys Arg Leu Val100 105 110 Arg Leu Leu Asp Asp Leu Lys Glu Ile Phe Pro Leu Asp Leu GluAla 115 120 125 Gln Arg Lys Tyr Asn Val Ser Phe Tyr Arg Lys His Met AsnArg Val 130 135 140 Met Thr Leu Phe Thr Ile Leu Cys Met Thr Tyr Thr SerSer Phe Ser 145 150 155 160 Phe Tyr Pro Ala Ile Lys Ser Thr Ile Lys TyrTyr Leu Met Gly Ser 165 170 175 Glu Ile Phe Glu Arg Asn Tyr Gly Phe HisIle Leu Phe Pro Tyr Asp 180 185 190 Ala Glu Thr Asp Leu Thr Val Tyr TrpPhe Ser Tyr Trp Gly Leu Ala 195 200 205 His Cys Ala Tyr Val Ala Gly ValSer Tyr Val Cys Val Asp Leu Leu 210 215 220 Leu Ile Ala Thr Ile Thr GlnLeu Thr Met His Phe Asn Phe Ile Ala 225 230 235 240 Asn Asp Leu Glu AlaTyr Glu Gly Gly Asp His Thr Asp Glu Glu Asn 245 250 255 Ile Lys Tyr LeuHis Asn Leu Val Val Tyr His Ala Arg Ala Leu Asp 260 265 270 Ile Asn LysLys Cys Thr Phe Gln Ser Ser Arg Ile Gly His Ser Ala 275 280 285 Phe AsnGln Asn Trp Leu Pro Cys Ser Thr Lys Tyr Lys Arg Ile Leu 290 295 300 GlnPhe Ile Ile Ala Arg Ser Gln Lys Pro Ala Ser Ile Arg Pro Pro 305 310 315320 Thr Phe Pro Pro Ile Ser Phe Asn Thr Phe Met Lys Val Ile Ser Met 325330 335 Ser Tyr Gln Phe Phe Ala Leu Leu Arg Thr Thr Tyr Tyr Gly 340 345350 39 1236 DNA Drosophila Melanogaster DOR114 39 atgttgacta agaaggatactcaaagtgcc aaggagcagg aaaagttgaa ggccattcca 60 ttgcacagct ttctgaaatatgccaacgtg ttctatttat cgattggaat gatggcctac 120 gatcacaagt acagtcaaaagtggaaggag gtcctgctgc actggacatt cattgcccag 180 atggtcaatc tgaatacagtgctcatctcg gaactgattt acgtattcct ggcgatcggc 240 aaaggtagca attttctggaggccaccatg aatctgtctt tcattggatt tgtcatcgtt 300 ggtgacttca aaatctggaacatttcgcgg cagagaaaga gactcaccca agtggtcagc 360 cgattggaag aactgcatccgcaaggcttg gctcaacaag aaccctataa tatagggcat 420 catctgagcg gctatagccgatatagcaaa ttttacttcg gcatgcacat ggtgctgata 480 tggacgtaca acctgtattgggccgtttac tatctggtct gtgatttctg gctgggaatg 540 cgtcaatttg agaggatgctgccctactac tgctgggttc cctgggattg gagtaccgga 600 tatagctact atttcatgtatatctcacag aatatcggcg gtcaggcttg tctgtccggt 660 cagctagcag ctgacatgttaatgtgcgcc ctggtcactt tggtggtgat gcacttcatc 720 cggctttccg ctcacatcgagagtcatgtt gcgggcattg gctcattcca gcacgatttg 780 gagttcctcc aagcgacggtggcgtatcac cagagcttga tccacctctg ccaggatatc 840 aatgagatat tcggtgtttcactgttgtcc aactttgtat cctcgtcgtt tatcatctgc 900 ttcgtgggtt tccagatgaccatcggcagc aagatcgaca acctggtaat gcttgtgctt 960 ttcctgtttt gtgccatggttcaggtcttc atgattgcca cccatgctca gaggctcgtt 1020 gatgcgagtg aacagattggtcaagcggtc tataatcacg actggttccg tgctgatctg 1080 cggtatcgta aaatgctgatcctgattatt aagagggccc aacagccgag tcgactcaag 1140 gccacaatgt tcctgaacatctcactggtc accgtgtcgg atctcttgca actctcgtac 1200 aaattctttg cccttctgcgcacaatgtac gtgaat 1236 40 412 PRT Drosophila Melanogaster DOR114 40 MetLeu Thr Lys Lys Asp Thr Gln Ser Ala Lys Glu Gln Glu Lys Leu 1 5 10 15Lys Ala Ile Pro Leu His Ser Phe Leu Lys Tyr Ala Asn Val Phe Tyr 20 25 30Leu Ser Ile Gly Met Met Ala Tyr Asp His Lys Tyr Ser Gln Lys Trp 35 40 45Lys Glu Val Leu Leu His Trp Thr Phe Ile Ala Gln Met Val Asn Leu 50 55 60Asn Thr Val Leu Ile Ser Glu Leu Ile Tyr Val Phe Leu Ala Ile Gly 65 70 7580 Lys Gly Ser Asn Phe Leu Glu Ala Thr Met Asn Leu Ser Phe Ile Gly 85 9095 Phe Val Ile Val Gly Asp Phe Lys Ile Trp Asn Ile Ser Arg Gln Arg 100105 110 Lys Arg Leu Thr Gln Val Val Ser Arg Leu Glu Glu Leu His Pro Gln115 120 125 Gly Leu Ala Gln Gln Glu Pro Tyr Asn Ile Gly His His Leu SerGly 130 135 140 Tyr Ser Arg Tyr Ser Lys Phe Tyr Phe Gly Met His Met ValLeu Ile 145 150 155 160 Trp Thr Tyr Asn Leu Tyr Trp Ala Val Tyr Tyr LeuVal Cys Asp Phe 165 170 175 Trp Leu Gly Met Arg Gln Phe Glu Arg Met LeuPro Tyr Tyr Cys Trp 180 185 190 Val Pro Trp Asp Trp Ser Thr Gly Tyr SerTyr Tyr Phe Met Tyr Ile 195 200 205 Ser Gln Asn Ile Gly Gly Gln Ala CysLeu Ser Gly Gln Leu Ala Ala 210 215 220 Asp Met Leu Met Cys Ala Leu ValThr Leu Val Val Met His Phe Ile 225 230 235 240 Arg Leu Ser Ala His IleGlu Ser His Val Ala Gly Ile Gly Ser Phe 245 250 255 Gln His Asp Leu GluPhe Leu Gln Ala Thr Val Ala Tyr His Gln Ser 260 265 270 Leu Ile His LeuCys Gln Asp Ile Asn Glu Ile Phe Gly Val Ser Leu 275 280 285 Leu Ser AsnPhe Val Ser Ser Ser Phe Ile Ile Cys Phe Val Gly Phe 290 295 300 Gln MetThr Ile Gly Ser Lys Ile Asp Asn Leu Val Met Leu Val Leu 305 310 315 320Phe Leu Phe Cys Ala Met Val Gln Val Phe Met Ile Ala Thr His Ala 325 330335 Gln Arg Leu Val Asp Ala Ser Glu Gln Ile Gly Gln Ala Val Tyr Asn 340345 350 His Asp Trp Phe Arg Ala Asp Leu Arg Tyr Arg Lys Met Leu Ile Leu355 360 365 Ile Ile Lys Arg Ala Gln Gln Pro Ser Arg Leu Lys Ala Thr MetPhe 370 375 380 Leu Asn Ile Ser Leu Val Thr Val Ser Asp Leu Leu Gln LeuSer Tyr 385 390 395 400 Lys Phe Phe Ala Leu Leu Arg Thr Met Tyr Val Asn405 410 41 1140 DNA Drosophila Melanogaster DOR115 41 atggagaagctaatgaagta cgctagcttc ttctacacag cagtgggcat acggccatat 60 accaatggtgaagaatccaa aatgaacaaa cttatatttc acatagtttt ttggtccaat 120 gtgattaacctcagcttcgt tggattattt gagagcattt acgtttacag tgccttcatg 180 gataataagttcctggaagc agtcactgcg ttgtcctaca ttggcttcgt aaccgtaggc 240 atgagcaagatgttcttcat ccggtggaag aaaacggcta taactgaact gattaatgaa 300 ttgaaggagatctatccgaa tggtttgatc cgagaggaaa gatacaatct gccgatgtat 360 ctgggcacctgctccagaat cagccttata tattccttgc tctactctgt tctcatctgg 420 acattcaacttgttttgtgt aatggagtat tgggtctatg acaagtggct caacattcga 480 gtggtgggcaaacagttgcc gtacctcatg tacattcctt ggaaatggca ggataactgg 540 tcgtactatccactgttatt ctcccagaat tttgcaggat acacatctgc agctggtcaa 600 atttcaaccgatgtcttgct ctgcgcggtg gccactcagt tggtaatgca cttcgacttt 660 ctctcaaatagtatggaacg ccacgaattg agtggagatt ggaagaagga ctcccgattt 720 ctggtggacattgttaggta tcacgaacgt atactccgcc tttcagatgc agtgaacgat 780 atatttggaattccactact actcaacttc atggtatcct cgttcgtcat ctgcttcgtg 840 ggattccagatgactgttgg agttccgccg gatatagttg tgaagctctt cctcttcctt 900 gtctcttcgatgagtcaggt ctatttgatt tgtcactatg gtcaactggt ggccgatgct 960 agctacggattttcggttgc cacctacaat cagaagtggt ataaagccga tgtgcgctat 1020 aaacgagccttggttattat tatagctaga tcgcagaagg taacttttct aaaggccact 1080 atattcttggatattaccag gtccactatg acagatgtac gcaactgtgt attgtcagtg 1140 42 380 PRTDrosophila Melanogaster DOR115 42 Met Glu Lys Leu Met Lys Tyr Ala SerPhe Phe Tyr Thr Ala Val Gly 1 5 10 15 Ile Arg Pro Tyr Thr Asn Gly GluGlu Ser Lys Met Asn Lys Leu Ile 20 25 30 Phe His Ile Val Phe Trp Ser AsnVal Ile Asn Leu Ser Phe Val Gly 35 40 45 Leu Phe Glu Ser Ile Tyr Val TyrSer Ala Phe Met Asp Asn Lys Phe 50 55 60 Leu Glu Ala Val Thr Ala Leu SerTyr Ile Gly Phe Val Thr Val Gly 65 70 75 80 Met Ser Lys Met Phe Phe IleArg Trp Lys Lys Thr Ala Ile Thr Glu 85 90 95 Leu Ile Asn Glu Leu Lys GluIle Tyr Pro Asn Gly Leu Ile Arg Glu 100 105 110 Glu Arg Tyr Asn Leu ProMet Tyr Leu Gly Thr Cys Ser Arg Ile Ser 115 120 125 Leu Ile Tyr Ser LeuLeu Tyr Ser Val Leu Ile Trp Thr Phe Asn Leu 130 135 140 Phe Cys Val MetGlu Tyr Trp Val Tyr Asp Lys Trp Leu Asn Ile Arg 145 150 155 160 Val ValGly Lys Gln Leu Pro Tyr Leu Met Tyr Ile Pro Trp Lys Trp 165 170 175 GlnAsp Asn Trp Ser Tyr Tyr Pro Leu Leu Phe Ser Gln Asn Phe Ala 180 185 190Gly Tyr Thr Ser Ala Ala Gly Gln Ile Ser Thr Asp Val Leu Leu Cys 195 200205 Ala Val Ala Thr Gln Leu Val Met His Phe Asp Phe Leu Ser Asn Ser 210215 220 Met Glu Arg His Glu Leu Ser Gly Asp Trp Lys Lys Asp Ser Arg Phe225 230 235 240 Leu Val Asp Ile Val Arg Tyr His Glu Arg Ile Leu Arg LeuSer Asp 245 250 255 Ala Val Asn Asp Ile Phe Gly Ile Pro Leu Leu Leu AsnPhe Met Val 260 265 270 Ser Ser Phe Val Ile Cys Phe Val Gly Phe Gln MetThr Val Gly Val 275 280 285 Pro Pro Asp Ile Val Val Lys Leu Phe Leu PheLeu Val Ser Ser Met 290 295 300 Ser Gln Val Tyr Leu Ile Cys His Tyr GlyGln Leu Val Ala Asp Ala 305 310 315 320 Ser Tyr Gly Phe Ser Val Ala ThrTyr Asn Gln Lys Trp Tyr Lys Ala 325 330 335 Asp Val Arg Tyr Lys Arg AlaLeu Val Ile Ile Ile Ala Arg Ser Gln 340 345 350 Lys Val Thr Phe Leu LysAla Thr Ile Phe Leu Asp Ile Thr Arg Ser 355 360 365 Thr Met Thr Asp ValArg Asn Cys Val Leu Ser Val 370 375 380 43 759 DNA DrosophilaMelanogaster DOR116 43 atggaactcc tgccattggc catgctaatg tacgatggaacccgggttac tgcgatgcag 60 tatttaattc cgggtctacc gcttgagaac aattattgctacgtagtcac gtacatgatt 120 cagacggtga caatgctcgt gcaaggagtc ggattctactccggtgattt gttcgtattt 180 ctcggcttaa cgcagatcct aactttcgcc gatatgctgcaggtgaaggt gaaagagcta 240 aacgatgccc tggaacaaaa agcggaatac agagctctagtccgagttgg agcttctatt 300 gatggagcgg aaaatcgtca acgccttctc ttggatgttataagatggca tcaattattc 360 acggactact gtcgcgccat aaatgccctc tactacgaattgatcgccac tcaggttctt 420 tcgatggctt tggccatgat gctcagcttc tgcattaatttgagcagctt tcacatgcct 480 tcggctatct ttttcgtggt ttctgcctac agcatgtccatctattgcat tctgggcacc 540 attcttgagt ttgcatatga ccaggtgtac gagagcatctgtaatgtgac ctggtatgag 600 ttgagtggcg aacagcgaaa gctttttggt tttttgttgcgggaatccca gtatccgcac 660 aatattcaga tacttggagt tatgtcgctt tccgtgagaacggctctgca gattgttaaa 720 ctaatttata gcgtatccat gatgatgatg aatcgggcg 75944 253 PRT Drosophila Melanogaster DOR116 44 Met Glu Leu Leu Pro Leu AlaMet Leu Met Tyr Asp Gly Thr Arg Val 1 5 10 15 Thr Ala Met Gln Tyr LeuIle Pro Gly Leu Pro Leu Glu Asn Asn Tyr 20 25 30 Cys Tyr Val Val Thr TyrMet Ile Gln Thr Val Thr Met Leu Val Gln 35 40 45 Gly Val Gly Phe Tyr SerGly Asp Leu Phe Val Phe Leu Gly Leu Thr 50 55 60 Gln Ile Leu Thr Phe AlaAsp Met Leu Gln Val Lys Val Lys Glu Leu 65 70 75 80 Asn Asp Ala Leu GluGln Lys Ala Glu Tyr Arg Ala Leu Val Arg Val 85 90 95 Gly Ala Ser Ile AspGly Ala Glu Asn Arg Gln Arg Leu Leu Leu Asp 100 105 110 Val Ile Arg TrpHis Gln Leu Phe Thr Asp Tyr Cys Arg Ala Ile Asn 115 120 125 Ala Leu TyrTyr Glu Leu Ile Ala Thr Gln Val Leu Ser Met Ala Leu 130 135 140 Ala MetMet Leu Ser Phe Cys Ile Asn Leu Ser Ser Phe His Met Pro 145 150 155 160Ser Ala Ile Phe Phe Val Val Ser Ala Tyr Ser Met Ser Ile Tyr Cys 165 170175 Ile Leu Gly Thr Ile Leu Glu Phe Ala Tyr Asp Gln Val Tyr Glu Ser 180185 190 Ile Cys Asn Val Thr Trp Tyr Glu Leu Ser Gly Glu Gln Arg Lys Leu195 200 205 Phe Gly Phe Leu Leu Arg Glu Ser Gln Tyr Pro His Asn Ile GlnIle 210 215 220 Leu Gly Val Met Ser Leu Ser Val Arg Thr Ala Leu Gln IleVal Lys 225 230 235 240 Leu Ile Tyr Ser Val Ser Met Met Met Met Asn ArgAla 245 250 45 1152 DNA Drosophila Melanogaster DOR117 45 atggatctgcgaaggtggtt tccgaccttg tacacccagt cgaaggattc gccagttcgc 60 tcccgagacgcgaccctgta cctcctacgc tgcgtcttct taatgggcgt ccgcaagcca 120 cctgccaagtttttcgtggc ctacgtgctc tggtccttcg cactgaattt ctgctcaaca 180 ttttatcagccaattggctt tctcacaggc tatataagcc atttatcaga gttctccccg 240 ggagagtttctaacttcgct gcaggtggcc tttaatgctt ggtcctgctc tacaaaagtc 300 ctgatagtgtgggcactagt taagcgcttt gacgaggcta ataaccttct cgacgagatg 360 gataggcgtatcacagaccc cggagagcgt cttcagattc atcgcgctgt ctccctcagt 420 aaccgtatattcttcttttt catggcagtc tacatggttt atgccactaa tacgtttctg 480 tcggcgatcttcattggaag gccaccgtac caaaattact acccttttct ggactggcga 540 tctagcactctgcatctagc tctgcaggcc ggtctggaat acttcgccat ggctggcgcc 600 tgcttccaggacgtttgcgt tgattgctac ccagtcaatt tcgttttggt cctgcgtgcc 660 cacatgtcgatcttcgcgga gcgccttcga cgtttgggaa cttatcctta tgaaagccag 720 gagcagaaatatgaacgatt ggttcagtgc atacaagatc acaaagtaat tttgcgattt 780 gttgactgcctgcgtcctgt tatttctggt accatcttcg tgcaattctt ggttgtgggg 840 ttggtgctgggctttaccct aattaacatt gtcctgttcg ccaacttggg atcggccatc 900 gcagcgctctcgtttatggc cgcagtgctt ctagagacga ctcccttctg catattgtgc 960 aattatctcacagaagactg ctacaagctg gccgatgccc tgtttcagtc aaactggatt 1020 gatgaggagaaacgatacca aaagacactc atgtacttcc tacagaaact gcagcagcct 1080 ataaccttcatggctatgaa cgtgtttcca atatctgtgg gaactaacat cagtgtaagc 1140 agatgtgccctt 1152 46 384 PRT Drosophila Melanogaster DOR117 46 Met Asp Leu Arg ArgTrp Phe Pro Thr Leu Tyr Thr Gln Ser Lys Asp 1 5 10 15 Ser Pro Val ArgSer Arg Asp Ala Thr Leu Tyr Leu Leu Arg Cys Val 20 25 30 Phe Leu Met GlyVal Arg Lys Pro Pro Ala Lys Phe Phe Val Ala Tyr 35 40 45 Val Leu Trp SerPhe Ala Leu Asn Phe Cys Ser Thr Phe Tyr Gln Pro 50 55 60 Ile Gly Phe LeuThr Gly Tyr Ile Ser His Leu Ser Glu Phe Ser Pro 65 70 75 80 Gly Glu PheLeu Thr Ser Leu Gln Val Ala Phe Asn Ala Trp Ser Cys 85 90 95 Ser Thr LysVal Leu Ile Val Trp Ala Leu Val Lys Arg Phe Asp Glu 100 105 110 Ala AsnAsn Leu Leu Asp Glu Met Asp Arg Arg Ile Thr Asp Pro Gly 115 120 125 GluArg Leu Gln Ile His Arg Ala Val Ser Leu Ser Asn Arg Ile Phe 130 135 140Phe Phe Phe Met Ala Val Tyr Met Val Tyr Ala Thr Asn Thr Phe Leu 145 150155 160 Ser Ala Ile Phe Ile Gly Arg Pro Pro Tyr Gln Asn Tyr Tyr Pro Phe165 170 175 Leu Asp Trp Arg Ser Ser Thr Leu His Leu Ala Leu Gln Ala GlyLeu 180 185 190 Glu Tyr Phe Ala Met Ala Gly Ala Cys Phe Gln Asp Val CysVal Asp 195 200 205 Cys Tyr Pro Val Asn Phe Val Leu Val Leu Arg Ala HisMet Ser Ile 210 215 220 Phe Ala Glu Arg Leu Arg Arg Leu Gly Thr Tyr ProTyr Glu Ser Gln 225 230 235 240 Glu Gln Lys Tyr Glu Arg Leu Val Gln CysIle Gln Asp His Lys Val 245 250 255 Ile Leu Arg Phe Val Asp Cys Leu ArgPro Val Ile Ser Gly Thr Ile 260 265 270 Phe Val Gln Phe Leu Val Val GlyLeu Val Leu Gly Phe Thr Leu Ile 275 280 285 Asn Ile Val Leu Phe Ala AsnLeu Gly Ser Ala Ile Ala Ala Leu Ser 290 295 300 Phe Met Ala Ala Val LeuLeu Glu Thr Thr Pro Phe Cys Ile Leu Cys 305 310 315 320 Asn Tyr Leu ThrGlu Asp Cys Tyr Lys Leu Ala Asp Ala Leu Phe Gln 325 330 335 Ser Asn TrpIle Asp Glu Glu Lys Arg Tyr Gln Lys Thr Leu Met Tyr 340 345 350 Phe LeuGln Lys Leu Gln Gln Pro Ile Thr Phe Met Ala Met Asn Val 355 360 365 PhePro Ile Ser Val Gly Thr Asn Ile Ser Val Ser Arg Cys Ala Leu 370 375 38047 1116 DNA Drosophila Melanogaster DOR118 47 atgaagttta ttggatggctgccccccaag cagggtgtgc tccggtatgt gtacctcacc 60 tggacgctaa tgacgttcgtgtggtgtaca acgtacctgc cgcttggctt ccttggtagc 120 tacatgacgc agatcaagtccttctcccct ggagagtttc tcacttcact ccaggtgtgc 180 attaatgcct acggctcatcggtaaaagtt gcaatcacat actccatgct ctggcgcctt 240 atcaaggcca agaacattttggaccagctg gacctgcgct gcaccgccat ggaggagcgc 300 gaaaagatcc acctagtggtggcccgcagc aaccatgcct ttctcatctt cacctttgtc 360 tactgcggat atgccggctccacctacctg agctcggttc tcagcgggcg tccgccctgg 420 cagctgtaca atccctttattgattggcat gacggcacac tcaagctctg ggtggcctcc 480 acgttggagt acatggtgatgtcaggcgcc gttctgcagg atcaactctc ggactcttac 540 ccattgatct ataccctcatccttcgtgct cacttggaca tgctaaggga gcgcatccga 600 cgcctccgtt ccgatgagaacctgagcgag gccgagagct atgaagagct ggtcaaatgt 660 gtgatggacc acaagctcattctaagatac tgcgcgatta ttaaaccagt aatccagggg 720 accatcttca cacagtttctgctgatcggc ctggttctgg gcttcacgct gatcaacgtg 780 tttttcttct cagacatctggacgggcatc gcatcattta tgtttgttat aaccattttg 840 ctgcagacct tccccttctgctacacatgc aacctcatca tggaggactg cgagtccttg 900 acccatgcta ttttccagtccaactgggtg gatgccagtc gtcgctacaa aacaacacta 960 ctgtattttc tccaaaacgtgcagcagcct atcgttttca ttgcaggcgg tatctttcag 1020 atatccatga gcagcaacataagtgtggca aagtttgctt tctccgtgat aaccattacc 1080 aagcaaatga atatagctgacaaatttaag acggac 1116 48 372 PRT Drosophila Melanogaster DOR118 48 MetLys Phe Ile Gly Trp Leu Pro Pro Lys Gln Gly Val Leu Arg Tyr 1 5 10 15Val Tyr Leu Thr Trp Thr Leu Met Thr Phe Val Trp Cys Thr Thr Tyr 20 25 30Leu Pro Leu Gly Phe Leu Gly Ser Tyr Met Thr Gln Ile Lys Ser Phe 35 40 45Ser Pro Gly Glu Phe Leu Thr Ser Leu Gln Val Cys Ile Asn Ala Tyr 50 55 60Gly Ser Ser Val Lys Val Ala Ile Thr Tyr Ser Met Leu Trp Arg Leu 65 70 7580 Ile Lys Ala Lys Asn Ile Leu Asp Gln Leu Asp Leu Arg Cys Thr Ala 85 9095 Met Glu Glu Arg Glu Lys Ile His Leu Val Val Ala Arg Ser Asn His 100105 110 Ala Phe Leu Ile Phe Thr Phe Val Tyr Cys Gly Tyr Ala Gly Ser Thr115 120 125 Tyr Leu Ser Ser Val Leu Ser Gly Arg Pro Pro Trp Gln Leu TyrAsn 130 135 140 Pro Phe Ile Asp Trp His Asp Gly Thr Leu Lys Leu Trp ValAla Ser 145 150 155 160 Thr Leu Glu Tyr Met Val Met Ser Gly Ala Val LeuGln Asp Gln Leu 165 170 175 Ser Asp Ser Tyr Pro Leu Ile Tyr Thr Leu IleLeu Arg Ala His Leu 180 185 190 Asp Met Leu Arg Glu Arg Ile Arg Arg LeuArg Ser Asp Glu Asn Leu 195 200 205 Ser Glu Ala Glu Ser Tyr Glu Glu LeuVal Lys Cys Val Met Asp His 210 215 220 Lys Leu Ile Leu Arg Tyr Cys AlaIle Ile Lys Pro Val Ile Gln Gly 225 230 235 240 Thr Ile Phe Thr Gln PheLeu Leu Ile Gly Leu Val Leu Gly Phe Thr 245 250 255 Leu Ile Asn Val PhePhe Phe Ser Asp Ile Trp Thr Gly Ile Ala Ser 260 265 270 Phe Met Phe ValIle Thr Ile Leu Leu Gln Thr Phe Pro Phe Cys Tyr 275 280 285 Thr Cys AsnLeu Ile Met Glu Asp Cys Glu Ser Leu Thr His Ala Ile 290 295 300 Phe GlnSer Asn Trp Val Asp Ala Ser Arg Arg Tyr Lys Thr Thr Leu 305 310 315 320Leu Tyr Phe Leu Gln Asn Val Gln Gln Pro Ile Val Phe Ile Ala Gly 325 330335 Gly Ile Phe Gln Ile Ser Met Ser Ser Asn Ile Ser Val Ala Lys Phe 340345 350 Ala Phe Ser Val Ile Thr Ile Thr Lys Gln Met Asn Ile Ala Asp Lys355 360 365 Phe Lys Thr Asp 370 49 1194 DNA Drosophila MelanogasterDOR119 49 atggcggtgt tcaagctaat caaaccggct ccgttgaccg agaaggtgcagtcccgccag 60 gggaatatat atctgtaccg tgccatgtgg ctcatcggat ggattccgccgaaggaggga 120 gtcctgcgct acgtgtatct cttctggacc tgcgtgccct tcgccttcggggtgttttac 180 ctgcccgtgg gcttcatcat cagctacgtg caggagttca agaacttcacgccgggcgag 240 ttccttacct cgctgcaggt gtgcatcaat gtgtatggcg cctcggtgaagtccaccatc 300 acctacctct tcctctggcg actgcgcaag acggagatcc ttctggactccctggacaag 360 aggctggcga acgacagcga tcgcgagagg atccacaata tggtggcgcgctgcaactac 420 gcctttctca tctacagctt catctactgc ggatacgcgg gttccactttcctgtcctac 480 gccctcagtg gtcgtcctcc gtggtccgtc tacaatccct tcatcgattggcgcgatggc 540 atgggcagcc tgtggatcca ggccatattc gagtacatca ccatgtccttcgccgtgctg 600 caggaccagc tatccgacac gtatcccctg atgttcacca ttatgttccgggcccacatg 660 gaggtcctca aggatcacgt gcggagcctg cgcatggatc ccgagcgcagtgaggcagac 720 aactatcagg atctggtgaa ctgcgtgctg gaccacaaga ctatactgaaatgctgtgac 780 atgattcgcc ccatgatatc ccgcaccatc ttcgtgcaat tcgcgctgattggttccgtt 840 ttgggcctga ccctggtgaa cgtgttcttc ttctcgaact tctggaagggcgtggcctcg 900 ctcctgttcg tcatcaccat cctgctgcag accttcccgt tctgctacacctgcaacatg 960 ctgatcgacg atgcccagga tctgtccaac gagattttcc agtccaactgggtggacgcg 1020 gagccgcgct acaaggcgac gctggtgctc ttcatgcacc atgttcagcagcccataatc 1080 ttcattgccg gaggcatctt tcccatctct atgaacagca acataaccgtggccaagttc 1140 gccttcagca tcattacaat agtgcgacaa atgaatctgg ccgagcagttccag 1194 50 398 PRT Drosophila Melanogaster DOR119 50 Met Ala Val PheLys Leu Ile Lys Pro Ala Pro Leu Thr Glu Lys Val 1 5 10 15 Gln Ser ArgGln Gly Asn Ile Tyr Leu Tyr Arg Ala Met Trp Leu Ile 20 25 30 Gly Trp IlePro Pro Lys Glu Gly Val Leu Arg Tyr Val Tyr Leu Phe 35 40 45 Trp Thr CysVal Pro Phe Ala Phe Gly Val Phe Tyr Leu Pro Val Gly 50 55 60 Phe Ile IleSer Tyr Val Gln Glu Phe Lys Asn Phe Thr Pro Gly Glu 65 70 75 80 Phe LeuThr Ser Leu Gln Val Cys Ile Asn Val Tyr Gly Ala Ser Val 85 90 95 Lys SerThr Ile Thr Tyr Leu Phe Leu Trp Arg Leu Arg Lys Thr Glu 100 105 110 IleLeu Leu Asp Ser Leu Asp Lys Arg Leu Ala Asn Asp Ser Asp Arg 115 120 125Glu Arg Ile His Asn Met Val Ala Arg Cys Asn Tyr Ala Phe Leu Ile 130 135140 Tyr Ser Phe Ile Tyr Cys Gly Tyr Ala Gly Ser Thr Phe Leu Ser Tyr 145150 155 160 Ala Leu Ser Gly Arg Pro Pro Trp Ser Val Tyr Asn Pro Phe IleAsp 165 170 175 Trp Arg Asp Gly Met Gly Ser Leu Trp Ile Gln Ala Ile PheGlu Tyr 180 185 190 Ile Thr Met Ser Phe Ala Val Leu Gln Asp Gln Leu SerAsp Thr Tyr 195 200 205 Pro Leu Met Phe Thr Ile Met Phe Arg Ala His MetGlu Val Leu Lys 210 215 220 Asp His Val Arg Ser Leu Arg Met Asp Pro GluArg Ser Glu Ala Asp 225 230 235 240 Asn Tyr Gln Asp Leu Val Asn Cys ValLeu Asp His Lys Thr Ile Leu 245 250 255 Lys Cys Cys Asp Met Ile Arg ProMet Ile Ser Arg Thr Ile Phe Val 260 265 270 Gln Phe Ala Leu Ile Gly SerVal Leu Gly Leu Thr Leu Val Asn Val 275 280 285 Phe Phe Phe Ser Asn PheTrp Lys Gly Val Ala Ser Leu Leu Phe Val 290 295 300 Ile Thr Ile Leu LeuGln Thr Phe Pro Phe Cys Tyr Thr Cys Asn Met 305 310 315 320 Leu Ile AspAsp Ala Gln Asp Leu Ser Asn Glu Ile Phe Gln Ser Asn 325 330 335 Trp ValAsp Ala Glu Pro Arg Tyr Lys Ala Thr Leu Val Leu Phe Met 340 345 350 HisHis Val Gln Gln Pro Ile Ile Phe Ile Ala Gly Gly Ile Phe Pro 355 360 365Ile Ser Met Asn Ser Asn Ile Thr Val Ala Lys Phe Ala Phe Ser Ile 370 375380 Ile Thr Ile Val Arg Gln Met Asn Leu Ala Glu Gln Phe Gln 385 390 39551 1233 DNA Drosophila Melanogaster DOR120 51 atgaccaagt tcttcttcaagcgcctgcaa actgctccac ttgatcagga ggtgagttcc 60 cttgatgcca gcgactactactaccgcatc gcatttttcc tgggctggac cccgcccaag 120 ggggctctgc tccgatggatctactccctg tggactctga ccacgatgtg gctgggtatc 180 gtgtacctgc cgctcggactgagcctcacc tatgtgaagc acttcgatag attcacgccg 240 acggagttcc tgacctccctgcaggtggat atcaactgca tcgggaacgt gatcaagtca 300 tgcgtaactt attcccagatgtggcgtttt cgccggatga atgagcttat ctcgtccctg 360 gacaagagat gtgtgactacgacacagcgt cgaattttcc ataagatggt ggcacgggtt 420 aatctcatcg tgattctgttcttgtccacg tacttgggct tctgctttct aactctgttc 480 acttcggttt tcgctggcaaagctccttgg cagctgtaca acccactggt ggactggcgg 540 aaaggccatt ggcagctatggattgcctcc atcctggagt actgtgtggt ctccattggc 600 accatgcagg agttgatgtccgacacctac gccatagtgt tcatctcctt gttccgctgc 660 cacctggcta ttctcagagatcgcatagct aatctgcggc aggatccgaa actcagtgag 720 atggaacact atgagcagatggtggcctgc attcaggatc atcgaaccat catacagtgc 780 tcccagatta ttcgacccatcctgtcgatc actatctttg cccagttcat gctggttggc 840 attgacttgg gtctggcggccatcagcatc ctcttctttc cgaacaccat ttggacgatc 900 atggcaaacg tgtcgttcatcgtggccatc tgtacagagt cctttccatg ctgcatgctc 960 tgcgagcatc tgatcgaggactccgtccat gtgagcaacg ccctgttcca ctcaaactgg 1020 ataaccgcgg acaggagctacaagtcggcg gttctgtatt tcctgcaccg ggctcagcaa 1080 cccattcaat tcacggccggctccatattt cccatttcgg tgcagagcaa catagccgtg 1140 gccaagttcg cgttcacaatcatcacaatc gtgaaccaaa tgaatctggg cgagaagttc 1200 ttcagtgaca ggagcaatggcgatataaat cct 1233 52 411 PRT Drosophila Melanogaster DOR120 52 Met ThrLys Phe Phe Phe Lys Arg Leu Gln Thr Ala Pro Leu Asp Gln 1 5 10 15 GluVal Ser Ser Leu Asp Ala Ser Asp Tyr Tyr Tyr Arg Ile Ala Phe 20 25 30 PheLeu Gly Trp Thr Pro Pro Lys Gly Ala Leu Leu Arg Trp Ile Tyr 35 40 45 SerLeu Trp Thr Leu Thr Thr Met Trp Leu Gly Ile Val Tyr Leu Pro 50 55 60 LeuGly Leu Ser Leu Thr Tyr Val Lys His Phe Asp Arg Phe Thr Pro 65 70 75 80Thr Glu Phe Leu Thr Ser Leu Gln Val Asp Ile Asn Cys Ile Gly Asn 85 90 95Val Ile Lys Ser Cys Val Thr Tyr Ser Gln Met Trp Arg Phe Arg Arg 100 105110 Met Asn Glu Leu Ile Ser Ser Leu Asp Lys Arg Cys Val Thr Thr Thr 115120 125 Gln Arg Arg Ile Phe His Lys Met Val Ala Arg Val Asn Leu Ile Val130 135 140 Ile Leu Phe Leu Ser Thr Tyr Leu Gly Phe Cys Phe Leu Thr LeuPhe 145 150 155 160 Thr Ser Val Phe Ala Gly Lys Ala Pro Trp Gln Leu TyrAsn Pro Leu 165 170 175 Val Asp Trp Arg Lys Gly His Trp Gln Leu Trp IleAla Ser Ile Leu 180 185 190 Glu Tyr Cys Val Val Ser Ile Gly Thr Met GlnGlu Leu Met Ser Asp 195 200 205 Thr Tyr Ala Ile Val Phe Ile Ser Leu PheArg Cys His Leu Ala Ile 210 215 220 Leu Arg Asp Arg Ile Ala Asn Leu ArgGln Asp Pro Lys Leu Ser Glu 225 230 235 240 Met Glu His Tyr Glu Gln MetVal Ala Cys Ile Gln Asp His Arg Thr 245 250 255 Ile Ile Gln Cys Ser GlnIle Ile Arg Pro Ile Leu Ser Ile Thr Ile 260 265 270 Phe Ala Gln Phe MetLeu Val Gly Ile Asp Leu Gly Leu Ala Ala Ile 275 280 285 Ser Ile Leu PhePhe Pro Asn Thr Ile Trp Thr Ile Met Ala Asn Val 290 295 300 Ser Phe IleVal Ala Ile Cys Thr Glu Ser Phe Pro Cys Cys Met Leu 305 310 315 320 CysGlu His Leu Ile Glu Asp Ser Val His Val Ser Asn Ala Leu Phe 325 330 335His Ser Asn Trp Ile Thr Ala Asp Arg Ser Tyr Lys Ser Ala Val Leu 340 345350 Tyr Phe Leu His Arg Ala Gln Gln Pro Ile Gln Phe Thr Ala Gly Ser 355360 365 Thr Phe Pro Ile Ser Val Gln Ser Asn Ile Ala Val Ala Lys Phe Ala370 375 380 Phe Thr Ile Ile Thr Ile Val Asn Gln Met Asn Leu Gly Glu LysPhe 385 390 395 400 Phe Ser Asp Arg Ser Asn Gly Asp Ile Asn Pro 405 41053 1203 DNA Drosophila Melanogaster DOR121 53 atgctgacgg acaagttcctccgactgcag tccgctttat ttcgccttct cggactcgaa 60 ttgttgcacg agcaggatgttggccatcga tatccttggc gcagcatctg ctgcattctc 120 tcggtggcca gtttcatgcccctgaccatt gcgtttggcc tgcaaaacgt ccaaaatgtg 180 gagcaattaa ccgactcactctgctcggtt ctcgtggatt tgctggccct gtgcaaaatc 240 gggcttttcc tttggctttacaaggacttc aagttcctaa tagggcagtt ctattgtgtt 300 ttgcaaacgg aaacccacaccgctgtcgct gaaatgatag tgaccaggga aagtcgtcgg 360 gatcagttca tcagtgctatgtatgcctac tgtttcatta cggctggcct ttcggcctgc 420 ctgatgtccc ctctatccatgctgattagc taccacgaac aggtgaattg cagccgaaat 480 ttccatttcc cagtgtgtaagaaaaagtac tgcttaatat ccagaatatt aagatacagt 540 ttctgcagat atccctgggacaatatgaag ctgtccaact acatcatttc ctatttctgg 600 aatgtgtgtg ctgcattgggcgtggcactg cccaccgttt gtgtggacac actgttctgt 660 tctctgagcc ataatctctgtgccctattc cagattgcca ggcacaaaat gatgcacttt 720 gagggcagaa ataccaaagagactcatgag aacttaaagc acgtgtttca actatatgcg 780 ttgtgtttga acctgggccatttcttaaac gaatatttca gaccgctcat ctgccagttt 840 gtggcagcct cactgcacttgtgtgtcctg tgctaccaac tgtctgccaa tatcctgcag 900 ccagcgttac tcttctatgccgcatttacg gcagcagttg ttggccaggt gtctatatac 960 tgcttctgcg gatcgagcatccattcggag tgtcagctat ttggccaggc catctacgag 1020 tccagctggc cccatctgctgcaggaaaac ctgcagcttg taagctcctt aaaaattgcc 1080 atgatgcgat cgagtttgggatgtcccatc gatggttact tcttcgaggc caatcgggag 1140 acgctcatca cggtgagtaaagcgtttata aaagtgtcca aaaagacacc tcaagtgaat 1200 gat 1203 54 401 PRTDrosophila Melanogaster DOR121 54 Met Leu Thr Asp Lys Phe Leu Arg LeuGln Ser Ala Leu Phe Arg Leu 1 5 10 15 Leu Gly Leu Glu Leu Leu His GluGln Asp Val Gly His Arg Tyr Pro 20 25 30 Trp Arg Ser Ile Cys Cys Ile LeuSer Val Ala Ser Phe Met Pro Leu 35 40 45 Thr Ile Ala Phe Gly Leu Gln AsnVal Gln Asn Val Glu Gln Leu Thr 50 55 60 Asp Ser Leu Cys Ser Val Leu ValAsp Leu Leu Ala Leu Cys Lys Ile 65 70 75 80 Gly Leu Phe Leu Trp Leu TyrLys Asp Phe Lys Phe Leu Ile Gly Gln 85 90 95 Phe Tyr Cys Val Leu Gln ThrGlu Thr His Thr Ala Val Ala Glu Met 100 105 110 Ile Val Thr Arg Glu SerArg Arg Asp Gln Phe Ile Ser Ala Met Tyr 115 120 125 Ala Tyr Cys Phe IleThr Ala Gly Leu Ser Ala Cys Leu Met Ser Pro 130 135 140 Leu Ser Met LeuIle Ser Tyr His Glu Gln Val Asn Cys Ser Arg Asn 145 150 155 160 Phe HisPhe Pro Val Cys Lys Lys Lys Tyr Cys Leu Ile Ser Arg Ile 165 170 175 LeuArg Tyr Ser Phe Cys Arg Tyr Pro Trp Asp Asn Met Lys Leu Ser 180 185 190Asn Tyr Ile Ile Ser Tyr Phe Trp Asn Val Cys Ala Ala Leu Gly Val 195 200205 Ala Leu Pro Thr Val Cys Val Asp Thr Leu Phe Cys Ser Leu Ser His 210215 220 Asn Leu Cys Ala Leu Phe Gln Ile Ala Arg His Lys Met Met His Phe225 230 235 240 Glu Gly Arg Asn Thr Lys Glu Thr His Glu Asn Leu Lys HisVal Phe 245 250 255 Gln Leu Tyr Ala Leu Cys Leu Asn Leu Gly His Phe LeuAsn Glu Tyr 260 265 270 Phe Arg Pro Leu Ile Cys Gln Phe Val Ala Ala SerLeu His Leu Cys 275 280 285 Val Leu Cys Tyr Gln Leu Ser Ala Asn Ile LeuGln Pro Ala Leu Leu 290 295 300 Phe Tyr Ala Ala Phe Thr Ala Ala Val ValGly Gln Val Ser Ile Tyr 305 310 315 320 Cys Phe Cys Gly Ser Ser Ile HisSer Glu Cys Gln Leu Phe Gly Gln 325 330 335 Ala Ile Tyr Glu Ser Ser TrpPro His Leu Leu Gln Glu Asn Leu Gln 340 345 350 Leu Val Ser Ser Leu LysIle Ala Met Met Arg Ser Ser Leu Gly Cys 355 360 365 Pro Ile Asp Gly TyrPhe Phe Glu Ala Asn Arg Glu Thr Leu Ile Thr 370 375 380 Val Ser Lys AlaPhe Ile Lys Val Ser Lys Lys Thr Pro Gln Val Asn 385 390 395 400 Asp 551122 DNA Drosophila Melanogaster DOR14 55 atggactacg atcgaattcgaccggtgcga tttttgacgg gagtgctgaa atggtggcgt 60 ctctggccga ggaaggaatcggtgtccaca ccggactgga ctaactggca ggcatatgcc 120 ttgcacgttc catttacattcttgtttgtg ttgcttttgt ggttggaggc aatcaagagc 180 agggatatac agcataccgccgatgtcctt ttgatttgcc taaccaccac tgccttggga 240 ggtaaagtta tcaatatctggaagtatgcc catgtggccc aaggcatttt gtccgagtgg 300 agcacgtggg atcttttcgagctgaggagc aaacaggaag tggatatgtg gcgattcgag 360 catcgacgtt tcaatcgtgtttttatgttt tactgtttgt gcagtgctgg tgtaatccca 420 tttattgtga ttcaaccgttgtttgatatc ccaaatcgat tgcccttctg gatgtggaca 480 ccattcgatt ggcagcagcctgttctcttc tggtatgcat tcatctatca ggccacaacc 540 attcctattg cctgtgcttgcaacgtaacc atggacgctg ttaattggta cttgatgctg 600 catctgtcct tgtgtttgcgtatgttgggc cagcgattga gtaagcttca gcatgatgac 660 aaggatctga gggagaagttcctggaactg atccatctgc accagcgact caagcaacag 720 gccttgagca ttgaaatctttatttcgaag agcacgttca cccaaattct ggtcagttcc 780 cttatcattt gcttcaccatttacagcatg cagatggact tgccaggatt tgccgccatg 840 atgcagtacc tagtggccatgatcatgcag gtcatgctgc ccaccatata tggtaacgcc 900 gtcatcgatt ctgcaaatatgttgaccgat tccatgtaca attcggattg gccggatatg 960 aattgccgaa tgcgtcgcctagttttaatg tttatggtgt acttaaatcg accggtgacc 1020 ttaaaagccg gtggcttttttcatattggt ttacctctgt ttaccaaggt tgtattttct 1080 actctggaaa atccttgtataagttatctt tatttcagac ca 1122 56 374 PRT Drosophila Melanogaster DOR1456 Met Asp Tyr Asp Arg Ile Arg Pro Val Arg Phe Leu Thr Gly Val Leu 1 510 15 Lys Trp Trp Arg Leu Trp Pro Arg Lys Glu Ser Val Ser Thr Pro Asp 2025 30 Trp Thr Asn Trp Gln Ala Tyr Ala Leu His Val Pro Phe Thr Phe Leu 3540 45 Phe Val Leu Leu Leu Trp Leu Glu Ala Ile Lys Ser Arg Asp Ile Gln 5055 60 His Thr Ala Asp Val Leu Leu Ile Cys Leu Thr Thr Thr Ala Leu Gly 6570 75 80 Gly Lys Val Ile Asn Ile Trp Lys Tyr Ala His Val Ala Gln Gly Ile85 90 95 Leu Ser Glu Trp Ser Thr Trp Asp Leu Phe Glu Leu Arg Ser Lys Gln100 105 110 Glu Val Asp Met Trp Arg Phe Glu His Arg Arg Phe Asn Arg ValPhe 115 120 125 Met Phe Tyr Cys Leu Cys Ser Ala Gly Val Ile Pro Phe IleVal Ile 130 135 140 Gln Pro Leu Phe Asp Ile Pro Asn Arg Leu Pro Phe TrpMet Trp Thr 145 150 155 160 Pro Phe Asp Trp Gln Gln Pro Val Leu Phe TrpTyr Ala Phe Ile Tyr 165 170 175 Gln Ala Thr Thr Ile Pro Ile Ala Cys AlaCys Asn Val Thr Met Asp 180 185 190 Ala Val Asn Trp Tyr Leu Met Leu HisLeu Ser Leu Cys Leu Arg Met 195 200 205 Leu Gly Gln Arg Leu Ser Lys LeuGln His Asp Asp Lys Asp Leu Arg 210 215 220 Glu Lys Phe Leu Glu Leu IleHis Leu His Gln Arg Leu Lys Gln Gln 225 230 235 240 Ala Leu Ser Ile GluIle Phe Ile Ser Lys Ser Thr Phe Thr Gln Ile 245 250 255 Leu Val Ser SerLeu Ile Ile Cys Phe Thr Ile Tyr Ser Met Gln Met 260 265 270 Asp Leu ProGly Phe Ala Ala Met Met Gln Tyr Leu Val Ala Met Ile 275 280 285 Met GlnVal Met Leu Pro Thr Ile Tyr Gly Asn Ala Val Ile Asp Ser 290 295 300 AlaAsn Met Leu Thr Asp Ser Met Tyr Asn Ser Asp Trp Pro Asp Met 305 310 315320 Asn Cys Arg Met Arg Arg Leu Val Leu Met Phe Met Val Tyr Leu Asn 325330 335 Arg Pro Val Thr Leu Lys Ala Gly Gly Phe Phe His Ile Gly Leu Pro340 345 350 Leu Phe Thr Lys Val Val Phe Ser Thr Leu Glu Asn Pro Cys IleSer 355 360 365 Tyr Leu Tyr Phe Arg Pro 370 57 1140 DNA DrosophilaMelanogaster DOR16 57 atgactgaca gcgggcagcc tgccattgcc gaccacttttatcggattcc ccgcatctcc 60 ggcctcattg tcggcctctg gccgcaaagg ataaggggcgggggcggtcg tccttggcac 120 gcccatctgc tcttcgtgtt cgccttcgcc atggtggtggtgggtgcggt gggcgaggtg 180 tcgtacggct gtgtccacct ggacaacctg gtggtggcgctggaggcctt ctgccccgga 240 accaccaagg cggtctgcgt tttgaagctg tgggtcttcttccgctccaa tcgccggtgg 300 gcggagttgg tccagcgcct gcgggctatt ttgtgggaatcgcggcggca ggaggcccag 360 aggatgctgg tcggactggc caccacggcc aacaggctcagcctgttgtt gctcagctct 420 ggcacggcga caaatgccgc cttcaccttg caaccgctgattatgggtct ctaccgctgg 480 attgtgcagc tgccaggtca aaccgagctg ccctttaatatcatactgcc ctcgtttgcc 540 gtgcagccag gagtctttcc gctcacctac gtgctgctgaccgcttccgg tgcctgcacc 600 gttttcgcct tcagcttcgt ggacggattc ttcatttgctcgtgcctcta catctgcggc 660 gctttccggc tggtgcagca ggacattcgc aggatatttgccgatttgca tggcgactca 720 gtggatgtgt tcaccgagga gatgaacgcg gaggtgcggcacagactggc ccaagttgtc 780 gagcggcaca atgcgattat cgatttctgc acggacctaacacgccagtt caccgttatc 840 gttttaatgc atttcctgtc cgccgccttc gtcctctgctcgaccatcct ggacatcatg 900 ttggtgagcc ccttttcaga ggccttcctt tggggcgggtatccttgggt ttgtcgcgcc 960 actggctttt cgcatcgcct gcattcggcg gctgttttaaaagtttttcc ctgttttcac 1020 tgtttgctgt ttttccctgg cttttccagc cgctccgttctgattcggtt ttcccgattt 1080 gtttgtttgc tttgtggctg cggctgcggc tctctccggtggcaatttat aagcgcatga 1140 58 379 PRT Drosophila Melanogaster DOR16 58Met Thr Asp Ser Gly Gln Pro Ala Ile Ala Asp His Phe Tyr Arg Ile 1 5 1015 Pro Arg Ile Ser Gly Leu Ile Val Gly Leu Trp Pro Gln Arg Ile Arg 20 2530 Gly Gly Gly Gly Arg Pro Trp His Ala His Leu Leu Phe Val Phe Ala 35 4045 Phe Ala Met Val Val Val Gly Ala Val Gly Glu Val Ser Tyr Gly Cys 50 5560 Val His Leu Asp Asn Leu Val Val Ala Leu Glu Ala Phe Cys Pro Gly 65 7075 80 Thr Thr Lys Ala Val Cys Val Leu Lys Leu Trp Val Phe Phe Arg Ser 8590 95 Asn Arg Arg Trp Ala Glu Leu Val Gln Arg Leu Arg Ala Ile Leu Trp100 105 110 Glu Ser Arg Arg Gln Glu Ala Gln Arg Met Leu Val Gly Leu AlaThr 115 120 125 Thr Ala Asn Arg Leu Ser Leu Leu Leu Leu Ser Ser Gly ThrAla Thr 130 135 140 Asn Ala Ala Phe Thr Leu Gln Pro Leu Ile Met Gly LeuTyr Arg Trp 145 150 155 160 Ile Val Gln Leu Pro Gly Gln Thr Glu Leu ProPhe Asn Ile Ile Leu 165 170 175 Pro Ser Phe Ala Val Gln Pro Gly Val PhePro Leu Thr Tyr Val Leu 180 185 190 Leu Thr Ala Ser Gly Ala Cys Thr ValPhe Ala Phe Ser Phe Val Asp 195 200 205 Gly Phe Phe Ile Cys Ser Cys LeuTyr Ile Cys Gly Ala Phe Arg Leu 210 215 220 Val Gln Gln Asp Ile Arg ArgIle Phe Ala Asp Leu His Gly Asp Ser 225 230 235 240 Val Asp Val Phe ThrGlu Glu Met Asn Ala Glu Val Arg His Arg Leu 245 250 255 Ala Gln Val ValGlu Arg His Asn Ala Ile Ile Asp Phe Cys Thr Asp 260 265 270 Leu Thr ArgGln Phe Thr Val Ile Val Leu Met His Phe Leu Ser Ala 275 280 285 Ala PheVal Leu Cys Ser Thr Ile Leu Asp Ile Met Leu Val Ser Pro 290 295 300 PheSer Glu Ala Phe Leu Trp Gly Gly Tyr Pro Trp Val Cys Arg Ala 305 310 315320 Thr Gly Phe Ser His Arg Leu His Ser Ala Ala Val Leu Lys Val Phe 325330 335 Pro Cys Phe His Cys Leu Leu Phe Phe Pro Gly Phe Ser Ser Arg Ser340 345 350 Val Leu Ile Arg Phe Ser Arg Phe Val Cys Leu Leu Cys Gly CysGly 355 360 365 Cys Gly Ser Leu Arg Trp Gln Phe Ile Ser Ala 370 375 591215 DNA Drosophila Melanogaster DOR20 59 atgagcaaag gagtagaaatcttttacaag ggccagaagg cattcttgaa catcctctcg 60 ttgtggcctc agatagaacgccggtggaga atcatccacc aggtgaacta tgtccacgta 120 attgtgtttt gggtgctgctctttgatctc ctcttggtgc tccatgtgat ggctaatttg 180 agctacatgt ccgaggttgtgaaagccatc tttatcctgg ccaccagtgc agggcacacc 240 accaagctgc tgtccataaaggcgaacaat gtgcagatgg aggagctctt taggagattg 300 gataacgaag agttccgtcctagaggcgcc aacgaagagt tgatctttgc agcagcctgt 360 gaaagaagta ggaagcttcgggacttctat ggagcgcttt cgtttgccgc cttgagcatg 420 attctcatac cccagttcgccttggactgg tcccaccttc cgctcaaaac atacaatccg 480 cttggcgaga ataccggctcacctgcttat tggctcctct actgctatca gtgtctggcc 540 ttgtccgtat cctgcatcaccaacatagga ttcgactcac tctgctcctc actgttcatc 600 ttcctcaagt gccagctggacattctggcc gtgcgactgg acaagatcgg tcggttaatc 660 actacttctg gtggcactgtggaacagcaa cttaaggaaa atatccgcta tcacatgacc 720 atcgttgaac tgtcgaaaaccgtggagcgt ctactttgca agccgatttc ggtgcagatc 780 ttctgctcgg ttttggtgctgactgccaat ttctatgcca ttgctgtggt gagctgtgaa 840 ttcgcaacaa gaagactatcagtatgtgac ctatcaggcg tgcatgttga ttcagatttt 900 tatattgtgc tactatgccgggtgggtatt ccatatccga aatgcctccc caggccagta 960 atgaatttca tcgtcagtgaggtaacccag cgcagcctgg accttccgca cgagctgtac 1020 aagacctcct gggtggactgggactacagg agccgaagga ttgcgctcct ctttatgcaa 1080 cgccttcact cgaccttgaggattaggaca cttaatccaa gtcttggttt tgacttaatg 1140 ctcttcagct cggtgagttctttccgtgtt ttgacttttt tgtgcactgt agccaatttc 1200 cataatgagg ctcat 121560 405 PRT Drosophila Melanogaster DOR20 60 Met Ser Lys Gly Val Glu IlePhe Tyr Lys Gly Gln Lys Ala Phe Leu 1 5 10 15 Asn Ile Leu Ser Leu TrpPro Gln Ile Glu Arg Arg Trp Arg Ile Ile 20 25 30 His Gln Val Asn Tyr ValHis Val Ile Val Phe Trp Val Leu Leu Phe 35 40 45 Asp Leu Leu Leu Val LeuHis Val Met Ala Asn Leu Ser Tyr Met Ser 50 55 60 Glu Val Val Lys Ala IlePhe Ile Leu Ala Thr Ser Ala Gly His Thr 65 70 75 80 Thr Lys Leu Leu SerIle Lys Ala Asn Asn Val Gln Met Glu Glu Leu 85 90 95 Phe Arg Arg Leu AspAsn Glu Glu Phe Arg Pro Arg Gly Ala Asn Glu 100 105 110 Glu Leu Ile PheAla Ala Ala Cys Glu Arg Ser Arg Lys Leu Arg Asp 115 120 125 Phe Tyr GlyAla Leu Ser Phe Ala Ala Leu Ser Met Ile Leu Ile Pro 130 135 140 Gln PheAla Leu Asp Trp Ser His Leu Pro Leu Lys Thr Tyr Asn Pro 145 150 155 160Leu Gly Glu Asn Thr Gly Ser Pro Ala Tyr Trp Leu Leu Tyr Cys Tyr 165 170175 Gln Cys Leu Ala Leu Ser Val Ser Cys Ile Thr Asn Ile Gly Phe Asp 180185 190 Ser Leu Cys Ser Ser Leu Phe Ile Phe Leu Lys Cys Gln Leu Asp Ile195 200 205 Leu Ala Val Arg Leu Asp Lys Ile Gly Arg Leu Ile Thr Thr SerGly 210 215 220 Gly Thr Val Glu Gln Gln Leu Lys Glu Asn Ile Arg Tyr HisMet Thr 225 230 235 240 Ile Val Glu Leu Ser Lys Thr Val Glu Arg Leu LeuCys Lys Pro Ile 245 250 255 Ser Val Gln Ile Phe Cys Ser Val Leu Val LeuThr Ala Asn Phe Tyr 260 265 270 Ala Ile Ala Val Val Ser Cys Glu Phe AlaThr Arg Arg Leu Ser Val 275 280 285 Cys Asp Leu Ser Gly Val His Val AspSer Asp Phe Tyr Ile Val Leu 290 295 300 Leu Cys Arg Val Gly Ile Pro TyrPro Lys Cys Leu Pro Arg Pro Val 305 310 315 320 Met Asn Phe Ile Val SerGlu Val Thr Gln Arg Ser Leu Asp Leu Pro 325 330 335 His Glu Leu Tyr LysThr Ser Trp Val Asp Trp Asp Tyr Arg Ser Arg 340 345 350 Arg Ile Ala LeuLeu Phe Met Gln Arg Leu His Ser Thr Leu Arg Ile 355 360 365 Arg Thr LeuAsn Pro Ser Leu Gly Phe Asp Leu Met Leu Phe Ser Ser 370 375 380 Val SerSer Phe Arg Val Leu Thr Phe Leu Cys Thr Val Ala Asn Phe 385 390 395 400His Asn Glu Ala His 405 61 1203 DNA Drosophila Melanogaster DOR25 61atgaacgact cgggttatca atcaaatctc agccttctgc gggtttttct cgacgagttc 60cgatcggttc tgcggcagga aagtcccggt ctcatcccac gcctggcttt ttactatgtt 120cgcgcctttc tgagcttgcc cctgtaccga tggatcaact tgttcatcat gtgcaatgtg 180atgaccattt tctggaccat gttcgtggcc ctgcccgagt cgaagaacgt gatcgaaatg 240ggcgacgact tggtttggat ttcggggatg gcactggtgt tcaccaagat cttttacatg 300catttgcgtt gcgacgagat cgatgaactt atttcggatt ttgaatacta caaccgggag 360ctgagacccc ataatatcga tgaggaggtg ttgggttggc agagactgtg ctacgtgata 420gaatcgggtc tatatatcaa ctgcttttgc ctggtcaact tcttcagtgc cgctattttc 480ctgcaacctc tgttgggcga gggaaagctg cccttccaca gcgtctatcc gtttcaatgg 540catcgcttgg atctgcatcc ctacacgttc tggttcctct acatctggca gagtctgacc 600tcgcagcaca acctaatgag cattctaatg gtggatatgg taggcatttc cacgttcctc 660cagacggcgc tcaatctcaa gttgctttgc atcgagataa ggaaactggg ggacatggag 720gtcagtgata agaggttcca cgaggagttt tgtcgtgtgg ttcgcttcca ccagcacatt 780atcaagttgg tggggaaagc caatagagct ttcaatggcg ccttcaatgc acaattaatg 840gccagtttct ccctgatttc catatccact ttcgagacca tggctgcagc ggctgtggat 900cccaaaatgg ccgccaagtt cgtgcttctc atgctggtgg cattcattca actgtcgctt 960tggtgcgtct ctggaacttt ggtttatact cagtcagtgg aggtggctca ggctgctttt 1020gatatcaacg attggcacac caaatcgcca ggcatccaga gggatatatc ctttgtgata 1080ctacgagccc agaaacccct gatgtatgtg gccgaaccat ttctgccctt caccctggga 1140acctatatgc ttgtactgaa gaactgctat cgtttgctgg ccctgatgca agaatcgatg 1200tag 1203 62 400 PRT Drosophila Melanogaster DOR25 62 Met Asn Asp Ser GlyTyr Gln Ser Asn Leu Ser Leu Leu Arg Val Phe 1 5 10 15 Leu Asp Glu PheArg Ser Val Leu Arg Gln Glu Ser Pro Gly Leu Ile 20 25 30 Pro Arg Leu AlaPhe Tyr Tyr Val Arg Ala Phe Leu Ser Leu Pro Leu 35 40 45 Tyr Arg Trp IleAsn Leu Phe Ile Met Cys Asn Val Met Thr Ile Phe 50 55 60 Trp Thr Met PheVal Ala Leu Pro Glu Ser Lys Asn Val Ile Glu Met 65 70 75 80 Gly Asp AspLeu Val Trp Ile Ser Gly Met Ala Leu Val Phe Thr Lys 85 90 95 Ile Phe TyrMet His Leu Arg Cys Asp Glu Ile Asp Glu Leu Ile Ser 100 105 110 Asp PheGlu Tyr Tyr Asn Arg Glu Leu Arg Pro His Asn Ile Asp Glu 115 120 125 GluVal Leu Gly Trp Gln Arg Leu Cys Tyr Val Ile Glu Ser Gly Leu 130 135 140Tyr Ile Asn Cys Phe Cys Leu Val Asn Phe Phe Ser Ala Ala Ile Phe 145 150155 160 Leu Gln Pro Leu Leu Gly Glu Gly Lys Leu Pro Phe His Ser Val Tyr165 170 175 Pro Phe Gln Trp His Arg Leu Asp Leu His Pro Tyr Thr Phe TrpPhe 180 185 190 Leu Tyr Ile Trp Gln Ser Leu Thr Ser Gln His Asn Leu MetSer Ile 195 200 205 Leu Met Val Asp Met Val Gly Ile Ser Thr Phe Leu GlnThr Ala Leu 210 215 220 Asn Leu Lys Leu Leu Cys Ile Glu Ile Arg Lys LeuGly Asp Met Glu 225 230 235 240 Val Ser Asp Lys Arg Phe His Glu Glu PheCys Arg Val Val Arg Phe 245 250 255 His Gln His Ile Ile Lys Leu Val GlyLys Ala Asn Arg Ala Phe Asn 260 265 270 Gly Ala Phe Asn Ala Gln Leu MetAla Ser Phe Ser Leu Ile Ser Ile 275 280 285 Ser Thr Phe Glu Thr Met AlaAla Ala Ala Val Asp Pro Lys Met Ala 290 295 300 Ala Lys Phe Val Leu LeuMet Leu Val Ala Phe Ile Gln Leu Ser Leu 305 310 315 320 Trp Cys Val SerGly Thr Leu Val Tyr Thr Gln Ser Val Glu Val Ala 325 330 335 Gln Ala AlaPhe Asp Ile Asn Asp Trp His Thr Lys Ser Pro Gly Ile 340 345 350 Gln ArgAsp Ile Ser Phe Val Ile Leu Arg Ala Gln Lys Pro Leu Met 355 360 365 TyrVal Ala Glu Pro Phe Leu Pro Phe Thr Leu Gly Thr Tyr Met Leu 370 375 380Val Leu Lys Asn Cys Tyr Arg Leu Leu Ala Leu Met Gln Glu Ser Met 385 390395 400 63 1368 DNA Drosophila Melanogaster DOR28 63 atgtactcaccggaagaggc ggccgaactg aagaggcgca actatcgcag catcagggag 60 atgatccgactctcctatac ggtgggcttc aacctgttgg atccttcccg atgcggacag 120 gtgctcagaatctggacaat tgtccttagc gtgagtagct tggcatcgct ttatgggcac 180 tggcaaatgttagccaggta cattcatgat attccacgca ttggagagac cgctggaact 240 gccctgcagttcctaacatc gatagcaaag atgtggtact ttctgtttgc ccatagacag 300 atatacgaattgctacgaaa ggcgcgctgc catgaattac tccaaaagtg tgagctcttt 360 gaaaggatgtcagatctacc tgttatcaaa gagattcgcc agcaggttga gtccacgatg 420 aatcggtactgggccagcac tcgtcggcaa attcttatct atttgtacag ctgtatttgt 480 attactacaaactactttat caactccttc gtaatcaacc tctatcgcta tttcactaaa 540 ccgaaaggatcctacgacat aatgttacct ctgccatctc tgtatcccgc ctgggagcac 600 aagggattagagtttcccta ctatcatata cagatgtacc tggaaacctg ttctctgtat 660 atctgcggcatgtgtgccgt tagctttgat ggagtcttta ttgtcctgtg ccttcatagc 720 gtgggacttatgaggtcact taaccaaatg gtggaacaag ccacatctga gttggttcct 780 ccagatcgcagggttgaata cttgcgatgc tgtatttatc agtaccaacg agtggcgaac 840 tttgcaaccgaggttaacaa ctgctttcgg cacatcactt tcacgcagtt cctgcttagc 900 cttttcaactggggcctggc cttgttccaa atgagcgtcg gattgggcaa caacagcagc 960 atcaccatgatccggatgac catgtacctg gtggcagccg gctatcagat agttgtgtac 1020 tgctacaatggccagcgatt tgcgactgct agcgaggaga ttgccaacgc cttttaccag 1080 gtgcgatggtacggagagtc cagggagttc cgccacctca tccgcatgat gctgatgcgc 1140 acgaaccggggattcaggct ggacgtgtcc tggttcatgc aaatgtcctt gcccacactc 1200 atggcggtgagtagcggagc agagcagagc aggggtcctg caggtcctgc aggtcctgca 1260 ggtccacccccaagggtccc ctcctacagc cagttccact tgattgattc gcagatggtc 1320 cggacaagtggacagtactt cctgctgctg cagaacgtca accagaaa 1368 64 456 PRT DrosophilaMelanogaster DOR28 64 Met Tyr Ser Pro Glu Glu Ala Ala Glu Leu Lys ArgArg Asn Tyr Arg 1 5 10 15 Ser Ile Arg Glu Met Ile Arg Leu Ser Tyr ThrVal Gly Phe Asn Leu 20 25 30 Leu Asp Pro Ser Arg Cys Gly Gln Val Leu ArgIle Trp Thr Ile Val 35 40 45 Leu Ser Val Ser Ser Leu Ala Ser Leu Tyr GlyHis Trp Gln Met Leu 50 55 60 Ala Arg Tyr Ile His Asp Ile Pro Arg Ile GlyGlu Thr Ala Gly Thr 65 70 75 80 Ala Leu Gln Phe Leu Thr Ser Ile Ala LysMet Trp Tyr Phe Leu Phe 85 90 95 Ala His Arg Gln Ile Tyr Glu Leu Leu ArgLys Ala Arg Cys His Glu 100 105 110 Leu Leu Gln Lys Cys Glu Leu Phe GluArg Met Ser Asp Leu Pro Val 115 120 125 Ile Lys Glu Ile Arg Gln Gln ValGlu Ser Thr Met Asn Arg Tyr Trp 130 135 140 Ala Ser Thr Arg Arg Gln IleLeu Ile Tyr Leu Tyr Ser Cys Ile Cys 145 150 155 160 Ile Thr Thr Asn TyrPhe Ile Asn Ser Phe Val Ile Asn Leu Tyr Arg 165 170 175 Tyr Phe Thr LysPro Lys Gly Ser Tyr Asp Ile Met Leu Pro Leu Pro 180 185 190 Ser Leu TyrPro Ala Trp Glu His Lys Gly Leu Glu Phe Pro Tyr Tyr 195 200 205 His IleGln Met Tyr Leu Glu Thr Cys Ser Leu Tyr Ile Cys Gly Met 210 215 220 CysAla Val Ser Phe Asp Gly Val Phe Ile Val Leu Cys Leu His Ser 225 230 235240 Val Gly Leu Met Arg Ser Leu Asn Gln Met Val Glu Gln Ala Thr Ser 245250 255 Glu Leu Val Pro Pro Asp Arg Arg Val Glu Tyr Leu Arg Cys Cys Ile260 265 270 Tyr Gln Tyr Gln Arg Val Ala Asn Phe Ala Thr Glu Val Asn AsnCys 275 280 285 Phe Arg His Ile Thr Phe Thr Gln Phe Leu Leu Ser Leu PheAsn Trp 290 295 300 Gly Leu Ala Leu Phe Gln Met Ser Val Gly Leu Gly AsnAsn Ser Ser 305 310 315 320 Ile Thr Met Ile Arg Met Thr Met Tyr Leu ValAla Ala Gly Tyr Gln 325 330 335 Ile Val Val Tyr Cys Tyr Asn Gly Gln ArgPhe Ala Thr Ala Ser Glu 340 345 350 Glu Ile Ala Asn Ala Phe Tyr Gln ValArg Trp Tyr Gly Glu Ser Arg 355 360 365 Glu Phe Arg His Leu Ile Arg MetMet Leu Met Arg Thr Asn Arg Gly 370 375 380 Phe Arg Leu Asp Val Ser TrpPhe Met Gln Met Ser Leu Pro Thr Leu 385 390 395 400 Met Ala Val Ser SerGly Ala Glu Gln Ser Arg Gly Pro Ala Gly Pro 405 410 415 Ala Gly Pro AlaGly Pro Pro Pro Arg Val Pro Ser Tyr Ser Gln Phe 420 425 430 His Leu IleAsp Ser Gln Met Val Arg Thr Ser Gly Gln Tyr Phe Leu 435 440 445 Leu LeuGln Asn Val Asn Gln Lys 450 455 65 1239 DNA Drosophila MelanogasterDOR30 65 atggcggtga gcactcgtgt ggccacaaag caggaagtgc ccgaatcccggcgagcgttt 60 aggaatctct tcaattgctt ctatgccctt ggcatgcagg caccggatggcagtcgaccg 120 accacgagca gcacatggca acgcatctac gcctgcttct cggtggtcatgtacgtgtgg 180 caactgctgc tggtgcccac attctttgtg atcagctatc ggtacatgggcggcatggag 240 attacccagg tgctgacctc cgcccaggtg gccatcgatg cggtcattctgccggccaag 300 attgtggcac tggcgtggaa tttgccattg ctgcgcagag cagagcatcatctggccgcc 360 ttggatgcgc ggtgcaggga acaggaggag ttccaattga tcctcgatgcggtgaggttt 420 tgcaactatc tggtatggtt ctaccagatc tgctatgcca tctactcctcgtcgacattt 480 gtgtgcgcct tcctgctggg ccaaccgcca tatgccctct atttgcctggcctcgattgg 540 cagcgttccc agatgcagtt ctgcatccag gcctggattg agttccttatcatgaactgg 600 acgtgcctgc accaagctag cgatgatgtg tacgccgtta tctatctgtatgtggtccgg 660 attcaagtgc aattgctggc caggcgggtg gagaagctgg gcacggatgatagtggccag 720 gtggagatct atcccgatga gcggcggcag gaggagcatt gcgcggaactgcagcgctgc 780 attgtagatc accagacgat gctgcagctg ctcgactgca ttagtcccgtcatctcgcgt 840 accatattcg ttcagttcct gatcaccgcc gccatcatgg gcaccaccatgatcaacatt 900 ttcattttcg ccaatacgaa cacgaagatc gcatcgatca tttacctgctggcggtgacc 960 ctgcagacgg ctccatgttg ctatcaggcc acctcgctga tgttggacaacgagaggctg 1020 gccctggcca tcttccagtg ccagtggctg ggccagagtg cccggttccgtaagatgctg 1080 ctctactatc ttcatcgcgc ccagcagccc atcacgctga ccgccatgaagctgtttccc 1140 atcaatctgg ccacgtactt cagtatagcc aagttctcgt tttcgctctacacgctcatc 1200 aaggggatga atctcggcga gcgattcaac aggacaaat 1239 66 413PRT Drosophila Melanogaster DOR30 66 Met Ala Val Ser Thr Arg Val Ala ThrLys Gln Glu Val Pro Glu Ser 1 5 10 15 Arg Arg Ala Phe Arg Asn Leu PheAsn Cys Phe Tyr Ala Leu Gly Met 20 25 30 Gln Ala Pro Asp Gly Ser Arg ProThr Thr Ser Ser Thr Trp Gln Arg 35 40 45 Ile Tyr Ala Cys Phe Ser Val ValMet Tyr Val Trp Gln Leu Leu Leu 50 55 60 Val Pro Thr Phe Phe Val Ile SerTyr Arg Tyr Met Gly Gly Met Glu 65 70 75 80 Ile Thr Gln Val Leu Thr SerAla Gln Val Ala Ile Asp Ala Val Ile 85 90 95 Leu Pro Ala Lys Ile Val AlaLeu Ala Trp Asn Leu Pro Leu Leu Arg 100 105 110 Arg Ala Glu His His LeuAla Ala Leu Asp Ala Arg Cys Arg Glu Gln 115 120 125 Glu Glu Phe Gln LeuIle Leu Asp Ala Val Arg Phe Cys Asn Tyr Leu 130 135 140 Val Trp Phe TyrGln Ile Cys Tyr Ala Ile Tyr Ser Ser Ser Thr Phe 145 150 155 160 Val CysAla Phe Leu Leu Gly Gln Pro Pro Tyr Ala Leu Tyr Leu Pro 165 170 175 GlyLeu Asp Trp Gln Arg Ser Gln Met Gln Phe Cys Ile Gln Ala Trp 180 185 190Ile Glu Phe Leu Ile Met Asn Trp Thr Cys Leu His Gln Ala Ser Asp 195 200205 Asp Val Tyr Ala Val Ile Tyr Leu Tyr Val Val Arg Ile Gln Val Gln 210215 220 Leu Leu Ala Arg Arg Val Glu Lys Leu Gly Thr Asp Asp Ser Gly Gln225 230 235 240 Val Glu Ile Tyr Pro Asp Glu Arg Arg Gln Glu Glu His CysAla Glu 245 250 255 Leu Gln Arg Cys Ile Val Asp His Gln Thr Met Leu GlnLeu Leu Asp 260 265 270 Cys Ile Ser Pro Val Ile Ser Arg Thr Ile Phe ValGln Phe Leu Ile 275 280 285 Thr Ala Ala Ile Met Gly Thr Thr Met Ile AsnIle Phe Ile Phe Ala 290 295 300 Asn Thr Asn Thr Lys Ile Ala Ser Ile IleTyr Leu Leu Ala Val Thr 305 310 315 320 Leu Gln Thr Ala Pro Cys Cys TyrGln Ala Thr Ser Leu Met Leu Asp 325 330 335 Asn Glu Arg Leu Ala Leu AlaIle Phe Gln Cys Gln Trp Leu Gly Gln 340 345 350 Ser Ala Arg Phe Arg LysMet Leu Leu Tyr Tyr Leu His Arg Ala Gln 355 360 365 Gln Pro Ile Thr LeuThr Ala Met Lys Leu Phe Pro Ile Asn Leu Ala 370 375 380 Thr Tyr Phe SerIle Ala Lys Phe Ser Phe Ser Leu Tyr Thr Leu Ile 385 390 395 400 Lys GlyMet Asn Leu Gly Glu Arg Phe Asn Arg Thr Asn 405 410 67 1191 DNADrosophila Melanogaster DOR31 67 atgattttta agtacattca agagccagtccttggatcct tatttcgatc ccgggattcg 60 ctgatctact taaacagatc catagatcaaatgggatgga gactgccgcc acgaactaag 120 ccgtactggt ggctctatta catttggacattggtggtca tagtactcgt ctttatcttt 180 ataccctatg gactgataat gactggaataaaggagttca agaacttcac gaccacggat 240 ctgtttacgt atgtccaggt gccggttaacaccaatgctt cgatcatgaa gggcattata 300 gtgttgttta tgcggcggcg attttcaagggctcagaaga tgatggacgc catggacatt 360 cgatgcacca agatggagga gaaagtccaggtgcaccgag cagcagcctt atgcaatcgt 420 gttgttgtga tttaccattg catatacttcggctatctat ccatggcctt aaccggagct 480 ctggtgattg ggaagactcc attctgtttgtacaatccac tggttaaccc cgacgatcat 540 ttctatctgg ccactgccat tgaatcggtcaccatggctg gcattattct ggccaatctc 600 attttggacg tatatcccat catatatgtggtcgttctgc ggatccacat ggagctcttg 660 agtgagcgaa tcaagacgct gcgtactgatgtggaaaaag gcgacgatca acattatgcc 720 gagctggtgg agtgtgtaaa ggatcacaagctaattgtcg aatatggaaa cactctgcgt 780 cccatgatat ccgccacgat gttcatccaactactatccg ttggcttact tttgggtctg 840 gcagcggtgt ccatgcagtt ctataacaccgtaatggagc gtgttgtctc cggggtctac 900 accatagcca ttctatccca gacctttccattttgctatg tctgtgagca gctgagcagc 960 gattgcgaat ccctgaccaa cacactgttccattccaagt ggattggagc tgagcgacga 1020 tacagaacca cgatgttgta cttcattcacaatgttcagc agtcgatttt gttcactgcg 1080 ggcggaattt tccccatatg tctaaacaccaatataaaga tggccaagtt cgctttctca 1140 gtggtgacca ttgtaaatga gatggacttggccgagaaat tgagaaggga g 1191 68 397 PRT Drosophila Melanogaster DOR31 68Met Ile Phe Lys Tyr Ile Gln Glu Pro Val Leu Gly Ser Leu Phe Arg 1 5 1015 Ser Arg Asp Ser Leu Ile Tyr Leu Asn Arg Ser Ile Asp Gln Met Gly 20 2530 Trp Arg Leu Pro Pro Arg Thr Lys Pro Tyr Trp Trp Leu Tyr Tyr Ile 35 4045 Trp Thr Leu Val Val Ile Val Leu Val Phe Ile Phe Ile Pro Tyr Gly 50 5560 Leu Ile Met Thr Gly Ile Lys Glu Phe Lys Asn Phe Thr Thr Thr Asp 65 7075 80 Leu Phe Thr Tyr Val Gln Val Pro Val Asn Thr Asn Ala Ser Ile Met 8590 95 Lys Gly Ile Ile Val Leu Phe Met Arg Arg Arg Phe Ser Arg Ala Gln100 105 110 Lys Met Met Asp Ala Met Asp Ile Arg Cys Thr Lys Met Glu GluLys 115 120 125 Val Gln Val His Arg Ala Ala Ala Leu Cys Asn Arg Val ValVal Ile 130 135 140 Tyr His Cys Ile Tyr Phe Gly Tyr Leu Ser Met Ala LeuThr Gly Ala 145 150 155 160 Leu Val Ile Gly Lys Thr Pro Phe Cys Leu TyrAsn Pro Leu Val Asn 165 170 175 Pro Asp Asp His Phe Tyr Leu Ala Thr AlaIle Glu Ser Val Thr Met 180 185 190 Ala Gly Ile Ile Leu Ala Asn Leu IleLeu Asp Val Tyr Pro Ile Ile 195 200 205 Tyr Val Val Val Leu Arg Ile HisMet Glu Leu Leu Ser Glu Arg Ile 210 215 220 Lys Thr Leu Arg Thr Asp ValGlu Lys Gly Asp Asp Gln His Tyr Ala 225 230 235 240 Glu Leu Val Glu CysVal Lys Asp His Lys Leu Ile Val Glu Tyr Gly 245 250 255 Asn Thr Leu ArgPro Met Ile Ser Ala Thr Met Phe Ile Gln Leu Leu 260 265 270 Ser Val GlyLeu Leu Leu Gly Leu Ala Ala Val Ser Met Gln Phe Tyr 275 280 285 Asn ThrVal Met Glu Arg Val Val Ser Gly Val Tyr Thr Ile Ala Ile 290 295 300 LeuSer Gln Thr Phe Pro Phe Cys Tyr Val Cys Glu Gln Leu Ser Ser 305 310 315320 Asp Cys Glu Ser Leu Thr Asn Thr Leu Phe His Ser Lys Trp Ile Gly 325330 335 Ala Glu Arg Arg Tyr Arg Thr Thr Met Leu Tyr Phe Ile His Asn Val340 345 350 Gln Gln Ser Ile Leu Phe Thr Ala Gly Gly Ile Phe Pro Ile CysLeu 355 360 365 Asn Thr Asn Ile Lys Met Ala Lys Phe Ala Phe Ser Val ValThr Ile 370 375 380 Val Asn Glu Met Asp Leu Ala Glu Lys Leu Arg Arg Glu385 390 395 69 1176 DNA Drosophila Melanogaster DOR32 69 atggaacctgtgcagtacag ctacgaggat ttcgctcgat tgcccacgac ggtgttctgg 60 atcatgggctacgacatgct gggcgttccg aagacccgct ctcgcaggat actatactgg 120 atatatcgtttcctctgtct cgccagccat ggggtctgtg taggagtcat ggtatttcgt 180 atggtggaggcaaagaccat tgacaatgtt tcgctgatca tgcggtatgc cactctggtc 240 acctatatcatcaactcgga tacgaaattc gcaactgtct tacaaaggag tgcaattcaa 300 agtctaaactcaaaactggc cgaactatat ccgaagacca cgctggacag gatctatcac 360 cgggtgaatgatcactattg gaccaagtca tttgtatatt tggttattat ctacattggt 420 tcgtcgattatggttgttat tggaccgatt attacgtcga ttatagctta cttcacgcac 480 aacgttttcacctacatgca ctgctatccg tactttttgt atgatcctga gaaggatccg 540 gtttggatctacatcagcat ctatgctctg gaatggttgc acagcacaca gatggtcatt 600 tcgaacattggcgcggatat ctggctgctg tactttcagg tgcagataaa tctccacttc 660 aggggcattatacgatcact ggcggatcac aagcccagtg tgaagcacga ccaggaggac 720 aggaaattcattgcgaaaat tgtcgacaag caggtgcacc tggtcagttt gcaaaacgat 780 ctgaatggtatctttggaaa atcgctgctt ctaagcctgc tgaccaccgc agcggttatc 840 tgcacggtggcggtgtacac tctgattcag ggtcccacct tggagggctt cacctatgtg 900 atcttcatcgggacttctgt gatgcaggtc tacctggtgt gctattacgg tcagcaagtt 960 ctcgacttgagcggcgaggt ggcccacgcc gtgtacaatc atgattttca cgatgcttct 1020 atagcgtacaagaggtacct gctcataatc attatcaggg cgcagcagcc cgtggaactt 1080 aatgccatgggctacctgtc catttcgctg gacaccttta aacagctgat gagcgtctcc 1140 taccgggttataaccatgct catgcagatg attcag 1176 70 392 PRT Drosophila MelanogasterDOR32 70 Met Glu Pro Val Gln Tyr Ser Tyr Glu Asp Phe Ala Arg Leu Pro Thr1 5 10 15 Thr Val Phe Trp Ile Met Gly Tyr Asp Met Leu Gly Val Pro LysThr 20 25 30 Arg Ser Arg Arg Ile Leu Tyr Trp Ile Tyr Arg Phe Leu Cys LeuAla 35 40 45 Ser His Gly Val Cys Val Gly Val Met Val Phe Arg Met Val GluAla 50 55 60 Lys Thr Ile Asp Asn Val Ser Leu Ile Met Arg Tyr Ala Thr LeuVal 65 70 75 80 Thr Tyr Ile Ile Asn Ser Asp Thr Lys Phe Ala Thr Val LeuGln Arg 85 90 95 Ser Ala Ile Gln Ser Leu Asn Ser Lys Leu Ala Glu Leu TyrPro Lys 100 105 110 Thr Thr Leu Asp Arg Ile Tyr His Arg Val Asn Asp HisTyr Trp Thr 115 120 125 Lys Ser Phe Val Tyr Leu Val Ile Ile Tyr Ile GlySer Ser Ile Met 130 135 140 Val Val Ile Gly Pro Ile Ile Thr Ser Ile IleAla Tyr Phe Thr His 145 150 155 160 Asn Val Phe Thr Tyr Met His Cys TyrPro Tyr Phe Leu Tyr Asp Pro 165 170 175 Glu Lys Asp Pro Val Trp Ile TyrIle Ser Ile Tyr Ala Leu Glu Trp 180 185 190 Leu His Ser Thr Gln Met ValIle Ser Asn Ile Gly Ala Asp Ile Trp 195 200 205 Leu Leu Tyr Phe Gln ValGln Ile Asn Leu His Phe Arg Gly Ile Ile 210 215 220 Arg Ser Leu Ala AspHis Lys Pro Ser Val Lys His Asp Gln Glu Asp 225 230 235 240 Arg Lys PheIle Ala Lys Ile Val Asp Lys Gln Val His Leu Val Ser 245 250 255 Leu GlnAsn Asp Leu Asn Gly Ile Phe Gly Lys Ser Leu Leu Leu Ser 260 265 270 LeuLeu Thr Thr Ala Ala Val Ile Cys Thr Val Ala Val Tyr Thr Leu 275 280 285Ile Gln Gly Pro Thr Leu Glu Gly Phe Thr Tyr Val Ile Phe Ile Gly 290 295300 Thr Ser Val Met Gln Val Tyr Leu Val Cys Tyr Tyr Gly Gln Gln Val 305310 315 320 Leu Asp Leu Ser Gly Glu Val Ala His Ala Val Tyr Asn His AspPhe 325 330 335 His Asp Ala Ser Ile Ala Tyr Lys Arg Tyr Leu Leu Ile IleIle Ile 340 345 350 Arg Ala Gln Gln Pro Val Glu Leu Asn Ala Met Gly TyrLeu Ser Ile 355 360 365 Ser Leu Asp Thr Phe Lys Gln Leu Met Ser Val SerTyr Arg Val Ile 370 375 380 Thr Met Leu Met Gln Met Ile Gln 385 390 71795 DNA Drosophila Melanogaster DOR38 71 atgcgtttga tcaaaatttcatattcggca cttaatgagg tgtgcgtttg gctgaaactg 60 aatggttctt ggccattaaccgaatcatcg aggccatgga ggagccaatc cttattggcc 120 accgcctaca tcgtgtgggcgtggtacgtc attgcatctg tgggcataac aatcagctat 180 cagacggcct ttttgctgaacaacctttcg gacattatta tcaccacgga aaattgttgc 240 accaccttta tgggtgtcctgaactttgtc cgactcatcc atcttcgcct caatcagagg 300 aaattccgcc agcttattgagaacttttcc tacgaaattt ggatacctaa ttcttccaaa 360 aacaatgttg ccgccgagtgtcgcagacgc atggttacct tcagcataat gacatccttg 420 ctagcgtgcc tgatcataatgtattgtgtc ctgccgctgg tggagatctt ctttggaccc 480 gccttcgatg cacagaacaagccgtttccc tacaagatga tctttccgta cgatgcccag 540 agcagttgga tccgatatgtgatgacctac atcttcacct cctacgcggg aatctgtgtg 600 gtcaccacct tgtttgcagaggacaccatt cttggcttct tcataaccta cacttgtggc 660 caatttcatt tgctacaccaacgaatcgca ggtttatttg cgggttccaa tgcggaattg 720 gccgagagca ttcagctggagcgactcaaa cgtattgtgg aaaaacacaa caatattatc 780 agcgcaaatt ctgta 795 72265 PRT Drosophila Melanogaster DOR38 72 Met Arg Leu Ile Lys Ile Ser TyrSer Ala Leu Asn Glu Val Cys Val 1 5 10 15 Trp Leu Lys Leu Asn Gly SerTrp Pro Leu Thr Glu Ser Ser Arg Pro 20 25 30 Trp Arg Ser Gln Ser Leu LeuAla Thr Ala Tyr Ile Val Trp Ala Trp 35 40 45 Tyr Val Ile Ala Ser Val GlyIle Thr Ile Ser Tyr Gln Thr Ala Phe 50 55 60 Leu Leu Asn Asn Leu Ser AspIle Ile Ile Thr Thr Glu Asn Cys Cys 65 70 75 80 Thr Thr Phe Met Gly ValLeu Asn Phe Val Arg Leu Ile His Leu Arg 85 90 95 Leu Asn Gln Arg Lys PheArg Gln Leu Ile Glu Asn Phe Ser Tyr Glu 100 105 110 Ile Trp Ile Pro AsnSer Ser Lys Asn Asn Val Ala Ala Glu Cys Arg 115 120 125 Arg Arg Met ValThr Phe Ser Ile Met Thr Ser Leu Leu Ala Cys Leu 130 135 140 Ile Ile MetTyr Cys Val Leu Pro Leu Val Glu Ile Phe Phe Gly Pro 145 150 155 160 AlaPhe Asp Ala Gln Asn Lys Pro Phe Pro Tyr Lys Met Ile Phe Pro 165 170 175Tyr Asp Ala Gln Ser Ser Trp Ile Arg Tyr Val Met Thr Tyr Ile Phe 180 185190 Thr Ser Tyr Ala Gly Ile Cys Val Val Thr Thr Leu Phe Ala Glu Asp 195200 205 Thr Ile Leu Gly Phe Phe Ile Thr Tyr Thr Cys Gly Gln Phe His Leu210 215 220 Leu His Gln Arg Ile Ala Gly Leu Phe Ala Gly Ser Asn Ala GluLeu 225 230 235 240 Ala Glu Ser Ile Gln Leu Glu Arg Leu Lys Arg Ile ValGlu Lys His 245 250 255 Asn Asn Ile Ile Ser Ala Asn Ser Val 260 265 731409 DNA Drosophila Melanogaster DOR48 73 atggagcgcc attatttcatggtgccaaag tttgcattat cgctgattgg tttttatccc 60 gaacagaagc gaacggttttggtgaaactt tggagtttct tcaacttttt catcctcacc 120 tacggctgtt atgcagaggcttactatggc atacactata taccgattaa catagccact 180 gcattggatg ccctttgtcctgtggcctcc agcattttgt cgctggtgaa aatggtcgcc 240 atttggtggt atcaagatgaattaaggagt ttgatagagc gggtaagatt tttaacagag 300 caacagaagt ccaagaggaaactgggctat aagaagaggt tctatacact ggcaacgcaa 360 ctaacattcc tgctactatgctgtggattt tgcaccagta cttcctattc cgtcagacat 420 ttgattgata atatcctgagacgcacccat ggcaaggact ggatctacga gactccgttc 480 aagatgatgt aaggaaagggaagaatggtt tatatatact tttggaacga aataatgatg 540 tgatctaaac aagatgcacttttttttagg ttccccgatc ttctcctgcg tttgccactc 600 tatcccatca cctatatactcgtgcattgg catggctaca ttactgtggt ttgttttgtc 660 ggcgcggatg gtttcttcctggggttctgt ttgtacttca ctgttttgct gctctgtctg 720 caggacgatg tttgtgatttactagaggtt gaaaacatcg agaagagtcc ctccgaagcg 780 gaggaagctc gcatagttcgggaaatggaa aaactggtgg accggcataa cgaggtggcc 840 gagctgacag aaagattgtcgggtgttatg gtggaaataa cactggccca ctttgttact 900 tcgagtttga taatcggaaccagcgtggtg gatattttat tagtgggtat ttacatttga 960 ttagatcctt tcgatatatgttcttaaatt ctagttttcc ggcctgggaa tcattgtgta 1020 tgtggtctac acttgtgccgtaggtgtgga aatatttcta tactgtttag gaggatctca 1080 tattatggaa gcggtatattcataagaaac tactataaag ttacttttaa attcattgca 1140 tttcttagtg ttccaatctagcgcgctcca cattttccag ccactggtat ggccacagtg 1200 ttcgggtcca aaagatgacccttttgatgg tagctcgtgc tcaacgagtt ctcacaatta 1260 aaattccttt cttttccccatcattagaga ctctaacttc ggtaagctta tgcgaaaatg 1320 ttatggtaca cacaagtctacatttctatg aggtcttgta gattttgcgc ttcactggat 1380 ctctgattgc cctggcaaagtcggttata 1409 74 369 PRT Drosophila Melanogaster DOR48 74 Met Glu ArgHis Tyr Phe Met Val Pro Lys Phe Ala Leu Ser Leu Ile 1 5 10 15 Gly PheTyr Pro Glu Gln Lys Arg Thr Val Leu Val Lys Leu Trp Ser 20 25 30 Phe PheAsn Phe Phe Ile Leu Thr Tyr Gly Cys Tyr Ala Glu Ala Tyr 35 40 45 Tyr GlyIle His Tyr Ile Pro Ile Asn Ile Ala Thr Ala Leu Asp Ala 50 55 60 Leu CysPro Val Ala Ser Ser Ile Leu Ser Leu Val Lys Met Val Ala 65 70 75 80 IleTrp Trp Tyr Gln Asp Glu Leu Arg Ser Leu Ile Glu Arg Arg Phe 85 90 95 TyrThr Leu Ala Thr Gln Leu Thr Phe Leu Leu Leu Cys Cys Gly Phe 100 105 110Cys Thr Ser Thr Ser Tyr Ser Val Arg His Leu Ile Asp Asn Ile Leu 115 120125 Arg Arg Thr His Gly Lys Asp Trp Ile Tyr Glu Thr Pro Phe Lys Met 130135 140 Met Phe Pro Asp Leu Leu Leu Arg Leu Pro Leu Tyr Pro Ile Thr Tyr145 150 155 160 Ile Leu Val His Trp His Gly Tyr Ile Thr Val Val Cys PheVal Gly 165 170 175 Ala Asp Gly Phe Phe Leu Gly Phe Cys Leu Tyr Phe ThrVal Leu Leu 180 185 190 Leu Cys Leu Gln Asp Asp Val Cys Asp Leu Leu GluVal Glu Asn Ile 195 200 205 Glu Lys Ser Pro Ser Glu Ala Glu Glu Ala ArgIle Val Arg Glu Met 210 215 220 Glu Lys Leu Val Asp Arg His Asn Glu ValAla Glu Leu Thr Glu Arg 225 230 235 240 Leu Ser Gly Val Met Val Glu IleThr Leu Ala His Phe Val Thr Ser 245 250 255 Ser Leu Ile Ile Gly Thr SerVal Val Asp Ile Leu Leu Phe Ser Gly 260 265 270 Leu Gly Ile Ile Val TyrVal Val Tyr Thr Cys Ala Val Gly Val Glu 275 280 285 Ile Phe Leu Tyr CysLeu Gly Gly Ser His Ile Met Glu Ala Cys Ser 290 295 300 Asn Leu Ala ArgSer Thr Phe Ser Ser His Trp Tyr Gly His Ser Val 305 310 315 320 Arg ValGln Lys Met Thr Leu Leu Met Val Ala Arg Ala Gln Arg Val 325 330 335 LeuThr Ile Lys Ile Pro Phe Phe Ser Pro Ser Leu Glu Thr Leu Thr 340 345 350Ser Ile Leu Arg Phe Thr Gly Ser Leu Ile Ala Leu Ala Lys Ser Val 355 360365 Ile 75 891 DNA Drosophila Melanogaster DOR56 75 atggatccggtggagatgcc catttttggt agcactctga agctaatgaa gttctggtca 60 tatctgtttgttcacaactg gcgccgctat gtcgcaatga ctccgtacat cattatcaac 120 tgtactcagtatgtggatat atatctgagc accgaatcct tggactttat catcagaaat 180 gtatacctggctgtattgtt taccaacacg gtggtcagag gtgtattgtt atgcgtacag 240 cggtttagctacgagcgttt cattaatatt ttgaaaagct tttacattga gttgttggtg 300 agtaccgaaagattatctca aaaatgcata ttgcataaat gggcagttct gccatatggc 360 atgtatttgcccactattga tgaatacaaa tacgcatcac cttactacga gattttcttt 420 gtgattcaagccattatggc tccaatgggg tgttgcatgt acataccata cacaaacatg 480 gtagtgacatttaccctttt cgccattctc atgtgtcgag tgttgcaaca taagttgaga 540 agcctagaaaagctgaaaaa tgaacaagta cgtggtgaaa tcgctcaaac aattgctcag 600 accgtcatagtcatcgcata catggtaatg atatttgcca acagtgtagt cctttactac 660 gtggccaatgagctatactt tcaaagcttt gatattgcca ttgctgccta tgagagcaat 720 tggatggactttgatgtgga cacacaaaag actttgaagt tcctcatcat gcgctcgcaa 780 aagcccttggcgagtctggt gggtggcaca tatcccatga acttgaaaat gcttcagtca 840 ctactaaatgccatttactc cttcttcacc cttctgcgtc gcgtttacgg c 891 76 297 PRT DrosophilaMelanogaster DOR56 76 Met Asp Pro Val Glu Met Pro Ile Phe Gly Ser ThrLeu Lys Leu Met 1 5 10 15 Lys Phe Trp Ser Tyr Leu Phe Val His Asn TrpArg Arg Tyr Val Ala 20 25 30 Met Thr Pro Tyr Ile Ile Ile Asn Cys Thr GlnTyr Val Asp Ile Tyr 35 40 45 Leu Ser Thr Glu Ser Leu Asp Phe Ile Ile ArgAsn Val Tyr Leu Ala 50 55 60 Val Leu Phe Thr Asn Thr Val Val Arg Gly ValLeu Leu Cys Val Gln 65 70 75 80 Arg Phe Ser Tyr Glu Arg Phe Ile Asn IleLeu Lys Ser Phe Tyr Ile 85 90 95 Glu Leu Leu Val Ser Thr Glu Arg Leu SerGln Lys Cys Ile Leu His 100 105 110 Lys Trp Ala Val Leu Pro Tyr Gly MetTyr Leu Pro Thr Ile Asp Glu 115 120 125 Tyr Lys Tyr Ala Ser Pro Tyr TyrGlu Ile Phe Phe Val Ile Gln Ala 130 135 140 Ile Met Ala Pro Met Gly CysCys Met Tyr Ile Pro Tyr Thr Asn Met 145 150 155 160 Val Val Thr Phe ThrLeu Phe Ala Ile Leu Met Cys Arg Val Leu Gln 165 170 175 His Lys Leu ArgSer Leu Glu Lys Leu Lys Asn Glu Gln Val Arg Gly 180 185 190 Glu Ile AlaGln Thr Ile Ala Gln Thr Val Ile Val Ile Ala Tyr Met 195 200 205 Val MetIle Phe Ala Asn Ser Val Val Leu Tyr Tyr Val Ala Asn Glu 210 215 220 LeuTyr Phe Gln Ser Phe Asp Ile Ala Ile Ala Ala Tyr Glu Ser Asn 225 230 235240 Trp Met Asp Phe Asp Val Asp Thr Gln Lys Thr Leu Lys Phe Leu Ile 245250 255 Met Arg Ser Gln Lys Pro Leu Ala Ser Leu Val Gly Gly Thr Tyr Pro260 265 270 Met Asn Leu Lys Met Leu Gln Ser Leu Leu Asn Ala Ile Tyr SerPhe 275 280 285 Phe Thr Leu Leu Arg Arg Val Tyr Gly 290 295 77 1134 DNADrosophila Melanogaster DOR58 77 atggacgcca gctactttgc cgtccagagaagagctctgg aaatagttgg attcgatccc 60 agtactccgc aactgagtct gaaacatcccatctgggccg ggattctcat cctgtccttg 120 atctctcaca actggcccat ggtagtctatgccctgcagg atctctccga cttgacccgt 180 ctgacggaca actttgcggt gtttatgcaaggatcacaga gcaccttcaa gttcctggtc 240 atgatggcga aacgaaggcg cattggatcgttgattcacc gtttgcataa gctaaaccag 300 gcggccagtg ccacgcccaa tcacctggagaagatcgaga gggaaaacca actggatagg 360 tatgtcgcca ggtcctttag aaatgccgcctacggagtga tttgtgcctc ggccatagcg 420 cccatgttgc ttggcctgtg gggatatgtggagacgggtg tatttacccc caccacaccc 480 atggagttca acttctggct ggacgagcgaaagcctcact tttattggcc catctacgtt 540 tggggcgtac tgggcgtggc agctgccgcctggttggcca ttgcaacgga caccctgttc 600 tcctggctga ctcacaatgt ggtgattcagttccaactac tggagcttgt tctcgaagag 660 aaggatctga atggcggaga ctctcgcctgaccgggtttg ttagtcgtca tcgtatagct 720 ctggatttgg ccaaggaact aagttcgattttcggggaga tcgtctttgt gaaatacatg 780 ctcagttacc tgcaactctg catgttggcctttcgcttca gccgcagtgg ctggagtgcc 840 caggtgccat ttagagccac cttcctagtggccatcatca tccaactgag ttcgtattgc 900 tatggaggcg agtatataaa gcagcaaagtttggccatcg cacaagccgt ttatggtcaa 960 atcaattggc cagaaatgac gccaaagaaaagaagactct ggcaaatggt gatcatgagg 1020 gcgcagcgac cggctaagat ttttggattcatgttcgttg tggacttgcc actgctgctt 1080 tgggtcatca gaactgcggg ctcatttctggccatgctta ggactttcga gcgt 1134 78 378 PRT Drosophila Melanogaster DOR5878 Met Asp Ala Ser Tyr Phe Ala Val Gln Arg Arg Ala Leu Glu Ile Val 1 510 15 Gly Phe Asp Pro Ser Thr Pro Gln Leu Ser Leu Lys His Pro Ile Trp 2025 30 Ala Gly Ile Leu Ile Leu Ser Leu Ile Ser His Asn Trp Pro Met Val 3540 45 Val Tyr Ala Leu Gln Asp Leu Ser Asp Leu Thr Arg Leu Thr Asp Asn 5055 60 Phe Ala Val Phe Met Gln Gly Ser Gln Ser Thr Phe Lys Phe Leu Val 6570 75 80 Met Met Ala Lys Arg Arg Arg Ile Gly Ser Leu Ile His Arg Leu His85 90 95 Lys Leu Asn Gln Ala Ala Ser Ala Thr Pro Asn His Leu Glu Lys Ile100 105 110 Glu Arg Glu Asn Gln Leu Asp Arg Tyr Val Ala Arg Ser Phe ArgAsn 115 120 125 Ala Ala Tyr Gly Val Ile Cys Ala Ser Ala Ile Ala Pro MetLeu Leu 130 135 140 Gly Leu Trp Gly Tyr Val Glu Thr Gly Val Phe Thr ProThr Thr Pro 145 150 155 160 Met Glu Phe Asn Phe Trp Leu Asp Glu Arg LysPro His Phe Tyr Trp 165 170 175 Pro Ile Tyr Val Trp Gly Val Leu Gly ValAla Ala Ala Ala Trp Leu 180 185 190 Ala Ile Ala Thr Asp Thr Leu Phe SerTrp Leu Thr His Asn Val Val 195 200 205 Ile Gln Phe Gln Leu Leu Glu LeuVal Leu Glu Glu Lys Asp Leu Asn 210 215 220 Gly Gly Asp Ser Arg Leu ThrGly Phe Val Ser Arg His Arg Ile Ala 225 230 235 240 Leu Asp Leu Ala LysGlu Leu Ser Ser Ile Phe Gly Glu Ile Val Phe 245 250 255 Val Lys Tyr MetLeu Ser Tyr Leu Gln Leu Cys Met Leu Ala Phe Arg 260 265 270 Phe Ser ArgSer Gly Trp Ser Ala Gln Val Pro Phe Arg Ala Thr Phe 275 280 285 Leu ValAla Ile Ile Ile Gln Leu Ser Ser Tyr Cys Tyr Gly Gly Glu 290 295 300 TyrIle Lys Gln Gln Ser Leu Ala Ile Ala Gln Ala Val Tyr Gly Gln 305 310 315320 Ile Asn Trp Pro Glu Met Thr Pro Lys Lys Arg Arg Leu Trp Gln Met 325330 335 Val Ile Met Arg Ala Gln Arg Pro Ala Lys Ile Phe Gly Phe Met Phe340 345 350 Val Val Asp Leu Pro Leu Leu Leu Trp Val Ile Arg Thr Ala GlySer 355 360 365 Phe Leu Ala Met Leu Arg Thr Phe Glu Arg 370 375 79 807DNA Drosophila Melanogaster DOR59 79 atgcacgaag cagataatcg ggagatggaacttttggtcg ccactcaggc ttatacacga 60 accattaccc tgttgatctg gataccatcggttattgctg gcctaatggc ctattcagac 120 tgcatctaca ggagtctgtt tctgccgaaatcggttttca atgtgccagc tgtgcgacgt 180 ggtgaggagc atcccattct gctatttcagctgtttccct tcggagaact ttgcgataac 240 ttcgttgttg gatacttggg accttggtatgctctgggcc tgggaatcac ggctatccca 300 ttgtggcaca cctttatcac ttgcctcatgaagtacgtaa atctcaagct gcaaatactc 360 aacaagcgag tggaggagat ggatattacccgacttaatt ccaaattggt aattggtcgc 420 ctaactgcca gtgagttaac cttctggcaaatgcaactct tcaaggaatt tgtaaaggaa 480 cagctgagga ttcgaaaatt tgtccaggaactacagtatc tgatttgcgt gcctgtgatg 540 gcagatttca ttatcttctc ggttctcatttgctttctct tttttgcctt gacagttggc 600 cacgatgaac tgagccttgc ttacttttcttgcggatggt acaacttcga aatgcctttg 660 cagaaaatgc tggtttttat gatgatgcatgcccaaaggc cgatgaagat gcgcgccctg 720 ctggtcgatt tgaatctgag gaccttcatagacattggcc gtggagccta cagctacttc 780 aatttgctgc gtagctccca cttgtat 80780 269 PRT Drosophila Melanogaster DOR59 80 Met His Glu Ala Asp Asn ArgGlu Met Glu Leu Leu Val Ala Thr Gln 1 5 10 15 Ala Tyr Thr Arg Thr IleThr Leu Leu Ile Trp Ile Pro Ser Val Ile 20 25 30 Ala Gly Leu Met Ala TyrSer Asp Cys Ile Tyr Arg Ser Leu Phe Leu 35 40 45 Pro Lys Ser Val Phe AsnVal Pro Ala Val Arg Arg Gly Glu Glu His 50 55 60 Pro Ile Leu Leu Phe GlnLeu Phe Pro Phe Gly Glu Leu Cys Asp Asn 65 70 75 80 Phe Val Val Gly TyrLeu Gly Pro Trp Tyr Ala Leu Gly Leu Gly Ile 85 90 95 Thr Ala Ile Pro LeuTrp His Thr Phe Ile Thr Cys Leu Met Lys Tyr 100 105 110 Val Asn Leu LysLeu Gln Ile Leu Asn Lys Arg Val Glu Glu Met Asp 115 120 125 Ile Thr ArgLeu Asn Ser Lys Leu Val Ile Gly Arg Leu Thr Ala Ser 130 135 140 Glu LeuThr Phe Trp Gln Met Gln Leu Phe Lys Glu Phe Val Lys Glu 145 150 155 160Gln Leu Arg Ile Arg Lys Phe Val Gln Glu Leu Gln Tyr Leu Ile Cys 165 170175 Val Pro Val Met Ala Asp Phe Ile Ile Phe Ser Val Leu Ile Cys Phe 180185 190 Leu Phe Phe Ala Leu Thr Val Gly His Asp Glu Leu Ser Leu Ala Tyr195 200 205 Phe Ser Cys Gly Trp Tyr Asn Phe Glu Met Pro Leu Gln Lys MetLeu 210 215 220 Val Phe Met Met Met His Ala Gln Arg Pro Met Lys Met ArgAla Leu 225 230 235 240 Leu Val Asp Leu Asn Leu Arg Thr Phe Ile Asp IleGly Arg Gly Ala 245 250 255 Tyr Ser Tyr Phe Asn Leu Leu Arg Ser Ser HisLeu Tyr 260 265 81 1143 DNA Drosophila Melanogaster DOR68 81 atgtcaaagctaatcgaggt gtttctgggt aatctgtgga cccagcgttt taccttcgcc 60 cgaatgggtttggatttgca gcccgataaa aagggcaatg ttttgcgatc tccgcttctt 120 tattgtattatgtgtctgac aacaagcttt gagctctgca ccgtgtgcgc ctttatggtc 180 caaaatcgcaaccaaatcgt gctttgttcc gaggccctga tgcacggact acagatggtc 240 tcctcgctactgaagatggc tatattcttg gccaaatctc acgacctggt ggacctaatt 300 caacagattcagtcgccttt tacagaggag gatcttgtag gtacagagtg gagatcccaa 360 aatcaaaggggacaactaat ggctgccatt tactttatga tgtgtgccgg tacgagtgtg 420 tcatttctgttgatgccagt ggctttgacc atgcttaagt accattccac tggggaattc 480 gcgcctgtcagctcgttccg ggttctgctt ccatacgatg tgacacaacc gcatgtttat 540 gccatggactgctgcttgat ggtatttgtg ttaagttttt tttgctgctc caccaccgga 600 gtggataccttatatggatg gtgtgcttta ggcgtgagtt tacaataccg tcgcctcggt 660 caacaacttaaaaggatacc ctcctgtttc aatccatctc ggtctgactt tggattaagt 720 gggatttttgtggagcatgc tcgtctgctt aaaatagtcc aacattttaa ttatagtttt 780 atggagatcgcatttgtgga ggttgttata atctgtggac tctattgctc agtaatttgt 840 cagtatataatgccacacac caaccaaaac ttcgcctttc tgggtttctt ttcattggta 900 gttaccacacagctgtgcat ctatcttttc ggtgccgaac aggtccgttt ggaggctgag 960 cgattttcccggctgctata cgaagtaatt ccttggcaaa accttcctcc taaacaccgg 1020 aaacttttcctttttccaat tgagcgcgcc caacgagaaa ctgttctcgg tgcttatttc 1080 ttcgaactaggcagacctct tcttgtttgg gtaagcatat tcctttttat tgtattatta 1140 ttt 1143 82381 PRT Drosophila Melanogaster DOR68 82 Met Ser Lys Leu Ile Glu Val PheLeu Gly Asn Leu Trp Thr Gln Arg 1 5 10 15 Phe Thr Phe Ala Arg Met GlyLeu Asp Leu Gln Pro Asp Lys Lys Gly 20 25 30 Asn Val Leu Arg Ser Pro LeuLeu Tyr Cys Ile Met Cys Leu Thr Thr 35 40 45 Ser Phe Glu Leu Cys Thr ValCys Ala Phe Met Val Gln Asn Arg Asn 50 55 60 Gln Ile Val Leu Cys Ser GluAla Leu Met His Gly Leu Gln Met Val 65 70 75 80 Ser Ser Leu Leu Lys MetAla Ile Phe Leu Ala Lys Ser His Asp Leu 85 90 95 Val Asp Leu Ile Gln GlnIle Gln Ser Pro Phe Thr Glu Glu Asp Leu 100 105 110 Val Gly Thr Glu TrpArg Ser Gln Asn Gln Arg Gly Gln Leu Met Ala 115 120 125 Ala Ile Tyr PheMet Met Cys Ala Gly Thr Ser Val Ser Phe Leu Leu 130 135 140 Met Pro ValAla Leu Thr Met Leu Lys Tyr His Ser Thr Gly Glu Phe 145 150 155 160 AlaPro Val Ser Ser Phe Arg Val Leu Leu Pro Tyr Asp Val Thr Gln 165 170 175Pro His Val Tyr Ala Met Asp Cys Cys Leu Met Val Phe Val Leu Ser 180 185190 Phe Phe Cys Cys Ser Thr Thr Gly Val Asp Thr Leu Tyr Gly Trp Cys 195200 205 Ala Leu Gly Val Ser Leu Gln Tyr Arg Arg Leu Gly Gln Gln Leu Lys210 215 220 Arg Ile Pro Ser Cys Phe Asn Pro Ser Arg Ser Asp Phe Gly LeuSer 225 230 235 240 Gly Ile Phe Val Glu His Ala Arg Leu Leu Lys Ile ValGln His Phe 245 250 255 Asn Tyr Ser Phe Met Glu Ile Ala Phe Val Glu ValVal Ile Ile Cys 260 265 270 Gly Leu Tyr Cys Ser Val Ile Cys Gln Tyr IleMet Pro His Thr Asn 275 280 285 Gln Asn Phe Ala Phe Leu Gly Phe Phe SerLeu Val Val Thr Thr Gln 290 295 300 Leu Cys Ile Tyr Leu Phe Gly Ala GluGln Val Arg Leu Glu Ala Glu 305 310 315 320 Arg Phe Ser Arg Leu Leu TyrGlu Val Ile Pro Trp Gln Asn Leu Pro 325 330 335 Pro Lys His Arg Lys LeuPhe Leu Phe Pro Ile Glu Arg Ala Gln Arg 340 345 350 Glu Thr Val Leu GlyAla Tyr Phe Phe Glu Leu Gly Arg Pro Leu Leu 355 360 365 Val Trp Val SerIle Phe Leu Phe Ile Val Leu Leu Phe 370 375 380 83 927 DNA DrosophilaMelanogaster DOR77 83 atggaattga tgcgagtgcc agtacagttt tacagaacgattggagagga tatctacgcc 60 catcgatcca cgaatcccct aaaatcgctt ctcttcaagatctatctata tgcgggattc 120 ataaatttta atctgttggt aatcggtgaa ctggtgttcttctacaactc aattcaggac 180 tttgaaacca ttcgattggc catcgcggtg gctccatgtatcggattttc tctggttgct 240 gattttaaac aagctgccat gattagaggc aagaaaacactaattatgct actcgatgat 300 ttggagaaca tgcatccgaa aaccctggca aagcaaatggaatacaaatt gccggacttt 360 gaaaagacca tgaaacgtgt gatcaatata ttcacctttctctgcttggc ctatacgact 420 acgttctcct tttatccggc catcaaggca tccgtgaaatttaatttctt gggctacgac 480 acctttgatc gaaattttgg tttcctcatc tggtttcccttcgatgcaac aaggaataat 540 ttgatatact ggatcatgta ctgggacata gcccatggggcctatctagc ggcctttcag 600 gtcaccgaat caacagtgga agtgattatt atttactgcatttttttgat gacctcgatg 660 gttcaggtat ttatggtgtg ctactatggg gatactttaattgccgcgag cttgaaagtg 720 ggcgatgccg cttacaacca aaagtggttt cagtgcagcaaatcctattg caccatgttg 780 aagttgctaa tcatgaggag tcagaaacca gcttcaataagaccgccgac ttttcccccc 840 atatccttgg ttacctatat gaagaatccc ttcaacaatctacccaaaca cagctcttcc 900 ctgcaaatca acgccaatcg ctatatc 927 84 309 PRTDrosophila Melanogaster DOR77 84 Met Glu Leu Met Arg Val Pro Val Gln PheTyr Arg Thr Ile Gly Glu 1 5 10 15 Asp Ile Tyr Ala His Arg Ser Thr AsnPro Leu Lys Ser Leu Leu Phe 20 25 30 Lys Ile Tyr Leu Tyr Ala Gly Phe IleAsn Phe Asn Leu Leu Val Ile 35 40 45 Gly Glu Leu Val Phe Phe Tyr Asn SerIle Gln Asp Phe Glu Thr Ile 50 55 60 Arg Leu Ala Ile Ala Val Ala Pro CysIle Gly Phe Ser Leu Val Ala 65 70 75 80 Asp Phe Lys Gln Ala Ala Met IleArg Gly Lys Lys Thr Leu Ile Met 85 90 95 Leu Leu Asp Asp Leu Glu Asn MetHis Pro Lys Thr Leu Ala Lys Gln 100 105 110 Met Glu Tyr Lys Leu Pro AspPhe Glu Lys Thr Met Lys Arg Val Ile 115 120 125 Asn Ile Phe Thr Phe LeuCys Leu Ala Tyr Thr Thr Thr Phe Ser Phe 130 135 140 Tyr Pro Ala Ile LysAla Ser Val Lys Phe Asn Phe Leu Gly Tyr Asp 145 150 155 160 Thr Phe AspArg Asn Phe Gly Phe Leu Ile Trp Phe Pro Phe Asp Ala 165 170 175 Thr ArgAsn Asn Leu Ile Tyr Trp Ile Met Tyr Trp Asp Ile Ala His 180 185 190 GlyAla Tyr Leu Ala Ala Phe Gln Val Thr Glu Ser Thr Val Glu Val 195 200 205Ile Ile Ile Tyr Cys Ile Phe Leu Met Thr Ser Met Val Gln Val Phe 210 215220 Met Val Cys Tyr Tyr Gly Asp Thr Leu Ile Ala Ala Ser Leu Lys Val 225230 235 240 Gly Asp Ala Ala Tyr Asn Gln Lys Trp Phe Gln Cys Ser Lys SerTyr 245 250 255 Cys Thr Met Leu Lys Leu Leu Ile Met Arg Ser Gln Lys ProAla Ser 260 265 270 Ile Arg Pro Pro Thr Phe Pro Pro Ile Ser Leu Val ThrTyr Met Lys 275 280 285 Asn Pro Phe Asn Asn Leu Pro Lys His Ser Ser SerLeu Gln Ile Asn 290 295 300 Ala Asn Arg Tyr Ile 305 85 1152 DNADrosophila Melanogaster DOR78 85 atgaagttca tgaagtacgc agttttcttttacacatcgg tgggcattga gccgtatacg 60 attgactcgc ggtccaaaaa agcgagcctatggtcacatc ttctcttctg ggccaatgtg 120 atcaatttaa gtgtcattgt tttcggagagatcctctatc tgggagtggc ctattccgat 180 ggaaagttca ttgatgccgt cactgtactgtcatatatcg gattcgtaat cgtgggcatg 240 agcaagatgt tcttcatatg gtggaagaagaccgatctaa gcgatttggt taaggaattg 300 gagcacatct atccaaatgg caaagctgaggaggagatgt atcggttgga taggtatctg 360 cgatcttgtt cacgaattag cattacctatgcactactct actccgtact catctggacc 420 ttcaatctgt tcagtatcat gcaattccttgtctatgaaa agttgcttaa aatccgagtg 480 gtcggccaaa cgctgccata tttgatgtactttccctgga actggcatga aaactggacg 540 tattatgtgc tgctgttctg tcaaaacttcgcaggacata cttcggcatc gggacagatc 600 tctacggatc ttttgctttg tgctgttgctacccaggtgg taatgcactt cgattacttg 660 gccagagtgg tggaaaaaca agtgttagatcgcgattgga gcgaaaactc cagatttttg 720 gcaaaaactg tacaatatca tcagcgcattcttcggctaa tggacgttct caacgatata 780 ttcgggatac cgctactgct taactttatggtctccacat ttgtcatctg ctttgtggga 840 ttccaaatga ccgtgggtgt cccgccggacatcatgatta agctcttctt gttcctgttc 900 tcgtccttgt cgcaagtgta cttgatatgccactacggcc agctgattgc cgatgcggta 960 agagactttc gaagctctag cttatcgatttctgcatata agcagaattg gcaaaatgct 1020 gacattcgct atcgtcgggc tctggtattctttatagctc gacctcagag gacaacttat 1080 ctaaaagcta caattttcat gaatataacaagggccacca tgacggacgt aagatacaat 1140 ttgaaatgtc at 1152 86 384 PRTDrosophila Melanogaster DOR78 86 Met Lys Phe Met Lys Tyr Ala Val Phe PheTyr Thr Ser Val Gly Ile 1 5 10 15 Glu Pro Tyr Thr Ile Asp Ser Arg SerLys Lys Ala Ser Leu Trp Ser 20 25 30 His Leu Leu Phe Trp Ala Asn Val IleAsn Leu Ser Val Ile Val Phe 35 40 45 Gly Glu Ile Leu Tyr Leu Gly Val AlaTyr Ser Asp Gly Lys Phe Ile 50 55 60 Asp Ala Val Thr Val Leu Ser Tyr IleGly Phe Val Ile Val Gly Met 65 70 75 80 Ser Lys Met Phe Phe Ile Trp TrpLys Lys Thr Asp Leu Ser Asp Leu 85 90 95 Val Lys Glu Leu Glu His Ile TyrPro Asn Gly Lys Ala Glu Glu Glu 100 105 110 Met Tyr Arg Leu Asp Arg TyrLeu Arg Ser Cys Ser Arg Ile Ser Ile 115 120 125 Thr Tyr Ala Leu Leu TyrSer Val Leu Ile Trp Thr Phe Asn Leu Phe 130 135 140 Ser Ile Met Gln PheLeu Val Tyr Glu Lys Leu Leu Lys Ile Arg Val 145 150 155 160 Val Gly GlnThr Leu Pro Tyr Leu Met Tyr Phe Pro Trp Asn Trp His 165 170 175 Glu AsnTrp Thr Tyr Tyr Val Leu Leu Phe Cys Gln Asn Phe Ala Gly 180 185 190 HisThr Ser Ala Ser Gly Gln Ile Ser Thr Asp Leu Leu Leu Cys Ala 195 200 205Val Ala Thr Gln Val Val Met His Phe Asp Tyr Leu Ala Arg Val Val 210 215220 Glu Lys Gln Val Leu Asp Arg Asp Trp Ser Glu Asn Ser Arg Phe Leu 225230 235 240 Ala Lys Thr Val Gln Tyr His Gln Arg Ile Leu Arg Leu Met AspVal 245 250 255 Leu Asn Asp Ile Phe Gly Ile Pro Leu Leu Leu Asn Phe MetVal Ser 260 265 270 Thr Phe Val Ile Cys Phe Val Gly Phe Gln Met Thr ValGly Val Pro 275 280 285 Pro Asp Ile Met Ile Lys Leu Phe Leu Phe Leu PheSer Ser Leu Ser 290 295 300 Gln Val Tyr Leu Ile Cys His Tyr Gly Gln LeuIle Ala Asp Ala Val 305 310 315 320 Arg Asp Phe Arg Ser Ser Ser Leu SerIle Ser Ala Tyr Lys Gln Asn 325 330 335 Trp Gln Asn Ala Asp Ile Arg TyrArg Arg Ala Leu Val Phe Phe Ile 340 345 350 Ala Arg Pro Gln Arg Thr ThrTyr Leu Lys Ala Thr Ile Phe Met Asn 355 360 365 Ile Thr Arg Ala Thr MetThr Asp Val Arg Tyr Asn Leu Lys Cys His 370 375 380 87 1203 DNADrosophila Melanogaster DOR81 87 atgatggaga cgctgcgaaa ttcgggcttgaatttgaaga acgatttcgg tataggccgc 60 aagatttgga gggtgttttc gttcacctacaatatggtga tacttcccgt aagtttccca 120 atcaactatg tgatacatct ggcggagttcccgccggagc tgctgctgca atccctgcaa 180 ctgtgcctca acacttggtg cttcgctctgaagttcttca ctctgatcgt ctatacgcac 240 cgcttggagc tggccaacaa gcactttgacgaattggata agtactgcgt gaagccggcg 300 gagaagcgca aggttcgcga catggtggccactattacaa gactgtacct gaccttcgtc 360 gtggtctacg tcctctacgc cacctccacgctactggacg gactactgca ccaccgtgtt 420 ccctacaata cgtactatcc gttcataaactggcgagtcg atcggaccca gatgtacatc 480 cagagttttc tggagtactt caccgtgggttatgccatat atgtggccac cgccaccgat 540 tcctaccctg tgatttacgt ggcagccctgcgaactcata ttctcttgct caaggaccgt 600 atcatttact tgggcgatcc cagcaacgagggtagcagcg acccgagcta catgtttaaa 660 tcgttggtgg attgtatcaa ggcacacagaaccatgctaa agtgcagttt ttgtgatgcc 720 attcaaccaa tcatctctgg cacgatatttgcccaattca tcatatgcgg atcgatcctg 780 ggcataatta tgatcaacat ggtattgttcgctgatcaat cgacccgatt cggcatagtc 840 atctacgtta tggccgtcct tctgcagacttttccgcttt gcttctactg caacgccatc 900 gtggacgact gcaaagaact ggcccacgcacttttccatt ccgcctggtg ggtgcaggac 960 aagcgatacc agcggactgt catccagttcctgcagaaac tgcagcagcc catgaccttc 1020 accgccatga acatatttaa cattaatttggccactaaca tcaatgtaag tccactgctc 1080 tcggttagaa cggggaagga agcaaagtccgaacttcaat ccttgcaggt agccaagttc 1140 gccttcaccg tgtacgccat cgcgagcggtatgaacctgg accaaaagtt aagcattaag 1200 gaa 1203 88 399 PRT DrosophilaMelanogaster DOR81 88 Met Met Glu Thr Leu Arg Asn Ser Gly Leu Asn LeuLys Asn Asp Phe 1 5 10 15 Gly Ile Gly Arg Lys Ile Trp Arg Val Phe SerPhe Thr Tyr Asn Met 20 25 30 Val Ile Leu Pro Val Ser Phe Pro Ile Asn TyrVal Ile His Leu Ala 35 40 45 Glu Phe Pro Pro Glu Leu Leu Leu Gln Ser LeuGln Leu Cys Leu Asn 50 55 60 Thr Trp Cys Phe Ala Leu Lys Phe Phe Thr LeuIle Val Tyr Thr His 65 70 75 80 Arg Leu Glu Leu Ala Asn Lys His Phe AspGlu Leu Asp Lys Tyr Cys 85 90 95 Val Lys Pro Ala Glu Lys Arg Lys Val ArgAsp Met Val Ala Thr Ile 100 105 110 Thr Arg Leu Tyr Leu Thr Phe Val ValVal Tyr Val Leu Tyr Ala Thr 115 120 125 Ser Thr Leu Leu Asp Gly Leu LeuHis His Arg Val Pro Tyr Asn Thr 130 135 140 Tyr Tyr Pro Phe Ile Asn TrpArg Val Asp Arg Thr Gln Met Tyr Ile 145 150 155 160 Gln Ser Phe Leu GluTyr Phe Thr Val Gly Tyr Ala Ile Tyr Val Ala 165 170 175 Thr Ala Thr AspSer Tyr Pro Val Ile Tyr Val Ala Ala Leu Arg Thr 180 185 190 His Ile LeuLeu Leu Lys Asp Arg Ile Ile Tyr Leu Gly Asp Pro Ser 195 200 205 Asn GluGly Ser Ser Asp Pro Ser Tyr Met Phe Lys Ser Leu Val Asp 210 215 220 CysIle Lys Ala His Arg Thr Met Leu Asn Phe Cys Asp Ala Ile Gln 225 230 235240 Pro Ile Ile Ser Gly Thr Ile Phe Ala Gln Phe Ile Ile Cys Gly Ser 245250 255 Ile Leu Gly Ile Ile Met Ile Asn Met Val Leu Phe Ala Asp Gln Ser260 265 270 Thr Arg Phe Gly Ile Val Ile Tyr Val Met Ala Val Leu Leu GlnThr 275 280 285 Phe Pro Leu Cys Phe Tyr Cys Asn Ala Ile Val Asp Asp CysLys Glu 290 295 300 Leu Ala His Ala Leu Phe His Ser Ala Trp Trp Val GlnAsp Lys Arg 305 310 315 320 Tyr Gln Arg Thr Val Ile Gln Phe Leu Gln LysLeu Gln Gln Pro Met 325 330 335 Thr Phe Thr Ala Met Asn Ile Phe Asn IleAsn Leu Ala Thr Asn Ile 340 345 350 Asn Val Ser Pro Leu Leu Ser Val ArgThr Gly Lys Glu Ala Lys Ser 355 360 365 Glu Leu Gln Ser Leu Gln Val AlaLys Phe Ala Phe Thr Val Tyr Ala 370 375 380 Ile Ala Ser Gly Met Asn LeuAsp Gln Lys Leu Ser Ile Lys Glu 385 390 395 89 1179 DNA DrosophilaMelanogaster DOR82 89 atggcatgca taccaagata tcaatggaaa ggacgccctactgaaagaca gttctacgct 60 tcggagcaaa ggatagtgtt ccttcttgga accatttgccagatattcca gattactgga 120 gtgcttatct attggtattg caatggccgt cttgccacggaaacgggcac ctttgtggca 180 caattatctg aaatgtgcag ttctttttgt ctaacatttgtgggattctg taacgtttat 240 gcgatctcta caaaccgcaa tcaaattgaa acattactcgaggagcttca tcagatatat 300 ccgagataca ggaaaaatca ctatcgctgc cagcattattttgacatggc catgacaata 360 atgagaattg agtttctttt ctatatgatc ttgtacgtgtactacaatag tgcaccatta 420 tgggtgcttc tttgggaaca cttgcacgag gaatatgatcttagcttcaa gacgcagacc 480 aacacttggt ttccatggaa agtccatggg tcggcacttggatttggtat ggctgtacta 540 agcataaccg tgggatcctt tgtgggcgta ggtttcagtattgtcaccca gaatcttatc 600 tgtttgttaa ccttccaact aaagttgcac tacgatggaatatccagtca gttagtatct 660 ctcgattgcc gtcgtcctgg agctcataag gagttgagcatcctcatcgc ccaccacagc 720 cgaatccttc agctgggcga ccaagtcaat gacataatgaactttgtatt cggctctagc 780 ctagtaggtg ccactattgc catttgtatg tcaagtgtttctataatgct actggactta 840 gcatctgcct tcaaatatgc cagtggtcta gtggcattcgtcctctacaa ctttgtcatc 900 tgctacatgg gaaccgaggt cactttagct gtgaagattggttcatatat ggacggaagg 960 cggtggatac ccaaagattc gttgctgaga tctcagaggctacaggtgct cgtcgcagtt 1020 ggatttttta atatatgtgt cctctcgaat cgtcgtcctaaaattgaaat tttgcttaga 1080 tattattacc atattatgtt ttattcattt aaattatatttttctttaag gaaaggtagc 1140 ctttggaaaa tcttgtcttc tttcacctta ttgaggatc1179 90 393 PRT Drosophila Melanogaster DOR82 90 Met Ala Cys Ile Pro ArgTyr Gln Trp Lys Gly Arg Pro Thr Glu Arg 1 5 10 15 Gln Phe Tyr Ala SerGlu Gln Arg Ile Val Phe Leu Leu Gly Thr Ile 20 25 30 Cys Gln Ile Phe GlnIle Thr Gly Val Leu Ile Tyr Trp Tyr Cys Asn 35 40 45 Gly Arg Leu Ala ThrGlu Thr Gly Thr Phe Val Ala Gln Leu Ser Glu 50 55 60 Met Cys Ser Ser PheCys Leu Thr Phe Val Gly Phe Cys Asn Val Tyr 65 70 75 80 Ala Ile Ser ThrAsn Arg Asn Gln Ile Glu Thr Leu Leu Glu Glu Leu 85 90 95 His Gln Ile TyrPro Arg Tyr Arg Lys Asn His Tyr Arg Cys Gln His 100 105 110 Tyr Phe AspMet Ala Met Thr Ile Met Arg Ile Glu Phe Leu Phe Tyr 115 120 125 Met IleLeu Tyr Val Tyr Tyr Asn Ser Ala Pro Leu Trp Val Leu Leu 130 135 140 TrpGlu His Leu His Glu Glu Tyr Asp Leu Ser Phe Lys Thr Gln Thr 145 150 155160 Asn Thr Trp Phe Pro Trp Lys Val His Gly Ser Ala Leu Gly Phe Gly 165170 175 Met Ala Val Leu Ser Ile Thr Val Gly Ser Phe Val Gly Val Gly Phe180 185 190 Ser Ile Val Thr Gln Asn Leu Ile Cys Leu Leu Thr Phe Gln LeuLys 195 200 205 Leu His Tyr Asp Gly Ile Ser Ser Gln Leu Val Ser Leu AspCys Arg 210 215 220 Arg Pro Gly Ala His Lys Glu Leu Ser Ile Leu Ile AlaHis His Ser 225 230 235 240 Arg Ile Leu Gln Leu Gly Asp Gln Val Asn AspIle Met Asn Phe Val 245 250 255 Phe Gly Ser Ser Leu Val Gly Ala Thr IleAla Ile Cys Met Ser Ser 260 265 270 Val Ser Ile Met Leu Leu Asp Leu AlaSer Ala Phe Lys Tyr Ala Ser 275 280 285 Gly Leu Val Ala Phe Val Leu TyrAsn Phe Val Ile Cys Tyr Met Gly 290 295 300 Thr Glu Val Thr Leu Ala ValLys Ile Gly Ser Tyr Met Asp Gly Arg 305 310 315 320 Arg Trp Ile Pro LysAsp Ser Leu Leu Arg Ser Gln Arg Leu Gln Val 325 330 335 Leu Val Ala ValGly Phe Phe Asn Ile Cys Val Leu Ser Asn Arg Arg 340 345 350 Pro Lys IleGlu Ile Leu Leu Arg Tyr Tyr Tyr His Ile Met Phe Tyr 355 360 365 Ser PheLys Leu Tyr Phe Ser Leu Arg Lys Gly Ser Leu Trp Lys Ile 370 375 380 LeuSer Ser Phe Thr Leu Leu Arg Ile 385 390 91 1209 DNA DrosophilaMelanogaster DOR83 91 atgcagttgg aggactttat gcggtacccg gacctcgtgtgtcaagcggc ccaacttccc 60 agatacacgt ggaatggcag acgatccttg gaagttaaacgcaacttggc aaaacgcatt 120 atcttctggc ttggagcagt aaatttggtt tatcacaatattggctgcgt catgtatggc 180 tatttcggtg atggaagaac aaaggatcca attgcgtatttagctgaatt ggcatctgtg 240 gccagcatgc ttggtttcac cattgtgggc accctcaacttgtggaagat gctgagcctt 300 aagacccatt ttgagaacct actaaatgaa ttcgaggaattatttcaact aatcaagcac 360 agggcgtatc gcatacacca ctatcaagaa aagtatacgcgtcatatacg aaatacattt 420 attttccata cctctgccgt tgtctactac aactcactaccaattcttct aatgattcgg 480 gaacatttct cgaactcaca gcagttgggc tatagaattcagagtaatac ctggtatccc 540 tggcaggttc agggatcaat tcctggattt tttgctgcagtcgcctgtca aatcttttcg 600 tgccaaacca atatgtgcgt caatatgttt atccagtttctgatcaactt ttttggtatc 660 cagctagaaa tacacttcga tggtttggcc aggcagctggagaccatcga tgcccgcaat 720 ccccatgcca aggatcaatt gaagtatctg attgtatatcacacaaaatt gcttaatcta 780 gccgacagag ttaatcgatc gtttaacttt acgtttctcataagtctgtc ggtatccatg 840 atatccaact gttttctggc attttccatg accatgttcgactttggcac ctctctaaaa 900 catttactcg gacttttgct attcatcaca tataatttttcaatgtgccg cagtggtacg 960 cacttgattt taacgagtgg caaagtattg ccagcggccttttataacaa ttggtatgaa 1020 ggcgatcttg tttatcgaag gatgctcctc atcctgatgatgcgtgctac gaaaccttat 1080 atgtggaaaa cctacaagct ggcacctgta tccataactacatatatggc agaatgcaaa 1140 acaaaagaag cccatgaaca acgccatttt agacgccatgaaagacaaaa acctcgggtt 1200 gcacgaata 1209 92 403 PRT DrosophilaMelanogaster DOR83 92 Met Gln Leu Glu Asp Phe Met Arg Tyr Pro Asp LeuVal Cys Gln Ala 1 5 10 15 Ala Gln Leu Pro Arg Tyr Thr Trp Asn Gly ArgArg Ser Leu Glu Val 20 25 30 Lys Arg Asn Leu Ala Lys Arg Ile Ile Phe TrpLeu Gly Ala Val Asn 35 40 45 Leu Val Tyr His Asn Ile Gly Cys Val Met TyrGly Tyr Phe Gly Asp 50 55 60 Gly Arg Thr Lys Asp Pro Ile Ala Tyr Leu AlaGlu Leu Ala Ser Val 65 70 75 80 Ala Ser Met Leu Gly Phe Thr Ile Val GlyThr Leu Asn Leu Trp Lys 85 90 95 Met Leu Ser Leu Lys Thr His Phe Glu AsnLeu Leu Asn Glu Phe Glu 100 105 110 Glu Leu Phe Gln Leu Ile Lys His ArgAla Tyr Arg Ile His His Tyr 115 120 125 Gln Glu Lys Tyr Thr Arg His IleArg Asn Thr Phe Ile Phe His Thr 130 135 140 Ser Ala Val Val Tyr Tyr AsnSer Leu Pro Ile Leu Leu Met Ile Arg 145 150 155 160 Glu His Phe Ser AsnSer Gln Gln Leu Gly Tyr Arg Ile Gln Ser Asn 165 170 175 Thr Trp Tyr ProTrp Gln Val Gln Gly Ser Ile Pro Gly Phe Phe Ala 180 185 190 Ala Val AlaCys Gln Ile Phe Ser Cys Gln Thr Asn Met Cys Val Asn 195 200 205 Met PheIle Gln Phe Leu Ile Asn Phe Phe Gly Ile Gln Leu Glu Ile 210 215 220 HisPhe Asp Gly Leu Ala Arg Gln Leu Glu Thr Ile Asp Ala Arg Asn 225 230 235240 Pro His Ala Lys Asp Gln Leu Lys Tyr Leu Ile Val Tyr His Thr Lys 245250 255 Leu Leu Asn Leu Ala Asp Arg Val Asn Arg Ser Phe Asn Phe Thr Phe260 265 270 Leu Ile Ser Leu Ser Val Ser Met Ile Ser Asn Cys Phe Leu AlaPhe 275 280 285 Ser Met Thr Met Phe Asp Phe Gly Thr Ser Leu Lys His LeuLeu Gly 290 295 300 Leu Leu Leu Phe Ile Thr Tyr Asn Phe Ser Met Cys ArgSer Gly Thr 305 310 315 320 His Leu Ile Leu Thr Ser Gly Lys Val Leu ProAla Ala Phe Tyr Asn 325 330 335 Asn Trp Tyr Glu Gly Asp Leu Val Tyr ArgArg Met Leu Leu Ile Leu 340 345 350 Met Met Arg Ala Thr Lys Pro Tyr MetTrp Lys Thr Tyr Lys Leu Ala 355 360 365 Pro Val Ser Ile Thr Thr Tyr MetAla Glu Cys Lys Thr Lys Glu Ala 370 375 380 His Glu Gln Arg His Phe ArgArg His Glu Arg Gln Lys Pro Arg Val 385 390 395 400 Ala Arg Ile 93 858DNA Drosophila Melanogaster DOR84 93 atggtgttta gtttttatgc cgaggtagcgactctggtgg acaggttacg cgataatgaa 60 aattttctcg agagctgcat cttactgagctacgtgtcct ttgtggtcat gggcctctcc 120 aagataggtg ctgtaatgaa aaaaaagccaaaaatgacag ctttggtcag gcaattggag 180 acctgctttc cgtcgccaag tgcaaaggttcaagaggaat atgctgtgaa gtcctggctg 240 aaacgctgcc atatatacac aaagggatttggtggtctct tcatgatcat gtatttcgct 300 cacgctctga ttcccttatt catatacttcattcaaagag tgctgctcca ctatccggat 360 gccaagcaga ttatgccgtt ttaccaactcgaaccttggg aatttcgcga ctcctggttg 420 ttttatccaa gctattttca ccagtcgtcggccggatata cggctacatg tggatccatt 480 gccggtgacc taatgatctt cgctgtggtcctgcaggtca tcatgcacta cgaaagactg 540 gccaaggttc ttagggagtt taagattcaagcccataacg cacccaatgg agctaaggag 600 gatataagga agttgcagtc cctagtcgccaatcacattg atatacttcg actcactgat 660 ctgatgaacg aggtctttgg aattcccttgttgctaaact ttattgcatc tgcgctgctg 720 gtctgcctgg tgggagttca attaaccatcgctttaagtc cagagtattt ttgcaagcag 780 atgctatttc tgatttccgt actgcttgaggtctatctcc tttgctcctt cagccagagg 840 ttaatagatg ctgtatgt 858 94 286 PRTDrosophila Melanogaster DOR84 94 Met Val Phe Ser Phe Tyr Ala Glu Val AlaThr Leu Val Asp Arg Leu 1 5 10 15 Arg Asp Asn Glu Asn Phe Leu Glu SerCys Ile Leu Leu Ser Tyr Val 20 25 30 Ser Phe Val Val Met Gly Leu Ser LysIle Gly Ala Val Met Lys Lys 35 40 45 Lys Pro Lys Met Thr Ala Leu Val ArgGln Leu Glu Thr Cys Phe Pro 50 55 60 Ser Pro Ser Ala Lys Val Gln Glu GluTyr Ala Val Lys Ser Trp Leu 65 70 75 80 Lys Arg Cys His Ile Tyr Thr LysGly Phe Gly Gly Leu Phe Met Ile 85 90 95 Met Tyr Phe Ala His Ala Leu IlePro Leu Phe Ile Tyr Phe Ile Gln 100 105 110 Arg Val Leu Leu His Tyr ProAsp Ala Lys Gln Ile Met Pro Phe Tyr 115 120 125 Gln Leu Glu Pro Trp GluPhe Arg Asp Ser Trp Leu Phe Tyr Pro Ser 130 135 140 Tyr Phe His Gln SerSer Ala Gly Tyr Thr Ala Thr Cys Gly Ser Ile 145 150 155 160 Ala Gly AspLeu Met Ile Phe Ala Val Val Leu Gln Val Ile Met His 165 170 175 Tyr GluArg Leu Ala Lys Val Leu Arg Glu Phe Lys Ile Gln Ala His 180 185 190 AsnAla Pro Asn Gly Ala Lys Glu Asp Ile Arg Lys Leu Gln Ser Leu 195 200 205Val Ala Asn His Ile Asp Ile Leu Arg Leu Thr Asp Leu Met Asn Glu 210 215220 Val Phe Gly Ile Pro Leu Leu Leu Asn Phe Ile Ala Ser Ala Leu Leu 225230 235 240 Val Cys Leu Val Gly Val Gln Leu Thr Ile Ala Leu Ser Pro GluTyr 245 250 255 Phe Cys Lys Gln Met Leu Phe Leu Ile Ser Val Leu Leu GluVal Tyr 260 265 270 Leu Leu Cys Ser Phe Ser Gln Arg Leu Ile Asp Ala ValCys 275 280 285 95 1155 DNA Drosophila Melanogaster DOR91 95 atggttcgttacgtgccccg gttcgctgat ggtcagaaag taaagttggc ttggcccttg 60 gcggtttttcggttaaatca catattctgg ccattggatc cgagcacagg gaaatggggc 120 cgatatctggacaaggttct agctgttgcg atgtccttgg tttttatgca acacaacgat 180 gcagagctgaggtacttgcg cttcgaggca agtaatcgga atttggatgc ctttctcaca 240 ggaatgccaacgtatttaat cctcgtggag gctcaattta gaagtcttca cattctactg 300 cacttcgagaagcttcagaa gtttttagaa atattctacg caaatattta tattgatccc 360 cgtaaggaacccgaaatgtt tcgaaaagtg gatggaaaga tgataattaa cagattagtt 420 tcggccatgtacggtgcagt tatctctctg tatctaatcg cacccgtttt ttccatcatt 480 aaccaaagcaaagattttct atactctatg atctttccgt tcgattcgga tcccttgtac 540 atatttgtgccactgctttt gacaaacgta tgggttggca ttgtaataga taccatgatg 600 ttcggggagacgaatttgtt gtgtgaacta attgtccacc taaatggtag ttatatgttg 660 ctcaagagggacttgcagtt ggccattgaa aagatattag ttgcaaggga ccgtccgcat 720 atggccaaacagctaaaggt tttaattaca aaaactctcc gaaagaatgt ggctctaaat 780 cagtttggccagcagctgga ggctcagtat actgtgcggg tttttattat gtttgcattc 840 gctgcgggccttttatgtgc tctttctttt aaggcttata cgacggattc cctcagcaca 900 atgtactaccttacccattg ggagcaaatc ctgcagtact ctacaaatcc cagcgaaaat 960 ctgcgattactaaagctcat taacttggcc attgagatga acagcaagcc cttctatgtg 1020 acagggctaaaatattttcg cgttagtctg caggctggct taaaacgtca aaagtttctg 1080 cggtctgccagctcatccac ccttagcacc gctgatgtgt tggcatttgc ttttgctttt 1140 actcgctggctgctt 1155 96 385 PRT Drosophila Melanogaster DOR91 96 Met Val Arg TyrVal Pro Arg Phe Ala Asp Gly Gln Lys Val Lys Leu 1 5 10 15 Ala Trp ProLeu Ala Val Phe Arg Leu Asn His Ile Phe Trp Pro Leu 20 25 30 Asp Pro SerThr Gly Lys Trp Gly Arg Tyr Leu Asp Lys Val Leu Ala 35 40 45 Val Ala MetSer Leu Val Phe Met Gln His Asn Asp Ala Glu Leu Arg 50 55 60 Tyr Leu ArgPhe Glu Ala Ser Asn Arg Asn Leu Asp Ala Phe Leu Thr 65 70 75 80 Gly MetPro Thr Tyr Leu Ile Leu Val Glu Ala Gln Phe Arg Ser Leu 85 90 95 His IleLeu Leu His Phe Glu Lys Leu Gln Lys Phe Leu Glu Ile Phe 100 105 110 TyrAla Asn Ile Tyr Ile Asp Pro Arg Lys Glu Pro Glu Met Phe Arg 115 120 125Lys Val Asp Gly Lys Met Ile Ile Asn Arg Leu Val Ser Ala Met Tyr 130 135140 Gly Ala Val Ile Ser Leu Tyr Leu Ile Ala Pro Val Phe Ser Ile Ile 145150 155 160 Asn Gln Ser Lys Asp Phe Leu Tyr Ser Met Ile Phe Pro Phe AspSer 165 170 175 Asp Pro Leu Tyr Ile Phe Val Pro Leu Leu Leu Thr Asn ValTrp Val 180 185 190 Gly Ile Val Ile Asp Thr Met Met Phe Gly Glu Thr AsnLeu Leu Cys 195 200 205 Glu Leu Ile Val His Leu Asn Gly Ser Tyr Met LeuLeu Lys Arg Asp 210 215 220 Leu Gln Leu Ala Ile Glu Lys Ile Leu Val AlaArg Asp Arg Pro His 225 230 235 240 Met Ala Lys Gln Leu Lys Val Leu IleThr Lys Thr Leu Arg Lys Asn 245 250 255 Val Ala Leu Asn Gln Phe Gly GlnGln Leu Glu Ala Gln Tyr Thr Val 260 265 270 Arg Val Phe Ile Met Phe AlaPhe Ala Ala Gly Leu Leu Cys Ala Leu 275 280 285 Ser Phe Lys Ala Tyr ThrThr Asp Ser Leu Ser Thr Met Tyr Tyr Leu 290 295 300 Thr His Trp Glu GlnIle Leu Gln Tyr Ser Thr Asn Pro Ser Glu Asn 305 310 315 320 Leu Arg LeuLeu Lys Leu Ile Asn Leu Ala Ile Glu Met Asn Ser Lys 325 330 335 Pro PheTyr Val Thr Gly Leu Lys Tyr Phe Arg Val Ser Leu Gln Ala 340 345 350 GlyLeu Lys Arg Gln Lys Phe Leu Arg Ser Ala Ser Ser Ser Thr Leu 355 360 365Ser Thr Ala Asp Val Leu Ala Phe Ala Phe Ala Phe Thr Arg Trp Leu 370 375380 Leu 385 97 1218 DNA Drosophila Melanogaster DOR92 97 atgtccgagtggttacgctt tctgaaacgc gatcaacagc tggatgtgta cttttttgca 60 gtgccccgcttgagtttaga cataatgggc tattggccgg gcaaaactgg tgatacatgg 120 ccctggagatccctgattca cttcgcaatc ctggccattg gcgtggccac cgaactgcat 180 gctggcatgtgttttctaga ccgacagcag attaccttgg cactggagac cctctgtcca 240 gctggcacatcggcggtcac gctgctcaag atgttcctaa tgctgcgctt tcgtcaggat 300 ctctccattatgtggaaccg cctgaggggc ctgctcttcg atcccaactg ggagcgaccc 360 gagcagcgggacatccggct aaagcactcg gccatggcgg ctcgcatcaa tttctggccc 420 ctgtcagccggattcttcac atgcaccacc tacaacctaa agccgatact gatcgcaatg 480 atattgtatctccagaatcg ttacgaggac ttcgtttggt ttacaccctt caatatgact 540 atgcccaaagttctgctaaa ctatccattt tttcccctga cctacatatt tattgcctat 600 acgggctatgtgaccatctt tatgttcggc ggctgtgatg gtttttattt cgagttctgt 660 gcccacctatcagctctttt cgaagtgctc caggcggaga tagaatcaat gtttagaccc 720 tacactgatcacttggaact gtcgccagtg cagctttaca ttttagagca aaagatgcga 780 tcagtaatcattaggcacaa tgccatcatc gatttgacca gattttttcg tgatcgctat 840 accattattaccctggccca ttttgtgtcc gccgccatgg tgattggatt cagcatggtt 900 aatctcctgacattgggcaa taatggtctg ggcgcaatgc tctatgtggc ctacacggtt 960 gccgctttgagccaactgct ggtttattgc tatggcggaa ctctggtggc cgaaagtagc 1020 actggtctgtgccgagccat gttctcctgt ccgtggcagc tttttaagcc taaacaacgt 1080 cgactcgttcagcttttgat tctcagatcg cagcgtcctg tttccatggc agtgccattc 1140 ttttcgccatcgttggctac ctttgctgcg attcttcaaa cttcgggttc cataattgcg 1200 ctggttaagtcctttcag 1218 98 406 PRT Drosophila Melanogaster DOR92 98 Met Ser GluTrp Leu Arg Phe Leu Lys Arg Asp Gln Gln Leu Asp Val 1 5 10 15 Tyr PhePhe Ala Val Pro Arg Leu Ser Leu Asp Ile Met Gly Tyr Trp 20 25 30 Pro GlyLys Thr Gly Asp Thr Trp Pro Trp Arg Ser Leu Ile His Phe 35 40 45 Ala IleLeu Ala Ile Gly Val Ala Thr Glu Leu His Ala Gly Met Cys 50 55 60 Phe LeuAsp Arg Gln Gln Ile Thr Leu Ala Leu Glu Thr Leu Cys Pro 65 70 75 80 AlaGly Thr Ser Ala Val Thr Leu Leu Lys Met Phe Leu Met Leu Arg 85 90 95 PheArg Gln Asp Leu Ser Ile Met Trp Asn Arg Leu Arg Gly Leu Leu 100 105 110Phe Asp Pro Asn Trp Glu Arg Pro Glu Gln Arg Asp Ile Arg Leu Lys 115 120125 His Ser Ala Met Ala Ala Arg Ile Asn Phe Trp Pro Leu Ser Ala Gly 130135 140 Phe Phe Thr Cys Thr Thr Tyr Asn Leu Lys Pro Ile Leu Ile Ala Met145 150 155 160 Ile Leu Tyr Leu Gln Asn Arg Tyr Glu Asp Phe Val Trp PheThr Pro 165 170 175 Phe Asn Met Thr Met Pro Lys Val Leu Leu Asn Tyr ProPhe Phe Pro 180 185 190 Leu Thr Tyr Ile Phe Ile Ala Tyr Thr Gly Tyr ValThr Ile Phe Met 195 200 205 Phe Gly Gly Cys Asp Gly Phe Tyr Phe Glu PheCys Ala His Leu Ser 210 215 220 Ala Leu Phe Glu Val Leu Gln Ala Glu IleGlu Ser Met Phe Arg Pro 225 230 235 240 Tyr Thr Asp His Leu Glu Leu SerPro Val Gln Leu Tyr Ile Leu Glu 245 250 255 Gln Lys Met Arg Ser Val IleIle Arg His Asn Ala Ile Ile Asp Leu 260 265 270 Thr Arg Phe Phe Arg AspArg Tyr Thr Ile Ile Thr Leu Ala His Phe 275 280 285 Val Ser Ala Ala MetVal Ile Gly Phe Ser Met Val Asn Leu Leu Thr 290 295 300 Leu Gly Asn AsnGly Leu Gly Ala Met Leu Tyr Val Ala Tyr Thr Val 305 310 315 320 Ala AlaLeu Ser Gln Leu Leu Val Tyr Cys Tyr Gly Gly Thr Leu Val 325 330 335 AlaGlu Ser Ser Thr Gly Leu Cys Arg Ala Met Phe Ser Cys Pro Trp 340 345 350Gln Leu Phe Lys Pro Lys Gln Arg Arg Leu Val Gln Leu Leu Ile Leu 355 360365 Arg Ser Gln Arg Pro Val Ser Met Ala Val Pro Phe Phe Ser Pro Ser 370375 380 Leu Ala Thr Phe Ala Ala Ile Leu Gln Thr Ser Gly Ser Ile Ile Ala385 390 395 400 Leu Val Lys Ser Phe Gln 405 99 1176 DNA DrosophilaMelanogaster DOR95 99 atgagcgaca aggtgaaggg aaaaaagcag gaggaaaaggatcaatcctt gcgggtgcaa 60 attctcgttt atcgctgcat gggcatcgat ttgtggagccccacgatggc gaatgaccgc 120 ccgtggctga cctttgtcac aatgggacca cttttcctgtttatggtgcc catgttcctg 180 gccgcccacg agtacatcac ccaggtgagc ctgctctccgacaccctggg ctccaccttc 240 gccagcatgc tcaccctggt caaattcctg ctcttctgctatcatcgcaa ggagttcgtc 300 ggcctgatct accacatcag ggccattctg gctaaagaaatcgaagtgtg gcctgatgcg 360 cgggaaatca tcgaggtgga gaaccaaagt gaccaaatgctcagtcttac gtacactcgc 420 tgttttggac tggctggaat ctttgcggcc ctgaagccctttgtgggcat catactctcc 480 tcgattcgcg gcgacgagat tcacctggag ctgccccacaacggcgttta cccgtacgat 540 ctccaggtgg tcatgtttta tgtgcccacc tatctgtggaatgtgatggc cagctatagt 600 gctgtaacca tggcactctg cgtggactcg ctgctcttctttttcaccta caacgtgtgc 660 gccattttca agatcgccaa gcaccggatg atccatctgccggcggtggg cggaaaggag 720 gagctggagg ggctcgtcca ggtgctgctg ctgcaccagaagggcctcca gatcgccgat 780 cacattgcgg acaagtaccg gccgctgatc tttttgcagttctttctgtc cgccttgcag 840 atctgcttca ttggattcca ggtggctgat ctgtttcccaatccgcagag tctctacttt 900 atcgcctttg tgggctcgct gctcatcgca ctgttcatctactcgaagtg cggcgaaaat 960 atcaagagtg ccagcctgga tttcggaaac gggctgtacgagaccaactg gaccgacttc 1020 tcgccaccca ctaaaagagc cctcctcatt gccgccatgcgcgcccagcg accttgccag 1080 atgaagggct actttttcga ggccagcatg gccaccttctcgacgattgt tcgctctgcc 1140 gtgtcgtaca tcatgatgtt gcgctccttt aatgcc 1176100 392 PRT Drosophila Melanogaster DOR95 100 Met Ser Asp Lys Val LysGly Lys Lys Gln Glu Glu Lys Asp Gln Ser 1 5 10 15 Leu Arg Val Gln IleLeu Val Tyr Arg Cys Met Gly Ile Asp Leu Trp 20 25 30 Ser Pro Thr Met AlaAsn Asp Arg Pro Trp Leu Thr Phe Val Thr Met 35 40 45 Gly Pro Leu Phe LeuPhe Met Val Pro Met Phe Leu Ala Ala His Glu 50 55 60 Tyr Ile Thr Gln ValSer Leu Leu Ser Asp Thr Leu Gly Ser Thr Phe 65 70 75 80 Ala Ser Met LeuThr Leu Val Lys Phe Leu Leu Phe Cys Tyr His Arg 85 90 95 Lys Glu Phe ValGly Leu Ile Tyr His Ile Arg Ala Ile Leu Ala Lys 100 105 110 Glu Ile GluVal Trp Pro Asp Ala Arg Glu Ile Ile Glu Val Glu Asn 115 120 125 Gln SerAsp Gln Met Leu Ser Leu Thr Tyr Thr Arg Cys Phe Gly Leu 130 135 140 AlaGly Ile Phe Ala Ala Leu Lys Pro Phe Val Gly Ile Ile Leu Ser 145 150 155160 Ser Ile Arg Gly Asp Glu Ile His Leu Glu Leu Pro His Asn Gly Val 165170 175 Tyr Pro Tyr Asp Leu Gln Val Val Met Phe Tyr Val Pro Thr Tyr Leu180 185 190 Trp Asn Val Met Ala Ser Tyr Ser Ala Val Thr Met Ala Leu CysVal 195 200 205 Asp Ser Leu Leu Phe Phe Phe Thr Tyr Asn Val Cys Ala IlePhe Lys 210 215 220 Ile Ala Lys His Arg Met Ile His Leu Pro Ala Val GlyGly Lys Glu 225 230 235 240 Glu Leu Glu Gly Leu Val Gln Val Leu Leu LeuHis Gln Lys Gly Leu 245 250 255 Gln Ile Ala Asp His Ile Ala Asp Lys TyrArg Pro Leu Ile Phe Leu 260 265 270 Gln Phe Phe Leu Ser Ala Leu Gln IleCys Phe Ile Gly Phe Gln Val 275 280 285 Ala Asp Leu Phe Pro Asn Pro GlnSer Leu Tyr Phe Ile Ala Phe Val 290 295 300 Gly Ser Leu Leu Ile Ala LeuPhe Ile Tyr Ser Lys Cys Gly Glu Asn 305 310 315 320 Ile Lys Ser Ala SerLeu Asp Phe Gly Asn Gly Leu Tyr Glu Thr Asn 325 330 335 Trp Thr Asp PheSer Pro Pro Thr Lys Arg Ala Leu Leu Ile Ala Ala 340 345 350 Met Arg AlaGln Arg Pro Cys Gln Met Lys Gly Tyr Phe Phe Glu Ala 355 360 365 Ser MetAla Thr Phe Ser Thr Ile Val Arg Ser Ala Val Ser Tyr Ile 370 375 380 MetMet Leu Arg Ser Phe Asn Ala 385 390 101 1170 DNA Drosophila MelanogasterDOR99 101 atggaggagt ttctgcgtcc gcagatgttc caggaggtgg ctcagatggtgcatttccag 60 tggcggagaa atccggtgga caacagcatg gtgaacgcat ccatggtccccttctgcttg 120 tcggcgtttc ttaatgtcct gtttttcggc tgcaatggtt gggacatcataggacatttt 180 tggctgggac atcctgccaa ccagaatccg cccgtgctta gcatcaccatttacttctcg 240 atcaggggat tgatgctata cctgaaacga aaggaaatcg ttgagtttgttaacgacttg 300 gatcgggagt gtccgcggga cttggtcagc cagttggaca tgcaaatggatgagacgtac 360 cgaaactttt ggcagcgcta tcgcttcatc cgtatctact cccatttgggtggtccgatg 420 ttctgcgttg tgccattagc tctattcctc ctgacccacg agggtaaagatactcctgtt 480 gcccagcacg agcagctcct tggaggatgg ctgccatgcg gtgtgcgaaaggacccaaat 540 ttctaccttt tagtctggtc cttcgacctg atgtgcacca cttgcggcgtctcctttttc 600 gttaccttcg acaacctatt caatgtgatg cagggacatt tggtcatgcatttgggccat 660 cttgctcgcc agttttcggc catcgatcct cgacagagtt tgaccgatgagaagcgattc 720 tttgtggatc ttaggttatt agttcagagg cagcagcttc ttaatggattgtgcagaaaa 780 tacaacgaca tctttaaagt ggccttcctg gtgagcaatt ttgtaggcgccggttccctc 840 tgcttctacc tctttatgct ctcggagaca tcagatgtcc ttatcatcgcccagtatata 900 ttacccactt tggtcctggt gggcttcaca tttgagattt gtctacggggaacccaactg 960 gaaaaggcgt cggagggact ggaatcgtcg ttgcgaagcc aggaatggtatttgggaagt 1020 aggcggtacc ggaagttcta tttgctctgg acgcaatatt gccagcgaacacagcaactg 1080 ggcgcctttg ggctaatcca agtcaatatg gtgcacttca ctgaaataatgcagctggcc 1140 tatagactct tcacttttct caaatctcat 1170 102 390 PRTDrosophila Melanogaster DOR99 102 Met Glu Glu Phe Leu Arg Pro Gln MetPhe Gln Glu Val Ala Gln Met 1 5 10 15 Val His Phe Gln Trp Arg Arg AsnPro Val Asp Asn Ser Met Val Asn 20 25 30 Ala Ser Met Val Pro Phe Cys LeuSer Ala Phe Leu Asn Val Leu Phe 35 40 45 Phe Gly Cys Asn Gly Trp Asp IleIle Gly His Phe Trp Leu Gly His 50 55 60 Pro Ala Asn Gln Asn Pro Pro ValLeu Ser Ile Thr Ile Tyr Phe Ser 65 70 75 80 Ile Arg Gly Leu Met Leu TyrLeu Lys Arg Lys Glu Ile Val Glu Phe 85 90 95 Val Asn Asp Leu Asp Arg GluCys Pro Arg Asp Leu Val Ser Gln Leu 100 105 110 Asp Met Gln Met Asp GluThr Tyr Arg Asn Phe Trp Gln Arg Tyr Arg 115 120 125 Phe Ile Arg Ile TyrSer His Leu Gly Gly Pro Met Phe Cys Val Val 130 135 140 Pro Leu Ala LeuPhe Leu Leu Thr His Glu Gly Lys Asp Thr Pro Val 145 150 155 160 Ala GlnHis Glu Gln Leu Leu Gly Gly Trp Leu Pro Cys Gly Val Arg 165 170 175 LysAsp Pro Asn Phe Tyr Leu Leu Val Trp Ser Phe Asp Leu Met Cys 180 185 190Thr Thr Cys Gly Val Ser Phe Phe Val Thr Phe Asp Asn Leu Phe Asn 195 200205 Val Met Gln Gly His Leu Val Met His Leu Gly His Leu Ala Arg Gln 210215 220 Phe Ser Ala Ile Asp Pro Arg Gln Ser Leu Thr Asp Glu Lys Arg Phe225 230 235 240 Phe Val Asp Leu Arg Leu Leu Val Gln Arg Gln Gln Leu LeuAsn Gly 245 250 255 Leu Cys Arg Lys Tyr Asn Asp Ile Phe Lys Val Ala PheLeu Val Ser 260 265 270 Asn Phe Val Gly Ala Gly Ser Leu Cys Phe Tyr LeuPhe Met Leu Ser 275 280 285 Glu Thr Ser Asp Val Leu Ile Ile Ala Gln TyrIle Leu Pro Thr Leu 290 295 300 Val Leu Val Gly Phe Thr Phe Glu Ile CysLeu Arg Gly Thr Gln Leu 305 310 315 320 Glu Lys Ala Ser Glu Gly Leu GluSer Ser Leu Arg Ser Gln Glu Trp 325 330 335 Tyr Leu Gly Ser Arg Arg TyrArg Lys Phe Tyr Leu Leu Trp Thr Gln 340 345 350 Tyr Cys Gln Arg Thr GlnGln Leu Gly Ala Phe Gly Leu Ile Gln Val 355 360 365 Asn Met Val His PheThr Glu Ile Met Gln Leu Ala Tyr Arg Leu Phe 370 375 380 Thr Phe Leu LysSer His 385 390 103 1917 DNA Drosophila Melanogaster DORA45 103ggcacgagct ggttccggaa agcctcatat ctcgtatctt aaagtatccc ggttaagcct 60taaagagtga aatgattgcc tagacgattg ctgcattact ggcactcaat taacccaagt 120gtaccagaca acaattacat ttgtattttt aaagttcaat agcaaggatg acaacctcga 180tgcagccgag caagtacacg ggcctggtcg ccgacctgat gcccaacatc cgggcgatga 240agtactccgg cctgttcatg cacaacttca cgggcggcag tgccttcatg aagaaggtgt 300actcctccgt gcacctggtg ttcctcctca tgcagttcac cttcatcctg gtcaacatgg 360ccctgaacgc cgaggaggtc aacgagctgt cgggcaacac gatcacgacc ctcttcttca 420cccactgcat cacgaagttt atctacctgg ctgttaacca gaagaatttc tacagaacat 480tgaatatatg gaaccaggtg aacacgcatc ccttgttcgc cgagtcggat gctcgttacc 540attcgatcgc actggcgaag atgaggaagc tgttctttct ggtgatgctg accacagtcg 600cctcggccac cgcctggacc acgatcacct tctttggcga cagcgtaaaa atggtggtgg 660accatgagac gaactccagc atcccggtgg agataccccg gctgccgatt aagtccttct 720acccgtggaa cgccagccac ggcatgttct acatgatcag ctttgccttt cagatctact 780acgtgctctt ctcgatgatc cactccaatc tatgcgacgt gatgttctgc tcttggctga 840tattcgcctg cgagcagctg cagcacttga agggcatcat gaagccgctg atggagctgt 900ccgcctcgct ggacacctac aggcccaact cggcggccct cttcaggtcc ctgtcggcca 960actccaagtc ggagctaatt cataatgaag aaaaggatcc cggcaccgac atggacatgt 1020cgggcatcta cagctcgaaa gcggattggg gcgctcagtt tcgagcaccc tcgacactgc 1080agtcctttgg cgggaacggg ggcggaggca acgggttggt gaacggcgct aatcccaacg 1140ggctgaccaa aaagcaggag atgatggtgc gcagtgccat caagtactgg gtcgagcggc 1200acaagcacgt ggtgcgactg gtggctgcca tcggcgatac ttacggagcc gccctcctcc 1260tccacatgct gacctcgacc atcaagctga ccctgctggc ataccaggcc accaaaatca 1320acggagtgaa tgtctacgcc ttcacagtcg tcggatacct aggatacgcg ctggcccagg 1380tgttccactt ttgcatcttt ggcaatcgtc tgattgaaga gagttcatcc gtcatggagg 1440ccgcctactc gtgccactgg tacgatggct ccgaggaggc caagaccttc gtccagatcg 1500tgtgccagca gtgccagaag gcgatgagca tatcgggagc gaaattcttc accgtctccc 1560tggatttgtt tgcttcggtt ctgggtgccg tcgtcaccta ctttatggtg ctggtgcagc 1620tcaagtaagt tgctgcgaag ctgatggatt tttgtaccag aaaagcgaat gccaagaagc 1680cacctaccgc cccttgcccc ctccgcactg tgcaaccagc aatatcacag agcaattata 1740acgcaaatta tatattttat acctgcgacg agcgagcctc gtggggcata atggagacat 1800tctggggcac atagaagcct gcaaatactt atcgattttg tacacgcgta gagcttttaa 1860tgtaaactca agatgcaaac taaataaatg tgtagtgaaa aaaaaaaaaa aaaaaaa 1917 104486 PRT Drosophila Melanogaster DORA45 104 Met Thr Thr Ser Met Gln ProSer Lys Tyr Thr Gly Leu Val Ala Asp 1 5 10 15 Leu Met Pro Asn Ile ArgAla Met Lys Tyr Ser Gly Leu Phe Met His 20 25 30 Asn Phe Thr Gly Gly SerAla Phe Met Lys Lys Val Tyr Ser Ser Val 35 40 45 His Leu Val Phe Leu LeuMet Gln Phe Thr Phe Ile Leu Val Asn Met 50 55 60 Ala Leu Asn Ala Glu GluVal Asn Glu Leu Ser Gly Asn Thr Ile Thr 65 70 75 80 Thr Leu Phe Phe ThrHis Cys Ile Thr Lys Phe Ile Tyr Leu Ala Val 85 90 95 Asn Gln Lys Asn PheTyr Arg Thr Leu Asn Ile Trp Asn Gln Val Asn 100 105 110 Thr His Pro LeuPhe Ala Glu Ser Asp Ala Arg Tyr His Ser Ile Ala 115 120 125 Leu Ala LysMet Arg Lys Leu Phe Phe Leu Val Met Leu Thr Thr Val 130 135 140 Ala SerAla Thr Ala Trp Thr Thr Ile Thr Phe Phe Gly Asp Ser Val 145 150 155 160Lys Met Val Val Asp His Glu Thr Asn Ser Ser Ile Pro Val Glu Ile 165 170175 Pro Arg Leu Pro Ile Lys Ser Phe Tyr Pro Trp Asn Ala Ser His Gly 180185 190 Met Phe Tyr Met Ile Ser Phe Ala Phe Gln Ile Tyr Tyr Val Leu Phe195 200 205 Ser Met Ile His Ser Asn Leu Cys Asp Val Met Phe Cys Ser TrpLeu 210 215 220 Ile Phe Ala Cys Glu Gln Leu Gln His Leu Lys Gly Ile MetLys Pro 225 230 235 240 Leu Met Glu Leu Ser Ala Ser Leu Asp Thr Tyr ArgPro Asn Ser Ala 245 250 255 Ala Leu Phe Arg Ser Leu Ser Ala Asn Ser LysSer Glu Leu Ile His 260 265 270 Asn Glu Glu Lys Asp Pro Gly Thr Asp MetAsp Met Ser Gly Ile Tyr 275 280 285 Ser Ser Lys Ala Asp Trp Gly Ala GlnPhe Arg Ala Pro Ser Thr Leu 290 295 300 Gln Ser Phe Gly Gly Asn Gly GlyGly Gly Asn Gly Leu Val Asn Gly 305 310 315 320 Ala Asn Pro Asn Gly LeuThr Lys Lys Gln Glu Met Met Val Arg Ser 325 330 335 Ala Ile Lys Tyr TrpVal Glu Arg His Lys His Val Val Arg Leu Val 340 345 350 Ala Ala Ile GlyAsp Thr Tyr Gly Ala Ala Leu Leu Leu His Met Leu 355 360 365 Thr Ser ThrIle Lys Leu Thr Leu Leu Ala Tyr Gln Ala Thr Lys Ile 370 375 380 Asn GlyVal Asn Val Tyr Ala Phe Thr Val Val Gly Tyr Leu Gly Tyr 385 390 395 400Ala Leu Ala Gln Val Phe His Phe Cys Ile Phe Gly Asn Arg Leu Ile 405 410415 Glu Glu Ser Ser Ser Val Met Glu Ala Ala Tyr Ser Cys His Trp Tyr 420425 430 Asp Gly Ser Glu Glu Ala Lys Thr Phe Val Gln Ile Val Cys Gln Gln435 440 445 Cys Gln Lys Ala Met Ser Ile Ser Gly Ala Lys Phe Phe Thr ValSer 450 455 460 Leu Asp Leu Phe Ala Ser Val Leu Gly Ala Val Val Thr TyrPhe Met 465 470 475 480 Val Leu Val Gln Leu Lys 485 105 1317 DNADrosophila melanogaster DOR44 105 atgaagagca cattcaagga agaaaggattaaggacgact ccaagcgtcg cgacctgttt 60 gtattcgtga ggcaaaccat gtgtatagcggccatgtatc ccttcggtta ctacgtgaat 120 ggatctggag tcctggccgt tctggtgcgattctgtgact tgacctacga gctctttaac 180 tacttcgttt cggtacacat agctggcctgtacatctgca ccatctacat caactatggg 240 caaggcgatt tggacttctt cgtgaactgtttgatacaaa ccattattta tctgtggaca 300 atagcgatga aactctactt tcggaggttcagacctggtt tgttgaatac cattctgtcc 360 aacatcaatg atgagtacga gacacgttcggctgtgggat tcagtttcgt cacaatggcg 420 ggatcctatc ggatgtccaa gctatggatcaaaacctatg tgtattgctg ctacataggc 480 accattttct ggctggctct tcccattgcctaccgggata ggagtcttcc tcttgcctgc 540 tggtatccct ttgactatac acaacccggtgtctatgagg tagtgttcct tctccaggcg 600 atgggacaga tccaagtggc cgcatcctttgcctcctcca gtggcctgca tatggtgctt 660 tgtgtgctga tatcagggca gtacgatgtcctcttttgca gtctcaagaa tgtattagcc 720 agcagctatg tccttatggg agccaatatgacggaactga atcaattgca ggctgagcaa 780 tctgcggccg atgtcgagcc aggtcagtatgcttactccg tggaggagga gacacctttg 840 caagaacttc taaaagttgg gagctcaatggacttctcct ccgcattcag gctgtctttt 900 gtgcggtgca ttcagcacca tcgatacatagtggcggcac tgaagaaaat tgagagtttc 960 tacagtccca tatggttcgt gaagattggcgaagtcacct ttcttatgtg cctggtagcc 1020 ttcgtctcca cgaagagcac cgcggccaactcattcatgc gaatggtctc cttgggccag 1080 tacctgctct tagttctcta cgagctgttcatcatctgct acttcgcgga catcgttttt 1140 cagaacagcc agcggtgcgg tgaagccctctggcgaagtc cttggcagcg acatttgaag 1200 gatgttcgca gtgattacat gttctttatgctgaattccc gcaggcagtt ccaacttacg 1260 gccggaaaaa taagcaatct aaacgtggatcgtttcagag gggtgggtat ccttact 1317 106 439 PRT Drosophila melanogasterDOR44 106 Met Lys Ser Thr Phe Lys Glu Glu Arg Ile Lys Asp Asp Ser LysArg 1 5 10 15 Arg Asp Leu Phe Val Phe Val Arg Gln Thr Met Cys Ile AlaAla Met 20 25 30 Tyr Pro Phe Gly Tyr Tyr Val Asn Gly Ser Gly Val Leu AlaVal Leu 35 40 45 Val Arg Phe Cys Asp Leu Thr Tyr Glu Leu Phe Asn Tyr PheVal Ser 50 55 60 Val His Ile Ala Gly Leu Tyr Ile Cys Thr Ile Tyr Ile AsnTyr Gly 65 70 75 80 Gln Gly Asp Leu Asp Phe Phe Val Asn Cys Leu Ile GlnThr Ile Ile 85 90 95 Tyr Leu Trp Thr Ile Ala Met Lys Leu Tyr Phe Arg ArgPhe Arg Pro 100 105 110 Gly Leu Leu Asn Thr Ile Leu Ser Asn Ile Asn AspGlu Tyr Glu Thr 115 120 125 Arg Ser Ala Val Gly Phe Ser Phe Val Thr MetAla Gly Ser Tyr Arg 130 135 140 Met Ser Lys Leu Trp Ile Lys Thr Tyr ValTyr Cys Cys Tyr Ile Gly 145 150 155 160 Thr Ile Phe Trp Leu Ala Leu ProIle Ala Tyr Arg Asp Arg Ser Leu 165 170 175 Pro Leu Ala Cys Trp Tyr ProPhe Asp Tyr Thr Gln Pro Gly Val Tyr 180 185 190 Glu Val Val Phe Leu LeuGln Ala Met Gly Gln Ile Gln Val Ala Ala 195 200 205 Ser Phe Ala Ser SerSer Gly Leu His Met Val Leu Cys Val Leu Ile 210 215 220 Ser Gly Gln TyrAsp Val Leu Phe Cys Ser Leu Lys Asn Val Leu Ala 225 230 235 240 Ser SerTyr Val Leu Met Gly Ala Asn Met Thr Glu Leu Asn Gln Leu 245 250 255 GlnAla Glu Gln Ser Ala Ala Asp Val Glu Pro Gly Gln Tyr Ala Tyr 260 265 270Ser Val Glu Glu Glu Thr Pro Leu Gln Glu Leu Leu Lys Val Gly Ser 275 280285 Ser Met Asp Phe Ser Ser Ala Phe Arg Leu Ser Phe Val Arg Cys Ile 290295 300 Gln His His Arg Tyr Ile Val Ala Ala Leu Lys Lys Ile Glu Ser Phe305 310 315 320 Tyr Ser Pro Ile Trp Phe Val Lys Ile Gly Glu Val Thr PheLeu Met 325 330 335 Cys Leu Val Ala Phe Val Ser Thr Lys Ser Thr Ala AlaAsn Ser Phe 340 345 350 Met Arg Met Val Ser Leu Gly Gln Tyr Leu Leu LeuVal Leu Tyr Glu 355 360 365 Leu Phe Ile Ile Cys Tyr Phe Ala Asp Ile ValPhe Gln Asn Ser Gln 370 375 380 Arg Cys Gly Glu Ala Leu Trp Arg Ser ProTrp Gln Arg His Leu Lys 385 390 395 400 Asp Val Arg Ser Asp Tyr Met PhePhe Met Leu Asn Ser Arg Arg Gln 405 410 415 Phe Gln Leu Thr Ala Gly LysIle Ser Asn Leu Asn Val Asp Arg Phe 420 425 430 Arg Gly Val Gly Ile LeuThr 435 107 363 PRT DROSOPHILA MELANOGASTER DOR61 107 Met Gly His LysAsp Asp Met Asp Ser Thr Asp Ser Thr Ala Leu Ser 1 5 10 15 Leu Lys HisIle Ser Ser Leu Ile Phe Val Ile Ser Ala Gln Tyr Pro 20 25 30 Leu Ile SerTyr Val Ala Tyr Asn Arg Asn Asp Met Glu Lys Val Thr 35 40 45 Ala Cys LeuSer Val Val Phe Thr Asn Met Leu Thr Val Ile Lys Ile 50 55 60 Ser Thr PheLeu Ala Asn Arg Lys Asp Phe Trp Glu Met Ile His Arg 65 70 75 80 Phe ArgLys Met His Glu Gln Cys Lys Tyr Arg Glu Gly Leu Asp Tyr 85 90 95 Val AlaGlu Ala Asn Lys Leu Ala Ser Phe Leu Gly Arg Ala Tyr Cys 100 105 110 ValSer Cys Gly Leu Thr Gly Leu Tyr Phe Met Leu Gly Pro Ile Val 115 120 125Lys Ile Gly Val Cys Arg Trp His Gly Thr Thr Cys Asp Lys Glu Leu 130 135140 Pro Met Pro Met Lys Phe Pro Phe Asn Asp Leu Glu Ser Pro Gly Tyr 145150 155 160 Glu Val Cys Phe Leu Tyr Thr Val Leu Val Thr Val Val Val ValAla 165 170 175 Tyr Ala Ser Ala Val Asp Gly Leu Phe Ile Ser Phe Ala IleAsn Leu 180 185 190 Arg Ala His Phe Gln Thr Leu Gln Arg Gln Ile Glu AsnTrp Glu Phe 195 200 205 Pro Ser Ser Glu Pro Asp Thr Gln Ile Arg Leu LysSer Ile Val Glu 210 215 220 Tyr His Val Leu Leu Leu Ser Leu Ser Arg LysLeu Arg Ser Ile Tyr 225 230 235 240 Thr Pro Thr Val Met Gly Gln Phe ValIle Thr Ser Leu Gln Val Gly 245 250 255 Val Ile Ile Tyr Gln Leu Val ThrAsn Met Asp Ser Val Met Asp Leu 260 265 270 Leu Leu Tyr Ala Ser Phe PheGly Ser Ile Met Leu Gln Leu Phe Ile 275 280 285 Tyr Cys Tyr Gly Gly GluIle Ile Lys Ala Glu Ser Leu Gln Val Asp 290 295 300 Thr Ala Val Arg LeuSer Asn Trp His Leu Ala Ser Pro Lys Thr Arg 305 310 315 320 Thr Ser LeuSer Leu Ile Ile Leu Gln Ser Gln Lys Glu Val Leu Ile 325 330 335 Arg AlaGly Phe Phe Val Ala Ser Leu Ala Asn Phe Pro Tyr Arg Leu 340 345 350 IleThr Leu Ile Lys Ser Ile Asp Ser Ile Cys 355 360 108 411 PRT DrosophilaMelanogaster DOR37 UNSURE (243)..(243) Unknown 108 Lys Val Asp Ser ThrArg Ala Leu Val Asn His Trp Arg Ile Phe Arg 1 5 10 15 Ile Met Gly IleHis Pro Pro Gly Lys Arg Thr Phe Trp Gly Arg His 20 25 30 Tyr Thr Ala TyrSer Met Val Trp Asn Val Thr Phe His Ile Cys Ile 35 40 45 Trp Val Ser PheSer Val Asn Leu Leu Gln Ser Asn Ser Leu Glu Thr 50 55 60 Phe Cys Glu SerLeu Cys Val Thr Met Pro His Thr Leu Tyr Met Leu 65 70 75 80 Lys Leu IleAsn Val Arg Arg Met Arg Gly Gln Met Ile Ser Ser His 85 90 95 Trp Leu LeuArg Leu Leu Asp Lys Arg Leu Gly Cys Asp Asp Glu Arg 100 105 110 Gln IleIle Met Ala Gly Ile Glu Arg Ala Glu Phe Ile Phe Arg Thr 115 120 125 IlePhe Arg Gly Leu Ala Cys Thr Val Val Leu Gly Ile Ile Tyr Ile 130 135 140Ser Ala Ser Ser Glu Pro Thr Leu Met Tyr Pro Thr Trp Ile Pro Trp 145 150155 160 Asn Trp Arg Asp Ser Thr Ser Ala Tyr Leu Ala Thr Ala Met Leu His165 170 175 Thr Thr Ala Leu Met Ala Asn Ala Thr Leu Val Leu Asn Leu SerSer 180 185 190 Tyr Pro Gly Thr Tyr Leu Ile Leu Val Ser Val His Thr LysAla Leu 195 200 205 Ala Leu Arg Val Ser Lys Leu Gly Tyr Gly Ala Pro LeuPro Ala Val 210 215 220 Arg Met Gln Ala Ile Leu Val Gly Tyr Ile His AspHis Gln Ile Ile 225 230 235 240 Leu Arg Xaa Val Ser Gly Asn Leu Ile SerGln Cys Lys Asn Phe Xaa 245 250 255 Ser Ile Ser Gly Val Leu Thr Phe IleGlu Arg Arg Met Tyr Thr His 260 265 270 Phe Gly Val Pro Asn Ile Phe IleVal Ile Glu Asp Tyr Tyr Ile Leu 275 280 285 Phe Leu Asn Tyr Ser Leu PheLys Ser Leu Glu Arg Ser Leu Ser Met 290 295 300 Thr Cys Phe Leu Gln PhePhe Ser Thr Ala Cys Ala Gln Cys Thr Ile 305 310 315 320 Cys Tyr Phe LeuLeu Phe Gly Asn Val Gly Ile Met Arg Phe Met Asn 325 330 335 Met Leu PheLeu Leu Val Ile Leu Thr Thr Glu Thr Leu Leu Leu Cys 340 345 350 Tyr ThrAla Glu Leu Pro Cys Lys Glu Gly Glu Ser Leu Leu Thr Ala 355 360 365 ValTyr Ser Cys Asn Trp Leu Ser Gln Ser Val Asn Phe Arg Arg Leu 370 375 380Leu Leu Leu Met Leu Ala Arg Cys Gln Ile Pro Met Ile Leu Val Ser 385 390395 400 Gly Val Ile Val Pro Ile Ser Met Lys Thr Phe 405 410

What is claimed is:
 1. An isolated nucleic acid molecule encoding aninsect odorant receptor.
 2. An isolated DNA, cDNA, genomic DNA,synthetic DNA or RNA of claim
 1. 3. An isolated nucleic acid molecule ofclaim 1, wherein the nucleic acid molecule encodes a Drosophila odorantreceptor.
 4. The isolated nucleic acid molecule of claim 3 whichcomprise: (a) one of the nucleic acid sequences as set forth in FIG. 8,(b) a sequence being degenerated to a sequence of (a) as a result of thegenetic code; or (c) a sequence encoding one of the amino acid sequencesas set forth in FIG.
 8. 5. A nucleic acid molecule of at least 12nucleotides capable of specifically hybridizing with the sequence of anucleic acid molecule of claim
 1. 6. A DNA, cDNA, genomic DNA, syntheticDNA or RNA of claim
 5. 7. A vector which comprises the isolated nucleicacid molecule of claim 1, or
 5. 8. An isolated nucleic acid molecule ofclaim 7 operatively linked to a regulatory element.
 9. A plasmid ofclaim
 8. 10. A host vector system for the production of a polypeptidehaving the biological activity of an insect odorant receptor whichcomprises the vector of claim 7 and a suitable host.
 11. A host vectorsystem of claim 10, wherein the suitable host is a bacterial cell, yeastcell, insect cell, or animal cell.
 12. A method of producing apolypeptide having the biological activity of an insect odorant receptorwhich comprising growing the host vector system of claim 11 underconditions permitting production of the polypeptide and recovering thepolypeptide so produced.
 13. A purified, insect odorant receptor.
 14. Apolypeptide encoded by the isolated nucleic acid molecule of claim 1.15. An antibody capable of specifically binding to an insect odorantreceptor.
 16. An antibody capable of competitively inhibiting thebinding of the antibody of claim
 15. 17. A monoclonal antibody of claim15 or
 16. 18. A method for identifying cDNA inserts encoding an insectodorant receptors comprising: (a) generating a cDNA library whichcontains clones carrying cDNA inserts from antennal or maxillary palpsensory neurons; (b) hybridizing nucleic acid molecules of the clonesfrom the cDNA libraries generated in step (a) with probes prepared fromthe antenna or maxillary palp neurons and probes from heads lackingantenna or maxillary palp neurons or from virgin female body tissue; (c)selecting clones which hybridized with probes from the antenna ormaxillary palp neurons but not from head lacking antenna or maxillarypalp neurons or virgin female body tissue; and (d) isolating cloneswhich carry the hybridized inserts, thereby identifying the insertsencoding odorant receptors.
 19. A method of claim 18, after step (c),further comprising: (a) amplifying the inserts from the selected clonesby polymerase chain reaction; (b) hybridizing the amplified inserts withprobes from the antennal or maxillary palp neurons; and (c) isolatingthe clones which carry the hybridized inserts, thereby identifying theinserts encoding the odorant receptors.
 20. A method of claim 19,wherein the probes are cDNA probes.
 21. The cDNA inserts identified bythe method of claim 18 or
 19. 22. A method for identifying DNA insertsencoding an insect odorant receptors comprising: (a) generating DNAlibraries which contain clones carrying inserts from a sample whichcontains at least one antennal or maxillary palp neuron; (b) contactingclones from the cDNA libraries generated in step (a) with nucleic acidmolecule of claim 5 in appropriate conditions permitting thehybridization of the nucleic acid molecules of the clones and thenucleic acid molecule; (c) selecting clones which hybridized with thenucleic acid molecule; and (d) isolating the clones which carry thehybridized inserts, thereby identifying the inserts encoding the odorantreceptors.
 23. A method to identify DNA inserts encoding an insectodorant receptors comprising: (a) generating DNA libraries which containclones with inserts from a sample which contains at least one antenna ormaxillary palp sensory neuron; (b) contacting the clones from the DNAlibraries generated in step (a) with appropriate polymerase chainreaction primers capable of specifically binding to nucleic acidmolecules encoding odorant receptors in appropriate conditionspermitting the amplification of the hybridized inserts by polymerasechain reaction; (c) selecting the amplified inserts; and (d) isolatingthe amplified inserts, thereby identifying the inserts encoding theodorant receptors.
 24. A method to isolate DNA molecules encoding insectodorant receptors comprising: (a) contacting a biological sample knownto contain nucleic acids with appropriate polymerase chain reactionprimers capable of specifically binding to nucleic acid moleculesencoding insect odorant receptors in appropriate conditions permittingthe amplification of the hybridized molecules by polymerase chainreaction; (b) isolating the amplified molecules, thereby identifying theDNA molecules encoding the insect odorant receptors.
 25. A method oftransforming cells which comprises transfecting a host cell with asuitable vector of claim
 7. 26. Transformed cells produced by the methodof claim
 25. 27. The transformed cells of claim 26, wherein the hostcells are not usually expressing odorant receptors.
 28. The transformedcells of claim 26, wherein the host cells are expressing odorantreceptors.
 29. A method of identifying a compound capable ofspecifically bind to an insect odorant receptor which comprisescontacting a transfected cells or membrane fractions of the transfectedcells of claim 26 with an appropriate amount of the compound underconditions permitting binding of the compound to such receptor,detecting the presence of any such compound Specifically bound to thereceptor, and thereby determining whether the compound specificallybinds to the receptor.
 30. A method of identifying a compound capable ofspecifically bind to an insect odorant receptor which comprisescontacting an appropriate amount of the purified odorant receptor ofclaim 13 with an appropriate amount of the compound under conditionspermitting binding of the compound to such purified receptor, detectingthe presence of any such compound specifically bound to the receptor,and thereby determining whether the compound specifically binds to thereceptor.
 31. A method of claim 30, wherein the purified receptor isembedded in a lipid bilayer.
 32. A method of identifying a compoundcapable of activating the activity of an insect odorant receptor whichcomprises contacting the transfected cells or membrane fractions of thetransfected cells of claim 26 with the compound under conditionspermitting the activation of a functional odorant receptor response, theactivation of the receptor indicating that the compound is capable ofactivating the activity of a odorant receptor.
 33. A method ofidentifying a compound capable of activating the activity of an odorantreceptor which comprises contacting a purified odorant receptor of claim13 with the compound under conditions permitting the activation of afunctional odorant receptor response, the activation of the receptorindicating that the compound is capable of activating the activity of aodorant receptor.
 34. A method of claim 33, wherein the purifiedreceptor is embedded in a lipid bilayer.
 35. A method of identifying acompound capable of inhibiting the activity of a odorant receptor whichcomprises contacting the transfected cells or membrane fractions of thetransfected cells of claim 26 with an appropriate amount of the compoundunder conditions permitting the inhibition of a functional odorantreceptor response, the inhibition of the receptor response indicatingthat the compound is capable of inhibiting the activity of a odorantreceptor.
 36. A method of identifying a compound capable of inhibitingthe activity of a odorant receptor which comprises contacting anappropriate amount of the purified odorant receptor of claim 13 with anappropriated amount of the compound under conditions permitting theinhibition of a functional odorant receptor response, the inhibition ofthe receptor response indicating that the compound is capable ofactivating the activity of a odorant receptor.
 37. A method of claim 30,wherein the purified receptor is embedded in a lipid bilayer.
 38. Amethod of claims 29, 30, 31, 32, 33, 34, 35, 36, or 37 wherein thecompound is not previously known.
 39. The compound identified by themethod of claim
 38. 40. A method of controlling pest populations whichcomprises identifying odorant ligands by the method of claims 29, 30,31, 32, 33, 34, 35, 36, or 37 which are alarm odorant ligands andspraying the desired area with the identified odorant ligands.
 41. Amethod of controlling a pest population which comprises identifyingodorant ligands by the method of claims 29, 30, 31, 32, 33, 34, 35, 36,or 37 which interfere with the interaction between the odorant ligandsand the odorant receptors which are associated with fertility.